Genetics and Molecular Biology

Edited by Yafeng Shan (Hong Kong University of Science and Technology)
Related

Contents
3697 found
Order:
1 — 50 / 3697
Material to categorize
  1. Les marqueurs du vivant : génétique et big data.Sophie Gerber & Stéphanie Mariette - 2023 - Terrestres 25.
    Comment imaginer une pratique scientifique qui résiste aux impératifs de la croissance, du big data et de l'innovation perpétuelle ? Deux chercheuses en génétique des populations réfléchissent ici aux évolutions récentes de leur discipline et à ses devenirs possibles.
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  2. A Wolf in Sheep's Clothing: Idealisations and the aims of polygenic scores.Davide Serpico - 2023 - Studies in History and Philosophy of Science Part A 102 (C):72-83.
    Research in pharmacogenomics and precision medicine has recently introduced the concept of Polygenic Scores (PGSs), namely, indexes that aggregate the effects that many genetic variants are predicted to have on individual disease risk. The popularity of PGSs is increasing rapidly, but surprisingly little attention has been paid to the idealisations they make about phenotypic development. Indeed, PGSs rely on quantitative genetics models and methods, which involve considerable theoretical assumptions that have been questioned on various grounds. This comes with epistemological and (...)
    Remove from this list   Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  3. Filosofski problemi na molekulnata biologii︠a︡.Stoi︠a︡n Nikolov - 1977
    Remove from this list  
     
    Export citation  
     
    Bookmark  
  4. Leyes, modelos y teorías en biología.Pablo Lorenzano - 2019 - Perspectivas 3 (2):55-88.
    Tres conceptos metacientíficos objeto de análisis filosófico son los de ley, modelo y teoría. El objetivo de este artículo es presentar la elucidación de estos conceptos, y de sus relaciones, hecha dentro del marco del Estructuralismo Metateórico o Sneediano (BALZER; MOULINES & SNEED, 1987), y de su aplicación a un caso del ámbito de la Biología: la Genética Clásica. El análisis realizado posibilitará fundamentar, en contra de lo que sostienen algunos filósofos de la ciencia en general y de la biología (...)
    Remove from this list   Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  5. Problemy teorii molekuli︠a︡rnoĭ ėvoli︠u︡t︠s︡ii.Vadim Aleksandrovich Ratner & R. I. Salganik (eds.) - 1985 - Novosibirsk: Izd-vo "Nauka," Sibirskoe otd-nie.
    Remove from this list  
     
    Export citation  
     
    Bookmark  
  6. Darwinian and Autopoietic Views of the Organism.Walter Veit & Heather Browning - 2022 - Constructivist Foundations 18 (1):103–105.
    Our goal is to illustrate that Darwinian and autopoietic views of the organism are not as squarely opposed to each other as is often assumed. Indeed, we will argue that there is much common ground between them and that they can usefully supplement each other.
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  7. RNA Decay Factor UPF1 Promotes Protein Decay: A Hidden Talent.Terra-Dawn M. Plank & Miles F. Wilkinson - 2018 - Bioessays 40 (1):1700170.
    The RNA-binding protein, UPF1, is best known for its central role in the nonsense-mediated RNA decay pathway. Feng et al. now report a new function for UPF1—it is an E3 ubiquitin ligase that specifically promotes the decay of a key pro-muscle transcription factor: MYOD. UPF1 achieves this through its RING-like domain, which confers ubiquitin E3 ligase activity. Feng et al. provide evidence that the ability of UPF1 to destabilize MYOD represses myogenesis. In the future, it will be important to define (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  8. Cell Polarity and Notch Signaling: Linked by the E3 Ubiquitin Ligase Neuralized?Gantas Perez-Mockus & Francois Schweisguth - 2017 - Bioessays 39 (11):1700128.
    Notch is a mechanosensitive receptor that requires direct cell–cell contact for its activation. Both the strength and the range of notch signaling depend on the size and geometry of the contact sites between cells. These properties of cell–cell contacts in turn depend on cell shape and polarity. At the molecular level, the E3 ubiquitin ligase Neuralized links receptor activation with epithelial cell remodeling. Neur regulates the endocytosis of the Notch ligand Delta, hence Notch activation. It also targets the apical polarity (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  9. Richard Lewontin and the “complications of linkage”.Michael R. Dietrich, Oren Harman & Ehud Lamm - 2021 - Studies in History and Philosophy of Science Part A 88 (C):237-244.
    During the 1960s and 1970s population geneticists pushed beyond models of single genes to grapple with the effect on evolution of multiple genes associated by linkage. The resulting models of multiple interacting loci suggested that blocks of genes, maybe even entire chromosomes or the genome itself, should be treated as a unit. In this context, Richard Lewontin wrote his famous 1974 book The Genetic Basis of Evolutionary Change, which concludes with an argument for considering the entire genome as the unit (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  10. ¿La transferencia genética horizontal, la simbiogénesis, la especiación por hibridación y la introgresión traen realmente dificultades para la concepción cladogenética de la evolución?Gustavo Caponi - 2022 - Culturas Cientificas 3 (1):03-18.
    En los últimos años, algunos autores han venido sosteniendo que la validez de la representación arborescente del patrón filético generado por la evolución está siendo menoscabada por el reconocimiento del impacto evolutivo que tendrían la transferencia genética horizontal, la simbiogénesis, la especiación por hibridación y la introgresión. Esa concepción o representación cladogenética de la evolución sólo nos dejaría ver un aspecto parcial de las relaciones de filiación que conectan a los diferentes linajes de seres vivos; ocultando otro aspecto cuya representación (...)
    Remove from this list   Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  11. A relic of design: against proper functions in biology.Emanuele Ratti & Pierre-Luc Germain - 2022 - Biology and Philosophy 37 (4):1-28.
    The notion of biological function is fraught with difficulties—intrinsically and irremediably so, we argue. The physiological practice of functional ascription originates from a time when organisms were thought to be designed and remained largely unchanged since. In a secularized worldview, this creates a paradox which accounts of functions as selected effect attempt to resolve. This attempt, we argue, misses its target in physiology and it brings problems of its own. Instead, we propose that a better solution to the conundrum of (...)
    Remove from this list   Direct download (3 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  12. The ‘Ethic of Knowledge’ and Responsible Science: Responses to Genetically Motivated Racism.Natan Elgabsi - 2022 - Social Studies of Science 52 (2):303-323.
    This study takes off from the ethical problem that racism grounded in population genetics raises. It is an analysis of four standard scientific responses to the problem of genetically motivated racism, seen in connection with the Human Genome Diversity Project (HGDP): (1) Discriminatory uses of scientific facts and arguments are in principle ‘misuses’ of scientific data that the researcher cannot be further responsible for. (2) In a strict scientific sense, genomic facts ‘disclaim racism’, which means that an epistemically correct grasp (...)
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark  
  13. Genetics on the neurodiversity spectrum: Genetic, phenotypic and endophenotypic continua in autism and ADHD.Polaris Koi - 2021 - Studies in History and Philosophy of Science Part A 89 (October 2021):52–62.
    How we ought to diagnose, categorise and respond to spectrum disabilities such as autism and Attention Deficit/Hyperactivity Disorder (ADHD) is a topic of lively debate. The heterogeneity associated with ADHD and autism is described as falling on various continua of behavioural, neural, and genetic difference. These continua are varyingly described either as extending into the general population, or as being continua within a given disorder demarcation. Moreover, the interrelationships of these continua are likewise often vague and subject to diverse interpretations. (...)
    Remove from this list   Direct download (4 more)  
     
    Export citation  
     
    Bookmark   7 citations  
  14. The Cyclical Return of the IQ Controversy: Revisiting the Lessons of the Resolution on Genetics, Race and Intelligence.Davide Serpico - 2021 - Journal of the History of Biology 54 (2):199-228.
    In 1976, the Genetics Society of America published a document entitled “Resolution of Genetics, Race, and Intelligence.” This document laid out the Society’s position in the IQ controversy, particularly that on scientific and ethical questions involving the genetics of intellectual differences between human populations. Since the GSA was the largest scientific society of geneticists in the world, many expected the document to be of central importance in settling the controversy. Unfortunately, the Resolution had surprisingly little influence on the discussion. In (...)
    Remove from this list   Direct download (4 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  15. From Obesity to Energy Metabolism: Ontological Perspectives on the Metrics of Human Bodies.Davide Serpico & Andrea Borghini - 2020 - Topoi 40 (3):577-586.
    In this paper, we aim at rethinking the concept of obesity in a way that better captures the connection between underlying medical aspects, on the one hand, and an individual’s developmental history, on the other. Our proposal rests on the idea that obesity is not to be understood as a phenotypic trait or character; rather, obesity represents one of the many possible states of a more complex phenotypic trait that we call ‘energy metabolism.’ We argue that this apparently simple conceptual (...)
    Remove from this list   Direct download (3 more)  
     
    Export citation  
     
    Bookmark   5 citations  
  16. Gregor Mendel, Thomas Hunt Morgan en experimenten in de klassieke genetica.Bert Leuridan - 2021 - Algemeen Nederlands Tijdschrift voor Wijsbegeerte 113 (1):107-135.
    Gregor Mendel, Thomas Hunt Morgan and experiments in classical genetics In the middle of the 19th century, Gregor Mendel performed a series of crosses with pea plants to investigate how hybrids are formed. Decades later, Thomas Hunt Morgan finalized the theory of classical genetics. An important aspect of Mendel’s and Morgan’s scientific approach is that they worked in a systematic, experimental fashion. But how did these experiments proceed? What is the relation between these experiments and Mendel’s and Morgan’s explanatory theories? (...)
    Remove from this list   Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  17. Jacques Derrida, Life Death. [REVIEW]Jonathan Basile - 2021 - Philosophy Today 65 (2):409-415.
  18. Eukaryotes first: how could that be? [REVIEW]Carlos Mariscal & W. Ford Doolittle - 2015 - Philosophical Transactions of the Royal Society B: Biological Sciences 370:1-10.
    In the half century since the formulation of the prokaryote : eukaryote dichotomy, many authors have proposed that the former evolved from something resembling the latter, in defiance of common (and possibly common sense) views. In such ‘eukaryotes first’ (EF) scenarios, the last universal common ancestor is imagined to have possessed significantly many of the complex characteristics of contemporary eukaryotes, as relics of an earlier ‘progenotic’ period or RNAworld. Bacteria and Archaea thus must have lost these complex features secondarily, through (...)
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark   2 citations  
  19. Germs, Genes, and Memes: Functional and Fitness Dynamics on Information Networks.Patrick Grim, Daniel J. Singer, Christopher Reade & Stephen Fisher - 2015 - Philosophy of Science 82 (2):219-243.
    It is widely accepted that the way information transfers across networks depends importantly on the structure of the network. Here, we show that the mechanism of information transfer is crucial: in many respects the effect of the specific transfer mechanism swamps network effects. Results are demonstrated in terms of three different types of transfer mechanism: germs, genes, and memes. With an emphasis on the specific case of transfer between sub-networks, we explore both the dynamics of each of these across networks (...)
    Remove from this list   Direct download (3 more)  
     
    Export citation  
     
    Bookmark   3 citations  
  20. Het laatste woord is niet gezegd: de moderne synthese voorbij.Nathalie Gontier - 2005 - In I. Tallon (ed.), Evolutie vandaag: hoe de dingen ontstaan en waarom ze veranderen. pp. 57-84.
  21. Historical and epistemological perspectives on what Lateral Gene Transfer mechanisms contribute to our understanding of evolution.Nathalie Gontier - 2015 - In Reticulate Evolution: Symbiogenesis, Lateral Gene Transfer, Hybridization and Infectious Heredity. pp. 121-178.
  22. Reticulate evolution everywhere.Nathalie Gontier - 2015 - In Reticulate Evolution: Symbiogenesis, Lateral Gene Transfer, Hybridization and Infectious Heredity. pp. 1-40.
  23. Uniting micro- with macroevolution into an Extended Synthesis: Reintegrating life’s natural history into evolution studies.Nathalie Gontier - 2015 - In Nathalie Gontier & Emanuele Serrelli (eds.), Macroevolution: Explanation, interpretation and Evidence. pp. 227-278.
  24. Symbiogenesis, History of.Nathalie Gontier - 2016 - In R. Kliman (ed.), Encyclopedia of Evolutionary Biology. pp. 261-271.
  25. Genes, Brains, and Language: Would Someone Please Pull the Brakes?Nathalie Gontier - 2008 - Review of General Psychology 2 (12):170-180.
  26. Big data in the experimental life sciences: Bruno J. Strasser: Collecting experiments: Making big data biology. Chicago: The University of Chicago Press, 2019, 392 pp, $45.00. [REVIEW]Emanuele Ratti - 2020 - Metascience 29 (3):403-408.
  27. Epigenetics, Responsiveness and Embodiment.Maria Kronfeldner - 2020 - In Dana Mahr & Martina von Arx (eds.), De-Sequencing: Identity Work With Genes.
    This short paper comments on the connections between epigenetics, responsiveness and embodiment. Epigenetics has solidified a new conception of DNA as “responsive,” and rightfully so. Yet, the discussion too easily falls back to metaphors of agency and can show a tendency to see responsiveness and embodiment as based on epigenetics, which is shown to be wrong.
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  28. (re)Producing mtEve.Marina DiMarco - 2020 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 83:101290.
    In their 1987 Nature publication, “Mitochondrial DNA and Human Evolution,” Rebecca Cann, Mark Stoneking, and Allan C. Wilson gave a new reconstruction of human evolution on the basis of differences in mitochondrial DNA among contemporary human populations. This phylogeny included an African common ancestor for all human mitochondrial DNA (mtDNA) lineages, and Cann et al.’s reconstruction became known as the “Out of Africa” hypothesis. Since mtDNA is inherited exclusively through the maternal line, the common ancestor who was first branded African (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  29. Calculus CL - From Baroque Logic to Artificial Intelligence.Jens Lemanski - 2020 - Logique Et Analyse 249:111-129.
    In the year 1714, Johann Christian Lange published a baroque textbook about a logic machine, supposed to simulate human cognitive abilities such as perception, judgement, and reasoning. From today’s perspective, it can be argued that this blueprint is based on an inference engine applied to a strict ontology which serves as a knowledge base. In this paper, I will first introduce Lange’s approach in the period of baroque logic and then present a diagrammatic modernization of Lange’s principles, entitled Calculus CL. (...)
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark   2 citations  
  30. You: A Natural History, by William B Irvine. [REVIEW]Ross Pain - 2020 - Quarterly Review of Biology 95 (3):250-251.
  31. The biosemiotic implications of 'bacterial wisdom'.Felipe-Andres Piedra & Donald R. Frohlich - manuscript
    Eshel Ben-Jacob’s manuscript entitled ‘Bacterial wisdom, Gödel’s theorem and creative genomic webs’ summarizes decades of work demonstrating adaptive mutagenesis in bacterial genomes. Bacterial genomes, each an essential part of a Kantian whole that is a single bacterium, are thus not independent of the environment as sensed; and a single bacterium is therefore a semiotic entity. Ben-Jacob suggests this but errs in 1) assigning autonomy to the genome, and 2) analogizing through computation without making clear whether he is doing so for (...)
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark  
  32. On Being the Right Size, Revisited: The Problem with Engineering Metaphors in Molecular Biology.Daniel J. Nicholson - 2020 - In Sune Holm & Maria Serban (eds.), Philosophical Perspectives on the Engineering Approach in Biology: Living Machines? London, UK: Routledge. pp. 40-68.
    In 1926, Haldane published an essay titled 'On Being the Right Size' in which he argued that the structure, function, and behavior of an organism are strongly conditioned by the physical forces that exert the greatest impact at the scale at which it exists. This chapter puts Haldane’s insight to work in the context of contemporary cell and molecular biology. Owing to their minuscule size, cells and molecules are subject to very different forces than macroscopic organisms. In a sense, macroscopic (...)
    Remove from this list   Direct download (3 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  33. Model Organisms.Rachel Ankeny & Sabina Leonelli - 2020 - Cambridge University Press.
    This Element presents a philosophical exploration of the concept of the 'model organism' in contemporary biology. Thinking about model organisms enables us to examine how living organisms have been brought into the laboratory and used to gain a better understanding of biology, and to explore the research practices, commitments, and norms underlying this understanding. We contend that model organisms are key components of a distinctive way of doing research. We focus on what makes model organisms an important type of model, (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark   15 citations  
  34. When Bioscience Meets Philosophy: Major Issues in the Philosophy of Biology.Sun Kyeong Yu - 2011 - Philosophy and Reality 91:99-110.
    CONTENT 1. Misconceptions of Darwin's Theory of Evolution 2. Darwinism against Essentialism and the Concept of Species 3. Function and Biological Explanation 4. The Gene 목차 1. 다윈의 진화론에 대한 오해들 2. 본질주의에 대한 진화론의 반대와 종(Species)의 개념 3. 기능(function)과 생명과학적 설명 4. 유전자 맺음말.
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  35. The Buddhist idea of Transmigration from the Bioscientific Perspective.Sun Kyeong Yu - 2020 - In Buddhism and Culture (Buddhist magazine in Korea). Seoul, South Korea: pp. The March Issue, 2020.
    죽고 다시 태어나는 반복의 과정을 논하는 불교의 윤회설은 끊임없이 변화하는 생명현상의 본래 모습을 그대로 보여준다. 어느 생명체도 변하지 않고 영구한 것은 없다. 오래된 개체의 삶이 끝나고 새로운 삶이 시작되는 반복의 자연현상이 윤회이다. 본고는 윤회를 생명과학적으로 해석하며 삼라만상에서 일어나는 윤회란 개체들뿐만 아니라 세포와 분자선상에서도 일어나는 자연스런 생명현상임을 밝히겠다.
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark  
  36. Reducing Biology.Sun Kyeong Yu - 2008 - Dissertation,
    This dissertation proposes a new working model of reductionism for biology and a new concept of the gene based on the new reduction model. My project aims to help biologists and philosophers understand what reductionism in biology really is, or, should be. Historical debates about reductionism testify us that the classical reduction model, i.e., Ernest Nagel's bridge-law model, offers us neither an appropriate ontological reductionism nor a reductive explanation about biological phenomena. Casting doubts on the received view of the layered (...)
    Remove from this list  
     
    Export citation  
     
    Bookmark  
  37. A Theory of Conceptual Advance: Explaining Conceptual Change in Evolutionary, Molecular, and Evolutionary Developmental Biology.Ingo Brigandt - 2006 - Dissertation, University of Pittsburgh
    The theory of concepts advanced in the dissertation aims at accounting for a) how a concept makes successful practice possible, and b) how a scientific concept can be subject to rational change in the course of history. Traditional accounts in the philosophy of science have usually studied concepts in terms only of their reference; their concern is to establish a stability of reference in order to address the incommensurability problem. My discussion, in contrast, suggests that each scientific concept consists of (...)
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark   3 citations  
  38. What is a hologenomic adaptation? Emergent individuality and inter-identity in multispecies systems.Javier Suárez & Vanessa Triviño - 2020 - Frontiers in Psychology 187 (11).
    Contemporary biological research has suggested that some host–microbiome multispecies systems (referred to as “holobionts”) can in certain circumstances evolve as unique biological individual, thus being a unit of selection in evolution. If this is so, then it is arguably the case that some biological adaptations have evolved at the level of the multispecies system, what we call hologenomic adaptations. However, no research has yet been devoted to investigating their nature, or how these adaptations can be distinguished from adaptations at the (...)
    Remove from this list   Direct download (7 more)  
     
    Export citation  
     
    Bookmark   11 citations  
  39. Behaving: what’s genetic, what’s not, and why should we care? [REVIEW]Polaris Koi - 2020 - Philosophical Psychology 33 (1):151-154.
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  40. Levels of Organization in the Biological Sciences.Daniel Stephen Brooks, James DiFrisco & William C. Wimsatt (eds.) - 2021 - Cambridge, Massachusetts: MIT Press.
    The subject of this edited volume is the idea of levels of organization: roughly, the idea that the natural world is segregated into part-whole relationships of increasing spatiotemporal scale and complexity. The book comprises a collection of essays that raise the idea of levels into its own topic of analysis. Owing to the wide prominence of the idea of levels, the scope of the volume is aimed at theoreticians, philosophers, and practicing researchers of all stripes in the life sciences. The (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  41. Macroevolution: Explanation, Interpretation and Evidence.Emanuele Serrelli & Nathalie Gontier (eds.) - 2015 - Springer.
    This book is divided in two parts, the first of which shows how, beyond paleontology and systematics, macroevolutionary theories apply key insights from ecology and biogeography, developmental biology, biophysics, molecular phylogenetics, and even the sociocultural sciences to explain evolution in deep time. In the second part, the phenomenon of macroevolution is examined with the help of real life-history case studies on the evolution of eukaryotic sex, the formation of anatomical form and body-plans, extinction and speciation events of marine invertebrates, hominin (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark   3 citations  
  42. Are Synthetic Genomes Parts of a Genetic Lineage?Gunnar Babcock - 2021 - British Journal for the Philosophy of Science 72 (4):995-1011.
    Biologists are nearing the creation of the first fully synthetic eukaryotic genome. Does this mean that we still soon be able to create genomes that are parts of an existing genetic lineage? If so, it might be possible to bring back extinct species. But do genomes that are synthetically assembled, no matter how similar they are to native genomes, really belong to the genetic lineage on which they were modelled? This article will argue that they are situated within the same (...)
    Remove from this list   Direct download (4 more)  
     
    Export citation  
     
    Bookmark   3 citations  
  43. Ca2+ -Dependent Hyperpolarization Pathways in Sleep Homeostasis and Mental Disorders.Shoi Shi & Hiroki R. Ueda - 2018 - Bioessays 40 (1):1700105.
    Although we are beginning to understand the neuronal and biochemical nature of sleep regulation, questions remain about how sleep is homeostatically regulated. Beyond its importance in basic physiology, understanding sleep may also shed light on psychiatric and neurodevelopmental disorders. Recent genetic studies in mammals revealed several non-secretory proteins that determine sleep duration. Interestingly, genes identified in these studies are closely related to psychiatric and neurodevelopmental disorders, suggesting that the sleep-wake cycle shares some common mechanisms with these disorders. Here we review (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  44. A Link Between Alzheimer's and Type II Diabetes Mellitus? Ca+2 -Mediated Signal Control and Protein Localization.Yuko Tsutsui & Franklin A. Hays - 2018 - Bioessays 40 (6):1700219.
    We propose protein localization dependent signal activation (PLDSA) as a model to describe pre‐existing protein partitioning between the cytosol, and membrane surface, as a means to modulate signal activation, specificity, and robustness. We apply PLDSA to explain possible molecular links between type II diabetes mellitus (T2DM) and Alzheimer's disease (AD) by describing Ca+2‐mediated interactions between the Src non‐receptor tyrosine kinase and p52Shc adaptor protein. We suggest that these interactions may serve as a contributing factor to disease development and progression. In (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  45. Hunger and Satiety Signaling: Modeling Two Hypothalamomedullary Pathways for Energy Homeostasis.Kazuhiro Nakamura & Yoshiko Nakamura - 2018 - Bioessays 40 (8):1700252.
    The recent discovery of the medullary circuit driving “hunger responses” – reduced thermogenesis and promoted feeding – has greatly expanded our knowledge on the central neural networks for energy homeostasis. However, how hypothalamic hunger and satiety signals generated under fasted and fed conditions, respectively, control the medullary autonomic and somatic motor mechanisms remains unknown. Here, in reviewing this field, we propose two hypothalamomedullary neural pathways for hunger and satiety signaling. To trigger hunger signaling, neuropeptide Y activates a group of neurons (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  46. How Polycomb‐Mediated Cell Memory Deals With a Changing Environment.Federica Marasca, Beatrice Bodega & Valerio Orlando - 2018 - Bioessays 40 (4):1700137.
    Cells and tissues are continuously exposed to a changing microenvironment, hence the necessity of a flexible modulation of gene expression that in complex organism have been achieved through specialized chromatin mechanisms. Chromatin-based cell memory enables cells to maintain their identity by fixing lineage specific transcriptional programs, ensuring their faithful transmission through cell division; in particular PcG-based memory system evolved to maintain the silenced state of developmental and cell cycle genes. In evolution the complexity of this system have increased, particularly in (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  47. mRNA Traffic Control Reviewed: N6-Methyladenosine (m6A) Takes the Driver's Seat.Abhirami Visvanathan & Kumaravel Somasundaram - 2018 - Bioessays 40 (1):1700093.
    Messenger RNA is a flexible tool box that plays a key role in the dynamic regulation of gene expression. RNA modifications variegate the message conveyed by the mRNA. Similar to DNA and histone modifications, mRNA modifications are reversible and play a key role in the regulation of molecular events. Our understanding about the landscape of RNA modifications is still rudimentary in contrast to DNA and histone modifications. The major obstacle has been the lack of sensitive detection methods since they are (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  48. Data science and molecular biology: prediction and mechanistic explanation.Ezequiel López-Rubio & Emanuele Ratti - 2019 - Synthese (4):1-26.
    In the last few years, biologists and computer scientists have claimed that the introduction of data science techniques in molecular biology has changed the characteristics and the aims of typical outputs (i.e. models) of such a discipline. In this paper we will critically examine this claim. First, we identify the received view on models and their aims in molecular biology. Models in molecular biology are mechanistic and explanatory. Next, we identify the scope and aims of data science (machine learning in (...)
    Remove from this list   Direct download (3 more)  
     
    Export citation  
     
    Bookmark   9 citations  
  49. The ELSI program of the US-American Human Genome Project – new perspectives for medical ethics?Nikola Biller-Andorno - 2001 - Ethik in der Medizin 13 (4):243-252.
    Definition of the problem: The ELSI (Ethical, Legal, and Social Issues) program of the Human Genome Project is the biggest bioethical research project to date. However, it has met with fairly critical reception. Arguments: ELSI is nevertheless an important element in current bioethics. We can learn not just from the results and methodology of the numerous studies that received ELSI funding, but also by looking at the pros and cons of its close institutional integration into the Human Genome Project. Finally, (...)
    Remove from this list   Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  50. On the Origins of Symmetry and Modularity in the Proteasome Family.Adrian C. D. Fuchs & Marcus D. Hartmann - 2019 - Bioessays 41 (5):1800237.
    The proteasome family of proteases comprises oligomeric assemblies of very different symmetry. In different sizes, it features ring‐like oligomers with dihedral symmetry that allow the stacking of further rings of regulatory subunits as observed in the modular proteasome system, but also less symmetric helical assemblies. Comprehensive sequence and structural analyses of proteasome homologs reveal a parsimonious scenario of how symmetry may have emerged from a monomeric ancestral precursor and how it may have evolved throughout the proteasome family. The four characterized (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
1 — 50 / 3697