The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert Advisory Group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since (...) the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs Programme. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating and integrating evidence to identify causes of human cancer. The advancements adopted include strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention. (shrink)

Finitary quasivarieties are characterized categorically by the existence of colimits and of an abstractly finite, regularly projective regular generator G. Analogously, infinitary quasivarieties are characterized: one drops the assumption that G be abstractly finite. For (finitary) varieties the characterization is similar: the regular generator is assumed to be exactly projective, i.e., hom(G, –) is an exact functor. These results sharpen the classical characterization theorems of Lawvere, Isbell and other authors.

This article will introduce Isaac Newton’s fundamental methodological concepts applied for a solution concerning a question of gravity in his Principia Mathematica. The method of deduction of propositions from phenomena can be described as demonstrative induction. The main aim is to show that this method proposed by Newton explicitly contains a criticism of hypothetico-deductive methodology as an inadequate approach to the study of nature. As opposed to hypothetico-deductive method, demonstrative induction is capable of producing theories with much richer empirical and (...) epistemological value. Delimitation against hypothetically deduced theories is closely connected with criticism of mechanical materialism, most notably in a form proposed by René Descartes. Consequently, it has led Newton to not only reject the universality of mechanical premise but also to certain level of immunization against all competitive hypothetically based theories. (shrink)

Model-theoretic concepts of saturation and categoricity are studied in the context of accessible categories. Accessible categories which are categorical in a strong sense are related to categories of $M$-sets ($M$ is a monoid). Typical examples of such categories are categories of $\lambda$-saturated objects.

In Fechner's psychophysics, the 'mental' and the 'physical' were conceived as two phenomenal domains, connected by functional relations, not as two ontologically different realms. We follow the path from Fechner's foundational ideas and Mach's radical programme of a unitary science to later approaches to primary, psychophysically neutral experience (phenomenology, protophysics). We propose an 'integral psychophysics' as a mathematical study of law-like, invariant structures of primary experience. This approach is illustrated by a reinterpretation of psychophysical experiments in terms of perceptual situations (...) involving a constructed apparatus and an instructed subject. The problematic notion of 'measurement of sensation' is thus eliminated: 'sensations' are merely indices for classes of perceptually equivalent configurations (states of the apparatus) specified by the instruction. The locus of the measured is in the inter-subjectively shared, communicable world—not inside the subject's mind. Finally we discuss the role of integral psychophysics as a scientia prima , logically and methodically preceding physics and psychology. (shrink)

The History of Indian Philosophy consists of fifty-eight chapters, written by specialists across a diverse range of general and particularized topics on Indic philosophical traditions. The editorial credit for this extensive volume also belongs to a number of associate editors, including Amy Rayner, John Powers, Christopher Chapple, Stephen Phillips, and Richard King. There is, however, a shift evident in the methodological approach of this volume as compared to earlier orientalist and historical accounts. As Bilimoria notes in his preface, the editors (...) have endeavored not only “to bring out the historical development of philosophical ideas within particular schools or against other critical systems, but also... their interaction with broader cultural, social and paradigm shifts within Indian civilization that may have influenced or thwarted the optimal achievement in the area”. (shrink)

Many experimental found footage films base their meanings and effects on an interaction between the figurative content of the image and its material-technological underpinnings. Can this interaction arise accidentally without artistic appropriation? A recently digitised film by the Czech cinema pioneer Jan Kříženecký, Opening Ceremony of the Čech Bridge (1908), presents such an exercise in accidental aesthetics. At one point, the horizontal and vertical trembling of the cinematograph – obtained from the Lumière brothers – translates into a trembling of the (...) figures on the bridge so precisely that the figurative and material spheres appear to cooperate towards a common aesthetic goal. To account for such phenomena, film theory, found footage filmmaking, and archival practice need to join forces with philosophy. More specifically, Gilbert Simondon's notion of transduction, a process based on the intersection of diverse realities within a domain, allows us to conceptualise the paradoxical interaction between the figurative and material dimensions and the unintentional meanings that arise out of it. Transduction enables the distribution of elements between these heterogeneous spheres while maintaining a certain stability within a system. In the case of archival films in which transduction occurs without prior intention or expectation, transduction can be foregrounded and prolonged. The connection between transduction and the “trembling meaning” of Opening Ceremony, understood within the wider context of camera instability in experimental found footage, will uncover the aesthetic potentialities held by the autonomous creativity of film matter and its interferences with the figurative content. (shrink)

We study search problems and reducibilities between them with known or potential relevance to bounded arithmetic theories. Our primary objective is to understand the sets of low complexity consequences of theories Si2 and Ti2 for a small i, ideally in a rather strong sense of characterization; or, at least, in the standard sense of axiomatization. We also strive for maximum combinatorial simplicity of the characterizations and axiomatizations, eventually sufficient to prove conjectured separation results. To this end two techniques based on (...) the Herbrand's theorem are developed. They characterize/axiomatize Σb1-consequences of Σb2-definable search problems, while the method based on the more involved concept of characterization is easier and gives more transparent results. This method yields new proofs of Buss' witnessing theorem and of the relation between PLS and Σb1, and also an axiomatization of Σb1. (shrink)

Přehledová studie sleduje a analyzuje proměny pojmu sociální inovace. Na základě silné společenské poptávky se z původně dílčí, teoreticky nediskutované a nefixované kategorie stává kategorie obecná. Pokrývá širokou oblast nemateriálních inovací a zároveň se profiluje jako aktivita normativní a intencionální, zaměřená na obecně uznávané sociální cíle. Co do ideově-hodnotových orientací současných koncepcí sociálních inovací studie identifikuje kromě mainstreamu, který zůstává u otevřených hodnotových charakteristik, ještě směr emancipačně-mobilizační a sociálně-tržně odpovědný. V epistemologické rovině se teoretici sociálních inovací hlásí především k praktickému (...) experimentování, pragmatismu, teorii komplexnosti a principům transdisciplinarity. (shrink)

The successful early acquisition of reading literacy represents a crucial learning process determining the further course of academic development (Stanovich, 2009). During this process, interactions between children and their proximal social environment are of utmost importance. Therefore, we introduce a systemic framework for the development of learning potential (e.g., Mudrak et al., 2015, 2019, 2019b; Ziegler & Stoeger, 2017) and explore the interactions between the social and motivational processes associated with reading literacy development in school-age children. We base our analysis (...) on a representative Czech sample of fourth-grade pupils involved in the Progress in International Reading Literacy study (PIRLS, Martin et al., 2016). On the basis of the systemic framework, we hypothesized hierarchical relationships among family socioeconomic status, related developmental resources (including parental support, expectations, and reading resources), children’s reading motivation (including reading engagement and reading confidence), and manifested learning outcomes (including school grades and reading competence). We implemented three structural equation models to test the hypothesized relationships. The first model tested the direct effect of developmental resources on reading competence. The second model included the motivational variables as mediators between resources and competence. The third model included school grades as mediators between resources and motivational variables. Our analyses indicated the good fit of the proposed models. The final model explained 37.8 % of the variance in children’s school grades and 46.5 % of the variance in reading literacy test scores (compared to 34.8 % in the first model). Moreover, parental socioeconomic status was strongly associated with parental expectations, which were associated with reading confidence, partially through the effect of parental expectations on children’s school grades. Reading confidence was the main predictor of reading literacy within the model, followed by the direct effects of parental resources. The results illustrate complex processes through which the family environment affects the development of learning competencies such as reading literacy by providing children with the relevant social and material resources associated with their motivation and school outcomes. We discuss some of the reasons that these relationships may take place and consider their implications for educational practice. (shrink)

The paper explores the philosophical treatment of sacrifice in four of Jiří Menzel’s films of the 1960’s, Closely observed trains, Capricious summer, Mr Balthazar’s death, his short film contribution to the anthology film of the New Wave, Pearls of the deep, and Larks on a string. The paper argues that Menzel problematizes romanticized versions of messianic sacrifice as they all too easily disregard the moral significance of mundane relations. By analysing the treatment of sacrifice in each of these films, the (...) paper makes a case for the significance of Menzel’s treatment of sacrifice for current philosophical debates. (shrink)

Anotace Following Carnap's Principle of Subject Matter, Pavel Tichý proposed a methodological principle I call the "Denotational Principle of Aboutness". It says that expressions are about their denotata. Denotata are modelled as possible world intensions or (common) extensions. Nearly the same principle was recently defended by Marie Duží and Pavel Materna under the name the "Parmenides Principle". However, Duží and Materna did not react to Tichý's late proposal which I call the "Constructional Principle of Aboutness". It says that the subject (...) matter of expressions consists not in their denotata but their meanings. The meanings are explicated by Tichý, and also by Duží and Materna, as so-called constructions; constructions are complex entities akin to algorithms, they construct intensions or extensions. In this paper, I argue in favour of the Constructional Principle of Aboutness. I show that there are not only single arguments, but whole net of methodological principles which support it. This is why the topic largely transcends the debate among Tichý's followers. (shrink)

Cognitive processes are often modelled in computational terms. Can this still be done if only minimal assumptions are made about any sort of representation of reality? Is there a purely knowledge-based theory of computation that explains the key phenomena which are deemed to be computational in both living and artificial systems as understood today? We argue that this can be done by means of techniques inspired by the modelling of dynamical systems. In this setting, computations are defined as curves in (...) suitable metaspaces and knowledge is generated by virtue of the operation of the underlying mechanism, whatever it is. Desirable properties such as compositionality will be shown to fit naturally. The framework also enables one to formally characterize the computational behaviour of both knowledge generation and knowledge recognition. The approach may be used in identifying when processes or systems can be viewed as being computational in general. Several further questions pertaining to the philosophy of computing are considered. (shrink)

If S, T are stationary subsets of a regular uncountable cardinal κ, we say that S reflects fully in $T, S , if for almost all α ∈ T (except a nonstationary set) S ∩ α is stationary in α. This relation is known to be a well-founded partial ordering. We say that a given poset P is realized by the reflection ordering if there is a maximal antichain $\langle X_p; p \in P\rangle$ of stationary subsets of $\operatorname{Reg}(\kappa)$ so that (...) $\forall p, q \in P \forall S \subseteq X_p, T \subseteq X_q \text{stationary}: (S We prove that if $V = L\lbrack\overset{\rightarrow\mathscr{U}}\rbrack, o^\mathscr{U} (\kappa) = \kappa^{++}$ , and P is an arbitrary well-founded poset of cardinality ≤ κ + then there is a generic extension where P is realized by the reflection ordering on κ. (shrink)

The classical liberal approach to deregulation is based on the consecutive elimination of state regulatory activities and their substitution by competitive market structure. Increasing competition accompanied with decreasing arbitrary state agencies’ interventions will undoubtedly cultivate the behaviour of market agents and bring benefits to consumers.The classical liberal approach to deregulation is incompatible with the EU deregulation model, which in case of network industries is still based on the permanent existence of regulatory agencies, Third-Party-Access, public service liability, centralized control of investments (...) and the negative reciprocity. The adoption of these principals will at least delay deregulation process in transition economies but will likely preserve the cartel structure on the utility markets.Economics of regulation and implicitly economics of deregulation is a product of the Chicago School of Economics. Since current “deregulation process” leads to tighter regulation, the adequate term for it should be the reregulation.L’approche libérale classique de la réglementation repose sur l’élimination de la réglementation étatique et leur substitution par des structures marchandes concurrentielles. Une concurrence accrue et une diminution des interventions arbitraires de l’état ne pourront que modifier le comportement des agents sur le marché et engendrer des bénéfices pour les consommateurs.L’approche de la déréglementation du libéralisme classique est incompatible avec le modèle de déréglementation de l’Union Européenne : dans le cas des industries en réseau, ce dernier demeure fondé sur l’existence continue d’agences de réglementation, la responsabilité du service public, le contrôle centralisé des investissements et la réciprocité négative. L’adoption de ces principes aura pour effet au moins de retarder le processus de déréglementation dans les économies en transition et probablement aussi de préserver la structure cartellisée des marchés de services publics.L’économie de la réglementation, et par implication, l’économie de la déréglementation est une contribution émanant de l’Ecole d’Economie de Chicago. Parce que les “processus de déréglemen- tation” en vigueur induisent des réglementations plus drastiques, l’expression appropriée devrait plutôt être la re-réglementation. (shrink)

From the end of the First World War, a broad discussion took place within the framework of the revived German constitutional teaching on the question of the physical normality of man. The founder of the so-called statistical concept of normality, which preceded the still widespread normal (reference) interval concept, is H. Rautmann, who gave it the character of a tool for discriminating between health and disease. Among some of his successors (Bauer, Borchardt, Günther), however, it was considered more a means (...) of establishing a type, without supposing any precise relation between the frequency of a character in the population and the probability of the occurrence of disease. The concept of a statistical norm as a certain region of the variation range of a character determined by the parameters of Gaussian distribution was criticized both by the supporters of the ideal norm (Hildebrandt) and those who were in favour of a ‘personal’ norm (Grote). The underlying motifs of these three conceptions of normality influenced German constitutional doctrine until after the end of the Second World War, but without a satisfactory solution to the diagnosis of physical normality being found. Since the 1950s, world medicine has moved more and more in the direction of prevention, with the emphasis on a study of individual dispositions to disease and its precursors. In this connection a new view of health has gained importance whereby it is considered a smoothly gradated condition, not sharply distinguished from disease (‘continual’ model of health and disease as opposed to the previous ‘alternative’ model). The purpose of diagnostic characters is no longer merely to place patients in clearly defined categories as healthy or affected by one disease or another, but has taken on the function of indices of the disposition to disease among those who exhibit ‘gross normality’. Discrimination between the alternative and continuous models allows a clarification to be made of the sources of the confusion in which the pre-war concept of statistical normality had found itself. Today many exceptions are known to the rule that the functional optimum lies in the region of the population mean, both for the population as a whole and for individuals; and immense variability has been found in the manner in which individuals in the population attain health. Thus a distinction between health and disease by statistical means alone (such as establishing some sort of species design) is not possible at all. The ideal of a personal norm is pursued today through the concept of a multivariate norm backed up by modern data processing methods, though it was anticipated in principle by Kaup even in the 1920s. CiteULike Connotea Del.icio.us What's this? (shrink)

I examine the familiar quadruple of categorical statements “Every F is/is not G.”, “Some F is/is not G.” as well as the quadruple of their modal versions “Necessarily, every F is/is not G.”, “Possibly, some F is/is not G.”. I focus on their existential import and its impact on the resulting Squares of Opposition. Though my construal of existential import follows modern approach, I add some extra details which are enabled by framing my definition of existential import within expressively rich (...) higher-order partial type logic. As regards the modal categorical statements, I find that so-called void properties bring existential import to them, so they are the only properties which invalidate subalternation, and thus also contrariety and subcontrariety, in the corresponding Square of Opposition. (shrink)

In his conception of worlds 1-3 Popper did not make clear how the world 3 can influence on world 2 or 1 . On example of music we can see that any human invention of “new” tone combination cannot affect already given tone combinatorics which is in world 3 . Similarily “new” scientific theory cannot make any change in world 3 where all theories are – according to Popper – settled. Opposite direction of influence seems neither possible: human mind can (...) only feel that it is somehow touched by abstract object during its creative activity; to all appearance abstract objects cannot causaly affect on – presumably material – medium of human thinking. (shrink)

In this paper we discuss the process of building a joint probability distribution from an input set of low-dimensional probability distributions. Since the solution of the problem for a consistent input set of probability distributions is known we concentrate on a setup where the input probability distributions are inconsistent. In this case the iterative proportional fitting procedure, which converges in the consistent case, tends to come to cycles. We propose a new algorithm that converges even in inconsistent case. The important (...) property of the algorithm is that it can be efficiently implemented exploiting decomposability of considered distributions. (shrink)

Two kinds of individuals are distinguished: abstract and concrete. Whereas abstract individuals belong to our conceptual sphere, concrete individuals (i.e. particulars) individuate the world of matter. A subject investigating the external world projects abstract individuals onto concrete ones. The proposal offers a solution to various metaphysical and epistemological puzzles concerned with individuals, e.g., the Ship of Theseus, the Polish Logician, problems with reidentification, or proper names.

[This paper is written in Czech language.] The aim of the article is to re-evaluate the still-surviving anthropological trope which, in reaction to an inquiry into the essence of man, compares humans with animals and points to culture as the means by which humans complete their “deficient” nature. This motif contrasting humans with animals has been extended by A. Gehlen who characterises humans as “beings of deficiencies”. In his view, the morphological-instinctive insufficiency of the human being must be stabilised by (...) cultural institutions, i.e. complexes of habitual actions. Merleau-Ponty, however, demonstrates that bodily beings always relate to their environment in an indirect way, on the basis of certain “standards” and “norms” of interaction, which exist by way of institution. The anthropological trope confronting humans and animals thus cannot produce, as in Gehlen, a contrast between an allegedly “direct” relationship to the world in animals, and a supposedly “indirect” relationship to the world in humans. It can be meaningfully retained only if it is interpreted in a Merleau-Pontyan way, that is, as an invitation to understand the transformation of the norms of indirect interaction with the world found in animals into those found in people, that is, if viewed as a comparison of their respective institutions. (shrink)

Studie ukazuje, jak se problm vle stval pro Heideggera v jeho zralm bytostn djinnm mylen problematickm. Heidegger se pozvolna zbavoval (od poloviny tictch let) voluntrnho pstupu ke jsoucnu, v bytostn djinnm obratu spl k ryzmu ne-chtn. Zaal se rsovat odstup od svta svvoln vdotechniky smrem k vt otevenosti vi byt. K tomu je zapoteb nachzet ryz tubyt (Da-sein) a pibliovat se k pvodnmu byt sammu (Seyn). Tehdy se me otevrat ne-voluntrn smysl uvlastovn byt, kdy se pekrauje novovka subjektivita a s (...) n tak technologick nihilismus doby; jde se spe cestou "mylen a bsnn", cestou odevzdanosti (Gelassenheit) a ne-chtn. Jen tak se me otevt zna opravdovho ivota, kdy lovka nesemele mechanismus technickhop zjednvn (Gestell) a mechnaisticky subjektivistick vle k moci a vle k vli. (shrink)

Během nedávno započaté hospodářské krize se paralelně s aplikací netradičních hospodářských politik zvýšil tlak na potlačení ortodoxních ekonomických teorií hlavního proudu a po několika desetiletích se v ekonomii znovu otevírá prostor pro nové teorie, metodologie, paradigmata. Cíle této práce jsou tři. Cílem prvním je obecná sumarizace základních východisek post keynesiánské ekonomické metodologie. Cílem druhým je pak jasné vymezení této heterogenní teorie vůči neoklasické metodologii s ambicí zcela od základů alternovat tuto starou metodologii. A konečně cílem třetím je analýza architektury post (...) keynesiánské makroekonomické metodologie včetně její primární metody zkoumání. Ta je spojena zejména s kritikou absence realismu v neoklasické ekonomii. (shrink)

The article presents an overview concerning Heidegger's work and life, especially with respect to the contemporary state of publishing of his texts. The article aims at showing a continuity in Heidegger's Thinking of Being on one hand, but, on the other hand, stresses also necessity of a new assessment of his thought, if we take into consideration some recently published manuscripts (especially vol. 65 and 66). The necessity of a new assessment concerns also his personal standpoints during the time of (...) his rectorate in 1933-34. The new documents are presented in volume 16 (published in 2000). The author is convinced that Heidegger is a philosopher of our future. We are still waiting for a truly philosophical assessment and exploiting of his work. (shrink)

The aim of this article is to demonstrate the phenomenologically grounded dynamics of hearing and listening as a possible approach to our sonic experience. Its starting point is the studies of contemporary urban spaces devoted to their sonic experience. The results of these studies and their interpretation will serve as a starting point for the introduction of dynamics of hearing and listening. In the next part of this article, I will focus on the elaboration of this relationship with regard to (...) the critique of Husserl’s concept of activity and passivity in his late work Experience and Judgment and Merleau-Ponty’s concept of being-in-the-world. Based on this, in the end, certain common features will be shown, connecting the thematization of activity and passivity with the relationship of hearing and listening. (shrink)

Analogy is taken into consideration by its didactive and heuristic functions. Analogic changes are analyzed in the form of syntactic-semantic graphs. Their recognizable structural similarity corresponds to the syntax or semantics in the analogy. The concept of analogy has subjective and objective aspects. The explanation in analogies is a dynamic transition from one concept structure to another. The possibility of analogy in the world is a statement about the disposition of the world. The possibility of analogy asserts something about the (...) behaviour of the environment. Analogy is considered as a means of explanation and a dynamic method of cognition. (shrink)