The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert Advisory Group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since (...) the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs Programme. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating and integrating evidence to identify causes of human cancer. The advancements adopted include strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention. (shrink)

David Lewis (1941-2001) was Class of 1943 University Professor of Philosophy at Princeton University. His contributions spanned philosophical logic, philosophy of language, philosophy of mind, philosophy of science, metaphysics, and epistemology. In On the Plurality of Worlds, he defended his challenging metaphysical position, "modal realism." He was also the author of the books Convention, Counterfactuals, Parts of Classes, and several volumes of collected papers.

I hear the patter of little feet around the house, I expect Bruce. What I expect is a cat, a particular cat. If I heard such a patter in another house, I might expect a cat but no particular cat. What I expect then seems to be a Meinongian incomplete cat. I expect winter, expect stormy weather, expect to shovel snow, expect fatigue---a season, a phenomenon, an activity, a state. I expect that someday mankind will inhabit at least five planets. (...) This time what I expect is a state of affairs. If we let surface grammar be our guide, the objects of expectation seem quite a miscellany. The same goes for belief, since expectation is one kind of belief. The same goes for desire: I could want Bruce, want a cat but no particular cat, want winter, want stormy weather, want to shovel snow, want fatigue, or want that someday mankind will inhabit at least five planets. The same goes for other attitudes to the extent that they consist partly of beliefs or desires or lacks thereof. But the seeming diversity of objects might be an illusion. Perhaps the objects of attitudes are uniform in category, and it is our ways of speaking elliptically about these uniform objects that are diverse. That indeed is our consensus. We mostly think that the attitudes uniformly have propositions as their objects. That is why we speak habitually of "propositional attitudes.". (shrink)

Biological species have been treated traditionally as spatiotemporally unrestricted classes. If they are to perform the function which they do in the evolutionary process, they must be spatiotemporally localized individuals, historical entities. Reinterpreting biological species as historical entities solves several important anomalies in biology, in philosophy of biology, and within philosophy itself. It also has important implications for any attempt to present an "evolutionary" analysis of science and for sciences such as anthropology which are devoted to the study of single (...) species. (shrink)

Newcomb's problem and similar cases show the need to incorporate causal distinctions into the theory of rational decision; the usual noncausal decision theory, though simpler, does not always give the right answers. I give my own version of causal decision theory, compare it with versions offered by several other authors, and suggest that the versions have more in common than meets the eye.

is the second-order theory of the part-whole relation. It can express such hypotheses about the size of Reality as that there are inaccessibly many atoms. Take a non-empty class to have exactly its non-empty subclasses as parts; hence, its singleton subclasses as atomic parts. Then standard set theory becomes the theory of the member-singleton function—better, the theory of all singleton functions—within the framework of megethology. Given inaccessibly many atoms and a specification of which atoms are urelements, a singleton function exists, (...) unique up to isomorphism. (This article is partly abridged from my Parts of Classes, partly a sequel.). (shrink)

In (2001), (2003), and elsewhere, Ted Sider presents two arguments concerning the existential quantifier which are justly central to the recent discussion of metaontology. What we will call Sider's indeterminacy argument is an attempted reductio of the suggestion that the existential quantifier might be semantically indeterminate. What we will call Sider's naturalness argument is an argument for the claim that the semantic value of the existential quantifier is the most eligible existence-like meaning there is, à la David Lewis' eligibility (...) theory of meaning. We will argue that these arguments cannot be jointly maintained: Sider must give up at least one. Before arguing this, we will present Sider's two arguments in a bit more detail, and discuss their relationship. A few remarks on the broader significance of our conclusions are in order at the outset. One may think that since one successful argument for a given conclusion is sufficient the point that Sider's arguments cannot both work is purely academic. But we think that Sider's two arguments at bottom reflect different ways of thinking about metaphysics. Moreover, we think that it is only the naturalness argument that promises to deliver all that Sider wants when it comes to metaontology, and it is only the indeterminacy argument that promises to deliver all that Sider wants when it comes to ontology. (shrink)

Inductive methods can be used to estimate the accuracies of inductive methods. Call a method immodest if it estimates that it is at least as accurate as any of its rivals. It would be unreasonable to adopt any but an immodest method. Under certain assumptions, exactly one of Carnap's lambda-methods is immodest. This may seem to solve the problem of choosing among the lambda-methods; but sometimes the immodest lambda-method is λ =0, which it would not be reasonable to adopt. We (...) should therefore reconsider the assumptions that led to this conclusion: for instance, the measure of accuracy. (shrink)

A belief common among philosophers and biologists alike is that Mendelian genetics has been or is in the process of being reduced to molecular genetics, in the sense of formal theory reduction current in the literature. The purpose of this paper is to show that there are numerous empirical and conceptual difficulties which stand in the way of establishing a systematic inferential relation between Mendelian and molecular genetics. These difficulties, however, have little to do with the traditional objections which have (...) been raised to reduction. (shrink)

The ethical behavior of marketing managers was examined by analyzing their responses to a series of different types of ethical dilemmas presented in vignette form. The ethical dilemmas addressed dealt with the issues of (1) coercion and control, (2) conflict of interest, (3) the physical environment, (4) paternalism, and (5) personal integrity. Responses were analyzed to discover whether managers' behavior varied by type of issue faced or whether there is some continuity to ethical behavior which transcends the type of ethical (...) problem addressed. (shrink)

I argue that, unlike your brain, you are not composed of other things: you are simple. My argument centers on what I take to be an uncontroversial datum: for any pair of conscious beings, it is impossible for the pair itself to be conscious. Consider, for instance, the pair comprising you and me. You might pinch your arm and feel a pain. I might simultaneously pinch my arm and feel a qualitatively identical pain. But the pair we form would not (...) feel a thing.1 Pairs of people themselves are incapable of experience. Call this The Datum. What explains The Datum? I think the following exhaust the reasonable options. (1) Pairs of people lack a sufficient number of immediate parts. (2) Pairs of people lack immediate parts capable of standing in the right sorts of relations to each other and their environment. (3) Pairs of people lack immediate parts of the right nature. (4) Pairs of people are not structures (they are unstructured collections of their two immediate parts). (5) Some combination of (1) – (4). Finally, (6) pairs of people are not simple. (shrink)

August Weismann rejected the inheritance of acquired characters on the grounds that changes to the soma cannot produce the kind of changes to the germ-plasm that would result in the altered character being transmitted to subsequent generations. His intended distinction, between germ-plasm and soma, was closer to the modern distinction between genotype and phenotype than to the modern distinction between germ cells and somatic cells. Recently, systems of epigenetic inheritance have been claimed to make possible the inheritance of acquired characters. (...) I argue that the sense in which these claims are true does not challenge fundamental tenets of neo-Darwinism. Epigenetic inheritance expands the range of options available to genes but evolutionary adaptation remains the product of natural selection of ‘random’ variation. (shrink)

The conception of social relationships as contractual lies at the core of our ideology. Indeed, that core is constituted by the intersection of this conception with the correlative conceptions of human activity as appropriate and of rationality as utility-maximizing. My concern is to clarify this thesis and to enhance its descriptive plausibility as a characterization of our ideology, but to undermine its normative plausibility as ideologically effective.

A natural view is that linguistic understanding is a source of justification or evidence: that beliefs about the meaning of a text or speech act are prima facie justified when based on states of understanding. Neglect of this view is largely due to the widely held assumption that understanding a text or speech act consists in knowledge or belief. It is argued that this assumption rests, in part, on confusing occurrent states of understanding and dispositions to understand. It is then (...) argued that occurrent states of understanding are not states of belief of knowledge since a subject may fail to believe that a text or speech act means what she understands it to mean if she doubts the reliability or truth- fulness of that understanding. States of understanding, it is maintained, belong in the same epistemic category as states of perception and memory. (shrink)

Part 1 sets out the logical/semantical background to ‘On Denoting’, including an exposition of Russell's views in Principles of Mathematics, the role and justification of Frege's notorious Axiom V, and speculation about how the search for a solution to the Contradiction might have motivated a new treatment of denoting. Part 2 consists primarily of an extended analysis of Russell's views on knowledge by acquaintance and knowledge by description, in which I try to show that the discomfiture between Russell's semantical and (...) epistemological commitments begins as far back as 1903. I close with a non-Russellian critique of Russell's views on how we are able to make use of linguistic representations in thought and with the suggestion that a theory of comprehension is needed to supplement semantic theory. (shrink)

Some forms of ethical relativism seem to endorse strict contradictions. Various forms of relativism are distinguished, And their vulnerability to such charges compared. Means of avoiding incoherence are considered. Relativistic justification seems either innocuous but nonrelativistic or else unintelligible. Relativistic analyses of moral judgments are implausible and seem required for no other purpose than to avoid charges of incoherence.

The Brock-Rosen problem has been one of the most thoroughly discussed objections to the modal fictionalism bruited in Gideon Rosen’s ‘Modal Fictionalism’. But there is a more fundamental problem with modal fictionalism, at least as it is normally explained: the position does not resolve the tension that motivated it. I argue that if we pay attention to a neglected aspect of modal fictionalism, we will see how to resolve this tension—and we will also find a persuasive reply to the Brock-Rosen (...) objection. Finally, I discuss an alternative reading of Rosen, and argue that this position is also able to fend off the Brock-Rosen objection. (shrink)

It is central to virtue ethics both that morally sound action follows from virtuous character, and that virtuous character is itself the product of habitual right judgement and choice: that, in short, we choose our moral characters. However, any such view may appear to encounter difficulty in those cases of moral conflict where an agent cannot simultaneously act (say) both honestly and sympathetically, and in which the choices of agents seem to favour the construction of different moral characters. This paper (...) argues, against possible counter-arguments, for a view of virtue ethics which embraces the diversity of moral character. (shrink)

Under what conditions, if any, do those the law addresses have a moral duty or obligation to obey it simply because it is the law? In this essay, I identify five general approaches to carrying out this task, and offer a somewhat detailed discussion of one or two examples of each approach. The approaches studied are: relational‐role approaches that appeal to the fact that an agent occupies the role of member in the political community; attempts to ground the duty to (...) obey the law in individual consent or fair play; natural duty approaches; instrumental approaches; and philosophical anarchism, an approach that denies that most subjects of contemporary states have a duty to obey the law simply in virtue of its status as such. (shrink)