New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

In the last three decades, the consideration of whether non-human animals should be ascribed any moral status, and if so in what way it ought to be ascribed to them, has become of central philosophical, political and economic importance. Thus, given thecontemporary significance of what may be called (jar simplicity’s sake) the “animal issue,” it is worthwhile to examine in what way Ancient Greek philosophy might contribute to our understanding of the issue and to our philosophical response to it. With (...) this in mind,in this essay I examine the issue of the moral status of animals from a “critical” Aristotelian perspective, on the basis of which I shall attempt: (§I) to show how, unlike the Cartesian view of animal nature, Aristotle’s conception of the non-moral status of animals stillinforms the prevailing contemporary view of the animal, and (§II) to establish that Aristotle’s failure to ascribe moral status to animals should be rejected (a) given his admission that animals are, by nature, capable of suffering while they are unable to engage in rational deliberation, and (b) given his understanding of the connection between moral blameworthiness, natural disposition, and various kinds of acts, particularly un-chosen and chosen willing acts. In this way, we shall show that although the prevailing contemporary view of the animal’s moral status represents a slightly more “elevated” view than Aristotle’s, insofar as (typically) we do not explicitly claim, as Aristotle did, that animals are due no moral consideration, by critically appropriating the relevant Aristotelian texts, we nonetheless findrich philosophical evidence that permits us to further elevate our conception of the moral status of animals such that we are prepared to grant them genuine moral significance, not just in theory but also in practice. (shrink)

In this essay I argue that the Stranger’s interest in keeping the philosopher and the sophist distinct is connected, primarily, to his assessment of the charges ofsophistry advanced against Socrates, which compels him to defend Socrates from these unduly advanced accusations. On this basis, I establish that the Stranger’s task in the Sophist, namely to keep philosophy distinct from sophistry, is intimately tied to the project of securing justice and is therefore not merely of theoretical importance but is also—and essentially—of (...) political and ethical significance. (shrink)

Burt Hopkins's The Philosophy of Husserl presents a challenging and thoughtful elucidation of Husserl's phenomenology that pays special attention to important methodological aspects of Husserl's philosophy, and, thereby, to Husserl's characterization of phenomenology as a pure and transcendental philosophy. Unlike other texts that attempt to elucidate Husserl's philosophy, Hopkins carries out his project in an unusual fashion, by beginning with a consideration of the conflict between Plato and Aristotle regarding the meaning and status of the eide, and ending with a (...) systematic critique of two of Husserl's most fierce opponents, Heidegger and Derrida. This review essay gives an overview of Hopkins's book and offers some critical remarks. (shrink)

In this paper I provide a compelling argument against the thesis that Aristotle’s understanding of the relation between the soul and the body can be construed asfunctionalist, despite some passages that would seem to support such an interpretation. Toward this end, in section I of the essay I offer an interpretation of Aristotle’s account of the soul-body relation that emphasizes the non-contingent nature of the connection between the soul and a specific kind of body, arguing that Aristotle’s account of the (...) soul as the “form” and “actuality” of the living thing, and of the organic body as its “matter” and “potentiality,” shows their necessary relation with one another. In section II, I present the functionalist account of mind, placing especial emphasis on its post-Cartesian genesis, which takes seriously the “problematic” status of the relation between mind and body. I then attempt to show, in section III, how because functionalism holds that psychic capacities can be realized within a number of different material bases, including physical and artificial systems, it is incompatible with Aristotle’s conception of the necessary soul-body relation, and thus that Aristotle’s account of psuche is not best construed as functionalist. (shrink)

In this article, I argue that the just society is vegetarian. However, I do so in a way not commonly attempted by contemporary animal rights theorists, insofar as I appeal to Plato to make my case. Although there are certainly other ways to argue for this position, appealing to Plato is a significant and interesting way to lend historical credibility to this argument, and as such, the argument offered in this article provides an important contribution to existing analyses that attempt (...) to establish that humans ought to be vegetarians. (shrink)

In this article we present (1) a close paraphrase--virtually a translation--of Heidegger's Sein und Zeit, §74, "Die Grundverfassung der Geschichtlichkeit," pp. 382-387, together with an analytical outline found in the Appendix; and (2) a brief commentary on the text. What Heidegger says about his own translation of Aristotle's Physics B 1 applies here as well: "The ‘translation' is already the interpretation proper. Thereafter only an explanation of the ‘translation' is called for.".

L’esperienza dell’istante is a book with two faces. On one hand it is an introduction to and commentary on Carlo Sini’s work; on the other hand it investigates the relationship between time and writing, time and utopian thinking, time and ethics. The opening section of the book begins with an analysis of Socrates’ attitude toward writing as it is shown in the Phaedrus. Carrera offers that by refusing to write, while at the same time claiming the role of judge as (...) far as the viability of writing is concerned, Socrates lays out the blueprint for any metaphysical judgment to come: Metaphysics is entitled to question the role of writing insofar as it takes no part in it, claiming that its authority comes from the unwritten voice instead—the voice of the soul. In the same manner, metaphysics judges the world and imposes its values on it by pretending to be removed from the world’s contingency. (shrink)

Alzheimer's disease is the most common form of dementia that gradually disrupts the brain network to impair memory, language and cognition. While the amyloid hypothesis remains the leading proposed mechanism to explain AD pathophysiology, anti-amyloid therapeutic strategies have yet to translate into useful therapies, suggesting that amyloid β-protein and its precursor, the amyloid precursor protein are but a part of the disease cascade. Further, risk of AD can be modulated by a number of factors, the most impactful being the ɛ4 (...) isoform of apolipoprotein E. A recent study reported a novel isoform-dependent transcriptional regulation of APP by apoE. These interesting new results add to the myriad of mechanisms that have been proposed to explain how apoE4 enhances AD risk, highlighting the complexities of not only apoE and AD pathophysiology, but also of disease itself. Also see the video abstract here: https://youtu.be/yd14MBdPkCY APP transcription is differentially modulated by apoE and its isoforms: how does this novel mechanism fit with the existing hypotheses? (shrink)

Due to natural phenomena like global warming and climate change, agricultural production is increasingly faced with threats that transcend farm boundaries. Management practices at the landscape or community level are often required to adequately respond to these new challenges (e.g., pest migration). Such decision-making at a community or beyond-farm level—i.e., practices that are jointly developed by farmers within a community—can be aided by computing and communications technology. In this study, we employ a translational research process to examine the social and (...) behavioral drivers of adoption of smart and connected farm networks among commodity crop farmers in the United States. We implement focus groups and questionnaires to bring to the fore views on the use of digital technologies in collaborative contexts. We find that participating farmers are concerned with several issues about the potential features of the network (e.g., the ability to ensure data validity while maintaining data privacy) and the nature of their interactions with the various stakeholders involved in the network management. The participatory approach we adopt helps provide insights into the process of developing technologies that are both actionable and trusted by potential end users. (shrink)

Western media coverage of female genital modifications in Africa has been hyperbolic and one-sided, presenting them uniformly as mutilation and ignoring the cultural complexities that underlie these practices. Even if we ultimately decide that female genital modifications should be abandoned, the debate around them should be grounded in a better account of the facts.

Les etudes ici rassemblees interrogent les articulations et desarticulations que Jean-Francois Lyotard place au principe du langage. Le volume dessine ainsi les lignes de force et les deplacements de sa pensee, ses presupposes et ses apories. Il montre les malentendus et les polemiques suscites par sa reecriture radicale de la rationalite. Pas de langage en general, dit Lyotard, mais des langages multiples, des types de discours heterogenes que la politique brasse sans pacifier leurs conflits. La recherche du consensus, dont l' (...) ethique de la discussion a souligne l'importance, tend a occulter les differends qui divisent les fins respectives des genres de discours. On ne peut pas etre pacifiste en matiere de phrases, et pas indifferent. Car tout enchainement discursif signe la victoire d'un genre et porte tort aux autres. Sans compter que la parole, quel qu'en soit le registre, eclipse par principe ce qui echappe aux contraintes linguistiques, ce champ de la sensation et du sentiment que Discours, figure explorait, des 1971, en inventant le figural. Apres 1983, apres l' ontologie des phrases du Differend, Lyotard cherche a cerner ce que les mots laissent en souffrance et dont ils doivent pourtant temoigner. Phrase-affect, infantia, donation sensible, Chose sont quelques-uns des noms sous lesquels il pense alors ce qui resiste au langage, le travaille de l'interieur et signe la difficulte de l'ecriture.Ont participe a ce volume Isabelle Aubert, Geoffrey Bennington, Gaelle Bernard, Corinne Enaudeau, Frederic Fruteau de Laclos, Alberto Gualandi, Laurence Kahn, Charlotte Murgier, Andreas Niederberger, Sophie Nordmann, Michel Olivier, Claire Pages, Ronit Peleg, Gerard Raulet, Jean-Francois Rey, Jean-Michel Salanskis, Francois-David Sebbah, Gerald Sfez, Rieke Trimcev. (shrink)

Les protestantes et leur contribution à l’émancipation des femmes sont sorties d’une zone d’ombre ces dernières années. Pourtant il reste encore beaucoup à apprendre sur les divers champs d’intervention et les luttes multiformes que rappelle Michelle Perrot, dans l’introduction de ce numéro thématique du Bulletin de la Société de l’Histoire du Protestantisme français : éducation des jeunes enfants, aide à l’enfance en difficulté, santé, hôpitaux, prisons… La modernité de l’analyse des protest...

This essay examines an aesthetics of disgust through an analysis of the work of Scottish painter Jenny Saville. Saville's paintings suggest that there is something valuable in retaining and interrogating our immediate and seemingly unambivalent reactions of disgust. I contrast Saville's representations of disgust to the repudiation of disgust that characterizes contemporary corporeal politics. Drawing on the theoretical work of Elspeth Probyn and Julia Kristeva, I suggest that an aesthetics of disgust reveals the fundamental ambiguity of embodiment, allowing us (...) to critically attend to the aesthetic and cultural objectification of the female body. (shrink)

Cretan icons often displayed a precious decoration of golden halos with incised, stippled, and/or impressed designs. The present study points out that these motifs should not be interpreted as manifestations of nostalgic and anachronistic attitudes on the part of post-Byzantine painters working in Candia for Greek Orthodox and Catholic clients. Rather, they appear already in several early Cretan works dating around 1400, which took inspiration from technical devices and ornamental motifs worked out in the workshops of Venice during the second (...) half of the fourteenth century and appropriated in icon painting probably through the mediation of mixed-style works produced in both the lagoon region and Venetian-ruled Candia. (shrink)

How does the philosophical problem about mental processes and states and behaviourism arise?—The first step is the one that altogether escapes notice. We talk of processes and states and leave their nature undecided. Sometimes perhaps we shall know more about them—we think. But that is just what commits us to a particular way of looking at the matter. And now the analogy which was to make us understand our thoughts falls to pieces. So we have to deny the yet uncomprehended (...) process in the yet unexplored medium. And now it looks as if we had denied mental processes. And naturally we don’t want to deny them. (shrink)

How does the philosophical problem about mental processes and states and behaviourism arise?—The first step is the one that altogether escapes notice. We talk of processes and states and leave their nature undecided. Sometimes perhaps we shall know more about them—we think. But that is just what commits us to a particular way of looking at the matter. And now the analogy which was to make us understand our thoughts falls to pieces. So we have to deny the yet uncomprehended (...) process in the yet unexplored medium. And now it looks as if we had denied mental processes. And naturally we don’t want to deny them. (shrink)

The problem of explaining color perception has fascinated painters, philosophers and scientists throughout the history. In many cases, the ideas and discoveries about color perception in one of these categories influenced the others, thus resulting in one of the most remarkable cross-fertilization of human thought. At the end of the nineteenth century, two models stood out as the most convincing ones: Young-Helmholtz’s trichromacy on one side, and Hering’s opponency on the other side. The former was mainly supported by painters and (...) scientists, although with some noticeable exceptions as, e.g., Otto Runge, while the majority of philosophers supported the latter. These two apparently incompatible models were proven to be two complementary parts of the hugely complex chain of events which leads to human color perception. Recently, a rigorous mathematical theory able to incorporate both trichromacy and opponency has been developed thanks to the use of the language and tools of quantum information. In this paper, we discuss the placement of this model within the philosophical theories about color. (shrink)

Article Paul Géhin/Michel Cacouros/Christian Förstel/Marie-Odile Germain/Philippe Hoffmann/Corinne Jouanno/Brigitte Mondrain avec la collaboration de Dominique Grosdidiers de Matons. Les manuscrits datés des XIIIe et XIVe siècles conservés dans les bibliothèques publiques de France was published on April 1, 2007 in the journal Byzantinische Zeitschrift (volume 100, issue 2).

This essay analyses the way in which the relation between surface and depth in modern painting is endowed with philosophical significance in the work of Michel Foucault, Maurice Merleau-Ponty and Michel Henry. Whereas Foucault considered the work of Magritte and Manet to undermine the notion of depth as such, by showing the movement of ‘similitude’, Merleau-Ponty and Henry saw post-impressionist painting as engendering an experience of depth that exceeds the Cartesian model of space as res extensa. The motif of painterly (...) surface thus brings into debate two significant movements in French twentieth-century thought: structuralism and phenomenology; in each case, the engagement with painterly technique becomes a way of grasping broader questions regarding the relation between perceptual experience and linguistic meaning. (shrink)

In October 2016, the White House, the European Parliament, and the UK House of Commons each issued a report outlining their visions on how to prepare society for the widespread use of artificial intelligence. In this article, we provide a comparative assessment of these three reports in order to facilitate the design of policies favourable to the development of a ‘good AI society’. To do so, we examine how each report addresses the following three topics: the development of a ‘good (...) AI society’; the role and responsibility of the government, the private sector, and the research community in pursuing such a development; and where the recommendations to support such a development may be in need of improvement. Our analysis concludes that the reports address adequately various ethical, social, and economic topics, but come short of providing an overarching political vision and long-term strategy for the development of a ‘good AI society’. In order to contribute to fill this gap, in the conclusion we suggest a two-pronged approach. (shrink)

An examination of the relation between war and politics, by one of the twentieth century’s most influential thinkers From 1971 until 1984 at the College de France, Michel Foucault gave a series of lectures ranging freely and conversationally over the range of his research. In Society Must Be Defended , Foucault deals with the emergence in the early seventeenth century of a new understanding of war as the permanent basis of all institutions of power, a hidden presence within society that (...) could be deciphered by an historical analysis. Tracing this development, Foucault outlines the genealogy of power and knowledge that had become his dominant concern. (shrink)

Global challenge-led research seeks to contribute to solution-generation for complex problems. Multicultural, multidisciplinary, and multisectoral teams must be capable of operating in highly deman...

Genetically modified cassava is currently being developed to address problems of diseases that threaten the food security of farmers in developing countries. The technologies are aimed at smallholder farmers, in hopes of reducing the vulnerability of cassava production to these diseases. In this paper we examine barriers to farmers’ voice in the development of GM cassava. We also examine the role of a translational research process to enhance farmers’ voice, to understand the sources of vulnerability farmers in a group in (...) Kenya’s Coast face, and to determine if their concerns are consistent with those of the scientists in agriculture addressing farmers’ needs. A two-way communication participatory process provided insights into the complex vulnerability context of farmers, their primary concerns with processing and markets of cassava in order to improve livelihoods, the lack of networks with two way communication flows, and the lack of information on GM technologies. The translational research engaged farmers and scientists in an iterative process where scientists are learning what farmers need, and farmers are learning about the potential benefits and risks from GM technologies, while at the same time expressing their concerns. (shrink)

... PREFACE Paul Gochet (Liege) "[...] une entite physique ne peut etre envisagee que comme une sorte de concretisation, de consolidation locale dans un ...

Schopenhauer’s invective is legendary among philosophers, and is unmatched in the historical canon. But these complaints are themselves worthy of careful consideration: they are rooted in Schopenhauer’s philosophy of language, which itself reflects the structure of his metaphysics. This short chapter argues that Schopenhauer’s vitriol rewards philosophical attention; not because it expresses his critical take on Fichte, Hegel, Herbart, Schelling, and Schleiermacher, but because it neatly illustrates his philosophy of language. Schopenhauer’s epithets are not merely spiteful slurs; instead, they reflect (...) deep-seated theoretical and methodological commitments to transparency of exposition. (shrink)

A growing body of work suggests that the presence of women and of independent directors on boards of directors is associated with higher corporate environmental performance. However, the mechanisms linking board composition to corporate environmental performance are not well understood. This study proposes and empirically tests the mediating role of sustainability-themed alliances in the relationship between board composition and corporate environmental performance. Using the population of public oil and gas firms in the United States as the sample, the study relies (...) on renewable energy alliances to measure sustainability-themed alliances and longitudinally analyzes lagged data for independent and control variables. The study found that the higher the representation of women on a firm’s board, the more likely the firm is to form sustainability-themed alliances, and the higher the representation of independent directors on a firm’s board, the more likely the firm is to form sustainability-themed alliances. Such alliances, in turn, positively contribute to corporate environmental performance. This paper discusses the study’s contributions to the board composition-social performance literature. (shrink)

Many linguists and philosophers of language explain linguistic meaning in terms of truth conditions. This book focuses on the meanings of expressions that escape such truth-conditional treatment, in particular the concessives: but , even if , and although . Corinne Iten proposes semantic analyses of these expressions based on the cognitive framework of relevance theory. A thoroughly cognitive approach to linguistic meaning is presented in which linguistic forms are seen as mapping onto mental entities, rather than individuals and properties (...) in the real world. Researchers and advanced students in pragmatics will find this account lucid, clear and accessible. (shrink)

This allegory is among the most well-traversed passages in Plato's dialogues and deservedly so. Its emotional impact is undeniable, yet it confronts the reader with several problems of interpretation. There is a strong sense that it is of central importance to the crucial questions of the Platonic philosopher's education and his role in society, and it possibly holds one key to an understanding of the Republic as a whole.

‘Philosophical dialogue’ indicates both a form of philosophical inquiry and its corresponding literary genre. In its written form, it typically features two or more characters who engage in a discussion concerning morals, knowledge, as well as a variety of topics that can be widely labelled as ‘philosophical’. Our philosophical dialogue takes place in Krakow, Poland. It is a rainy morning and two strangers are waiting at a tram stop. One of them is dressed neatly, and cannot stop fidgeting with his (...) closed umbrella. The other was caught unprepared by the morning downpour and water is dripping from his worn, soaked jacket. (shrink)

Our study has two concerns. The first falls under the methodological aspect of collaborative research : how researchers and teachers introduce each other to the world of the other and at their respective referents? What are the characteristics of their interactions, how do they facilitate mutual understanding? The second falls within the terms of the partnership : how to negotiate the subject of mutual concern, that is to say what will become both object of research and object of training? This (...) study shows that professional development actors rooted in a negotiation - conversion process, through the involvement of bifacial objects. In this sense, collaboration takes shape around the same object, each actor takes care of one side of the bifacial object and needs the experience of the other to develop this side. We can then speak of reciprocal acculturation. This research shows that collaboration is established once it has acquired the characteristics of a work situation in which and by which the activity of each category of actors produces development. (shrink)