New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

In this article we present a new kind of computing device that uses biochemical reactions networks as building blocks to implement logic gates. The architecture of a computing machine relies on these generic and composable building blocks, computation units, that can be used in multiple instances to perform complex boolean functions. Standard logical operations are implemented by biochemical networks, encapsulated and insulated within synthetic vesicles called protocells. These protocells are capable of exchanging energy and information with each other through transmembrane (...) electron transfer. In the paradigm of computation we propose, protoputing, a machine can solve only one problem and therefore has to be built specifically. Thus, the programming phase in the standard computing paradigm is represented in our approach by the set of assembly instructions that directs the wiring of the protocells that constitute the machine itself. To demonstrate the computing power of protocellular machines, we apply it to solve a NP-complete problem, known to be very demanding in computing power, the 3-SAT problem. We show how to program the assembly of a machine that can verify the satisfiability of a given boolean formula. Then we show how to use the massive parallelism of these machines to verify in less than 20 min all the valuations of the input variables and output a fluorescent signal when the formula is satisfiable or no signal at all otherwise. (shrink)

A small consortium of philosophers has begun work on the implications of epistemic networks (Zollman 2008 and forthcoming; Grim 2006, 2007; Weisberg and Muldoon forthcoming), building on theoretical work in economics, computer science, and engineering (Bala and Goyal 1998, Kleinberg 2001; Amaral et. al., 2004) and on some experimental work in social psychology (Mason, Jones, and Goldstone, 2008). This paper outlines core philosophical results and extends those results to the specific question of thresholds. Epistemic maximization of certain types does show (...) clear threshold effects. Intriguingly, however, those effects appear to be importantly independent from more familiar threshold effects in networks. (shrink)

Thomas Aquinas has argued that the passion of hope is the movement of the sensitive appetite and the first of the irascible passion. The first part of the article aims to explore the cause and the mechanism of the passion of hope, and tries to clarify the relationship between the passion of hope and the perception. In human beings, it is possible that the passion of hope is caused by false judgement of the perception, which will lead to the result (...) of false hope. In Aquinas’s argument, the problem of false hope could be solved through the moral virtue and the prudence. In the second part of this article, the aim is to analyse how the virtue of magnanimity, humility and the prudence work impact on the passion of hope and perfect it.Contribution: This research concentrates on the topic of the passion of hope of Thomas Aquinas, and provides a new perspective on the understanding of the relationship between the passion and the virtue. (shrink)

Although wonder is a response to what is extraordinary or regarded as such, this covers a variety of things. Hence, wonder covers a spectrum from mere surprise or puzzlement to stronger responses like dread or amazement; moreover, it is often linked to other powerful responses like fear or admiration, and it can lead people into many pursuits and areas of reflection. I look at the variety of the objects of wonder, and of the neighbouring responses and conceptual connections found here, (...) then I discuss the response of wonder itself, and its causes and effects. Finally, I ask why the sense of wonder can atrophy, and whether it can be suppressed deliberately. (shrink)

Agroecological farming is widely considered to reconcile improved working and living conditions of farmers while promoting social, economic, and ecological sustainability. However, most existing research primarily focuses on relatively narrow trade-offs between workload, economic and ecological outcomes at farm level and overlooks the critical role of contextual factors. This article conducts a critical literature review on the complex nature of agroecological farm work and proposes the holistic concept of sustainable farm work (SFW) in agroecology together with a heuristic evaluation framework. (...) The latter was applied to ten case studies to test its relevance, affirming positive outcomes of agroecology on SFW, such as improved food sovereignty, biodiversity conservation, and social inclusiveness, but also showing trade-offs, including increased workload and potential yield reductions. Further, results show that contextual factors, such as policy support, market regulation, and access to resources, heavily influence the impact of agroecological practices on SFW. This article strongly argues for the importance of a holistic understanding of SFW and its contextualization within multiple socio-ecological system levels. The proposed framework establishes clear relationships between agroecology and SFW. An explicit recognition of these multidimensional relationships is essential for maximizing positive outcomes of agroecology in different contexts and fostering SFW. On a theoretical level, this research concludes that, from a holistic perspective, work is an entry point to studying the potential of agroecology to drive a sustainable agroecological transition in economic, social, and ecological terms. (shrink)

ABSTRACT Nietzsche's investigation into the origins of morality bears some striking similarities to contemporary investigations into human evolution. Here I investigate these similarities, using a comparison between Nietzsche's GM and Gould and Lewontin's influential “Spandrels” essay as a departure point. I argue that Nietzsche defends a proto-evolutionary psychology about morality, where the inheritance of enduring biological drives conflicts with our culturally evolved moral system. While Nietzsche's claims about the evolution of morality fit well within a Darwinian framework of natural selection, (...) his claims about our underlying biology do not. Those claims cohere better with the non-Darwinian views found in nineteenth-century German biology and embryology. (shrink)

Relativism is the view that the truth of a sentence is relative both to a context of utterance and to a context of assessment. That the truth of a sentence is relative to a context of utterance is uncontroversial in contemporary semantics. This chapter focuses on three points: whether the version of contextualism is vulnerable to the disagreement and retraction arguments, and if so, whether these problems can be avoided by a more sophisticated contextualist theory. The points include: whether relativism (...) really does avoid the four problems posed for the other theories; and whether there are other theories that also avoid the problems, without running into the problems facing relativism or problems of their own. The chapter concentrates on two families of views that have been called relativist: Relativism about propositional truth; and Relativism about utterance truth. (shrink)

There are several argumentative strategies for advancing the thesis that moral responsibility is incompatible with causal determinism. One prominent such strategy is to argue that agents who meet compatibilist conditions for moral responsibility can nevertheless be subject to responsibility-undermining manipulation. In this paper, I argue that incompatibilists advancing manipulation arguments against compatibilism have been shouldering an unnecessarily heavy dialectical burden. Traditional manipulation arguments present cases in which manipulated agents meet all compatibilist conditions for moral responsibility, but are (allegedly) not responsible (...) for their behavior. I argue, however, that incompatibilists can make do with the more modest (and harder to resist) claim that the manipulation in question is mitigating with respect to moral responsibility. The focus solely on whether a manipulated agent is or is not morally responsible has, I believe, masked the full force of manipulation-style arguments against compatibilism. Here, I aim to unveil their real power. (shrink)

The plane was going to crash, but it didn't. Johnny was going to bleed to death, but he didn't. Geach sees here a changing future. In this paper, I develop Geach's primary argument for the (almost universally rejected) thesis that the future is mutable (an argument from the nature of prevention), respond to the most serious objections such a view faces, and consider how Geach's view bears on traditional debates concerning divine foreknowledge and human freedom. As I hope to show, (...) Geach's view constitutes a radically new view on the logic of future contingents, and deserves the status of a theoretical contender in these debates. (shrink)

In this article I argue that revisionists in just war theory must further revise their proportionality principles. I show that on the revisionist view it is possible for a war to be proportionate,...

Schechtman’s ‘Person Life View’ offers an account of personal identity whereby persons are the unified loci of our practical and ethical judgment. PLV also recognises infants and permanent vegetative state patients as being persons. I argue that the way PLV handles these cases yields an unexpected result: the dead also remain persons, contrary to the widely-accepted ‘Termination Thesis.’ Even more surprisingly, this actually counts in PLV’s favor: in light of our social and ethical practices which treat the dead as moral (...) patients, PLV gives a more plausible account of the status of the dead than its rival theories. (shrink)

Stokes’ earlier chapter in this volume argued that, given the role ethical considerations play in our judgments of what to believe, ethical factors will put limits on the extent to which we can embrace particularism about conspiracy theories. However, that will only be the case if there are ethical problems with conspiracy theory as a practice (rather than simply as a formal class of explanation). Utilising the Lakatosian framework for analysing conspiracy theories developed by Steve Clarke, this paper identifies a (...) morally costly feature of conspiracy theorizing: its tendency to generate and expand new accusations purely to defend the core theory from countervailing evidence. Such 'auxiliary accusations' violate important norms around justified accusation, which supplies a defeasible, but important, reason to be reluctant to take part in the practice of conspiracy theorizing. (shrink)

We characterize Weihrauch reducibility in $ \operatorname {\mathrm {E-PA^{\omega }}} + \operatorname {\mathrm {QF-AC^{0,0}}}$ and all systems containing it by the provability in a linear variant of the same calculus using modifications of Gödel’s Dialectica interpretation that incorporate ideas from linear logic, nonstandard arithmetic, higher-order computability, and phase semantics.

Perhaps the best-known theory of fairness is John Broome’s: that fairness is the proportional satisfaction of claims. In this article, I question whether claims are the appropriate focus for a theory of fairness, at least as Broome understands them in his current theory. If fairness is the proportionate satisfaction of claims, I argue, then the following would be true: fairness could not help determine the correct distribution of claims; fairness could not be used to evaluate the distribution of claims; fairness (...) could not guide us in distributing claims (or unowed goods); we could not have a claim to be treated fairly; and we would not be wronged when treated unfairly. These entailments mean that it is questionable that fairness is concerned with claims in the way Broome suggests. At the very least, the relationship between fairness and claims appears to be more complex than the picture painted by Broome. (shrink)

Since St. Thomas Aquinas holds that death is a substantial change, a popular current interpretation of his anthropology must be mistaken. According to that interpretation – the ‘survivalist’ view – St. Thomas holds that we human beings survive our deaths, constituted solely by our souls in the interim between death and resurrection. This paper argues that St. Thomas must have held the ‘corruptionist’ view: the view that human beings cease to exist at their deaths. Certain objections to the corruptionist view (...) are also met. (shrink)

At criminal trial, we demand that those accused of criminal wrongdoing be presumed innocent until proven guilty beyond any reasonable doubt. What are the moral and/or political grounds of this demand? One popular and natural answer to this question focuses on the moral badness or wrongness of convicting and punishing innocent persons, which I call the direct moral grounding. In this essay, I suggest that this direct moral grounding, if accepted, may well have important ramifications for other areas of the (...) criminal justice process, and in particular those parts in which we (through our legislatures and judges) decide how much punishment to distribute to guilty persons. If, as the direct moral grounding suggests, we should prefer under-punishment to over-punishment under conditions of uncertainty, due to the moral seriousness of errors which inappropriately punish persons, then we should also prefer erring on the side of under-punishment when considering how much to punish those who may justly be punished. Some objections to this line of thinking are considered. (shrink)

Patrick Frierson - Learning to Love: From Egoism to Generosity in Descartes - Journal of the History of Philosophy 40:3 Journal of the History of Philosophy 40.3 313-338 Learning to Love: From Egoism to Generosity in Descartes Patrick R. Frierson The whole of philosophy is like a tree. The roots are metaphysics, the trunk is physics, and the branches emerging from the trunk are all the other sciences, which may be reduced to three principal ones, namely medicine, mechanics, (...) and morals. Descartes is well known for his metaphysics and physics, the roots and trunk of his philosophical project. But Descartes's morals are generally neglected, partly because they are so difficult to find. He does not dedicate a major published work to morality. His most direct comments on it are in letters to Princess Elizabeth and Pierre Chanut. The published work that most touches on moral issues is The Passions of the Soul, which is primarily a treatise on the relationship between mind and body. As a result of this lack of primary sources , there have been only a few significant studies of Descartes's moral philosophy in French, and only two major works devoted to it in English. This neglect of Descartes's ethics is unfortunate, not least since ethical concerns sometimes influence his work in other areas. This.. (shrink)

Rawls’s difference principle and the position dubbed ‘luck egalitarianism’ are often viewed as competing theories of distributive justice. However, recent work has emphasised that Rawlsians and luck egalitarians are working with different understandings of the concept of justice, and thus not only propose different theories, but different theories of different things. Once they are no longer seen in direct competition, there are some questions to be asked about whether these two theories can be consistently endorsed alongside one another. In this (...) essay, I (begin to) investigate whether Rawls’s theory (or elements of it) and (some form of) luck egalitarianism can be consistently endorsed. -/- I begin by outlining the main aspects of Rawls’s theory and luck egalitarianism, showing them to be different kinds of theory and therefore not in direct competition. I then propose an understanding of how these ideas came to be seen to be in direct competition. Finally, I outline five different ways in which one might consistently be (some kind of) a luck egalitarian and (some kind of) a Rawlsian, and try to say something about what is to be said for and against each of these ways of combining the theories. (shrink)

Children are expensive to raise. Ensuring that they are raised in such a way that they are able to lead a minimally decent life costs time and money, and lots of both. Who is responsible for bearing the costs of the things that children are undoubtedly owed? This is a question that has received comparatively little scrutiny from political philosophers,despite children being such a drain on public and private finances alike. To the extent that there is a debate, two main (...) views can be identified. The Parents Pay view says that parents, responsible for the existence of the costs, must foot the bill. The Society Pays view says that a next generation is a benefit to all, and so to allow parents to foot the bill alone is the worst kind of free-riding. In this article, I introduce a third potentially liable party currently missing from the debate: children themselves. On my backward-looking view, we are entitled to ask people to contribute to the raising of children on the basis that they have benefited from being raised themselves. (shrink)

The fundamental problem considered is that of the existence of a joint probability distribution for momentum and position at a given instant. The philosophical interest of this problem is that for the potential energy functions (or Hamiltonians) corresponding to many simple experimental situations, the joint "distribution" derived by the methods of Wigner and Moyal is not a genuine probability distribution at all. The implications of these results for the interpretation of the Heisenberg uncertainty principle are analyzed. The final section consists (...) of some observations concerning the axiomatic foundations of quantum mechanics. (shrink)

Philosophers, anthropologists and biologists have long puzzled over the question of human nature. It is also a question that Kant thought about deeply and returned to in many of his writings. In this lucid and wide-ranging introduction to Kant’s philosophy of human nature - which is essential for understanding his thought as a whole - Patrick R. Frierson assesses Kant’s theories and examines his critics. He begins by explaining how Kant articulates three ways of addressing the question ‘what is (...) the human being?’: the transcendental, the empirical, and the pragmatic. He then considers some of the great theorists of human nature who wrestle with Kant’s views, such as Hegel, Marx, Darwin, Nietzsche, and Freud; contemporary thinkers such as E.O.Wilson and Daniel Dennett, who have sought biological explanations of human nature; Thomas Kuhn, Michel Foucault, and Clifford Geertz, who emphasize the diversity of human beings in different times and places; and existentialist philosophers such as Sartre and Heidegger. He argues that whilst these approaches challenge and enrich Kant’s views in significant ways, all suffer from serious weaknesses that Kant’s anthropology can address. Taking a core insight of Kant’s - that human beings are fundamentally free but finite - he argues that it is the existentialists, particularly Sartre, who are the most direct heirs of his transcendental anthropology. The final part of the book is an extremely helpful overview of the work of contemporary philosophers, particularly Christine Korsgaard and Jürgen Habermas. Patrick R. Frierson explains how these philosophers engage with questions of naturalism, historicism, and existentialism while developing Kantian conceptions of the human being. Including chapter summaries and annotated further reading, What is the Human Being? is an outstanding introduction to some fundamental aspects of Kant’s thought and a judicious assessment of leading theories of human nature. It is essential reading for all students of Kant and the philosophy of human nature, as well as those in related disciplines such as anthropology, politics and sociology. (shrink)

Many of the formalisms used in Attribute Value grammar are notational variants of languages of propositional modal logic, and testing whether two Attribute Value Structures unify amounts to testing for modal satisfiability. In this paper we put this observation to work. We study the complexity of the satisfiability problem for nine modal languages which mirror different aspects of AVS description formalisms, including the ability to express re-entrancy, the ability to express generalisations, and the ability to express recursive constraints. Two main (...) techniques are used: either Kripke models with desirable properties are constructed, or modalities are used to simulate fragments of Propositional Dynamic Logic. Further possibilities for the application of modal logic in computational linguistics are noted. (shrink)

Awareness that moral beliefs and practices have changed across time threatens our confidence in our current moral beliefs: if past moral beliefs turned out to be wrong, how can we be sure ours aren't likewise mistaken? In this paper, I set up four desiderata for a successful theory of moral progress: it must allow us to judge that progress has occurred, avoid the image of increasing correspondence towards ahistorical truthmakers, allow for revision in belief, and yet not be disobligating. Rorty's (...) pragmatist account of moral progress delivers on the first three, but at the cost of failing to meet the fourth: it drains moral beliefs of their categorical force. I then outline K.E. Løgstrup’s understanding of the relation between the ‘ethical demand’ and changing, socially mediated norms. While Løgstrup does posit an unchanging ground of normativity - the "ethical demand" to act for the sake of the other whose welfare is in our hands – he also thinks that changing social norms are an indispensable part of ethical life. I argue that Løgstrup's discussion of the ‘refraction’ of the ethical demand through changing social norms provides resources for an account of moral progress that fulfils these four desiderata. (shrink)

Griinbaum's own article sets forth his views on the ontology of the curvature of empty space, especially in the geometrodynamics of Clifford and Wheeler. ...

Innovative therapy is the name we give to novel medical interventions, radically different from the standard of care, provided in order to benefit a patient, rather than to acquire new knowledge. They are paradigmshifting, not incremental, responses to serious patient problems that standard medical care inadequately addresses. Innovative therapies are often devised by clinicians, not basic science researchers; they do not follow the linear model of basic research, to translation, to clinical research, to application. Instead, they come from thinking backwards (...) from the patient’s circumstances, and forward from deep knowledge of how the body functions, to challenge the limits of current mechanisms for effecting cures. (shrink)

It has been argued that St. Thomas Aquinas’s anthropological views fall prey to the problem of “Too Many Thinkers.” The worry, roughly, is that his views entail that I—a human person—am able to think, but that my soul—which is not a human person—is also able to think. Hence, too many thinkers: there are too many ofus having my thoughts. In this paper, I show why this is not a problem for St. Thomas. Along the way, I also address Peter Unger’s (...) argument for substance dualism. (shrink)

Who gets to parent whom? Anca Gheaus claims that each child should be parented by the “best available parent” and that parental interests should play no role in assigning parental authority. I investigate this view. I find that it does not clearly rule out parental interests and is underspecified. Various further specifications do not seem to be about giving children the best available parent, but rather concern familiar distributive principles that attempt to balance competing interests. At the level of policy, (...) I find the view less radical than it may first appear. (shrink)

In his book Democratic Authority, David Estlund puts forward a case for democracy, which he labels epistemic proceduralism, that relies on democracy's ability to produce good – that is, substantively just – results. Alongside this case for democracy Estlund attacks what he labels ‘utopophobia’, an aversion to idealistic political theory. In this article I make two points. The first is a general point about what the correct level of ‘idealisation’ is in political theory. Various debates are emerging on this question (...) and, to the extent that they are focused on ‘political theory’ as a whole, I argue, they are flawed. This is because there are different kinds of political concept, and they require different kinds of ideal. My second point is about democracy in particular. If we understand democracy as Estlund does, then we should see it as a problem-solving concept – the problem being that we need coercive institutions and rules, but we do not know what justice requires. As democracy is a response to a problem, we should not allow our theories of it, even at the ideal level, to be too idealised – they must be embedded in the nature of the problem they are to solve, and the beings that have it. (shrink)