New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

This chapter presents the different purposes of observation and experiment in physics using examples that allow us to grasp the historical transformations linked to the development of instrumentation. We cover both the observational and experimental aspects of this discipline, which range from astronomy and astrophysics to nuclear and particle physics, including optics and solid-state physics.

Pathologizing ugliness refers to the use of disease language and medical processes to foster and support the claim that undesirable features are pathological conditions requiring medical or surgical intervention. Primarily situated in cosmetic surgery, the practice appeals to the concept of “aesthetic pathology”, which is a medical designation for features that deviate from some designated aesthetic norms. This article offers a two-pronged conceptual analysis of aesthetic pathology. First, I argue that three sets of claims, derived from normativist and naturalistic accounts (...) of disease, inform the framing of ugliness as a disease. These claims concern: (1) aesthetic harms, (2) aesthetic dysfunction, and (3) aesthetic deviation. Second, I introduce the notion of a hybridization loop in medicine, which merges the naturalist and normative understanding of the disease that potentially enables pathologizing practices. In the context of cosmetic surgery, the loop simultaneously promotes the framing of beauty ideals as normal biological attributes and the framing of normal appearance as an aesthetic ideal to legitimize the need for cosmetic interventions. The article thus offers an original discussion of the conceptual problems arising from a specific practice in cosmetic surgery that depicts ugliness as the disease. (shrink)

Pathologizing ugliness refers to the framing of unattractive features as a type of disease or deformity. By framing ugliness as pathology, cosmetic procedures are reframed as therapy rather than enhancement, thereby potentially avoiding ethical critiques regularly levelled against cosmetic surgery. As such, the practice of pathologizing ugliness and the ensuing therapeuticalization of cosmetic procedures require an ethical analysis that goes beyond that offered by current enhancement critiques. In this article, I propose using a thick description of the goals of medicine (...) as an ethical framework for evaluating problematic medical practices. I first describe the goals of medicine based on Daniel Callahan's account. I then propose that the goals work best in conjunction with ancillary ethical concepts, namely medical knowledge and skills, standards of practice and medical duties and virtues. Next, I apply the thick description of the goals of medicine in critiquing the practice of framing ugliness as disease. Here, I demonstrate ethical conflicts between aesthetic judgments that underpin the practice of pathologizing ugliness and medical judgments that inform ethical medical practices. In particular, the thick description of the goals of medicine helps reveal ethical conflicts in at least three key domains common to clinical practices, which include (a) disease determination, (b) diagnostic evaluation and (c) establishing clinical indications. My analysis offers a novel way of critiquing the practice of pathologizing ugliness in cosmetic surgery, which tends to be neglected by enhancement critiques. (shrink)

Résumé – Dans l'œuvre de Ferdinand Gonseth, on voit culminer le désir de rapprocher, dans leurs objectifs et dans leurs méthodes, le philosophe et le savant.Cette idée méme a guidé, compte tenu des exigences historiques, les développements qui précèdent.Après un parcours rapide, évoquant les vingt premières années de Dialectics, le rôle scientifique joué dans cet imposant répertoire par son fondateur, rôle fortement accru par ses livres, on trouvera done une enquête sur des thèmes favoris dont l'intérêt s'est confirmé, et dont (...) les objets ont une haute valeur, pour qui voudrait analyser les courants de pensée capables d'enrichir la philosophie scientifique et d'affecter utilement le proche avenir de Dialectica. (shrink)

Comment interpréter le regain d'intérêt pour les réflexions sur la transcendance, la quête de sens, la morale et l'éthique dans nos sociétés contemporaines? C'est ce sur quoi Lawrence Olivier et Yves Boisvert se sont penchés dans cet ouvrage ; le premier accuse les théoriciens de la postmodernité d'être de grands fabulateurs qui font la promotion de la reconfiguration des systèmes moraux, tandis que le second reproche aux nihilistes d'être de grands nostalgiques de la Vérité qui ont sombré dans un (...) fatalisme total et un individualisme radical face à l'échec du projet de la modernité. Leur désaccord portant principalement sur l'interprétation à donner à ce retour des grands questionnements sur les valeurs et le sens de la vie, l'hypothèse de base est que les individus ont besoin de croire à une certaine forme de transcendance et qu'ils ressentent un profond besoin de donner un sens à leur vie. Invités à se prononcer sur cette question, anthropologues, philosophes, politicologues, sociologues et théologiens livrent ici leurs propres analyses de cette problématique par un riche panorama des réflexions sur la sexualité, la mort, la mode, l'art, les jeunes de la rue, les activités extrêmes, la religion et la pop psycho. Sans épuiser la problématique de la transcendance contemporaine, cet ouvrage stimulera la curiosité de tous les lecteurs intéressés aux nouvelles valeurs culturelles ou aux nouveaux comportements sociétaux. (shrink)

« L'expression la plus adéquate que j'ai trouvée pour désigner les trois expériences hors du commun qu'il m'a été donné de vivre est celle utilisée par Romain Rolland dans sa correspondance avec Freud : le sentiment océanique. Romain Rolland aurait emprunté le magnifique et mystérieux terme « océanique » à la mystique indienne, notamment à Ramakrishna. Ce dernier parlait de son extase comme d'un « océan de joie ineffable ». Alors, qu'est-ce donc que ce sentiment océanique? Ce serait l'expérience rare, (...) fulgurante et généralement brève d'être Un avec le Tout. Comme si les frontières entre le Moi et le monde s'évanouissaient au profit d'un sentiment d'unité, de compréhension et de conscience élargie. » (Yves Vaillancourt) Rassemblant les morceaux épars de la littérature, de la psychanalyse et de la musique, l'auteur retrouve les pierres d'un chemin à la fois singulier et universel. (shrink)

Ce ne sont pas les poètes qui deviennent fous Ce sont les joueurs d’échecs Chesterton Quelle est la quête symbolisée par le jeu d’échecs? Quels liens pouvons-nous établir entre Beth Harmon de la récente série télévisée The Queen’s Gambit et des personnages littéraires comme Loujine ou Monsieur B., de Nabokov ou Stefan Zweig? Les joueurs d’échecs sont-ils des fous de Dieu, des mystiques de l’absolu? Veulent-ils s’affranchir des limites imparties à la condition humaine et s’élever à un niveau de calcul (...) surhumain, comme s’ils étaient dotés de l’omniscience? Dans cet essai, l’auteur se propose de revisiter un certain nombre d’œuvres littéraires et artistiques qui mettent en scène le jeu d’échecs. Il part de l’hypothèse chère à Borgès selon laquelle les échecs sont un petit théâtre reproduisant le drame cosmique, où l’être humain, même surdoué, se brûle les ailes dans son désir de perfection. (shrink)

A comprehensive study of mathematical thought, taking the actual works for its basis, will examine mathematical activity first. Such activity has always set itself mutually dependent aims of two sorts:The solving of problems, i.e. determining some unknown element under precise conditions;And the achieving of a synthesis which, in the presence of new problems, simplifies and, if necessary, coordinates anew the known facts of whatever sort .This is what allows us to draw up a specific scheme regarding the historical evolution of (...) deductive science, the dialectical aspect of that evolution has been stressed as far as possible. It brings in Logic in a natural way, and shows clearly how 〈mathematisation〉 operates in a wide field. (shrink)

Interrogations philosophiques contemporaines en france / Christian Descamps -- Vingt ans de phénoménologie française / Jocelyn Benoist -- De l'impossibilité de la phénoménologie / Eric Alliez.

Scheinerman (2023) proposes that at the Human Genome Editing Initiative international summit (held in March 2023) there should have been a parallel, separate Citizens’ Jury, and that the Human Geno...

This review aims to identify (1) sources of knowledge and (2) important themes of the ethical debate related to surgical alteration of facial features in East Asians. This article integrates narrative and systematic review methods. In March 2014, we searched databases including PubMed, Philosopher’s Index, Web of Science, Sociological Abstracts, and Communication Abstracts using key terms “cosmetic surgery,” “ethnic*,” “ethics,” “Asia*,” and “Western*.” The study included all types of papers written in English that discuss the debate on rhinoplasty and blepharoplasty (...) in East Asians. No limit was put on date of publication. Combining both narrative and systematic review methods, a total of 31 articles were critically appraised on their contribution to ethical reflection founded on the debates regarding the surgical alteration of Asian features. Sources of knowledge were drawn from four main disciplines, including the humanities, medicine or surgery, communications, and economics. Focusing on cosmetic surgery perceived as a westernising practice, the key debate themes included authenticity of identity, interpersonal relationships and socio-economic utility in the context of Asian culture. The study shows how cosmetic surgery of ethnic features plays an important role in understanding female identity in the Asian context. Based on the debate themes authenticity of identity, interpersonal relationships, and socio-economic utility, this article argues that identity should be understood as less individualistic and more as relational and transformational in the Asian context. In addition, this article also proposes to consider cosmetic surgery of Asian features as an interplay of cultural imperialism and cultural nationalism, which can both be a source of social pressure to modify one’s appearance. (shrink)

The popularity of surgical modifications of race-typical features among Asian women has generated debates on the ethical implications of the practice. Focusing on blepharoplasty as a representative racial surgery, this article frames the ethical discussion by viewing Asian cosmetic surgery as an example of medicalization, which can be interpreted in two forms: treatment versus enhancement. In the treatment form, medicalization occurs by considering cosmetic surgery as remedy for pathologized Asian features; the pathologization usually occurs in reference to western features as (...) the norm. In the enhancement form, medicalization occurs by using medical means to improve physical features to achieve a certain type of beauty or physical appearance. Each type of medicalization raises slightly different ethical concerns. The problem with treatment medicalization lies in the pathologization of Asian features, which is oppressive as it continues to reinforce racial norms of appearance and negative stereotypes. Enhancement medicalization is ethically problematic because cosmetic surgery tends to conflate beauty and health as medical goals of surgery, overemphasizing the value of appearance that can further displace women’s control over their own bodies. I conclude that in both forms of medicalization, cosmetic surgery seems to narrowly frame a complex psychosocial issue involving physical appearance as a matter that can be simply solved through surgical means. (shrink)

a classification of educational theories with authors.

Niccolò Machiavelli is the most prominent and notorious theorist of violence in the history of European political thought - prominent, because he is the first to candidly discuss the role of violence in politics; and notorious, because he treats violence as virtue rather than as vice. In this original interpretation, Yves Winter reconstructs Machiavelli's theory of violence and shows how it challenges moral and metaphysical ideas. Winter attributes two central theses to Machiavelli: first, violence is not a generic technology (...) of government but a strategy that tends to correlate with inequality and class conflict; and second, violence is best understood not in terms of conventional notions of law enforcement, coercion, or the proverbial 'last resort', but as performance. Most political violence is effective not because it physically compels another agent who is thus coerced; rather, it produces political effects by appealing to an audience. As such, this book shows how in Machiavelli's world, violence is designed to be perceived, experienced, remembered, and narrated. (shrink)

This article provides a critical comparative analysis of the substantive and procedural values and ethical concepts articulated in guidelines for allocating scarce resources in the COVID-19 pandemic. We identified 21 local and national guidelines written in English, Spanish, German and French; applicable to specific and identifiable jurisdictions; and providing guidance to clinicians for decision making when allocating critical care resources during the COVID-19 pandemic. US guidelines were not included, as these had recently been reviewed elsewhere. Information was extracted from each (...) guideline on: 1) the development process; 2) the presence and nature of ethical, medical and social criteria for allocating critical care resources; and 3) the membership of and decision-making procedure of any triage committees. Results of our analysis show the majority appealed primarily to consequentialist reasoning in making allocation decisions, tempered by a largely pluralistic approach to other substantive and procedural values and ethical concepts. Medical and social criteria included medical need, co-morbidities, prognosis, age, disability and other factors, with a focus on seemingly objective medical criteria. There was little or no guidance on how to reconcile competing criteria, and little attention to internal contradictions within individual guidelines. Our analysis reveals the challenges in developing sound ethical guidance for allocating scarce medical resources, highlighting problems in operationalising ethical concepts and principles, divergence between guidelines, unresolved contradictions within the same guideline, and use of naïve objectivism in employing widely used medical criteria for allocating ICU resources. (shrink)

"Christian philosophy" is commonly regarded as an oxymoron, philosophy being thought incompatible with the assumptions and conclusions required by religious faith. According to this way of thinking, philosophy and theology must forever remain distinct. In From Theology to Theological Thinking, Jean-Yves Lacoste takes a different approach. Stepping back from contemporary philosophical concerns, Lacoste--a leading figure in the philosophy of religion--looks at the relationship between philosophy and theology from the standpoint of the history of ideas. He notes in particular that (...) theology and philosophy were not considered separate realms until the high Middle Ages, this distinction being a hallmark of the modern era that is coming to an end. Lacoste argues that the intellectual task before us now is to work in the frontier region between or beyond these domains, work he identifies as "the task of thinking." With this argument, Lacoste resets our understanding of Western Christian thought, contending that a new way of thinking that is at once philosophical and theological will be the lasting discourse of Christianity. (shrink)

Depuis les années 1960, Gilbert Durand a fondé et développé une méthodologie et une épistémologie novatrices de l'étude des imaginaires individuels et culturels qui ont inspiré une Ecole de Grenoble, qui n'a cessé d'essaimer à travers un grand nombre de centres de recherches en France et dans le monde. Sa pensée, connue à travers la mythocritique et la mythanalyse, enrichie par une vaste culture historique et pluriculturelle, a été appliquée dans les domaines les plus divers des sciences humaines et sociales. (...) Loin d'être un système clos, son oeuvre a inspiré une épistémologie ouverte qui a permis, sur la base des acquis fondamentaux, de se préciser, de s'adapter à des champs nouveaux, de recevoir les apports d'autres écoles, courants ou traditions culturelles. Les contributions ici rassemblées permettront de mieux situer l'émergence de la problématique de l'imaginaire dans différentes disciplines ou champs d'études, de présenter les innovations théoriques apportées par l'anthropologie de l'imaginaire de G Durand, d'illustrer les innovations qu'elles auront permises, d'amorcer des éléments de prospective pour les chantiers actuellement en cours d'exploration. (shrink)

Les hommes ont toujours agi sur eux-mêmes, et pris en charge leur propre évolution. Avec aujourd'hui deux traits absolument nouveaux. D'une part, les capacités d'action de l'espèce humaine sur elle-même sont incomparablement plus puissantes que par le passé, notamment dans le domaine des technologies de la vie. D'autre part, nous contrôlons si bien notre milieu et l'avons si parfaitement aménagé pour notre survie que nous avons mis en danger notre environnement. Le philosophe Peter Sloterdijk conduit une réflexion peu conventionnelle sur (...) ce double déséquilibre, déséquilibre de la domestication de l'homme par lui-même, déséquilibre de l'environnement par la mobilisation infinie des ressources. En prolongeant ses réflexions, il s'agit ici de réfléchir à cette situation. Faut-il poursuivre et même accélérer sur la voie de la mutation, en inventant le nouvel homme, c'est-à-dire le surhomme? Ou faut-il à nouveau penser la nature humaine dans sa finitude et, contre la mobilisation infinie, en appeler à la dé-mobilisation et à la voie du Tao, mais au risque de l'étouffement dans la mesure, la sagesse et l'ennui? (shrink)

L'objectif est ici de déterminer la mesure dans laquelle nous serions aujourd'hui sortis des catégories conceptuelles sur lesquelles la pensée politique moderne s'est construite.

Source et limites de l'unité dans la mathématique, par Georges Bouligand. Bibliographie (p. 16)--La crise de l'unité dans la physique contemporaine, par Jean Abelé.--A la recherche de l'unité de la matière; point de vue du chimiste, par Jean Moretti.--Le problème de l'unité de la vie. Polygénisme ou monogénisme; le problème de l'unité de l'espèc humaine, par J. Carles.