The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

We propose a characterization of mathematical experiments in terms of a setup, a process with an outcome, and an interpretation. Using a broad notion of process, this allows us to consider arithmetic calculations and geometric constructions as components of mathematical experiments. Moreover, we argue that mathematical experiments should be considered within a broader context of an experimental research project. Finally, we present a particular case study of the genesis of a geometric construction to illustrate the experimental use of hand drawings (...) and computers in mathematical practice. (shrink)

We show that it is impossible in quantum mechanics to describe two separated physical systems. This is due to the mathematical structure of quantum mechanics. It is possible to give a description of two separated systems in a theory which is a generalization of quantum mechanics and of classical mechanics, in the sense that this theory contains both theories as special cases. We identify the axioms of quantum mechanics that make it impossible to describe separated systems. One of these axioms (...) is equivalent to the superposition principle. We show how these findings throw a different light on the paradox of Einstein, Podolsky, and Rosen. (shrink)

We show that the Bohmian approach in terms of persisting particles that move on continuous trajectories following a deterministic law can be literally applied to QFT. By means of the Dirac sea model – exemplified in the electron sector of the standard model neglecting radiation – we explain how starting from persisting particles, one is led to standard QFT employing creation and annihilation operators when tracking the dynamics with respect to a reference state, the so-called vacuum. Since on the level (...) of wave functions, both formalisms are mathematically equivalent, this proposal provides for an ontology of QFT that includes a dynamics of individual processes, solves the measurement problem and explains the appearance of creation and annihilation events. (shrink)

In Miletus, about 550 B.C., together with our world-picture cosmology was born. This book tells the story. In Part One the reader is introduced in the archaic world-picture of a flat earth with the cupola of the celestial vault onto which the celestial bodies are attached. One of the subjects treated in that context is the riddle of the tilted celestial axis. This part also contains an extensive chapter on archaic astronomical instruments. Part Two shows how Anaximander (610-547 B.C.) blew (...) up this archaic world-picture and replaced it by a new one that is essentially still ours. He taught that the celestial bodies orbit at different distances and that the earth floats unsupported in space. This makes him the founding father of cosmology. Part Three discusses topics that completed the new picture described by Anaximander. Special attention is paid to the confrontation between Anaxagoras and Aristotle on the question whether the earth is flat or spherical, and on the battle between Aristotle and Heraclides Ponticus on the question whether the universe is finite or infinite. (shrink)

Stoicism was one of the new philosophical movements of the Hellenistic period. The name derives from the porch (stoa poikilê) in the Agora at Athens decorated with mural paintings, where the members of the school congregated, and their lectures were held. Unlike ‘epicurean,’ the sense of the English adjective ‘stoical’ is not utterly misleading with regard to its philosophical origins. The Stoics did, in fact, hold that emotions like fear or envy (or impassioned sexual attachments, or passionate love of anything (...) whatsoever) either were, or arose from, false judgements and that the sage—a person who had attained moral and intellectual perfection—would not undergo them. The later Stoics of Roman Imperial times, Seneca and Epictetus, emphasise the doctrines (already central to the early Stoics' teachings) that the sage is utterly immune to misfortune and that virtue is sufficient for happiness. Our phrase ‘stoic calm’ perhaps encapsulates the general drift of these claims. It does not, however, hint at the even more radical ethical views which the Stoics defended, e.g. that only the sage is free while all others are slaves, or that all those who are morally vicious are equally so. Though it seems clear that some Stoics took a kind of perverse joy in advocating views which seem so at odds with common sense, they did not do so simply to shock. Stoic ethics achieves a certain plausibility within the context of their physical theory and psychology, and within the framework of Greek ethical theory as that was handed down to them from Plato and Aristotle. It seems that they were well aware of the mutually interdependent nature of their philosophical views, likening philosophy itself to a living animal in which logic is bones and sinews; ethics and physics, the flesh and the soul respectively (another version reverses this assignment, making ethics the.. (shrink)

People undergo many idiosyncratic experiences throughout their lives that may contribute to individual differences in the size and structure of their knowledge representations. Ultimately, these can have important implications for individuals' cognitive performance. We review evidence that suggests a relationship between individual experiences, the size and structure of semantic representations, as well as individual and age differences in cognitive performance. We conclude that the extent to which experience-dependent changes in semantic representations contribute to individual differences in cognitive aging remains unclear. (...) To help fill this gap, we outline an empirical agenda that utilizes network analysis and involves the concurrent assessment of large-scale semantic networks and cognitive performance in younger and older adults. We present preliminary data to establish the feasibility and limitations of such empirical, network-analytical approaches. (shrink)

The importance of digital technologies for social and economic developments and a growing focus on data collection and privacy concerns have made the Internet a salient and visible issue in global politics. Recent developments have increased the awareness that the current approach of governments and business to the governance of the Internet and the adjacent technological spaces raises a host of ethical issues. The significance and challenges of the digital age have been further accentuated by a string of highly exposed (...) cases of surveillance and a growing concern about issues of privacy and the power of this new industry. This special issue explores what some have referred to as the “Internet-industrial complex”—the intersections between business, states, and other actors in the shaping, development, and governance of the Internet. (shrink)

Places the development of Anaximander's thought within social, political, cosmological, astronomical, and technological contexts.

This book is a sequel to Heaven and Earth in Ancient Greek Cosmology. With the help of many pictures, the reader is introduced into the way of thinking of ancient believers in a flat earth. The first part offers new interpretations of several Presocratic cosmologists and a critical discussion of Aristotle’s proofs that the earth is spherical. The second part explains and discusses the ancient Chinese system called gai tian. The last chapter shows that, inadvertently, ancient arguments and ideas return (...) in the curious modern flat earth cosmologies. (shrink)

Le présent article fait le point sur la théorie aristotélicienne des fonctions cérébrales. La première section établit les raisons qui incitent Aristote à rejeter les théories encéphalocentristes, popularisées par certains de ses devanciers, qui faisaient du cerveau le siège des activités psychiques. Sur la base d’arguments anatomiques, Aristote conclut que le cerveau ne possède aucune fonction sensorielle ou intellectuelle. Or cette exclusion n’implique pas que le cerveau est sans importance physiologique, comme le relève la seconde section. Dans la physiologie aristotélicienne, (...) le cerveau forme avec le cœur et la méninge vascularisée un véritable système intégré de régulation thermique fondé sur l’équilibre des contraires. Tout en étant essentiel à la santé et responsable de la production du sommeil, ce système contribue en outre à l’optimisation des activités sensorielles, et partant, à l’optimisation des activités cognitives qui dépendent de la sensation. Examiner ainsi le rôle du cerveau dans toutes ses ramifications fait incidemment apprécier comment la notion de juste milieu, en l’occurrence de juste milieu thermique, permet à Aristote de problématiser l’efficacité du corps en tant qu’outil de la sensation. (shrink)

In his writings on the foundations of logic, Gottlob Frege, the father of modern logic, sketched a conception of truth that focuses on the following questions: What is the sense of the word “true”? Is truth a definable concept or a primitive one? What are the kinds of things of which truth is predicated? What is the role of the concept of truth in judgment, assertion and recognition? What is the logical category of truth? What is the significance of the (...) concept of truth for science in general and for logic in particular? The present volume is dedicated to the interpretation, reconstruction and critical assessment of Frege’s conception of truth. It is of interest to all those working on Frege, the history of logic and semantics, or theories of truth. The volume brings together nine original papers whose authors are all widely known to Frege scholars. The main topics are: the role of the concept of truth in Frege’s system, the nature of the truth-values, the logical category of truth, the relationship between truth and judgment, and the conception of the truth-bearers. (shrink)

We show that the Bohmian approach in terms of persisting particles that move on continuous trajectories following a deterministic law can be literally applied to quantum field theory. By means of the Dirac sea model—exemplified in the electron sector of the standard model neglecting radiation—we explain how starting from persisting particles, one is led to standard QFT employing creation and annihilation operators when tracking the dynamics with respect to a reference state, the so-called vacuum. Since on the level of wave (...) functions, both formalisms are mathematically equivalent, this proposal provides for an ontology of QFT that includes a dynamics of individual processes, solves the measurement problem, and explains the appearance of creation and annihilation events. 1Bohmian Mechanics from Quantum Mechanics to Quantum Field Theory2The Dirac Sea Model3Equilibrium States and the Vacuum4Excitations of the Vacuum and the Fock Space Formalism5The Appearance of Particle Creations and Annihilations6The Merits of the Bohmian Approach. (shrink)

Surveys the ideals of friendship in ancient Greco-Roman philosophy. The notion of the best friendship inevitably reflects the various conceptions of a good life.

Dirk Paul Bogner widmet sich der Frage, welche Relevanz Kurt Lewins Feldtheorie im Bereich der pädagogischen Diagnostik haben könnte. Er untermauert die These, dass die Lewin’sche Feldtheorie eine völlig neue Sicht auf Lern-, Entwicklungs- und Erziehungsprozesse eröffnen würde, und legt dar, inwiefern die Einbeziehung der Dimension des Raumes die Analyse dieser erziehungswissenschaftlich relevanten Topoi verfeinern könnte. Er erörtert mittels hermeneutischer Textauslegung und vergleichender Dokumentenanalyse, warum Lewin keine erziehungswissenschaftliche Resonanz erzeugen konnte, obwohl in der Erziehungswissenschaft auch heute noch intensiv Begriffe, (...) die entweder direkt aus der Feldtheorie stammen oder aber von dieser konsequent definiert wurden, verwendet werden. (shrink)

Plato’s Phaedrus is a dialogue of journeys, a tale of transitions. It begins with Socrates’ question, ‘Where to and from whence, my dear Phaedrus?’ and concludes with the Socrates’ decision, ‘Let’s go’ (sc. back into the city from whence they’ve come). In the speech that forms its centre-piece Socrates narrates another famous journey—the descent of the soul into the body and its reascent to the realm of Forms through erotic madness. It is not too implausible to suppose that Plato himself (...) saw fit to relate his powerful images of the human soul’s fall and re-ascent by dramatic means that highlight the movement from one place to another. This explains how Hermias of Alexandria -- author of the longest sustained work on the Phaedrus to survive from antiquity related the physical journey to the Ilissus to the soul's descent and ascent. This seemingly implausible allegorising gains a certain kind of sense when we consider that the Neoplatonic commentary tradition formed part of a philosophic way of life with an ethical telos. (shrink)

Later versions of Platonic ethics fit the frame of eudaimonism and specify a telos based on Theaetetus 176B and Timaeus 90A-D: 'likeness to god in so far as possible'. This paper examines the development of this idea from the middle Platonist Alcinous to the Neoplatonist Proclus. It examines the way in which Proclus makes this specification of human happiness a bit less "other worldy".

The thesis of mental fragmentation has recently attracted increased attention as a way of explaining facts about mind and language. This volume provides an accessible introduction and essays on foundations and applications of fragmentation.

We identify a normative paradox of responsible management education. Business educators aim to promote social values and develop ethical habits and socially responsible mindsets through education, but they attempt to do so with theories that have normative underpinnings and create actual normative effects that counteract their intentions. We identify a limited conceptualization of freedom in economic theorizing as a cause of the paradox. Economic theory emphasizes individual freedom and understands this as the freedom to choose from available options. However, conceptualizing (...) individuals as profit-maximizing actors neglects their freedom to reflect on the purposes and goals of their actions. We build on the work of pragmatist philosopher John Dewey, who distinguishes between habitualized and creative problem-solving behaviors, conceptualizes knowledge construction as a process of interdependent scientific social inquiry, and understands actors as having the freedom to determine what kind of people they wish to be. We apply pragmatist theory to business education and suggest equipping students with a plurality of theories, supplementing neoclassical economics with other economic perspectives and views from other disciplines on economic behavior. Moreover, we suggest putting students into learning situations that require practical problem solution through interdependent social inquiry, encouraging ethical reflection. In doing so, we contribute by linking the problematic conceptions of freedom identified in economic theorizing to the debate on responsible management education. We conceptualize a pragmatist approach to management education that explicitly re-integrates the freedom to discursively reflect on the individual and societal purpose of business activity and thereby makes existing tools and pedagogies useful for bringing potential freedom back into business. (shrink)

ABSTRACT:This article assesses the proliferation of international accountability standards (IAS) in the recent past. We provide a comprehensive overview about the different types of standards and discuss their role as part of a new institutional infrastructure for corporate responsibility. Based on this, it is argued that IAS can advance corporate responsibility on a global level because they contribute to the closure of some omnipresent governance gaps. IAS also improve the preparedness of an organization to give an explanation and a justification (...) to relevant stakeholders for its judgments, intentions, acts and omissions when appropriately called upon to do so. However, IAS also face a variety of problems impeding their potential to help address social and environmental issues. The contribution of the four articles in this special section is discussed in the context of standards’ problems and opportunities. The article closes by outlining a research agenda to further develop and extend the scholarly debate around IAS. (shrink)

It is widely supposed that Epicurus' identification of aponia (painlessness) and the absence of anxiety (ataraxia) yields as a consequence the claim that the most pleasant life is one that requires little in the way of resources or power. This paper argues that the remarks in Cicero which attempt to reconstruct Epicurus' reasons for thinking that aponia and ataraxia are the limit of pleasure are best interpreted if we suppose that the inference runs the other direction. Epicurus supposed that it (...) was a pre-theoretical constraint on any account of human happiness that it should be natural. Moreover, its naturalness means its in-principle availability to most humans. (shrink)

In the context of some criticism about social responsibility education in business schools, the paper reports findings from a survey of CSR education (teaching and research) in Europe. It analyses the extent of CSR education, the different ways in which it is defined and the levels at which it is taught. The paper provides an account of the efforts that are being made to mainstream CSR teaching and of the teaching methods deployed. It considers drivers of CSR courses, particularly the (...) historical role of motivated individuals and the anticipation of future success being dependent on more institutional drivers. Finally it considers main developments in CSR research both by business school faculty and PhD students, tomorrow''s researchers and the resources devoted to CSR research. The conclusion includes questions that arise and further research directions. (shrink)

This text provides an introduction to the history and current state of theories of word meanings.

Since existentialism lost its influence in philosophy in the 1960s, postmodern theory has taken over criticizing basic concepts of western thought. From a postmodern point of view, the main shortcomings of existentialism is that it criticizes traditional unitarian concepts, while re-inventing new unitarian models. Against these unitarian approaches postmodernism holds that the world can only be described in terms of difference. In this article the postmodern program and its differences from existentialism are explained in reference to three concepts of western (...) philosophy: subject, truth, and ethics. Applying these concepts, the relevance of postmodernism for medical theory is illustrated. (shrink)

International reports on environmental policy promote ‘education for sustainable development’ as an instrument for realising environmental awareness, values and attitudes consistent with the liberal concept of ‘sustainable development’. In this paper the ethical and political-philosophical assumptions of (education for) sustainable development will be criticised. First, it will be argued that (Rawlsian) liberal ethics cannot include obligations towards future generations. Second, the commentary focuses on the economic perspective underlying this liberal framework, its anthropocentric bias and the hierarchical distinction between public and (...) private spheres. Third, to offer a more adequate framework for environmental education, some fruitful ideas within neo-republicanism will be examined. (shrink)

Ethics, published (anonymously) by Coornhert in 1586, is a remarkable publication for a number of reasons: it is the first work on ethics written in a European vernacular; it is a mature work, appearing four years before Coornhert’s death, and summarizes a lifetime of writing and thinking about the good life; it is considered to be fundamentally pagan because of the absence in Zedekunst of biblical references or any direct mention of Christ. Asked why he did not write about such (...) things as the future establishment of God’s kingdom on earth, Coornhert answered: ‘Because I have a greater desire to learn how to live well, than to learn how to know much.’ This is the first English translation of this important work. It will enhance our insight into the ethical outlook of this prominent freethinker and controversialist of the early Dutch Republic. Also available in E-book: ISBN 9789087045586. (shrink)

Verhandeling door de zestiende-eeuwse Nederlandse denker over ethiek en het leiden van een deugdzaam leven.

The idea of the spherical world, poised in space, and encircled at different distances by the celestial bodies, was introduced by the early Greek cosmologists. With some modifications, it is still our Western world-picture. It differs fundamentally from that of other cultures, which all accept, in one version or another, the idea of a flat earth with the dome of the celestial vault above it. The Greek conception, however, entails the problem of falling. How to account for the earth's stability? (...) Why is it that the earth does not fall? This anxious question has already bothered the Presocratics. Aristotle provided the solution that was satisfying for many hundred of years. Falling, according to Aristotle, is not the problem, but the answer, as the earth, consisting of the heaviest of the elements, finds its natural place in the centre of the spherical universe. For the same reason the earth itself, according to Aristotle, has to be spherical. Thus, his main line of argumentation was what we now would call 'metaphysical'. Recently, some scholars have argued that the early Greek idea of a spherical earth was developed as a protoscientifie hypothesis, based on empirical reasoning and observation. In this article, we show this to be an example of the 'anachronistic fallacy' that seriously obscures our understanding of the ancient Greek philosophers. Aristotle's conception held for two millennia, until the work of Copernicus, Kepler, and Thomas Digges overthrew it. Consequently, Newton had to cope with the fear of falling again — a fear that still haunts our modern world-picture and that was brilliantly articulated by Blaise Pascal, in his Pensées. (shrink)