Combining philosophy of art with film criticism, Strohl flips conventional notions of good and bad on their heads and makes the case that the ultimate value of a work of art lies in what it can add to our lives. By this measure, some of the worst movies ever made are also among the best.

This essay argues that the "classical" or "standard" computation model of an enviroment of thought may hamstring the nascent cognitive science of religion by masking the ways in which the bare biological brain is prosthetically extended and embedded in the surrounding landscape. The motivation for distinsuishing between the problem-solving profiles of the basic brain and the brain-plus-scaffolding is that in many domains non-biological artifacts support and augment biological modes of computation - often allowing us to overcome some of the brain's (...) native computation limitations. The recognition that in some contexts not all of the relevant computational machinery fits inside the head suggests that we should reconsider the possible role and significance of material culture in religious cognition. More specifically, the broad spectrum of rituals, music, relics, scriptures, statues and buildings typically associated with religious traditions may be more than quaint ethnographic window dressing. Rather than thin cultural wrap arounds that decorate the real cognitive processes going on underneath, these elements could represent central components of the relevant machinery of religious thought. By introducing tangible features of the world that can be physically manipulated and tracked in real-time, for example, the cognitive scaffolding that religious material culture affords seems tailor-made for allowing people to exchange the intricate "off-line" problems that arise from dealing with invisible, counter-intuitive supernatural agents for the kinds of "on-line" cognitive tasks they are naturally good at doing. (shrink)

What is the significance of and logic behind Jacques Derrida's recent "political" writings? While Derrida's work refuses to obey any singular movement or register, he does, nonetheless, make recurrent attempts to negotiate between a politics of identity and difference. A similar undertaking can be found in the radical democratic writings of Ernesto Laclau and Chantal Mouffe. An encounter between these thinkers is here carried out in order to elucidate key themes in Derrida's The Other Heading. The reading aims at developing (...) and contextualising Derrida's relation to radical democratic thought so that his political strategies can be made more explicit. (shrink)

Critics often suggest that Socrates’ portrait of the philosopher’s inspired madness in his second speech in Plato’s Phaedrus is incompatible with the other types of divine madness outlined in the same speech, namely poetic, prophetic, and purificatory madness. This incompatibility is frequently taken to show that Socrates’ characterisation of philosophers as mad is disingenuous or misleading in some way. While philosophical madness and the other types of divine madness are distinguished by the non-philosophical crowd’s different interpretations of them, I aim (...) to show that they are not, in fact, presented as incompatible. Socrates’ pair of speeches demonstrates that madness can be divided into harmful and beneficial kinds, and in Socrates’ key discussion of philosophical madness (249c4-e4), I argue that the crowd correctly recognises that the philosopher is mad on the basis of his eccentricity, but wrongly assumes that the philosopher’s madness is of the harmful type because it fails to realise that the philosopher is enthused. Socrates’ second speech provides information about human souls and gods which shows that philosophical madness belongs to the beneficial type and so falls under the heading of divine enthusiasm after all. Importantly, human souls and gods are shown in the speech to be roughly isomorphic. Both philosophical and other kinds of divine madness involve having something divine inside a human body (entheos): in the former a human soul has become godlike; in the latter a human soul has been displaced by a god. Because of this, I propose that philosophy is presented as a genuine form of divine madness alongside the other more conventional examples. (shrink)

Reasons are considerations that figure in sound reasoning. This is considered by many philosophers to be little more than a platitude. I argue that it actually has surprising and far-reaching metanormative implications. The view that reasons are linked to sound reasoning seems platitudinous only because we tend to assume that soundness is a normative property, in which case the view merely relates one normative phenomenon (reasons) to another (soundness). I argue that soundness is also a descriptive phenomenon, one we can (...) pick out with purely descriptive terms, and that the connection between normative reasons and sound reasoning therefore provides the basis for a reductive account of reasons. Like all proposed reductions, this one must confront some version of G. E. Moore’s open question argument. I argue that a reductive view rooted in the idea that reasons figure in sound reasoning is well-equipped to meet the open question challenge head on. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Conflicts—and Consensus—about Conflicts of Interest in MedicineMatthew K. Wynia and Bette–Jane Crigger*This fascinating collection of essays about individual experiences of conflict of interest leaves little doubt that physicians remain divided about the importance, impact and meaning of conflicts of interest in their work. These essays offer differing views about what conflicts of interest look and feel like “on the ground” and about whether specific conflicts of interest are bad, (...) just a fact of life, or maybe even good.Conflict, Conflict EverywhereThese essays situate conflict of interest in a variety of contexts: the treatment recommendations a physician makes for an individual patient; the relationship between teaching physician and medical student or practicing physician and health care organization; the interaction between academic researchers and industry collaborators or professional bodies and industry supporters. In this, the narratives taken together reflect the scope of concern about conflict of interest in medicine familiar in the literature. In his classic 1993 essay, Dennis Thompson noted that concerns about conflict of interest encompass issues of physician self–referral, risk sharing between physicians and health care institutions, gifts from industry, hospital purchasing practices, as well as sponsored research and research with patients (Thompson 1993). To that list have subsequently been added relationships with industry in medical education at all levels, physicians’ service as consultants to industry or members of industry speakers bureau, and development of clinical practice guidelines (Lo & Fields 2009).That almost none of these essays draw attention to some widely publicized situations of conflict of interest—for example, gifts to physicians or the provision of drug samples—should, we think, be seen more as an artifact of the authors’ varied individual experiences than as a failure by the authors to engage key concerns in the ongoing professional and public debate. It could also be that the authors, asked to submit personal stories, assumed that yet another essay about the ‘traditional’ issues in the conflicts of interest literature would be seen as redundant, routine or even boring. Or, there is the tantalizing possibility that the absence of some of the more familiar conflicts from these narratives is the early fruit of efforts to address these traditional issues through policies governing interactions between physicians and industry promulgated by academic medical centers and health systems, medical specialty societies, and industry.One significant area of concern that has emerged in recent years is conflict of interest in the development of clinical practice guidelines. E.g., Choudry et al. 2002; Sniderrman & Furberg 2009; Guyatt et al. 2010. Although none of the essays in this [End Page 101] collection address it head on, Perlmutter touches on several key issues. His depiction of how an FDA committee process limited the input he was able to provide as an expert, undermined his potential to contribute to the professional dialogue, and raised concerns about the objectivity of the drug approval process echoes concerns about objectivity, the role of expert opinion, and the presence on guideline development panels of individuals with financial interests in the recommendations to be developed that have been explored at some length in the literature, most recently by the Institute of Medicine in reports on evidentiary standards (Eden et al 2011) and principles for guideline development (Graham et al. 2011).Conflict of Interest or Dual Agency?Several essays set out physicians’ experience in navigating situations of diverging expectations. Bierut, for example, reflects on the disjunction between the goals and products of academic researchers and commercial sponsors. She saw herself advancing basic knowledge and was forced to grapple with the reality of sponsors’ goals to advance commercial ends as well. Nagldinne and Mikulec each recall struggles to reconcile their obligation to exercise professional judgment on behalf of patients with the demands of health care organizations focussed also on the bottom line. Cruz–Flores attests to the challenge of making recommendations for care when one is both a practicing clinician and a clinical investigator engaged in research that might offer benefit to a patient for whom there are limited options.Thompson defined conflicts of interest as “a set of conditions in which professional judgment concerning a primary interest (such as a patient’s welfare or the validity of... (shrink)

This article seeks evidence of Herodotus's conception of his historical enterprise in the recurring scenes in which he portrays barbarian kings as inquirers and investigators. Through these scenes-involving most notably Psammetichus, Etearchus, Croesus, Cyrus, Cambyses, Darius, and Xerxes-the historian not only explores the character of autocrats, but also holds up a mirror to his own activity as inquirer. Once we recognize the metahistorical dimension of Herodotus's representation of inquiring kings, we can better understand the scenes in which these figures appear (...) and the historian who sees his own enterprise reflected or distorted in their efforts. I argue first that the tale of Darius's inquiry concerning the Paeonian wonder-woman is a paradigmatic Herodotean treatment of kingly inquiry in the way the historian both identifies with, and distances himself from, his kingly investigator. I then assess kingly research under three headings that reflect some of the many ways that Herodotean kings use and abuse investigation: Measurement and Self-Aggrandizement; Exploration and Conquest; Trial, Torture, and Test. Under the final rubric, kingly experiments are the focus, some involving human subjects , others involving the divine . Herodotus's extensive analysis of inquiring kings indicates that any earlier investigator-measurer, explorer, or experimenter-is a potential rival for him. If Herodotus is conscious that he is following in the footsteps of inquiring kings, however, his critique of their techniques and motives suggests that his inquiry is intellectually and ethically superior to theirs. Ultimately, then, Herodotus's exploration of regal investigation helps both to define and to lend authority to the historiê that he undertakes in the Histories. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Patricia Kelly, Ressourcement Theology:A Review EssayMatthew K. MinerdIntroductionAlthough now over seventy years in the past, the theological and ecclesiastical events of the 1940s, most often styled under some banner akin to "the crisis over the nouvelle théologie," leading up to the promulgation of the encyclical Humani Generis, retain a currency and interest to this very day. No doubt, the later influence of many of the so-called nouveaux théologiens leading (...) up to, during, and following the Second Vatican Council has contributed to the continued currency of their thought and the debates connected to it. Numerous monographs continue to be written concerning themes of "ressourcement," theological reform, and engagement with the world, all of which were dear to many of those who were embroiled in the philosophical and theological controversies of the 1930s and 1940s. Moreover, increased interest in certain long-buried conservative Thomist thinkers from this same era has led to renewed consideration regarding the concerns that they expressed at the time. In fact, it would seem that today, in 2022, the evaluation expressed in Nineteenth Century Scholasticism: The Search for a Unitary Method by Fr. Gerald McCool (from a perspective rather different from my own) remains true, as the Church continues to live in the midst of an ongoing crisis of modernity that places us in tight continuity with so much of the past several centuries of European Christian intellectual history:In contemporary Catholic theology, the relationship between apologetics, or fundamental theology, and speculative theology is as much [End Page 353] an issue as it was in the nineteenth century.... And in contemporary Catholic theology, the relation between positive theology and speculative theology still remains a problem whose solution demands the use of a coherent system of epistemology and metaphysics.... The contemporary debate over theological method is simply another phase in the dialectical movement of Catholic theology's response to post-Enlightenment thought from the beginning of the nineteenth century through Vatican I, Aeterni Patris, the modernist crisis, between-the-wars Thomism, the New Theology controversy, and Vatican II up to the present.1The great crisis of the 1940s—whether we name it nouvelle théologie, after the reform-advocates of the era, or dialogue theologique, in honor of the Toulouse Dominicans' attempt to present a Scholastic position between, on the one hand, Fr. Chenu's and Congar's view of what the Saulchoir should be, and, on the other hand, the more-conservative Thomism of Frs. Garrigou-Lagrange, Gagnebet, and Gillon in Rome2—was and remains, in the words of Etienne Fouilloux, "the only theological debate of real [quelque] importance, at least in France, from the condemnation of Modernism to the time of the Second Vatican Council."3 And like any truly great event or crisis in intellectual-spiritual culture, it remains with us today in its fruits, both resolved and unresolved.Thus, when a new work is published dedicated to these events and the figures involved therein, the Catholic intellectual world should take heed, for our own self-understanding—whatever sui iuris Church in which we are ascribed—is at stake. Hence, the arrival of the collection of translations by Dr. Patricia Kelly of the University of St. Andrews is an event to be welcomed, even if elements of its publication also give rise to concern. This volume, Ressourcement Theology: A Sourcebook,4 gathering together essays by various parties involved on both sides of the specifically Francophone debates over theological method and truth that came to a head in the 1940s, provides the reading public with a dual "service": it presents in English a [End Page 354] number of texts not heretofore available, while also, unfortunately, bearing witness to the academic prejudices lingering against the authors writing from Rome and Toulouse concerning certain veins of thought in theological methodology during the inter-war and immediate post-war era. Although my review will be somewhat negative on certain points—both for technical textual reasons and because of the slanted narrative presented by Dr. Kelly—I wish only the best to her and her work, hoping that the concerns that I voice can serve as a springboard to dialogue, not retrenchment... (shrink)

In previous studies investigating entrainment and person perception, synchronized movements were found to enhance memory for incidental person attributes. Although this effect is robust, including in dance, the process by which it is actuated are less well understood. In this study, two hypotheses are investigated: that enhanced memory for person attributes is the result of (1) increased gaze time between in-tempo dancers, and/or (2) greater attentional focus between in-tempo dancers. To explore these possible mechanisms in the context of observing dance, (...) an eye-tracking study was conducted in which subjects watched videos of pairs of laterally positioned dancers; only one of the dancers was synchronized with the music, the other being asynchronous. The results were consistent with the first hypothesis—music-dance synchrony gives rise to increased visual inspection times. In addition, there was a preference for upper-body fixations over lower-body fixations across both synchronous and asynchronous conditions. A subsequent, single-dancer eye-tracking study investigated fixations across different body regions, including head, torso, legs and feet. Significantly greater dwell times were recorded for head than torso and legs; feet attracted significantly less dwell time than any other body region. Lastly, the study sought to identify dance gestures responsible for torso- and head-directed fixations. Specifically we asked whether there are features in dance that are specially designed to direct an observer’s gaze towards the face—the main “communicative portal” with respect to the transmission of intent, affect and empathy. (shrink)

In this chapter I focus on two problems facing immigration systems around the world, and Australia in particular. The topics addressed are chosen because each one involves important fundamental rights and because significant improvement in these areas is possible even if each state acts alone, without significant coordination with others. First, I examine refugee programmes, focussing specifically on the ‘two- tier’ refugee programmes pioneered by Australia with the introduction of Temporary Protection Visas by the Howard Government in 1999. Next, I (...) look at recent declines in refugee resettlement schemes from already stingy levels and, in relation to Australia in particular, I show how the tying of resettlement numbers to the number of affirmative asylum claims granted is both wrong- headed and counterproductive. The second area of immigration policy explored is family migration, another area where immigration systems around the world have been moving in the wrong direction, often via less than transparent administrative processes. Australia is no exception. While Australia’s family migration system is reasonably good on its face, in practice there are several factors which make the programme significantly less than satisfactory from the perspective of protecting the basic rights of migrants and, arguably more importantly, citizens. These problems can and should be fixed in straightforward ways, and since doing so would be more just, would have few— if any— significant negative consequences, and in fact would have a number of clear benefits, those changes should be made. (shrink)

This paper compares late eighteenth-century claims for the authenticity of Macpherson's Ossian and for the existence of Welsh Indians. It shows that although both claims were supported in part by appeals to similarities between Celtic and American Indian languages, the appeals in each case were very different. On the one hand, the Edinburgh literati who supported Ossian's authenticity focused on expressive structures shared by all primitive societies. On the other hand, radically Protestant antiquarians and philologists focused on lexical similarities that (...) they argued demonstrate a genetic link between certain American Indians and the Welsh. The paper uses this fundamental difference underlying a superficial similarity, to explore in greater detail the distinction between philosophical historians among the Edinburgh literati, who were religiously moderate, politically conservative, and promoted Scotland's integration into a modern, polite, commercial and English-speaking empire, and the Welsh antiquarians, who were religious and political radicals and whose interest in the Welsh Indians reflected and reinforced their attempts to resurrect a distant golden age of Celtic Britain. pe’nguin. (1) A bird. This bird was found with this name, as is supposed, by the first discoverers of America; and penguin signifying in Welsh a white head, and the head of this fowl being white, it has been imagined, that America was peopled from Wales … —Samuel Johnson, Dictionary of the English Language, 1755. (shrink)

Based on participant observation and in-depth interviews, this article analyzes the ways that male residents in a drug treatment program signified a masculine self through compensatory manhood acts. I analyze four strategies of identity work that men used during group accountability sessions called “games”: signifying masculinity through aggression; subordinating women and nonconventional men; calling others to account as men; and “keeping your head”: managing emotions to assert control. This article adds to our understanding of the ways that compensatory manhood (...) acts are structured locally through interaction, highlighting ways that men’s interactions may be self-defeating and also reproduce inequality by reinforcing dominant ideologies of misogyny and homophobia. In addition, it speaks to the ways that masculine subjectivity is constructed against and through dominant narratives of addiction and treatment. (shrink)

There is a tension between the “growing block” account of time (closed past, open future) and the possibility of backwards time travel. If Tim the time traveler can someday travel backwards through time, then he has (in a certain sense) already been. He might discover this fact before (in another sense) he goes. Hence a dilemma: it seems that either Tim’s future is determined in an odd way or cases of (temporary) ontic indeterminate identity are possible. Either Tim cannot avoid (...) heading for the past or he is only indeterminately that guy who appeared in the past with many of Tim’s memories. Determinacy in the past implies a degree of determinism in the future; indeterminism about the future seeps back to the past. (shrink)

Flint arrowheads, spearheads, and axe heads made by prehistoric Europeans were generally considered before the eighteenth century to be a naturally produced stone that formed in storm clouds and fell with lightning. These stones were called ceraunia, or thunderstones, and it was not until the sixteenth century that their status as a natural phenomenon was challenged. During the seventeenth century natural historians and antiquaries began to suggest that these ceraunia were not thunderstones but ancient human artifacts. I argue that natural (...) history museums, European contact with the stone-tool using peoples in the New World, and the close relationship between natural history and antiquarianism were critical to this reinterpretation of ceraunia. Once these objects were recognized to be ancient artifacts they could be used to investigate the earliest periods of human history from sources other than texts. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Recovering the Vestiges of Primeval Europe: Archaeology and the Significance of Stone Implements, 1750–1800Matthew R. GoodrumFor the antiquaries of the seventeenth and eighteenth centuries who studied the few broken monuments and obscure artifacts that survived from the earliest periods of human history there was a dawning realization that these remote epochs were not as inaccessible as had previously been believed. This attitude was mirrored in geological research where natural (...) historians were using fossils and geological formations to reconstruct the history of the earth, which was turning out to be considerably longer and more dynamic than had previously been thought.1 Antiquarianism and natural history shared many features and problems in common during this period and their fates would become more intertwined than either discipline realized at the time.2Despite the growing hope that archaeological monuments could illuminate the past, a great deal of early human history remained hidden, enveloped in a fog that the antiquary could only occasionally peer through.3 Yet [End Page 51] the nascent science of archaeology made great strides during the seventeenth and eighteenth centuries. Antiquaries throughout Europe were investigating field monuments, collecting artifacts, and excavating barrows in an attempt to throw some light on the original inhabitants of the continent. 4 Antiquarianism, a scholarly discipline dedicated to the study of antiquities and other historical documents, had close links with natural history during this period and many antiquaries employed methods and a mode of reasoning drawn from the sciences.5 By By the late eighteenth century, antiquarianism itself was changing and a new science of archaeology was emerging and defining its own professional identity.6Among the objects investigated by these antiquaries was a particularly curious class of artifacts that had long been collected and examined in Europe. Natural historians throughout the early modern period had collected a type of stone called ceraunia, or thunderstones. It was not until the end of the seventeenth century that antiquaries and natural historians suggested that these stones were not produced in clouds by natural processes but instead were stone arrowheads, axe-heads, and other implements fabricated by early Europeans. Once these objects were accepted as ancient human artifacts, entirely new sets of questions arose: for example, why would early Europeans make tools out of stone instead of metal, what were these objects used for, and what could they tell us about the culture of ancient peoples.7 The latter question was all the more disturbing since it [End Page 52] was apparent that the stone artifacts found in Europe were very similar to the stone implements and weapons used by the so-called “savages” of the New World and the South Pacific. By the middle of the eighteenth century there was an increasing amount of evidence and a growing consensus that the inhabitants of many parts of northern Europe prior to the Roman era possessed only stone implements and culturally were rude and barbarous peoples. This idea that early Europeans had been barbarians was not new; Roman historians had asserted as much, but what was new was the quantity of archaeological evidence for this idea and the way it was understood within the context of European contact with the indigenous peoples of the New World and the South Pacific who still used stone tools.Antiquaries and natural historians during the first half of the eighteenth century were still accumulating evidence to support the idea that so-called thunderstones were in fact archaeological artifacts. They were also attempting to understand what they meant as historical and cultural artifacts, and importantly they were trying to integrate this new understanding within the traditional biblical view of human history.8 A great deal has been written about the study of prehistoric stone artifacts in the early nineteenth century, especially since it was during this period that Scandinavian archaeologists formulated the Three Age System that organized prehistory into a succession of periods from the Stone Age through the Bronze Age to the Iron Age.9 In addition, the important theoretical breakthroughs of the early nineteenth century, combined with the expansion and professionalization of archaeology as a discipline during this period, have tended to focus the attention of historians of archaeology... (shrink)

This article aims to serve as an accessible introduction to the idea of "ontotheology" and to the so-called "ontotheological critique of Western metaphysics" for which the twentieth-century German philosopher Martin Heidegger is especially well known. I begin by distinguishing two uses of "ontotheology" employed respectively by Kant and Heidegger, and go on to develop the Heideggerian interpretation and critique of ontotheology under three main headings: The Onto-theo-logical Constitution of Western Metaphysics; Ontotheology's Problematic Legacy: Anxiety, Calculation, Oblivion; and Ontotheology and God. (...) The article concludes with an annotated bibliography of helpful resources for learning more about ontotheology, the critique of ontotheology, and directions the critique has taken after Heidegger. (shrink)

This essay argues the image of the ‘Mystical Body’ or ‘Body of Christ’ is fully intelligible only in light of the Cross. The Body of Christ is a cruciform Body. As the Body of Christ crucified and risen, it is presently being configured to Christ in the world through self-sacrificial love. The essay traces the place of the Cross in some representative twentieth-century Catholic theologies of the Mystical Body, in light of the perspective of Thomas Aquinas. I first survey four (...) theologians from the first half of the century who, in their understandings of the Mystical Body, gave a place to the Cross: Emile Mersch, Fulton Sheen, Charles Journet, and Pius Pasch. Here I also examine Pope Pius XII's encyclical Mystici Corporis. Second, I explore the approach of some notable Thomistic theologians or interpreters of Aquinas from the early 1960s onward: Jerome Hamer, M. J. Le Guillou, George Sabra, Jean-Pierre Torrell, and Herwi Rikhof. In this section, I also examine Vatican II's Lumen Gentium. My third and final section treats Aquinas himself, in order to reflect upon the place of the Cross in his understanding of the Mystical Body, as found in his biblical commentaries and the Summa theologiae. (shrink)

The original version of this article unfortunately contained a mistake. Section Heading numbers were erroneously removed in the article.

The destruction and pollution of the natural environment poses two problems for philosophers. The first is political and pragmatic: which theory of the environment is best equipped to impact policymakers heading as we are toward a series of potential ecocatastrophes? The second is more central: On the environment philosophers tend to fall either side of an irreconcilable divide. Either our moral concerns are grounded directly in nature, or the appeal is made via an anthropocentric set of interests. The lack of (...) a common ground is disturbing. In this paper I attempt to diagnose the reason for this lack. I shall agree that wild nature lacks features of intrinsic moral worth, and that leaves a puzzle: Why is it once we subtract the fact that there is such a lack, we are left with strong intuitions against the destruction and/or pollution of wild nature? Such intuitions can be grounded only in a strong sense of aesthetic concern combined with a common-sense regard for the interests of sentient life as it is indirectly affected by the quality of the environment. I suggest also that of the positions on offer, a hybrid theory of the environment is best suited to address our first problem, that of having an effective influence in the polity. (shrink)

Cognitive Science, Volume 46, Issue 10, October 2022.

In responding to Mathias Beck's thought-provoking article, it seems helpful to begin with an outline and comments on Beck's case as I understand it. For me, this overview throws up three problematic areas that I explore further under the headings of 1. examining the New Testament evidence, 2. sin as disobedience, and 3. obedience, grace, and freedom. Clearly, the author's thoughts in all their nuances are not always adequately accessible in translation. Nevertheless, I hope that I have grasped the main (...) thread of his argument. If I am right in my interpretation then Beck still has work to do to clarify and make explicit what is not only barely implicit but what is obscured by his central theme: that obedience to God's will is the mainstay of our relationship to God. (shrink)

In some views, philosophy’s glory days in bioethics are over. While philosophers were especially important in the early days of the field, so the argument goes, the majority of the work in bioethics today involves the “simple” application of existing philosophical principles or concepts, as well as empirical work in bioethics. Here, we address this view head on and ask: What is the role of philosophy in bioethics today? This paper has three specific aims: (1) to respond to skeptics (...) and make the case that philosophy and philosophers still have a very important and meaningful role to play in contemporary bioethics, (2) to discuss some of the current challenges to the meaningful integration of philosophy and bioethics, and (3) to make suggestions for what needs to happen in order for the two fields to stay richly connected. We outline how bioethics center directors, funders, and philosopher bioethicists can help. (shrink)

This paper aims to provide an argument for saying that a publicly funded health care system, available to all free at the point of delivery, is morally superior to a market system, and to provide a framework for deciding questions about which forms of health care should be included in such a public system. The argument presents health care as a ‘head’, in the sense of something to which human beings are morally entitled as a necessary condition for a (...) life worthy of human dignity. Alternative arguments for similar conclusions, proposed by Daniels and Buchanan, are critically examined and rejected. (shrink)

The following reviews Kristeva's 2011 text on artistic, cultural, and political uses of images of severed heads.

This paper reports on a quiz robot experiment in which we explore similarities and differences in human participant speech, gaze, and bodily conduct in responding to a robot’s speech, gaze, and bodily conduct across two languages. Our experiment involved three-person groups of Japanese and English-speaking participants who stood facing the robot and a projection screen that displayed pictures related to the robot’s questions. The robot was programmed so that its speech was coordinated with its gaze, body position, and gestures in (...) relation to transition relevance places, key words, and deictic words and expressions in both languages. Contrary to findings on human interaction, we found that the frequency of English speakers’ head nodding was higher than that of Japanese speakers in human-robot interaction. Our findings suggest that the coordination of the robot’s verbal and non-verbal actions surrounding TRPs, key words, and deictic words and expressions is important for facilitating HRI irrespective of participants’ native language. Keywords: coordination of verbal and non-verbal actions; robot gaze comparison between English and Japanese; human-robot interaction ; transition relevance place ; conversation analysis. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for (...) the stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Accountable Care Organizations are a key mechanism of the Patient Protection and Affordable Care Act. ACOs will influence incentives for providers, who must understand these changes to make well-considered treatment decisions. Our paper defines an ethical framework for physician decisions and action within ACOs. Emerging ethical pressures providers will face as members of an ACO were classified under major headings representing three of the four principles of bioethics: autonomy, beneficence, and justice. Conflicts include a bias against transient populations, a motive (...) to undertreat conditions lacking performance measures, and the mandate to improve population health incentivizing life intrusions. After introducing and explaining each conflict, recommendations are offered for how providers ought to precede in the face of novel ethical choices. Our description of novel ethical choices will help providers know what to expect and our recommendations can guide providers in choosing well. (shrink)

Bayesians take “definite” or “single-case” probabilities to be basic. Definite probabilities attach to closed formulas or propositions. We write them here using small caps: PROB(P) and PROB(P/Q). Most objective probability theories begin instead with “indefinite” or “general” probabilities (sometimes called “statistical probabilities”). Indefinite probabilities attach to open formulas or propositions. We write indefinite probabilities using lower case “prob” and free variables: prob(Bx/Ax). The indefinite probability of an A being a B is not about any particular A, but rather about the (...) property of being an A. In this respect, its logical form is the same as that of relative frequencies. For instance, we might talk about the probability of a human baby being female. That probability is about human babies in general — not about individuals. If we examine a baby and determine conclusively that she is female, then the definite probability of her being female is 1, but that does not alter the indefinite probability of human babies in general being female. Most objective approaches to probability tie probabilities to relative frequencies in some way, and the resulting probabilities have the same logical form as the relative frequencies. That is, they are indefinite probabilities. The simplest theories identify indefinite probabilities with relative frequencies.3 It is often objected that such “finite frequency theories” are inadequate because our probability judgments often diverge from relative frequencies. For example, we can talk about a coin being fair (and so the indefinite probability of a flip landing heads is 0.5) even when it is flipped only once and then destroyed (in which case the relative frequency is either 1 or 0). For understanding such indefinite probabilities, it has been suggested that we need a notion of probability that talks about possible instances of properties as well as actual instances.. (shrink)

© Copyright 2015, Mary Ann Liebert, Inc..Signal transducer and activator of transcription factor 3 is hyperactivated in head and neck squamous cell carcinomas. Cumulative evidence indicates that IL-6 production by HNSCC cells and/or stromal cells in the tumor microenvironment activates STAT3 and contributes to tumor progression and drug resistance. A library of 94,491 compounds from the Molecular Library Screening Center Network was screened for the ability to inhibit interleukin-6 -induced pSTAT3 activation. For contractual reasons, the primary high-content screening campaign (...) was conducted over several months in 3 distinct phases; 1,068 primary HCS actives remained after cytotoxic or fluorescent outliers were eliminated. One thousand one hundred eighty-seven compounds were cherry-picked for confirmation; actives identified in the primary HCS and compounds selected by a structural similarity search of the remaining MLSCN library using hits identified in phases I and II of the screen. Actives were confirmed in pSTAT3 IC50 assays, and an IFNγ-induced pSTAT1 activation assay was used to prioritize selective inhibitors of STAT3 activation that would not inhibit STAT1 tumor suppressor functions. Two hundred three concentration-dependent inhibitors of IL-6-induced pSTAT3 activation were identified and 89 of these also produced IC50s against IFN-γ-induced pSTAT1 activation. Forty-nine compounds met our hit criteria: they reproducibly inhibited IL-6-induced pSTAT3 activation by ≥70% at 20 μM; their pSTAT3 activation IC50s were ≤25 μM; they were ≥2-fold selective for pSTAT3 inhibition over pSTAT1 inhibition; a cross target query of PubChem indicated that they were not biologically promiscuous; and they were ≥90% pure. Twenty-six chemically tractable hits that passed filters for nuisance compounds and had acceptable drug-like and ADME-Tox properties by computational evaluation were purchased for characterization. The hit structures were distributed among 5 clusters and 8 singletons. Twenty-four compounds inhibited IL-6-induced pSTAT3 activation with IC50s ≤20 μM and 13 were ≥3-fold selective versus inhibition of pSTAT1 activation. Eighteen hits inhibited the growth of HNSCC cell lines with average IC50s ≤ 20 μM. Four chemical series were progressed into lead optimization: the guanidinoquinazolines, the triazolothiadiazines, the amino alcohols, and an oxazole-piperazine singleton. (shrink)

Climate and evolution represents an important contribution to evolutionary biogeography, that influenced several authors, notably Karl P. Schmidt, George S. Myers, George G. Simpson, Philip J. Darlington, Ernst Mayr, Thomas Barbour, John C. Poynton, Allen Keast, Léon Croizat, Robin Craw, Michael Heads, and Osvaldo A. Reig. Authors belonging to the “New York School of Zoogeography” –a research community including Matthew, Schmidt, Myers and Simpson– accepted Matthew’s “Holarcticism” and the permanence of ocean basins and continents, whereas others, especially panbiogeographers (...) and cladistic biogeographers, were extremely critical and reacted against these ideas. “Holarcticism” has been falsified and rejected by dispersalists and the “New York School of Zoogeography” disappeared in the 1970s. Matthew, however, continues being identified by panbiogeographers and cladistic biogeographers as a key representative of classic dispersalism, helping provide some cohesion to their research communities. (shrink)

Beneath the stylized violence and thrilling car crashes, the Mad Max films consider universal questions about the nature of human life, order and anarchy, justice and moral responsibility, society and technology, and ultimately, human redemption. In Mad Max and Philosophy, a diverse team of political scientists, historians, and philosophers investigates the underlying themes of the blockbuster movie franchise, following Max as he attempts to rebuild himself and the world. -/- This book guides you through the barren wastelands of a post-apocalyptic (...) future as you explore ethics and politics in The Wasteland, the importance of costumes and music, humankind's relationship with nature, commerce, gender, religion, madness, and more. (shrink)

The first edition of The Scientific Background to Modern Philosophy took the dialogue of science and philosophy from Aristotle through to Newton. This second edition adds eight chapters, taking the dialogue through the Enlightenment and up to Darwin. This anthology is an attempt to help bridge the gap between the history of science and the history of philosophy.

This paper initiates analytic inquiry into the metaphysics of masculinity. I argue that individual masculinities (such as ‘clone masculinity’ and ‘incel masculinity’) are distinct homeostatic property cluster kinds related to gender structures via processes of adherence, failed-adherence, selective adherence, and/or reinterpretation with respect to male-coded social norms.

Gareth Matthews suggests that we can better understand the nature of philosophical inquiry if we recognize the central role played by perplexity. The seminal representation of philosophical perplexity is in Plato's dialogues; Matthews examines the intriguing shifts in Plato's attitude to perplexity and suggests that these may represent a course of philosophical development that philosophers follow even today.

Recent research on the evolution of religion has focused on whether religion is an unselected by-product of evolutionary processes or if it is instead an adaptation by natural selection. Adaptive hypotheses for religion include direct fitness benefits from improved health and indirect fitness benefits mediated by costly signals and/or cultural group selection. Herein, I propose that religious denominations achieve indirect fitness gains for members through the use of ecologically arbitrary beliefs, rituals, and moral rules that function as recognition markers of (...) cultural inheritance analogous to kin and species recognition of genetic inheritance in biology. This recognition signal hypotheses could act in concert with either costly signaling or cultural group selection to produce evolutionarily altruistic behaviors within denominations. Using a cultural phylogenetic analysis, I show that a large set of religious behaviors among extant Christian denominations supports the prediction of the recognition signal hypothesis that characters change more frequently near historical schisms. By incorporating demographic data into the model, I show that more-distinctive denominations, as measured through dissimilar characteristics, appear to be protected from intrusion by nonmembers in mixed-denomination households, and that they may be experiencing greater biological growth of their populations even in the present day. (shrink)

I distinguish two ways of explaining our capacity for ‘transparent’ knowledge of our own present beliefs, perceptions, and intentions: an inferential and a reflective approach. Alex Byrne (2011) has defended an inferential approach, but I argue that this approach faces a basic difficulty, and that a reflective approach avoids the difficulty. I conclude with a brief sketch and defence of a reflective approach to our transparent self-knowledge, and I show how this approach is connected with the thesis that we must (...) distinguish between a kind of self-knowledge that is of oneself as agent and another kind that is of oneself as patient. (shrink)

An important theme in recent experimental philosophy is that certain judgements (e.g. our judgements involving intentional action and causation) exhibit a kind of normative penetration whereby, in spite of a not-obviously-normative subject matter, they turn out to be sensitive to, and co-vary with, our normative attitudes in interesting and surprising ways. We present the results of several new experimental studies that suggest that our judgements about feasibility also appear to exhibit this kind of normative penetration in at least some cases; (...) that the best explanation of it involves attributing to subjects a certain kind of extensional error that results from conflating the question at hand with another question that is more salient given their normative attitudes; and that these conclusions have significant, though not straightforward, implications for our understanding of both normative penetration and feasibility, respectively. (shrink)

Research that involves the creation of animals with human-derived parts opens the door to potentially valuable scientific and therapeutic advances, yet invokes unsettling moral questions. Critics and champions alike stand to gain from clear identification and careful consideration of the strongest ethical objections to this research. A prevailing objection argues that crossing the human/nonhuman species boundary introduces inexorable moral confusion (IMC) that warrants a restriction to this research on precautionary grounds. Though this objection may capture the intuitions of many who (...) find this research unsettling, it relies on mistaken views of both biology and moral standing, ultimately distorting the morally relevant facts. We critically examine IMC, identify mistaken essentialist assumptions, and reframe ethical concerns. The upshot is a stronger line of objection that encourages a more inclusive and productive ethical discourse. (shrink)

MacIntyre argues that management embodies emotivism, and thus is inherently amoral and manipulative. His claim that management is necessarily Weberian is, at best, outdated, and the notion that management aims to be neutral and value free is incorrect. However, new forms of management, and in particular the increased emphasis on leadership which emerged after MacIntyre’s critique was published, tend to support his central charge. Indeed, charismatic and transformational forms of leadership seem to embody emotivism to a greater degree than do (...) more Weberian, bureaucratic forms of management; hence, MacIntyre’s central contention about our emotivistic culture seems to be well founded. Having criticised the details but defended the essence of MacIntyre’s critique of management, this paper sketches a MacIntyrean approach to management and leadership by highlighting the affinities between MacIntyre’s political philosophy and Greenleaf’s concept of servant leadership. (shrink)

Ageing causes progressive decline in metabolic, behavioural, and physiological functions, leading to a reduced health span. The extracellular matrix (ECM) is the three‐dimensional network of macromolecules that provides our tissues with structure and biomechanical resilience. Imbalance between damage and repair/regeneration causes the ECM to undergo structural deterioration with age, contributing to age‐associated pathology. The ECM ‘Ageing Across the Life Course’ interdisciplinary research network (ECMage) was established to bring together researchers in the United Kingdom, and internationally, working on the emerging field (...) of ECM ageing. Here we report on a consultation at a joint meeting of ECMage and the Medical Research Council / Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing, held in January 2023, in which delegates analysed the key questions and research opportunities in the field of ECM ageing. We examine fundamental biological questions, enabling technologies, systems of study and emerging in vitro and in silico models, alongside consideration of the broader challenges facing the field. (shrink)