New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

If the theory advanced below is correct, then what is the difference (I know she [Philippa Foot]] will ask) between the moral must/must not and the must/must not of etiquette or the clubhouse? Looking forward to the conclusion I shall reach, let me reply, roughly and readily, that the difference will reside not in anything formal but in the depth, spread, and felt authority of the attachments to which the moral must/must not appeals-and categorically appeals.

'Foot stands out among contemporary ethical theorists because of her conviction that virtues and vices are more central ethical notions than rights, duties, justice, or consequences - the primary focus of most other contemporary theorists. This volume brings together a dozen essays published between 1957 and 1977, and includes two new ones as well. In the first, Foot argues explicitly for an ethic of virtue, and in the next five discusses abortion, euthanasia, free will/determination, and the ethics of Hume and (...) Nietzsche. The final eight essays chart her growing disenchantment with emotivism and prescriptivism and their account of moral arguments. All the essays embody to some extent her commitment to an ethics of virtue... Foot's style is straightforward and readable, her arguments subtle, ingenious, and some of them important.' Choice. (shrink)

This fitting Festschrift contains twelve essays by students, colleagues and friends of Philippa Foot, all of them leading figures in philosophy. Some deal directly and even centrally with Foot’s own work, the others with topics she has herself written on and in a manner relatively sympathetic to what she has said about those topics. Foot’s interests in ethics have been fairly wide-ranging, and that fact is well reflected in the essays of the present volume. Elizabeth Anscombe writes on ‘Practical (...) Inference’; Simon Blackburn on ‘The Flight to Reality’; Rosalind Hursthouse on ‘Applying Virtue Ethics’; Anthony Kenny on ‘Philippa Foot on Double Effect’; Gavin Lawrence on ‘The Rationality of Morality’; John McDowell on ‘Two Sorts of Naturalism’; Warren Quinn on ‘Putting Rationality in its Place’; David Sachs on ‘Notes on Unfairly Gaining More: Pleonexia’; Thomas Scanlon on ‘Fear of Relativism’; Michael Thompson on ‘The Representation of Life’; David Wiggins on ‘Categorical Requirements: Kant and Hume on the Idea of Duty’; and Bernard Williams on ‘Acts and Omissions: Doing and Not Doing’. A short review cannot hope to do justice to all the interesting (and controversial) material to be found in these dedicatory essays. And rather than attempt to discuss even two or three of them, I think it better to choose a single one for closer consideration, namely, Warren Quinn’s rich and fascinating critique of subjectivist/instrumentalist views of practical reason. (shrink)

'Foot stands out among contemporary ethical theorists because of her conviction that virtues and vices are more central ethical notions than rights, duties, justice, or consequences - the primary focus of most other contemporary theorists. This volume brings together a dozen essays published between 1957 and 1977, and includes two new ones as well. In the first, Foot argues explicitly for an ethic of virtue, and in the next five discusses abortion, euthanasia, free will/determination, and the ethics of Hume and (...) Nietzsche. The final eight essays chart her growing disenchantment with emotivism and prescriptivism and their account of moral arguments. All the essays embody to some extent her commitment to an ethics of virtue... Foot's style is straightforward and readable, her arguments subtle, ingenious, and some of them important.' Choice. (shrink)

This volume contains twelve essays by friends, colleagues, and former students of Philippa Foot: Anscombe, Blackburn, Hursthouse, Kenny, Lawrence, McDowell, Quinn, Sachs, Scanlon, Michael Thompson, Wiggins, and Williams. The essays concern issues relevant to or raised by Foot's work in moral philosophy, only sometimes specifically addressing her views. Unfortunately, there is no contribution by Foot herself, either in the form of replies or a new paper. This certainly lessens the interest of the volume. Perhaps Foot was driven by (...) modesty in not wanting the focus to be on her comments, or by the need to conserve her time for larger ongoing projects. Whatever the explanation, readers would have benefited from the chance to hear her latest thinking on the issues raised in some of these papers (especially those by Blackburn and McDowell). (shrink)

This volume of essays in honour of Philippa Foot constitutes a high quality Festschrift. There is no doubt that Philippa Foot's career is worthy of such a volume. She is one of the most influential philosophers of the past few decades and her work has given rise to, and seeded, much debate in contemporary moral philosophy. She has written on a wide variety of topics — virtue ethics, the doctrine of double effect, naturalism, and practical reasoning. The essays (...) in this volume touch on all of these issues. They are written by such distinguished philosophers as G. E. M. Anscombe, Simon Blackburn, Rosalind Hursthouse, Anthony Kenny, Gavin Lawrence, John McDowell, Warren Quinn, David Sachs, T. M. Scanlon, Michael Thompson, David Wiggins, and Bernard Williams. They all succeed in honouring Professor Foot's work. Given space considerations, and considering the forum for this review, I will focus on those essays that are of most relevance to consequentialism. (shrink)

The best classes have a life of their own, powered by student-led conversations that explore texts, ideas, and essential questions. In these classes, the teacher’s role shifts from star player to observer and coach as the students ▪ Think critically, ▪ Work collaboratively, ▪ Participate fully, ▪ Behave ethically, ▪ Ask and answer high-level questions, ▪ Support their ideas with evidence, and ▪ Evaluate and assess their own work. The Spider Web Discussion is a simple technique that puts this kind (...) of class within every teacher’s reach. The name comes from the weblike diagram the observer makes to record interactions as students actively participate in the discussion, lead and support one another’s learning, and build community. It’s proven to work across all subject areas and with all ages, and you only need a little know-how, a rubric, and paper and pencil to get started. As students practice Spider Web Discussion, they become stronger communicators, more empathetic teammates, better problem solvers, and more independent learners—college and career ready skills that serve them well in the classroom and beyond. Educator Alexis Wiggins provides a step-by-step guide for the implementation of Spider Web Discussion, covering everything from introducing the technique to creating rubrics for discussion self-assessment to the nuts-and-bolts of charting the conversations and using the data collected for formative assessment. She also shares troubleshooting tips, ideas for assessment and group grading, and the experiences of real teachers and students who use the technique to develop and share content knowledge in a way that’s both revolutionary and truly inspiring. (shrink)

One of the reasons why most of us feel puzzled about the problem of abortion is that we want, and do not want, to allow to the unborn child the rights that belong to adults and children. When we think of a baby about to be born it seems absurd to think that the next few minutes or even hours could make so radical a difference to its status; yet as we go back in the life of the fetus we (...) are more and more reluctant to say that this is a human being and must be treated as such. No doubt this is the deepest source of our dilemma, but it is not the only one. For we are also confused about the general question of what we may and may not do where the interests of human beings conflict. We have strong intuitions about certain cases; saying, for instance, that it is all right to raise the level of education in our country, though statistics allow us to predict that a rise in the suicide rate will follow, while it is not all right to kill the feeble-minded to aid cancer research. It is not easy, however, to see the principles involved, and one way of throwing light on the abortion issue will be by setting up parallels involving adults or children once born. So we will be able to isolate the “equal rights” issue and should be able to make some advance... (shrink)

Philippa Foot has for many years been one of the most distinctive and influential thinkers in moral philosophy. Long dissatisfied with the moral theories of her contemporaries, she has gradually evolved a theory of her own that is radically opposed not only to emotivism and prescriptivism but also to the whole subjectivist, anti-naturalist movement deriving from David Hume. Dissatisfied with both Kantian and utilitarian ethics, she claims to have isolated a special form of evaluation that predicates goodness and defect (...) only to living things considered as such; she finds this form of evaluation in moral judgements. Her vivid discussion covers topics such as practical rationality, erring conscience, and the relation between virtue and happiness, ending with a critique of Nietzsche's immoralism. This long-awaited book exposes a highly original approach to moral philosophy and represents a fundamental break from the assumptions of recent debates. Foot challenges many prominent philosophical arguments and attitudes; but hers is a work full of life and feeling, written for anyone intrigued by the deepest questions about goodness and human. (shrink)

In this book Philippa Hoskin offers an account of the pastoral theory and practice of Robert Grosseteste, bishop of Lincoln 1235-1253, within his diocese. Grosseteste has been considered as an eminent medieval philosopher and theologian, and as a bishop focused on pastoral care, but there has been no attempt to consider how his scholarship influenced his pastoral practice. Making use of Grosseteste's own writings - philosophical and theological as well as pastoral and administrative - Hoskin demonstrates how Grosseteste's famous (...) interventions in his diocese grew from his own theory of personal obligation in pastoral care as well as how his personal involvement in his diocese could threaten well-developed clerical and lay networks. (shrink)

Le propre des grands œuvres est d’être une source infinie de réflexion pour les siècles qui la suivent. L’attraction de Platon se compte, comme un petit nombre d’autres auteurs, en millénaires. Ses dialogues n’en finissent pas d’émerveiller : hauteur de vue, atopie des analyses, diversité des thèmes, subtil congé donné à la vanité philosophique dans un mélange de jeu et de sérieux, mise en scène de personnages croqués rapidement ou peints lentement au fil du dialogue, ressorts infinis du styl...

"Foot stands out among contemporary ethical theorists because of her conviction that virtues and vices are more central ethical notions than rights, duties, justice, or consequences--the primary focus of most other contemporary moral theorists....[These] essays embody to some extent her commitment to an ethics of virtue. Foot's style is straightforward and readable, her arguments subtle..."--Choice.

1. There is a tendency nowadays for linguists, philosophers and other theorists of language, to dismiss the notion of an object like the English language or the Polish language as simply mythological or mythopoeic—as of no interest to any serious science of language. Some theorists even appear to deny that there are such things as languages . ‘This notion [of a public language] is unknown to empirical inquiry and raises what seem to be irresolvable problems’, Chomsky said in a lecture (...) he gave recently in London. (shrink)

Within the historiography of early modern science, trust and credibility have become synonymous with genteel identity. While we should not overlook the cultural values attached to social hierarchy and how it shaped the credibility of knowledge claims, this has limitations when thinking about how contemporaries regarded the origins of that knowledge and its location in different types of workers and skillsets. Using the example of seamen in the circles of the Royal Society, this article employs the category of experience, and (...) by extension expertise, to illustrate how recognized forms of knowledge and skill acted as routes to credibility and authority in early modern science. It argues that, within the experimental community, the seaman’s authority derived from their direct experience of novel and remote phenomena and the cumulative effect of their wider experience. The accumulated experience they acquired from frequent practice, observation, and exposure translated into a form of “expertness” that rendered seamen trustworthy and credible observers and thinkers. The gentlemanly trust model does not accommodate nor acknowledge the ways the seaman’s direct and accumulated experience were recognized and valued in inquiry and discourse. The article therefore sets out a new model for understanding trust, credibility, and authority in early modern science that can take us beyond a restrictive mono-model that locates trust in one sociocultural category to highlight the multiple, and sometimes competing, claims to epistemological authority. (shrink)

Kantian moral concepts concerning respect for human dignity have played a central role in articulating ethical guidelines for medical practice and research, and for articulating some central positions within bioethical debates more generally. The most common of these Kantian moral concepts is the obligation to respect the dignity of patients and of human research subjects as autonomous, self-determining individuals. This article describes Kant’s conceptual distinction between dignity and autonomy as values, and draws on the work of several contemporary Kantian philosophers (...) who employ the distinction to make sense of some common moral intuitions, feelings, and norms. Drawing on this work, the article argues that the conceptual distinction between dignity and autonomy as values is indispensable in the context of considering our obligations to those who are dependent and vulnerable. (shrink)

This paper revisits Ronald Dworkin’s influential position that a person’s advance directive for future health care and medical treatment retains its moral authority beyond the onset of dementia, even when respecting this authority involves foreshortening the life of someone who is happy and content and who no longer remembers or identifies with instructions included within the advance directive. The analysis distils a eudaimonist perspective from Dworkin’s argument and traces variations of this perspective in further arguments for the moral authority of (...) advance directives by other authors. It then critiques a feature of the eudaimonist perspectives within these arguments—namely, the position that dementia has a retroactive negative impact on what a person has previously valued—and challenges the commonly held assumption underlying them that a person’s life and well-being have relatively low value beyond the onset of dementia. Although advance directives have moral authority as a means of guiding one’s future health care, accounts that dismiss the value of the lives and well-being of people living with dementia should be questioned to the extent that such accounts are used to support the moral authority of advance directives stipulating measures to foreshorten individuals’ lives. (shrink)

Karl Jaspers' phenomenology remains important today, not solely because of its continuing influence in some areas of psychiatry, but because, if fully understood, it can provide a method and set of concepts for making new progress in the science of psychopathology. In order to understand this method and set of concepts, it helps to recognize the significant influence that Edmund Husserl's early work, Logical investigations, exercised on Jaspers' formulation of them. We trace the Husserlian influence while clarifying the main components (...) of Jaspers' method. Jaspers adopted Husserl's notions of intuition, description, and presuppositionlessness, transforming them when necessary in order to serve the investigations of the psychopathologist. Jaspers also took over from Wilhelm Dilthey and others the tools of understanding (Verstehen) and self-transposal. The Diltheyian procedures were integrated into the Husserlian ones to produce a method that enables psychiatrists to define the basic kinds of psychopathological mental states. (shrink)

By illuminating the striking affinity between the most innovative aspects of postmodern thought and religious mystical discourse, Shadow of Spirit challenges the long established assumption that western thought is committed to nihilism. This collection of essays by internationally recognized scholars explores the implications of the fascination with the "sacred," "divine" or "infinite" which characterizes much contemporary thought. It shows how these concerns have surfaced in the work of Derrida, Baudrillard, Lyotard, Kristeva, Irigaray and others. Examining the connection between this postmodern (...) "turn" and the current search for a new discourse of ethics and politics, it also stresses the contribution made by feminist thought to this unexpected intellectual direction. (shrink)

This chapter contains section titled: Communities and Persons A Phenomenological Distinction between Community and Society Community Society The Self and its Social Roles Dispositional Vectors and the Shaping of Personality The Personality The Sociopathic Personality Type Conclusion.

David Ross made the first sustained attack on Moore's agathistic utilitarianism or ethical neutralism a damaging concession to consequentialism.

Philippa Foot; V—Moral Beliefs, Proceedings of the Aristotelian Society, Volume 59, Issue 1, 1 June 1959, Pages 83–104, https://doi.org/10.1093/aristotelian/59.

The question may be asked why many workers are still being paid below subsistence wages and I believe the answer can be found in the confusion over what exactly constitutes a “living wage” and who has the duty to pay these wages. This article therefore clarifies what a living wage is and gives a concrete example of how a living wage can be calculated. To understand who has the obligation to pay living wages I look to the theory of Alan (...) Gewirth on individual and institutional responsibility and the account of Robert Mayer on structural exploitation to argue that all parts of the supply chain have the duty. The final part of this paper willoutline the inclusion of a living wage calculation into corporate codes of conduct to ensure that workers at the end of the supply chain receive living wages. (shrink)

Moral Dilemmas is the second volume of collected essays by the eminent moral philosopher Philippa Foot, gathering the best of her work from the late 1970s to the 1990s. It fills the gap between her famous 1978 collection Virtues and Vices and her acclaimed monograph Natural Goodness, published in 2001. In this new collection Professor Foot develops further her critique of the dominant ethical theories of the last fifty years, and discusses such topics as the nature of moral judgement, (...) practical rationality, and the conflict of virtue with desire and self-interest. Moral Dilemmas, alongside her other two books, completes the summation of her distinctive and lasting contribution to twentieth-century moral philosophy. (shrink)