Researchers are concerned about whether manipulations have the intended effects. Many journals and reviewers view manipulation checks favorably, and they are widely reported in prestigious journals. However, the prototypical manipulation check is a verbal (rather than behavioral) measure that always appears at the same point in the procedure (rather than its order being varied to assess order effects). Embedding such manipulation checks within an experiment comes with problems. While we conceptualize manipulation checks as measures, they can also act as interventions (...) which initiate new processes that would otherwise not occur. The default assumption that manipulation checks do not affect experimental conclusions is unwarranted. They may amplify, undo, or interact with the effects of a manipulation. Further, the use of manipulation checks in mediational analyses does not rule out confounding variables, as any unmeasured variables that correlate with the manipulation check may still drive the relationship. Alternatives such as nonverbal and behavioral measures as manipulation checks and pilot testing are less problematic. Reviewers should view manipulation checks more critically, and authors should explore alternative methods to ensure the effectiveness of manipulations. (shrink)

Diferentes investigaciones han abordado el fenómeno de cómo el jugador de ajedrez alcanza un nivel alto de experticia; sin embargo, la gran mayoría se han llevado a cabo desde una perspectiva en tercera persona, es decir, sin tomar en cuenta la experiencia subjetiva del ajedrecista. El presente trabajo tiene como objetivos: 1) analizar la experticia de ajedrecistas de nivel proficiente desde una perspectiva fenomenológica, esto es, desde la experiencia subjetiva del jugador; 2) señalar los estados internos que parecen ser cognitivamente (...) relevantes en las acciones de los ajedrecistas; 3) teorizar sobre el eventual papel que juega la intuición en las acciones de los jugadores de ajedrez. Para ello se realizó un estudio exploratorio con cinco jugadores de ajedrez durante una competencia de corte nacional en México, utilizando como método la entrevista microfenomenológica propuesta por Claire Petitmengin. Los resultados indican que hay regularidades en los estados internos de los jugadores a nivel intra e interpersonal asociadas implícitamente a momentos críticos de las partidas. Lo anterior permite ofrecer una definición operacional de la intuición y afirmar que esta, en efecto, forma parte de los procesos cognitivamente relevantes de los ajedrecistas de nivel proficiente, aunque las acciones de estos aún dependen, en buena medida, de los cálculos explícitos que realizan durante los momentos críticos. (shrink)

This paper analyzes the process of perceptual recalibration (PR) in light of two cases of technologically-mediated cognition: sensory substitution and perceptual modification. We hold that PR is a very useful concept - perhaps necessary - for explaining the adaptive capacity that natural perceptive systems display as they respond to functional demands from the environment. We also survey critically related issues, such as the role of learning, training, and nervous system plasticity in the recalibrating process. Attention is given to the interaction (...) between technology and cognition, and the case of epistemic prostheses is presented as an illustration. Finally, we address the following theoretical issues: (1) the dynamic character of spatial perception; (2) the role of functional demands in perception; (3) the nature and interaction of sensory modalities. We aim to show that these issues may be addressed empirically and conceptually - hence, the usefulness of sensory-substitution and perceptual-modification studies in the analysis of perception, technologically-mediated cognition, and cognition in general. (shrink)

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

In a variety of synaesthesia, photisms result from affect-laden stimuli as emotional words, or faces of familiar people. For R, who participated in this study, the sight of a familiar person triggers a mental image of "a human silhouette filled with colour". Subjective descriptions of synaesthetic experiences induced by the visual perception of people's figures and faces show similarities with the reports of those who claim to possess the ability to see the aura. It has been proposed that the purported (...) auric perception may be easily explained by the presence of a specific subtype of cross-modal perception. We analyse the subjective reports of four synaesthetes who experience colours in response to human faces and figures. These reports are compared with descriptions of alleged auric phenomena found in the literature and with claims made by experts in esoteric spheres. The discrepancies found suggest that both phenomena are phenomenologically and behaviourally dissimilar. (shrink)

We performed an EEG graph analysis on data from 31 typical readers and 24 dyslexics, recorded while they were engaged in an audiovisual task and during resting-state. The task simulates reading acquisition as participants learned new letter-sound mappings via feedback. EEG data was filtered for the delta, theta, alpha, and beta bands. We computed the Phase Lag Index to provide an estimate of the functional connectivity between all pairs of electrodes per band. Then, networks were constructed using a Minimum Spanning (...) Tree, a unique sub-graph connecting all nodes without loops, aimed at minimizing bias in between groups and conditions comparisons. Both groups showed a comparable accuracy increase during task blocks, indicating that they correctly learned the new associations. The EEG results revealed lower task-specific theta connectivity, and lower theta degree correlation over both rest and task recordings, indicating less network integration in dyslexics compared to typical readers. This pattern suggests a role of theta oscillations in dyslexia and may reflect differences in task engagement between the groups, although robust correlations between MST metrics and performance indices were lacking. (shrink)

Some properties and an algorithm for solving systems of multivariate polynomial equations over finite fields are presented. It is then shown how formulas of propositional logics can be translated into polynomials over finite fields in such a way that several logic problems are expressed in terms of algebraic problems. Consequently, algebraic properties and algorithms can be used to solve the algebraically-represented logic problems. The methods described herein combine and generalise those of various previous works.

In this article, we present results from a literature review of intrinsic, instrumental, and relational values of nature conducted for the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services, as part of the Methodological Assessment of the Diverse Values and Valuations of Nature. We identify the most frequently recurring meanings in the heterogeneous use of different value types and their association with worldviews and other key concepts. From frequent uses, we determine a core meaning for each value type, which is (...) sufficiently inclusive to serve as an umbrella over different understandings in the literature and specific enough to help highlight its difference from the other types of values. Finally, we discuss convergences, overlapping areas, and fuzzy boundaries between different value types to facilitate dialogue, reduce misunderstandings, and improve the methods for valuation of nature's contributions to people, including ecosystem services, to inform policy and direct future research. © 2023 The Author(s). Published by Oxford University Press on behalf of the American Institute of Biological Sciences. (shrink)

This book is a rich blend of analyses by leading experts from various cultures and disciplines. A compact introduction to a complex field, it illustrates biotechnology's profound impact upon the environment and society. Moreover, it underscores the vital relevance of cultural values. This book empowers readers to more critically assess biotechnology's value and effectiveness within both specific cultural and global contexts.

The idea that appearances provide justifications for beliefs—the principle of phenomenal conservatism—is self-evidently true. In the case of cognitive penetration, however, it seems that certain irrational etiologies of a belief may influence the epistemic quality of that belief. Susanna Siegel argues that these etiologies lead to ‘epistemic downgrade.’ Instead of providing us with a decisive objection, cognitive penetration calls for us to clarify our epistemic framework by understanding the formative parts of appearances. In doing so, the two different but inseparable (...) ideas of sensation and intellection provide us with a basis of our appearances. These appearances, in turn, provide us with the objective evidence needed to test our judgements. Thus, the extra-sensory concepts of intellectual identification and the appearances they help form become an epistemic groundwork. (shrink)

Metallothioneins (MTs) are ubiquitous proteins with the capacity to bind heavy metal ions (mainly Cd, Zn or Cu), and they have been found in animals, plants, eukaryotic and prokaryotic micro‐organisms. We have carried out a comparative analysis of ciliate MTs (Tetrahymena species) to well‐known MTs from other organisms, discussing their exclusive features, such as the presence of aromatic amino acid residues and almost exclusive cysteine clusters (CCC) present in cadmium‐binding metallothioneins (CdMTs), higher heavy metal‐MT stoichiometry values, and a strictly conserved (...) modular–submodular structure. Based on this last feature and an extensive gene duplication, we propose a possible model for the evolutionary history of T. thermophila MTs. We also suggest possible functions for these MTs from consideration of their differential gene expressions and discuss the potential use of these proteins and/or their gene promoters for designing molecular or whole‐cell biosensors for a fast detection of heavy metals in diverse polluted ecosystems. (shrink)

The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

Mary Gentile’s Giving Voice to Values presents an approach to ethics training based on the idea that most people would like to provide input in times of ethical conflict using their own values. She maintains that people recognize the lapses in organizational ethical judgment and behavior, but they do not have the courage to step up and voice their values to prevent the misconduct. Gentile has developed a successful initiative and following based on encouraging students and employees to learn how (...) to engage in communication or action to express their values within an organization’s formal and informal value system. The purpose of this analysis is to examine the Giving Voice to Values approach to empowering the individual to take action to deal with lapses in organizational ethics. We examine the role of Giving Voice to Values in business ethics education, considerations for implementing GVV, and recommendations for business educators and corporate ethics officers. We conclude that while GVV is an effective tool, it is not a comprehensive or holistic approach to ethics education and organizational ethics programs. (shrink)

Directional deep brain stimulation contacts provide greater spatial flexibility for therapy than traditional ring-shaped electrodes, but little is known about longitudinal changes of impedance and orientation. We measured monopolar and bipolar impedance of DBS contacts in 31 patients who underwent unilateral subthalamic nucleus deep brain stimulation as part of a randomized study. At different follow-up visits, patients were assigned new stimulation configurations and impedance was measured. Additionally, we measured the orientation of the directional lead during surgery, immediately after surgery, and (...) 1 year later. Here we contrast impedances in directional versus ring contacts with respect to local anatomy, active stimulation contact, and over time. Directional contacts display larger impedances than ring contacts. Impedances generally increase slightly over the first year of therapy, save for a transient decrease immediately post-surgery under general anesthesia during pulse generator placement. Local impedances decrease at active stimulation sites, and contacts in closest proximity to internal capsule display higher impedances than other anatomic sites. DBS leads rotate slightly in the immediate postoperative period but otherwise remain stable over the following year. These data provide useful information for setting clinical stimulation parameters over time. (shrink)

The initial stage for the discussion is the distinction between bona fide and fiat objects drawn by Barry Smith and collaborators in the context of formal ontology. This paper aims at both producing a rationale for introducing a hitherto unrecognized kind of object—here called ‘Interactive Fiat Objects’ (IFOs)—into the ontology of objects, and casting light on the relationship between embodied cognition and interactive ontology with the aid of the concepts of affordance and ad hoc category. I conclude that IFOs are (...) similar to fiat objects, affordances and ad hoc categories in a number of ways, yet they differ from these in important respects. Interaction is key to understanding the existence and peculiarities of IFOs. By adopting an embodied perspective on cognition, we can enrich our ontological typologies and highlight relevant features of our physical and symbolic environment that are otherwise overlooked. This should improve our understanding of object ontology and persuade us to include IFOs in our metaphysical inventories. (shrink)

The following dilemma is discussed: On the one hand, the growing impact of Technology of communication and information (ICT) in everyday habits seems to influence the dynamics of public opinion by reinforcing irrational beliefs and creating the impression that the autonomy of people’s opinion and decisions is just a myth. On the other hand, people seem to act most of the time, under the normal circumstances of daily life, in a rational way, as if their habitual actions result from relatively (...) autonomous decisions. A way out of this dilemma is suggested with the hypothesis that people can be rational most of the time, but nevertheless have their opinions influenced by insufficient, distorted information, or by previously acquired emotional dispositions. This hypothesis, in turn, is going to be scrutinized by considering, from a philosophical-interdisciplinary perspective, the role of rational choices in the dynamics of autonomous opinion. With illustrations of diagrams, we claim that the qualitative Complex Systems paradigm might help us to understand the possible role of emotional dispositions in the dynamics of autonomous opinion formation. (shrink)

Teniendo en cuenta que la filosofía es hija de la polis, a primera vista, el tema de la filosofía de la ciudad puede no revelar nada nuevo. De hecho, la filosofía y la ciudad cuentan una historia paralela. Es en el ágora, un espacio privilegiado para el ejercicio de la ciudadanía, donde la filosofía se desarrolla como debate de argumentos. Pero, aunque a lo largo de la historia las ciudades puedan reflejar un deseo civilizatorio, lo cierto es que la ciudad (...) contemporánea refleja muy poco de la realidad política de la polis, de la indiferenciación medieval entre lo público y lo privado o de la racionalidad normativa de la ciudad moderna. Las ciudades en el siglo xx, y especialmente en el siglo xxi, tienen que ver más con las relaciones sociales y económicas de la ciudad industrial y posindustrial. La progresiva mecanización del siglo xix y su extensión, en el siglo xx, a la automatización y a la digitalización, cambian definitivamente la forma en que nos relacionamos, pensamos y trabajamos —en resumen, cómo vivimos—. Con el establecimiento de un capitalismo de orden económico que afecta a todas las dimensiones de la vida de la ciudad, esta queda delimitada por el poder, revela las contradicciones de las sociedades urbanas diseñadas por los mercados y da lugar, según David Harvey, a la apropiación privada de la vida y los espacios. (shrink)

Open peer commentary on the article “Exploring the Depth of Dream Experience: The Enactive Framework and Methods for Neurophenomenological Research” by Elizaveta Solomonova & Xin Wei Sha. Upshot: Enaction and neurophenomenology are indeed appropriate and productive theoretical and methodological tools for studying perception. But moving from the perceptual domain to the hallucinatory and dreaming domain with these tools requires a prior careful examination of the similarities and differences across these domains. The authors point in the right direction for studying dream (...) experience, but underestimate the objective and subjective differences between domains, producing thereby both an unwarranted blurring of their boundaries and an unnecessary explanatory burden on the approach defended. (shrink)

The principle objective of a diagnosis is not to categorise symptoms, or group a combination of signs or clinical symptoms in a coherent way, but to cure a patient or improve their quality of life. Diagnoses that are technically correct, but do not seek this objective may become unnecessary labels which convert healthy people, or those who do not consider themselves to be sick, into patients. We propose a limitation of the diagnostic effort in order to reduce the iatrogenic consequences (...) of these unnecessary labels or diagnoses, a new imperative which, in Kantian terms, can be expressed as: examine and treat your patients in such a way that, at the very least, the effects of your actions always improve the quality of their lives. (shrink)

Many philosophers and scientists rightly take hallucinations to be phenomena that challenge in a most pressing way our theories of perception and cognition, and epistemology in general. However, very few challenge the received views on the hallucinatory experience and even fewer critically delve into the subject with both breadth and depth. There are all kinds of problems concerning hallucinations—including conceptual, methodological, and empirical issues—that call for a multilevel analysis and an interdisciplinary approach which in turn provide the detail and scope (...) that the subject demands. In this paper, I present and briefly discuss four interrelated problems: (1) definitions, (2) dependence on perception, (3) two views on hallucinations, and (4) methodology. Neglect or underestimation of these problems, among other things, continue to prevent a proper understanding of the concept and the corresponding experience, giving rise to misconceptions and even plain myths on the subject. Hallucinations do occur; but in order to productively investigate them (for whatever end), we first need to get clear on the concept and develop a suitable epistemological framework for their analysis. (shrink)

This paper analyzes the process of perceptual recalibration in light of two cases of technologically-mediated cognition: sensory substitution and perceptual modification. We hold that PR is a very useful concept — perhaps necessary — for explaining the adaptive capacity that natural perceptive systems display as they respond to functional demands from the environment. We also survey critically related issues, such as the role of learning, training, and nervous system plasticity in the recalibrating process. Attention is given to the interaction between (...) technology and cognition, and the case of epistemic prostheses is presented as an illustration. Finally, we address the following theoretical issues: the dynamic character of spatial perception; the role of functional demands in perception; the nature and interaction of sensory modalities. We aim to show that these issues may be addressed empirically and conceptually — hence, the usefulness of sensory-substitution and perceptual-modification studies in the analysis of perception, technologically-mediated cognition, and cognition in general. (shrink)

Nowadays, around half of the global population lives in urban areas. This rate is expected to increase up to two-thirds by the year 2050. Most studies analyze urban dynamics in wide geographic ranges, focusing mainly on cities. According to them, the global population is spatially distributed in two extremes: large urban agglomerations and rural deserts. However, this remark is excessively general and imprecise. For this reason, it remains essential to analyze these dynamics at other spatial scales. A close-up look in (...) thinly populated regions shows how urban dynamics are also noticeable. In this paper, we analyze spatiotemporal patterns of population distribution in a predominantly rural area by applying a local-scale approach. These patterns are represented by using spatial networks with nodes representing the human settlements and links showing hierarchies between nodes. This case study is conducted in a small municipality located in northwestern Spain. It is a predominantly rural area with a very particular spatial pattern of population distribution. (shrink)

The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the colinearity with rice (...) of ESTs assigned to the group 2 consensus bin map. A total of 2600 loci generated from 1110 ESTs were mapped to group 2 chromosomes by Southern hybridization onto wheat aneuploid chromosome and deletion stocks. A consensus map was constructed of 552 ESTs mapping to more than one group 2 chromosome. Regions of high gene density in distal bins and low gene density in proximal bins were found. Two interstitial gene-rich islands flanked by relatively gene-poor regions on both the short and long arms and having good synteny with rice were discovered. The map locations of two ESTs indicated the possible presence of a small pericentric inversion on chromosome 2B. Wheat chromosome group 2 was shown to share syntenous blocks with rice chromosomes 4 and 7. (shrink)

Background: Depressive disorder is one of the main health problems worldwide. Many risk factors have been associated with this pathology. However, while the association between risks factors and adult depression is well established, the mechanisms behind its impact remains poorly understood. A possible, yet untested explanation is the mediating impact of levels of personality functioning, i.e., impairments with regard to self and interpersonal.Method: Around 162 patients were assessed at the beginning of their therapy, with regard to risk factors, such as (...) sociodemographic, physical, hereditary, and adverse childhood experiences. Depressive symptoms and personality functioning were also measured. Associations between the related variables as well as other possible covariates were examined by means of zero-order correlations and bootstrapping-based mediation analysis.Results: Of all the risk factors taken into account, level of education and physical illness were associated with depression. On the other hand, the most significant predictor of depressive symptomatology was ACE, and this relationship was mediated by personality functioning. This indicates that patients presenting adverse childhood experiences are more likely to develop deficiencies in personality functioning, which in turn increases their likelihood of developing depressive symptomatology.Conclusion: These results reaffirm the importance of incorporating risk and vulnerability factors such as personality functioning in understanding depression. (shrink)

The páramos of Boyacá in Colombia are earmarked for delimitation to prevent the expansion of the agricultural frontier and protect endemic flora that contribute to water provision for cities. A varied conservation toolbox will be used, including the creation of protected areas for re-wilding and the ‘sustainable’ transitioning of livelihoods identified as environmentally destructive. Agriculture and cattle livestock farming has been identified for transitioning. Despite the negative discourse related to livestock holding, this paper argues that small-scale agropastoralism contributes to re-peasantisation (...) and provides the foundations for an agrobiodiverse conservation approach. Agropastoralism facilitates re-peasantisation through strong socio-economic networks, interconnected communities, the solidarity economy, and self-management of natural resources. Whilst, agropastoral mobility spatially binds social networks across large and disconnected spaces. Mobility is also fundamental to dynamic land access and pasture management, as it prevents over-grazing. This exemplifies how resilient socio-economic networks and mobile production strategies could be harnessed for agrobiodiversity, instead of land sparing and other sedentary ‘green’ economies. This paper makes conceptual contributions to ‘autonomy’ in re-peasantisation by empirically demonstrating the importance of mobile and flexible systems of production. It also makes a novel methodological contribution in applying a spatial lens that further unpacks how movement across the páramos facilitates autonomy and re-peasantisation. These themes are explored using interview data from 53 semi-structured interviews with key stakeholders and small-scale agropastoralists from across the páramos and field observation. The paper concludes by recommending a harnessing of agropastoral knowledge, to potentiate agrobiodiversity, for a more socio-ecologically just approach to farming and conservation in the páramos. (shrink)