The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert Advisory Group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since (...) the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs Programme. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating and integrating evidence to identify causes of human cancer. The advancements adopted include strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention. (shrink)

Offers a compelling vision of how to achieve and conduct a liberal but democratic society through the ideal of Neutrality--between people and ideas of the good--and using the tool of Neutral dialogue.

Since the introduction of mathematical population genetics, its machinery has shaped our fundamental understanding of natural selection. Selection is taken to occur when differential fitnesses produce differential rates of reproductive success, where fitnesses are understood as parameters in a population genetics model. To understand selection is to understand what these parameter values measure and how differences in them lead to frequency changes. I argue that this traditional view is mistaken. The descriptions of natural selection rendered by population genetics models are (...) in general neither predictive nor explanatory and introduce avoidable conceptual confusions. I conclude that a correct understanding of natural selection requires explicitly causal models of reproductive success. *Received May 2006; revised December 2006. †To contact the author, please write to: Department of Philosophy, Kansas State University, 201 Dickens Hall, Manhattan, KS 66506; e‐mail: [email protected] . (shrink)

Editors provide a substantive introduction to the history and theories of perfectionism and neutrality, expertly contextualizing the essays and making the collection accessible.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Good and Bad Ways to Think about Religion and Politics by Robert Benne, and: The Way of Peace: Christian Life in the Face of Discord by James M. Childs Jr.Bruce P. RittenhouseGood and Bad Ways to Think about Religion and Politics Robert Benne Grand Rapids, Mich.: Eerdmans, 2010. 127 pp. $14.00The Way of Peace: Christian Life in the Face of Discord James M. Childs Jr. Minneapolis: Fortress (...) Press, 2008. 149 pp. $19.00A comparison of Robert Benne’s Good and Bad Ways to Think about Religion and Politics and James Childs’s The Way of Peace illustrates the current divisions in political theology in the US Lutheran tradition. Benne’s book is a polemic aimed at the leadership of the mainline Protestant denominations and their mode of engagement with the American political process. In Benne’s account, these denominations draw too direct and exclusive a line between Christian faith and liberal political commitments; conversely, he sees greater agreement between core Christian norms and conservative political concerns. By contrast, Childs’s book provides an exegetical development of Christian norms of peace and peacemaking, followed by direct applications of Christian norms to public issues of economic justice and war that parallel the positions of secular liberals.Benne seeks to explore anew the issue of how Christians should interact with the political process. Unlike H. Richard Niebuhr, who undertook a similar project in Christ and Culture, Benne engages contemporary secular interpretations and critiques of religious engagement in politics. Benne rejects the strict separationist positions of the new atheists such as Richard Dawkins and the fusionist positions he attributes to Paul Tillich and the leadership of the contemporary mainline denominations in favor of a critical engagement model based on the Lutheran two kingdoms doctrine. Benne’s passion is not matched by the strength of his arguments. There is a straw man quality to his characterization of his antagonists. For example, Benne describes Tillich as seeing no difference between the demands of the Christian faith and democratic socialism. But Tillich explicitly recognizes the limitations of democratic [End Page 195] socialism in expressing Christian ideals and makes clear that his preference for this form of government is conditioned on a historical situation in which the alternatives are laissez-faire capitalism, fascism, and communism. Benne displays epistemological hubris when he questions mainstream scientific judgments. For example, he mocks the “alleged global warming consensus” (35) without offering any evidence that he possesses the necessary evidence or expertise to judge that consensus. He adds questionable historical claims, exaggerating Nazi persecution of Christians and minimizing the religious motivation of the European wars following the Reformation.Childs’s treatment of the question of how Christians are to engage in the US political process is even more problematic than Benne’s. His political prescriptions are written as if the problem did not exist, as if there existed a unified Christian polity fully faithful to its ideals that could express those ideals directly in the nation’s public policies. In this, there is a lack of the moral realism that Lutherans traditionally express through the doctrine that Christians are simul justus et peccator (at the same time justified and sinner). It is telling that the only sins that Childs acknowledges in the church are those that correspond to secular liberal norms: “racism, sexism, classism, and other forms of discrimination” (110). Childs’s representations of the church as holy, a community of peacemakers, and a sign of peace are normative not descriptive, effacing the traditional Lutheran distinction between the visible and invisible church. Childs also demonstrates a lack of political realism with respect to the influence of Christians in the American political process. In proposing that public policy be directed by Christian ideals, Childs either presupposes a significant conversion of our pluralistic society or he imagines that those not presently acting in the political process according to Christian moral principles can be persuaded to selflessness without conversion. The former position is not an empirical reality, and the latter contradicts the traditional Lutheran understanding of original sin, which holds that in the absence of faith human beings are curvatus in se, curved in upon themselves.Benne makes a... (shrink)

Near-death experiences, transcendental experiences that frequently occur on the threshold of death, precipitate profound personality transformations that have defied explanation in terms of current psychodynamic and neurophysiologic models. A biosociological approach based on information and systems theories can elucidate anomalous features of both near-death phenomenology and the bipolar aftereffects of these mystical experiences. This biosociological model makes testable predictions about near-death experiencers and suggests fruitful future directions for the scientific study of mystical experience.

This paper examines the dominant Western image of Being as presence. It then explores William Poteat's alternative picture of our mindbodily inherence in a world and its relevance for a more adequate understanding of our lived existence.

This paper examines many similarities in the methodological and ontological views of George Soros and Friedrich Hayek.

Many of our inherited civic institutions are dead or dying. We need an ambitious reform program to revive democratic life. This essay advances a four-pronged “citizenship agenda”: a campaign finance initiative granting each voter fifty “patriot dollars” to fund candidates and political parties of his or her choice; a proposal for a new national holiday, Deliberation Day, held before each national election, enabling citizens to deliberate on the merits of rival candidates; a system of federally financed electronic news-vouchers to permit (...) professional journalism to survive the destruction of its traditional business model; and a new form of citizenship inheritance, which provides $80,000 to all Americans as they start off life as adults. Working with collaborators, I have developed each of these initiatives at book length. This essay suggests how the “citizenship agenda” yields a whole that is larger than the sum of its parts. (shrink)

According to Blanshard, the aim of philosophy is to understand the world. This understanding is achieved, he thinks, only when we can offer a special kind of answer to the question Why? as it may be directed to any thing or event that puzzles us. The answer given will provide an explanation of the puzzling thing or event. The relevant kind of explanation is "logical," and the answer given must be "ultimate," that is, self-evidently true or such that it can (...) be seen to follow from something that is self-evident. (shrink)

Hegel’s philosophy won acceptance in France only through a narrowing down of the scope of the dialectic to the domain of historical action, and indeed, of human history, rather than that of a Spirit beyond humanity.

A diagram that places two planets in orbit around the sun was inserted into the textual space of a Timaeus manuscript of the late 11th century as well as three more in the 12th century. The diagram derives from a Carolingian tradition of study of Martianus Capella’s astronomy and shows his continued authority into the twelfth century. By way of Capella and through similarly-inspired commentaries on Macrobius’ Commentary on the Dream of Scipio, the idea of circumsolar motion for Mercury and (...) Venus became a well-known and authoritative theme for William of Conches and other scholars in the eleventh and twelfth centuries wo interpreted Plato in terms of current scientific knowledge. (shrink)

This morning, as I ate breakfast, I started David Foster Wallace's short story "Good People."1 I began. … Wait a minute! Damn it! Why not Wallace's, or David Wallace's short story? I've never seen nor heard his name other than as a trio; the same is so with others, such as Louisa May Alcott, William Carlos Williams, Joyce Carol Oates, Robert Louis Stevenson, Katherine Anne Porter, et al. One finds it even in operas—for example, in Giacomo Puccini's Turandot we have (...) Ping, Pang, and Pong, who rarely solo or sing duets. And consider the Christian or Hindu trinities as being clearly acknowledged as further instances of the power of three names, as well as the three ancient Greek gods of Zeus, Poseidon, and Hades; the... (shrink)

This article pursues the idea of inferring aspects of phonological underlying forms directly from surface contrasts by looking at optimality theoretic linguistic systems (Prince & Smolensky, 1993/2004). The main result proves that linguistic systems satisfying certain conditions have the faithful contrastive feature property: Whenever 2 distinct morphemes contrast on the surface in a particular environment, at least 1 of the underlying features on which the 2 differ must be realized faithfully on the surface. A learning procedure exploiting the faithful contrastive (...) feature property, contrast analysis, can set the underlying values of some features, even where featural minimal pairs do not exist, but is nevertheless fundamentally limited in what it can set. This work suggests that observation of surface contrasts between pairs of words can contribute to the learning of underlying forms, while still supporting the view that interaction with the phonological mapping will be necessary to fully determine underlying forms. (shrink)

In the two-envelope problem, a reasoner is offered two envelopes, one containing exactly twice the money in the other. After observing the amount in one envelope, it can be traded for the unseen contents of the other. It appears that it should not matter whether the envelope is traded, but recent mathematical analyses have shown that gains could be made if trading was a probabilistic function of amount observed. As a problem with a purely probabilistic solution, it provides a potentially (...) interesting way to test people's consistency with probabilistic models. Three experiments did this by varying the size of both the observed and maximum amounts, and their possible distribution. The results showed that trading decisions were affected by where the observed amount in the opened envelope fell in the distribution, though its size did not always do so. This suggests that participants’ trade decisions could be affected by the perceived probabilities of different observed amounts, which is consistent with the pro.. (shrink)