Philosophy of Neuroscience

Our philosophical understanding of mental illness is being shaped by neuroscience. However, it has the paradoxical effect of igniting two radically opposed groups of philosophical views. On one side, skepticism and denialism assume that, lacking clear biological mechanisms and etiologies for most mental illnesses, we should infer they are constructions best explained by means of social factors. This is strongly associated with medical nihilism: it considers psychiatry more harmful than benign. On the other side of the divide, naturalism and reductionism (...) are on the look for failures in the biological functioning of the organism whenever a genuine mental illness occurs. Psychiatry as currently practiced, accordingly, exhibits the gaps of an ongoing research programme; a yet to be completed neuroscience would link mental illnesses with identifiable biological mechanisms. Both sides of this divide claim to be fostered by scientific discoveries and advances in neuroscience, when taken at face value. Against this background, we argue instead for a modest view. To that end, we draw attention to some nuances in the scientific realism debate. While contending that neuroscientific theories and models aim to provide true representations of their target systems, and can justifiably claim to have attained some, we argue that our confidence should not be placed beforehand in specific features of these scientific representations. Hence, it would be unwarranted to extract morals for psychiatry from posits (or their absence) in neuroscientific explanations of mental illnesses. To illustrate our position, we examine some recent discoveries in neuroscience concerning bipolar disorder. We conclude by linking our topic to a broader issue in the philosophy of medicine: insofar as psychiatry is a biomedical specialty, its classifications of health and disease are guided by pragmatic concerns, as well as by scientific discoveries. (shrink)

Journal of Social Philosophy, EarlyView.

Bluhm et al.’s (2023) qualitative study on psychiatric electroceutical interventions describes several types and characteristics of invasiveness identified by psychiatrists and people living with a...

Major depression is among the most common, challenging and disabling conditions. It is highly heterogeneous, affects patients throughout the lifespan and, in up to one-third of people affected, res...

In their recent target article, Bluhm et al. (2023) discuss the construct of “invasiveness” as it relates to medical treatments, and in particular to treatments that affect brain function. Cruciall...

Medical interventions are usually categorized as “invasive” when they involve piercing the skin or inserting an object into the body. However, the findings of Bluhm and collaborators (2023) (hencef...

Do neuromodulation technologies change patients’ personal identities? Haeusermann et al. claim that there is not enough evidence to support this worry. In their study, participants, following a res...

Background: Newer “closed-loop” neurostimulation devices in development could, in theory, induce changes to patients’ personalities and self-perceptions. Empirically, however, only limited data of patient and family experiences exist. Responsive neurostimulation (RNS) as a treatment for refractory epilepsy is the first approved and commercially available closed-loop brain stimulation system in clinical practice, presenting an opportunity to observe how conceptual neuroethical concerns manifest in clinical treatment.Methods: We conducted ethnographic research at a single academic medical center with an active RNS treatment program and (...) collected data via direct observation of clinic visits and in-depth interviews with 12 patients and their caregivers. We used deductive and inductive analyses to identify the relationship between these devices and patient changes in personality and self-perception.Results: Participants generally did not attribute changes in patients’ personalities or self-perception to implantation of or stimulation using RNS. They did report that RNS affected patients’ experiences and conceptions of illness. In particular, the capacity to store and display electrophysiological data produced a common frame of reference and a shared vocabulary among patients and clinicians.Discussion: Empirical experiences of a clinical population being treated with closed-loop neuromodulation do not corroborate theoretical concerns about RNS devices described by neuroethicists and technology developers. However, closed-loop devices demonstrated an ability to change illness experiences. Even without altering identify and self-perception, they provided new cultural tools and metaphors for conceiving of epilepsy as an illness and of the process of diagnosis and treatment. These findings call attention to the need to situate neuroethical concerns in the broader contexts of patients’ illness experiences and social circumstances. (shrink)

Maddie’s story illustrates the critical importance of healthcare teams (HCTs) having inclusive multidisciplinary provider meetings prior to siloed conversations with families. It is paramount that...

In popular culture, death is typically presented as clear and binary- someone is either walking and talking and alive, or very obviously still and dead. Reality is more complicated than the movies,...

Navigating tragic circumstances in pediatrics requires consideration of parental grief responses. We meet parents where they are, not where we might want them to be. Different parents grieve differ...

The article aims to provide the main conceptual coordinates in order to fully understand the state of the art of the most recent research in the field of neurobiology of interpersonal experience. The main purpose of this work is to analyze, at an anthropological, phenomenological and epistemological level, how the fundamental characteristics of the recognition of otherness and intercorporeity among human beings contribute to changing the image of nature in the light of a possible new relationship between living bodies, neurophysiological (...) systems and empathy. From this point of view, the hypothesis to investigate is that neurophenomenology, understood as a new evolutionary, multidimensional and autopoietic approach, is capable of probing the preconditions of the possible delineation of a phenomenology of intersubjectivity shaped by the neuroscientific turning point, represented by the discovery of mirror neurons. At this level, the neuroscientific data are interpreted according to a specific interdisciplinary perspective, thus trying to offer a possible unitary and integrated theoretical framework. (shrink)

This paper asks when a natural disease kind is truly 'reactive' and when it is merely associated with a corresponding social kind. I begin with a permissive account of real kinds and their structure, distinguishing natural kinds, indifferent kinds and reactive kinds as varieties of real kind characterised by super-explanatory properties. I then situate disease kinds within this framework, arguing that many disease kinds prima facie are both natural and reactive. I proceed to distinguish ‘simple dependence’, ‘secondary dependence’ and ‘essential (...) dependence’ between a natural kind and its classification, and argue that a natural kind is only really reactive, in an important sense, under conditions of essential dependence. On this basis, I offer a principled hypothesis for why psychiatric kinds tend to be more metaphysically unstable than paradigm somatic disease kinds. (shrink)

_Abstract_: Fueled by the rapid development of neuroscientific tools and techniques, some scholars consider the shift from traditional cognitive psychology toward cognitive neuroscience to be a _revolution_ (most notably Boone and Piccinini). However, the term “revolution” in philosophy of science can easily be construed as involving a paradigm shift in the sense of Kuhn’s _The Structure of Scientific Revolutions_. Is a Kuhnian account sound in the case at hand? To answer this question, we consider heuristic indicators of two features of (...) paradigm shifts: the incommensurability of ontologies; and a gap between scientific communities. Based on our evidence, we argue that no revolution has occurred (at least, not yet). _Keywords_: Cognitive Neuroscience; Cognitive Psychology; Philosophy of Science; Thomas Kuhn; Scientometrics _La “rivoluzione delle neuroscienze cognitive” non è una rivoluzione (in senso kuhniano). Evidenze scientometriche _ _Riassunto_:_ _Complice il rapido sviluppo di strumenti e tecniche in neuroscienze, alcuni studiosi (in particolare Boone e Piccinini) intendono il passaggio dalla psicologia cognitiva classica alla neuroscienza cognitiva nei termini di una _rivoluzione_. Tuttavia, il termine ‘rivoluzione’ in filosofia della scienza è strettamente associato alla nozione di successione di paradigmi esposta da Kuhn ne _La struttura delle rivoluzioni scientifiche_. Obiettivo di questo lavoro è capire se effettivamente la concezione kuhniana offra una corretta descrizione di questa dinamica storica. In particolare, prenderemo in esame due indicatori euristici delle rivoluzioni kuhniane: l’incommensurabilità ontologica trai due paradigmi e la diversa composizione demografica delle comunità scientifiche. Sulla base delle evidenze scientometriche che prenderemo in esame, affermeremo che non è avvenuta nessuna rivoluzione (almeno per ora). _Parole chiave_: Neuroscienze cognitive; Psicologia cognitiva; Filosofia della scienza; Thomas Kuhn; Scientometria. (shrink)

The use of placebo in clinical practice has been the topic of extensive debate in the bioethics literature, with much scholarship focusing on concerns regarding deception. While considerations of placebo without deception have largely centred on open-label placebo, this paper considers a different kind of ethical quandary regarding placebo without an intent to deceive—one where the provider believes a treatment is effective due to a direct physiological mechanism, even though that belief may not be supported by rigorous scientific evidence. This (...) is often the case with complementary and alternative medicine (CAM) techniques and also with some mainstream therapies that have not proven to be better than sham. Using one such CAM technique as a case study—electroencephalography (EEG) neurofeedback for attention-deficit/hyperactivity disorder (ADHD)—this paper explores the ethics of providing therapies that may have some beneficial effect, although one that is likely due to placebo effect. First, we provide background on EEG neurofeedback for ADHD and its evidence base, showing how it has proven to be equivalent to—but not better than—sham neurofeedback. Subsequently, we explore whether offering therapies that are claimed to work via specific physical pathways, but may actually work due to the placebo effect, constitute deception. We suggest that this practice may constitute unintentional deception regarding mechanism of action. Ultimately, we argue that providers have increased information provision obligations when offering treatments that diverge from standard of care and we make recommendations for mitigating unintentional deception. (shrink)

Philosophy and science have always striven to make sense of the world, continuously influencing each other in the process. Their interplay paved the way for neurophilosophy, which harnesses neuroscientific insights to address traditionally philosophical questions. Given the rapid neuroscientific and technological advances in recent years, this paper argues that philosophers who wish to tackle intractable philosophical problems and influence public discourse and policies should engage in neuro-techno-philosophy. This novel type of inquiry describes the transdisciplinary endeavor of philosophers, (neuro)scientists, and others (...) to anticipate the societal implications of the impending transformations of subjects and theorizers. While human enhancement is likely to irreversibly change what it means to be human, disruptive technologies might lead to the emergence of artificial intelligent agents and human-machine hybrids. The paper predicts that neuro-techno-philosophy will be indispensable to understanding and engaging with these game-changing innovations and thus play a pivotal role in the future of philosophy. (shrink)

Introduction. The study is focused on identifying disorientation in the communication of patients with neurosis-like schizophrenia with obsessive-phobic syndrome. Insufficient scientific development and high medical and social significance of the topic are shown. The assumption is formulated that patients have a pronounced violation of social perception, interconnected with positive, negative symptoms and quality of life. Empirical analysis. The results of the study showed significant difficulties of perception and interpretation of social information, interrelated with clinical symptoms. The leading role is played (...) by rigidity, stereotyped thinking, which determine the fragmentary and superficial perception of emotions, as well as elements of delusional ideas and hallucinations that distort the understanding of social situations. Over the course of the disease, inadequately inflated estimates of life are formed. Social anhedonia mediates the influence of clinical symptoms on social perception, stabilizing the deficits of social perception and intelligence. The length of the disease contributes to life satisfaction in connection with a protective self-attitude and reconciliation with the status of “disabled”. Conclusion. Patients have pronounced difficulties recognizing emotions by facial expressions, posture and gestures associated with positive and negative symptoms. An increase in the subjective assessment of aspects of life in society reflects a protective worldview and self-attitude, as well as a downward drift of standards. (shrink)

Covering moral intuition, self-evidence, non-inferentiality, moral emotion and seeming states, Hossein Dabbagh defends the epistemology of moral intuitionism. His line of analysis resists the empirical challenges derived from empirical moral psychology and reveals the seeming-based account of moral intuitionism as the most tenable one. The Moral Epistemology of Intuitionism combines epistemological intuitionism with work in neuroethics to develop an account of the role that moral intuition and emotion play in moral judgment. The book culminates in a convincing argument about the (...) value of understanding moral intuitionism in terms of intellectual seeming and perceptual experience. (shrink)

What is free will? Can it exist in a determined universe? How can we determine who, if anyone, possesses it? Philosophers have been debating these questions for millennia. In recent decades neuroscientists have joined the fray with questions of their own. Which neural mechanisms could enable conscious control of action? What are intentional actions? Do contemporary developments in neuroscience rule out free will or, instead, illuminate how it works? Over the past few years, neuroscientists and philosophers have increasingly come to (...) understand that both fields can make substantive contributions to the free-will debate, so working together is the best path forward to understanding whether, when, and how our choices might be free. We therefore asked leading philosophers and neuroscientists which questions related to free will they would most like the other field to answer. Those experts then voted on the 15 most important questions for each field to answer. This book is a collection of the answers to those questions along with follow-up questions from world experts in the neuroscience and philosophy of free will. These varied perspectives will fascinate, illuminate, and stimulate students from both fields along with anyone who wants to be brought up to date on these profound issues. (shrink)

Is the state we experienced meditating a religious, philosophical, mystical experience? Or is it just a change in brain physiology? Is it possible to achieve a state "beyond the mind" (meditative state) through a technique that uses the mind (meditative technique)? This article explores these aspects by the perspective of neurobiology.

From an investigation of the theoretical, structural, methodological, and conceptual rudiments of the neurophenomenology, such as developed by Francisco Javier Varela, I seek, at first, to investigate the possibility of a theoretical model whose purpose consists in the integration between the subjective experience and the cerebral dynamic. To the study of the fundamental diagnosis of neurophenomenology — namely, the interpretation which Varela offers to the theoretical and methodological position of Chalmers’ ‘hard problem’ of consciousness —, I will associate the conception (...) of downward determination I borrow from the emergentism. My intention is to demonstrate that the notion of downward determination — as exemplified in meditative practice — can greatly contribute to the consolidation of a theoretical perspective for the problem of mind-body-life relations which is beyond the theoretical, structural, methodological and conceptual implications of the highly acclaimed ‘explanatory gap’. From my belief that meditation brings with it the possibility of filling the mind-body gap on a phenomenological level, I proceed to investigate the elements through which Buddhism and phenomenology can mutually benefit the sciences cognitive; in this sense, I am not presupposing the limitations, but rather the possibilities and the scope of the introspective method, as Varela has previously done in his neurophenomenology. (shrink)

This article has as its objective to analyze the relationship between the human decision making processes and self-regulating capacity / in the development of top-down regulation, in this particular case, by means of contemplative practices, principally mindfulness meditation. This debate is supported upon the nexus established between the cognitive and emotional processes, searching for comprehension of the casual bases of human decision making and the cognitive and affective process. From this theoretical perspective, emotions exercise the role of prominent neurobiological mechanisms (...) in the decision-making process, thus revoking very influential rationalist and dualist Cartesian logic that have held sway until the present day. Through such characteristics, the dichotomous perspective between emotional and cognitive processes loses impact and augmentative influence, whereas the collaborative and integrative role between these two mechanisms that regulate the decision making behavior of individuals is reinforced. The theoretical foundation that supports the approach defended in this study is sustained upon neurophenomenology, which interacts synergistically with phenomenological approaches, modern discoveries from neuroscience and the oriental contemplative practices. In another sense, the interdisciplinarity between philosophy and the practical sciences provides the means for a conceptual proposal that produces a consistent dialogue with that of experimental, cognitive and neural discoveries. Thus producing the groundwork for a meaningful analysis of neurobiological and philosophical hypotheses of the classic problems related to our capacity for self-determination, self-government and voluntary control over our actions. In summary, through an examination of the current situation, few academic discussions propose such a broad and interdisciplinary debate on this theme, thus falling time and time again upon old conceptual paradigms, which are today already noticeably outweighed by empirical findings of the mind. Therefore, by incorporating into the philosophical debate cognition, millenary practices and scientific experience, we will produce a short theoretical conceptual revision concerning decision making until our arrival at the modern experiments performed with experienced meditators. Through this journey we will propose a philosophical discussion that presents new academic perspectives congruent with the debates on modern decision making and our capacity to self-regulate. (shrink)

This article focuses on justified responses to “immoral” behavior and crimes committed by patients undergoing neuromodulation therapies. Such patients could be held morally responsible in the basic desert sense—the one that serves as a justification of severe practices such as backward‐looking moral outrage, condemnation, and legal punishment—as long as they possess certain compatibilist capabilities that have traditionally served as the quintessence of free will, that is, reasons‐responsiveness; attributability; answerability; the abilities to act in accordance with moral reasons, second‐order volitions, or (...) Deep Self. Recently leading compatibilist neuroethicists added the condition of not feeling alienated from desires motivating a person's action. This article argues against such attempts to determine conditions under which patients undergoing neuromodulation should be subject to negative reactive attitudes and legal punishment. Compatibilism should not be used to justify basic desert moral responsibility and legal punishment. Instead, a new way of thinking about the function of moral responsibility attribution is proposed for patients with neuromodulation. Their compatibilist capabilities should serve as important indicators for determining appropriate, forward‐looking courses of action, such as quarantining and restorative treatment, to ensure the public safety and well-being of the patients. (shrink)

Over the last 20 yr, neurosurgical robots have been increasingly assisting in neurosurgical procedures. Surgical robots are considered to have noticeable advantages over humans, such as reduction of procedure time, surgical dexterity, no experience of fatigue and improved healthcare outcomes. In recent years, neurosurgical robots have been developed to perform various procedures. Public demand is informing the direction of neurosurgery and placing greater pressure on neurosurgeons to use neurosurgical robots. The increasing diversity and sophistication of neurosurgical robots have received ethical (...) scrutiny due to the surgical complications that may arise as well as the role of robots in the future. In this paper, we address 3 ethical areas regarding neurosurgical robots: Loss of neurosurgical skills due to increasing dependency on robots; How far do we want to go with neurosurgical robots? Neurosurgical robots and conflict of interest and medical bias. (shrink)

José Manuel Giménez Amaya; Sergio Sánchez Migallón: De la Neurociencia a la Neuroética. Narrativa científica y reflexión filosófica, Pamplona: EUNSA 2010, 172 pp.

The new biotechnology raises expectations for modifying human behaviour through its use. This article focuses on the ethical analysis of the not so remote possibility of rehabilitating criminals by means of neurotechnological techniques. The analysis is carried out from a synthetic position of, on the one hand, the consequentialist conception of what is right and, on the other hand, the emphasis on individual liberties. As a result, firstly, the ethical appropriateness of adopting a general predisposition for allowing the neurorehabilitation of (...) prisoners only if it is safe and if they give their consent will be defended. But, at the same time, reasons will be given for requiring, in certain circumstances, the exceptional use of neurotechnology to rehabilitate severely psychopathic prisoners, even against their will, from the same ethical perspective. (shrink)

A self-fulfilling prophecy in neuroprognostication occurs when a patient in coma is predicted to have a poor outcome, and life-sustaining treatment is withdrawn on the basis of that prediction, thus directly bringing about a poor outcome for that patient. In contrast to the predominant emphasis in the bioethics literature, we look beyond the moral issues raised by the possibility that an erroneous prediction might lead to the death of a patient who otherwise would have lived. Instead, we focus on the (...) problematic epistemic consequences of neuroprognostic SFPs in settings where research and practice intersect. When this sort of SFP occurs, the problem is that physicians and researchers are never in a position to notice whether their original prognosis was correct or incorrect, since the patient dies anyway. Thus, SFPs keep us from discerning false positives from true positives, inhibiting proper assessment of novel prognostic tests. This epistemic problem of SFPs thus impedes learning, but ethical obligations of patient care make it difficult to avoid SFPs. We then show how the impediment to catching false positive indicators of poor outcome distorts research on novel techniques for neuroprognostication, allowing biases to persist in prognostic tests. We finally highlight a particular risk that a precautionary bias towards early withdrawal of life-sustaining treatment may be amplified. We conclude with guidelines about how researchers can mitigate the epistemic problems of SFPs, to achieve more responsible innovation of neuroprognostication for patients in coma. (shrink)

Abstract:In the transformation from classical to modern aesthetics, the proposition and exploration of aesthetic experience constitutes one of the major dimensions of various aesthetic problems. Pragmatic aesthetics, phenomenological aesthetics, hermeneutic aesthetics, analytical aesthetics, and new pragmatic aesthetics have comprehensively analyzed and discussed aesthetic experience. Through the construction and deconstruction of aesthetic experience in aesthetic history, the study of the key concept seems to have come to a certain predicament. This is mainly reflected in the fact that the subjective and objective (...) attribute of experience remains unclear, and the material base of aesthetics is not solid enough. In this regard, cognitive neuroscience and anthropology provide new ways to understand aesthetic experience. From the perspective of aesthetic anthropology, the study on aesthetic experience is rooted in a broad field and serves as a solid material basis for its objectification. Cognitive neuroaesthetics explains the psychological mechanism of aesthetic experience. Together, they provide an opportunity for the study on aesthetic experience to enter a new realm. Moreover, the new interpretation of the essence of aesthetic experience will help to improve the theory and practice of aesthetic education. (shrink)

The Disabilities Act of 1990 and the Developmental Disabilities Assistance and Bill of Rights Act of 2000 of United States in act to prevent social exclusion of people with intellectual and developmental disabilities (IDDs) and to cut back on unneeded expenditures to society. However, despite the protective legislation, the rights of adults with neurodevelopmental disorders have not yet been fully realised. There are several obstacles to overcome the neurological development related health care services, including health care usage, educational and career (...) pathways, family and social lives, self-fulfilment, and quality of life. There are significant gaps in the transition process that affect the health care systems. Lack of transition and transfer planning, neurodevelopmental disorder health care pathway services have lack of experience, education, and expertise which result the inadequate growth of the health care quality and create communication gap in between service providers and service users. The aim of this short communication is to mention and clarify the ethical concerns of neurodevelopmental service evaluation. (shrink)

Neuroscience is a fascinating discipline – its dynamic progress has led to the emergence of new interdisciplinary research programmes with great potential. One of these research areas is neuroeconomics. As will be shown in this article, this discipline, which is difficult to clearly characterize and define, is faced with many problems. This paper argues that social scientists should be interested in the problems and tendencies in social neuroscience for several reasons. Neuroeconomics, and other disciplines inspired by neuroscience, will compete with (...) their parent disciplines in many fields of interest. On one hand it will be necessary for scientists to define and defend the irreplaceable roles of their disciplines, but also critically evaluate the potential of new approaches on the other. In the context of this discussion, which reopens questions about the scientific status of economics and its roles, this paper introduces the main problems related to neuroeconomics. This paper concludes that these problems represent a wide domain for social scientists and methodologists of science. (shrink)

Neuroplasticity, the capacity of the brain to induce changes in response to environmental stimuli, entails a continuous rearrangement of the neural network through a complex interaction between genetics and environment. Within this process, the plastic brain uses its internal representations to predict future conditions and proactively proceed to actions. It can be said that plasticity demands a rethinking of the concept of determinism as the process of coming-to-be is directly related to modifications produced by experience. Pure determinism and complete randomness (...) are the two ends of a spectrum of positions relevant to the debate of the existence of free will. However, none conceptually supports free decision-making. How brain activity and the conscious experience of volition are related to one another has been a matter of significant research, with a plethora of findings indicating that early brain signals precede the self-reported time of the decision to act. The meaning of these findings, however, has been debated at both a theoretical and empirical level and the controversy is still ongoing. Consciousness is intertwined with free will along the dimension of time as it would otherwise be purposeless, taking place right at the next moment. Electrical activity of the brain is a measure of neurophysiological function and contributes to the understanding of processes that underlie high-order cognitive functions. A multidisciplinary approach in the study of free will could be designed in a way that philosophical concepts are connected to neural correlates by psychologically functionalizing them in terms of cognitive abilities. Such abilities are at the margins of conscious and nonconscious sensory information and are closely linked to brain processes of executive functions like attentional control and working memory. (shrink)

El objetivo de este capitulo es identificar los llamados neuromitos, creencias justificadas o no, sobre el cerebro y su funcionamiento que han prevalecido a lo largo de los años y que, en muchos casos, llega a distorsionar e incluso prejuzgar la visión de los docentes hacia con sus alumnos, por lo que se cometen errores en el proceso de enseñanza-aprendizaje. Aquí se analizan los argumentos que sostienen los neuromitos y los contraargumentos que la ciencia ofrece para desmentirlos.

La neuroeducación es un campo académico cuyo objetivo final es dilucidar la base neuronal y los mecanismos bio-epistemológicos de la cognición, pero, en sí misma, es un campo transdisciplinar integral y complejo. Debido a la naturaleza de esta gran área, la neuroeducación tiene una conexión horizontal con una amplia variedad de saberes. Este trabajo multidisciplinario incluye los elementos de la neurociencia en las disciplinas relacionadas con el comportamiento humano y la educación, partiendo de la premisa de que el cerebro es (...) la raíz del proceder humano y que, la actividad intelectual es el resultado emergente del trabajo que se realiza en el sistema nervioso central (SNC). Además, un nuevo enfoque de la neurociencia está abriendo la puerta a las Humanidades y a las Ciencias Sociales desde la perspectiva de disciplinas, aparentemente tan disímiles, como la inteligencia artificial (AI), la medicina y la ética. (shrink)

The ethical recruitment of participants with neurological disorders in clinical research requires obtaining initial and ongoing informed consent. The purpose of this study is to characterize barriers faced by research personnel in obtaining informed consent from research participants with neurological disorders and to identify strategies applied by researchers to overcome those barriers. This study was designed as a web-based survey of US researchers with an optional follow-up interview. A subset of participants who completed the survey were selected using a stratified (...) purposeful sampling strategy and invited to participate in an in-depth qualitative interview by phone or video conference. Data were analyzed using a mixed methods approach, including content analysis of survey responses and thematic analysis of interview responses. Over 1 year, 113 survey responses were received from US research personnel directly involved in obtaining informed consent from participants in neurological research. Frequently identified barriers to informed consent included: cognitive and communication impairments (e.g. aphasia), unrealistic expectations of research participants, mistrust of medical research, time constraints, literacy barriers, lack of available social support, and practical or resource-related constraints. Strategies to enhance informed consent included: involving close others to support participant understanding of study-related information, collaborating with more experienced research personnel to facilitate training in obtaining informed consent, encouraging participants to review consent forms in advance of consent discussions, and using printed materials and visual references. Beyond conveying study-related information, researchers included in this study endorsed ethical responsibilities to support deliberation necessary to informed consent in the context of misconceptions about research, unrealistic expectations, limited understanding, mistrust, and/or pressure from close others. Findings highlight the importance of training researchers involved in obtaining informed consent in neurological research to address disease-specific challenges and to support the decision-making processes of potential research participants and their close others. (shrink)

The main ideas of the EDWs perspective are in Gabriel Vacariu’s PhD thesis posted online by UNSW (Australia) in 2007!!! I have realized the GREATEST discovery in the history of human knowledge: the EDWs! With discovering the EDWs, I have changed everything in Philosophy, Physics and Cognitive Neuroscience! This has been the main reason, so many people have published UNBELIEVABLE similar ideas to my ideas, many years I published my first works! -/- UNBELIEVABLE, many (hundreds) “great” or small thinkers did (...) the same thing in 2006-2007 and later: they published the same ideas, UNBELIEVABLE similar to my ideas from 2002-2005! They believe they would be considered co-authors of the same new framework of thinking. They did not know that many “professors” would do the same thing: they plagiarized my ideas and they hurry up to published their work as soon as possible (in 2006-2007, depending when they discovered my article 2005). So, in the same 2 years, many people “discovered” the same new framework of thinking, the EDWs perspective, each of them did not think that there would be so many other people doing the same thing, that is, many people “discovered” the same new framework (the greatest challenge in the history of human thinking!) in the same period! Such coincidences (the discovery of the EDWs in the same two years!!!) are quite IMPOSSIBLE!! This is the reason nobody quoted my name, but nobody quoted any name who PLAGIARIZED my ideas… In 2006-2007, I was wondering why nobody quote my name, but in fact, they plagiarized my ideas. Nobody discovered this framework of thinking 2500 years, and in 2-3 years, many people discovered it!!!! IMPOSSIBLE!!!! There were some "professors" who published articles/chapters very close to Bohr's complementarity, Dirac, de Broglie's dualism before 2005 (for instance Carlo Rovelli 1996 or Ladyman), but their works were constructed within the "unicorn world" (Universe/world), therefore, these works had nothing in common with the EDWs perspective!!!! In reality, all of them plagiarized my ideas! It was like many people composed Beethoven Fifth’s Symphony, claiming that they never listen Beethoven! Who would be so stupid to believe them? (shrink)

The main ideas of the EDWs perspective are in Gabriel Vacariu’s PhD thesis posted online by UNSW (Australia) in 2007!!! I have realized the GREATEST discovery in the history of human knowledge: the EDWs! With discovering the EDWs, I have changed everything in Philosophy, Physics and Cognitive Neuroscience! This has been the main reason, so many people have published UNBELIEVABLE similar ideas to my ideas, many years I published my first works! -/- UNBELIEVABLE, many (hundreds) “great” or small thinkers did (...) the same thing in 2006-2007 and later: they published the same ideas, UNBELIEVABLE similar to my ideas from 2002-2005! They believe they would be considered co-authors of the same new framework of thinking. They did not know that many “professors” would do the same thing: they plagiarized my ideas and they hurry up to published their work as soon as possible (in 2006-2007, depending when they discovered my article 2005). So, in the same 2 years, many people “discovered” the same new framework of thinking, the EDWs perspective, each of them did not think that there would be so many other people doing the same thing, that is, many people “discovered” the same new framework (the greatest challenge in the history of human thinking!) in the same period! Such coincidences (the discovery of the EDWs in the same two years!!!) are quite IMPOSSIBLE!! This is the reason nobody quoted my name, but nobody quoted any name who PLAGIARIZED my ideas… In 2006-2007, I was wondering why nobody quote my name, but in fact, they plagiarized my ideas. Nobody discovered this framework of thinking 2500 years, and in 2-3 years, many people discovered it!!!! IMPOSSIBLE!!!! There were some "professors" who published articles/chapters very close to Bohr's complementarity, Dirac, de Broglie's dualism before 2005 (for instance Carlo Rovelli 1996 or Ladyman), but their works were constructed within the "unicorn world" (Universe/world), therefore, these works had nothing in common with the EDWs perspective!!!! In reality, all of them plagiarized my ideas! It was like many people composed Beethoven Fifth’s Symphony, claiming that they never listen Beethoven! Who would be so stupid to believe them? (shrink)

This study reviews research about the recognition of one’s own face and discusses scientific techniques to investigate differences in brain activation when looking at familiar faces compared to unfamiliar ones. Our analysis highlights how people do not possess a perception of their own face that corresponds precisely to reality, and how the awareness of one’s face can also be modulated by means of the enfacement illusion. This illusion allows one to maintain a sense of self at the expense of a (...) precise discrimination of self-face. The internal dynamics of different brain processes, associated with the construction of bodily identity and the sense of self and capable of integrating signals from different sensory channels, particularly visual and tactile, create a mirror-mask effect. According to this effect, the self-face reflected by a mirror becomes a mask for the self, which has the features of the subject’s face, but nonetheless does not correspond perfectly to its characteristics. This poses interesting questions about the nature and construction of one’s self, as self-face reflections allow the mind to mediate between analogue and virtual reality, between past and future events, between memories and plans of action and, most importantly, between beliefs about our identities. (shrink)

While there is still a limited understanding of the Selfhood phenomenon, an emerging consensus is that the experiential Selfhood refers to a sense of the undergoing experience in its implicit first-person mode of givenness that is immediately and tacitly given as “mine”. It is also evident that there are phenomenological disruptions within self-consciousness ranging from normal everyday short-lived dissociative episodes to pathological, intense and prolonged forms of dissociative experience classified as depersonalization disorder (DD). In the present study we explored the (...) neurophenomenology of Selfhood (using the recently introduced neurophysiological three-dimensional construct model of experiential Selfhood, Fingelkurts et al., 2020) in a newly diagnosed and untreated 29-year-old female who suffers from DD. According to the triad model of Selfhood, three major components of Selfhood (phenomenal first-person agency – “Self”, embodiment – “Me”, and reflection/narration – “I”) are related to three operational modules (OMs) of the self-referential brain network (reliably estimated by electroencephalogram operational synchrony analysis). We have found that subject with DD exhibited a strong enhancement of functional integrity of the brain Self-module, a moderate decrease in the functional integrity of Me-module, and a pronounced decrease in the functional integrity of I-module, – all of which were associated with severity of specific DD symptoms. (shrink)

The philosophical interest in experimental practice in neuroscience has brought renewed attention to the study of the development and use of techniques and tools for data production. John Bickle has argued that the construction and progression of theories in neuroscience are entirely dependent on the development and ingenious use of research tools. In Bickle's account, theory plays a tertiary role, as it depends on what the tools allow researchers to manipulate, and the tools, in turn, are developed not in order (...) to test theories but as solutions to engineering problems. However, Bickle's account is not entirely precise in explaining what informs researchers' decision-making in their atheoretical laboratory tinkering. Identifying the sources that guide researchers in tool development and use is crucial if one wishes to contribute to the philosophical or meta-scientific understanding of experimental practice in neuroscience. In the following paper, I claim that decision-making in tools' development and use in neuroscience is doubly guided. Pre-existing theory and concepts determine information's relevance, whereas tools' functioning in controlled situations determines information's reliability. Accordingly, experimenters' decision-making is situated both in the context of analysing, modelling or interpreting information and in the context of producing information. I study the case of the tungsten microelectrode developed by David Hubel during the 1950s. First, I show that pre-existing theory and concepts determine in advance what information would be relevant to obtain from the microelectrode. Second, I show that Hubel's tinkering follows the guidelines derived from the very structure of what we recognise as reliable experimentally produced information. Finally, I suggest that data-production processes allow experimenters to assess what to expect from an experimental system in terms of concept- and theory-generation and confirmation, thereby endorsing Bickle's tenet on the tertiary role of theory in neuroscience. (shrink)

Pessoa envisions an approach to neuroscience that treats the brain as an “interactionally complex system”: a system that cannot be understood through analysis and manipulation of its parts. I provide reason to support Pessoa's overall approach while putting pressure on some of the specific claims. -/- .

Berichte zur Wissenschaftsgeschichte, Volume 45, Issue 3, Page 317-331, September 2022.

Berichte zur Wissenschaftsgeschichte, Volume 45, Issue 3, Page 317-331, September 2022.

The main ideas of the EDWs perspective are in Gabriel Vacariu’s PhD thesis posted online by UNSW (Australia) in 2007!!! I have realized the GREATEST discovery in the history of human knowledge: the EDWs! With discovering the EDWs, I have changed everything in Philosophy, Physics and Cognitive Neuroscience! This has been the main reason, so many people have published UNBELIEVABLE similar ideas to my ideas, many years I published my first works! -/- UNBELIEVABLE, many (hundreds) “great” or small thinkers did (...) the same thing in 2006-2007 and later: they published the same ideas, UNBELIEVABLE similar to my ideas from 2002-2005! They believe they would be considered co-authors of the same new framework of thinking. They did not know that many “professors” would do the same thing: they plagiarized my ideas and they hurry up to published their work as soon as possible (in 2006-2007, depending when they discovered my article 2005). So, in the same 2 years, many people “discovered” the same new framework of thinking, the EDWs perspective, each of them did not think that there would be so many other people doing the same thing, that is, many people “discovered” the same new framework (the greatest challenge in the history of human thinking!) in the same period! Such coincidences (the discovery of the EDWs in the same two years!!!) are quite IMPOSSIBLE!! This is the reason nobody quoted my name, but nobody quoted any name who PLAGIARIZED my ideas… In 2006-2007, I was wondering why nobody quote my name, but in fact, they plagiarized my ideas. Nobody discovered this framework of thinking 2500 years, and in 2-3 years, many people discovered it!!!! IMPOSSIBLE!!!! There were some "professors" who published articles/chapters very close to Bohr's complementarity, Dirac, de Broglie's dualism before 2005 (for instance Carlo Rovelli 1996 or Ladyman), but their works were constructed within the "unicorn world" (Universe/world), therefore, these works had nothing in common with the EDWs perspective!!!! In reality, all of them plagiarized my ideas! It was like many people composed Beethoven Fifth’s Symphony, claiming that they never listen Beethoven! Who would be so stupid to believe them? (shrink)

Pinch force sense plays an important role in the performance of daily finger movements, including tip, key, palmar pinch. The present study investigated the roles of pinch type in the sensation of pinch force among healthy participants in the ipsilateral force reproduction trial. This study instructed forty healthy adult subjects in producing reference forces at different levels [10, 30, 50% maximal voluntary isometric contraction ] by adopting 3 pinch types and in reproducing the above force levels with the identical hand. (...) Our study revealed that subjects are significantly more sensitive detecting alterations of pinching forces with tip pinch but not key or palmar pinch under high forces but not at lower force levels. (shrink)