Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Eduardo Arroyo, Armelle Auris, François Boissonnet, Paul HENRY, Pierre-Jean LABARRIERE, MATIEU, Gilles AILLAUD, Gérad THALMANN, Nicole MATHIEU, Jacques VIMARD, Michel QUAREZ, Leonardo CREMONINI, L'atelier d'Eduardo Arryo: Le carré blanc du ring, Rue Descartes, No. 7, Logiques de l'éthique (Juin 1993), pp. 149-168.

Anthony Pagden, de origen británico, es profesor de historia y ciencia política en la Universidad de California. Posee una extensa trayectoria, ha pasado por algunas de las más reconocidas universidades británicas y norteamericanas. Tiene publicada una amplia serie de libros cuyo eje principal es la historia de las ideas. El texto que ahora reseñamos es la traducción de su última obra dedicada a la Ilustración, a la que ha dedicado particular atención. Compuesto por una introducción, ocho capítulos y una conclusión. (...) _La Ilustración. Y por qué sigue siendo importante para nosotros,_ se configura como un compendio de historia de las ideas, una síntesis alimentada por una sucesión de argumentos, ninguno completamente original, producto de investigaciones y de una herencia de conocimientos acumulados por varias generaciones de investigadores. Exenta de caracterizarse como una interminable enciclopedia temática sobre el fenómeno intelectual que analiza, esta obra no fue pensada para descifrar en qué pudo consistir la Ilustración, sino con un propósito explícitamente apologético, como puede leerse en su subtítulo. (shrink)

_The Power of Religion in the Public Sphere_, co-edited by Eduardo Mendieta and Jonathan VanAntwerpen, represents a rare opportunity to experience a diverse group of preeminent philosophers confronting one pervasive contemporary concern: what role does, or should, religion play in our public lives? Reflecting on her recent work concerning state violence in Israel-Palestine, Judith Butler explores the potential of religious perspectives for renewing cultural and political criticism, while Jürgen Habermas, best known for his seminal conception of the public sphere, (...) thinks through the ambiguous legacy of the concept of "the political" in contemporary theory. Charles Taylor argues for a radical redefinition of secularism, and Cornel West defends civil disobedience and emancipatory theology. Eduardo Mendieta and Jonathan VanAntwerpen detail the immense contribution of these philosophers to contemporary social and political theory, and an afterword by Craig Calhoun places these attempts to reconceive the significance of both religion and the secular in the context of contemporary national and international politics. (shrink)

Se postula en este artículo que existe a lo largo de la historia del pensamiento una fascinación por la capacidad creativa, considerándosela una facultad distintiva a través de la cual los individuos y las sociedades pueden expandir sus posibilidades más allá de lo existente, y se desarrolla la hipótesis de tres niveles ascendentes de creatividad que contienen a su vez tres “metodologías” para su desarrollo. Estos niveles son: las técnicas de aprendizaje creativo, el cambio de paradigma y el viaje al (...) interior de uno mismo. (shrink)

The paper outlines an interpretation of one of the most important and original contributions of David Hilbert’s monograph Foundations of Geometry , namely his internal arithmetization of geometry. It is claimed that Hilbert’s profound interest in the problem of the introduction of numbers into geometry responded to certain epistemological aims and methodological concerns that were fundamental to his early axiomatic investigations into the foundations of elementary geometry. In particular, it is shown that a central concern that motivated Hilbert’s axiomatic investigations (...) from very early on was the aim of providing an independent basis for geometry. Accordingly, these concerns about an independent grounding for elementary geometry determined very clear methodological constraints in the process of embedding it into a formal axiomatic system. It is argued that Hilbert not only sought to show that geometry could be considered a pure mathematical theory, once it was presented as a formal axiomatic system; he also aimed at showing that in the construction of such an axiomatic system one could proceed purely geometrically, avoiding concept formations borrowed from other mathematical disciplines like arithmetic or analysis. (shrink)

Este texto recoge la propuesta de algunas tradiciones espirituales sobre la existencia de un arte objetivo, vinculado al estado de meditación y a la posibilidad del ser humano de adquirir una conciencia objetiva, señalándose lo lejana que está esta propuesta de la cultura de la modernidad y la postmodernidad. Pese a ello, sostiene que existiría un puente entre este arte objetivo y el arte crítico que devela el ocultamiento ideológico permitiendo mirar con los propios ojos, a través de sostener que (...) tienen en común la búsqueda de comprensión de la realidad, pero diferenciándose en cómo la comprenden. (shrink)

When discussing Logical Pluralism several critics argue that such an open-minded position is untenable. The key to this conclusion is that, given a number of widely accepted assumptions, the pluralist view collapses into Logical Monism. In this paper we show that the arguments usually employed to arrive at this conclusion do not work. The main reason for this is the existence of certain substructural logics which have the same set of valid inferences as Classical Logic—although they are, in a clear (...) sense, non-identical to it. We argue that this phenomenon can be generalized, given the existence of logics which coincide with Classical Logic regarding a number of metainferential levels—although they are, again, clearly different systems. We claim this highlights the need to arrive at a more refined version of the Collapse Argument, which we discuss at the end of the paper. (shrink)

El libro de Oriana Zorrilla es un texto de investigación periodística importante, que instala en el debate nacional un tema que coloca la experiencia existencial del maltrato en el escenario democrático, retratando una realidad desconocida de acoso laboral a los empleados públicos, constituyéndose en un tema político sobre la calidad y profundidad de nuestra democracia. Ya en el prólogo Armando Uribe señala que el libro “es la denuncia bien fundada en la historia personal y colectiva, y tiene..

Um novo livro da colecção "Obras de Eduardo Lourenço" que a Gradiva tem vindo a editar e que desta vez entra pelo mundo da arte, com a pintura em destaque. O percurso de Eduardo Lourenço na descoberta da arte é uma viagem abrangente, em que apresenta uma multiplicidade de pontos de vista e de abordagens, numa obra organizada em três secções: Estética, Exposições, Pintores. Tendo a pintura como pano de fundo, o filósofo revela uma enorme sensibilidade, uma elevadíssima (...) capacidade de observação e de reflexão, um imenso talento para estabelecer analogias. No texto inicial ("Eduardo Lourenço, um olhar sem fim"), Barbara Aniello refere: "Todavia não é apenas de crónica diarística, de pinceladas traçadas na mais silenciosa intimidade, que as páginas que se seguem são amostra reveladora. [...] Repletas de sabedoria e de experiência, estas considerações nascem de uma abordagem à arte filtrada pela cultura do pensador que, ao contrário do espelho da música, mergulha aqui num mundo ‘outro’ com todas as ferramentas da sua erudição." Esta obra contém material maioritariamente inédito. (shrink)

El autor plantea que si Dios ha regresado, es porque en realidad nunca se fue; aunque debió refugiarse en la gruta de los místicos. Si ha vuelto es porque las grandes tradiciones espirituales de todos los tiempos: sufismo, hinduismo, budismo, cristianismo, y también las tradiciones chamánicas del mundo latino y norteamericano previo a la invasión europea, han vuelto a hacer oír su voz profunda en el territorio de la modernidad occidental. Y lo han hecho con su misma enseñanza profunda presentada (...) bajo nuevas formas. Pero también su Dios regresó es porque la cultura hegemónica occidental está y las personas han vuelto a tener oídos para Dios. Ilustra este proceso el autor con la presentación de algunos maestros espirituales contemporáneos y sus fuentes, a la vez que con una breve historia de su influencia en Chile. (shrink)

This paper focuses on the extension of AGM that allows change for a belief base by a set of sentences instead of a single sentence. In [FH94], Fuhrmann and Hansson presented an axiomatic for Multiple Contraction and a construction based on the AGM Partial Meet Contraction. We propose for their model another way to construct functions: Multiple Kernel Contraction, that is a modification of Kernel Contraction, proposed by Hansson [Han94] to construct classical AGM contractions and belief base contractions. This construction (...) works out the unsolved problem pointed out by Hansson in [Han99, pp. 369]. (shrink)

This important collection of essays by Andrew Feenberg presents his critical theory of technology, an innovative approach to philosophy and sociology of technology based on a synthesis of ideas drawn from STS and Frankfurt School Critical Theory. The volume includes chapters on citizenship, modernity, and Heidegger and Marcuse.

Who Comes After the Subject offers the most comprehensive overview to date of contemporary French thinking on the question of the "subject." Nineteen philosophers and critics offer diverse perspectives on the subject as it has manifested itself in our modern discourses: the subject of philosophy, of the State, of history, of psychoanalysis. Each contribution asks What has become of the subject? or What has the subject become? in the wake of its critiques and deconstructions .

Although sustainable and responsible investment (SRI) has quite recently become a hot research topic, scarcely any systematic research has been paid to the performance of this non-conventional approach to investment during the financial crisis that emerged in mid-2008 when the resilience of the financial markets was sorely tested. Such real-world resilience in practice is the subject of the current research which tests whether environmental, social and governance screens provides ethical investors with adaptive resilience in bull and bear market conditions by (...) focussing on the SRI equity index of one of the most active markets in Europe in terms of ethical investment, the FTSE4Good-Ibex in Spain. Multivariate Generalized Autoregressive Conditional Heteroskedasticity (M-GARCH) analysis indicates that ethical investors in the equity market examined with evidence that greater resilience in severe business cycle shocks could be attributable to SRI by companies. Although limited to a single country study, the results have implications for investors seeking resilience in crisis: when individual values and beliefs towards sustainability tie with personal investment strategy, the end result is adaptive financial resilience, social well-being and environmental defence. (shrink)

In 1997, I introduced the concept and the phrase “bio art”, originally in relation to my artwork “Time Capsule”. This work approached the problem of wet interfaces and human hosting of digital memory through the implantation of a microchip. The work consisted of a microchip implant, seven sepia-toned photographs, a live television broadcast, a webcast, interactive telerobotic webscanning of the implant, a remote database intervention, and additional display elements, including an X-ray of the implant. While “bio art” is applicable to (...) a large gamut of in vivo works that employ biological media, made by myself and others, in 1998, I started to employ the more focused term “transgenic art”. Republished in Ars Electronica ‘99—Life Science, ed. Gerfried Stocker and Christine Schopf, 289–296.) to describe a new art form based on the use of genetic engineering to create unique living beings. Art that manipulates or creates life must be pursued with great care, with acknowledgment of the complex issues it raises and, above all, with a commitment to respect, nurture, and love the life created. I have been creating and exhibiting a series of transgenic artworks since 1999. I have also been creating bio art that is not transgenic. The implications of this ongoing body of work have particular esthetic and social ramifications, crossing several disciplines and providing material for further reflection and dialog. What follows is an overview of theses works, the issues they evoke, and the debates they have elicited. (shrink)

En este artículo se trata de evaluar críticamente las tesis fundamentales del libro de Carlos Fernández Liria y Luis Alegre Zahonero, El orden de El Capital (2010), en tanto que potencial lectura republicana de Marx.

In this article, we will present a number of technical results concerning Classical Logic, ST and related systems. Our main contribution consists in offering a novel identity criterion for logics in general and, therefore, for Classical Logic. In particular, we will firstly generalize the ST phenomenon, thereby obtaining a recursively defined hierarchy of strict-tolerant systems. Secondly, we will prove that the logics in this hierarchy are progressively more classical, although not entirely classical. We will claim that a logic is to (...) be identified with an infinite sequence of consequence relations holding between increasingly complex relata: formulae, inferences, metainferences, and so on. As a result, the present proposal allows not only to differentiate Classical Logic from ST, but also from other systems sharing with it their valid metainferences. Finally, we show how these results have interesting consequences for some topics in the philosophical logic literature, among them for the debate around Logical Pluralism. The reason being that the discussion concerning this topic is usually carried out employing a rivalry criterion for logics that will need to be modified in light of the present investigation, according to which two logics can be non-identical even if they share the same valid inferences. (shrink)

This paper deals with the ways in which jurists and law professors applied transnational systems of public law, in particular US constitutionalism and French droit administratif, in their approaches to the state building process in late nineteenth century Argentina. In covering these movements of adaptation of a nascent legal culture to changing ideological and political circumstances, this article attempts to illuminate the strong links between the process of institutionalization of certain academic disciplines or forms of social knowledge, and modern state (...) building in Latin America. (shrink)

The claim according to which there is a categorial gap between meaning and saying ¿ between what sentences mean and what we say by using them on particular occasions ¿ has come to be widely regarded as being exclusively a claim in the philosophy of language. The present essay collection takes a different approach to these issues. It seeks to explore the ways in which that claim ¿ as defended first by ordinary language philosophy and, more recently, by various contextualist (...) projects ¿ is grounded in considerations that transcend the philosophy of language. More specifically, the volume seeks to explore how that claim is inextricably linked to considerations about the nature of truth and representation. It is thus part of the objective of this volume to rethink the current way of framing the debates on these issues. By framing the debate in terms of an opposition between "ideal language theorists" and their semanticist heirs on the one hand and "communication theorists" and their contextualist heirs on the other, one brackets important controversies and risks obscuring the undoubtedly very real oppositions that exist between different currents of thought. (shrink)

This important new volume brings together Habermas' key writing on religion and religious belief. Habermas explores the relations between Christian and Jewish thought, on the one hand, and the Western philosophical tradition on the other. In so doing, he examines a range of important figures, including Benjamin, Heidegger, Johann Baptist Metz and Gershom Scholem. In a new introduction written especially for this volume, Eduardo Mendieta places Habermas' engagement with religion in the context of his work as a whole. Mendieta (...) also discusses Habermas' writings in relation to Jewish Messianism and the Frankfurt School, showing how the essays in Religion and Rationality, one of which is translated into English for the first time, foreground an important, yet often neglected, dimension of critical theory. The volume concludes with an original extended interview, also in English for the first time, in which Habermas develops his current views on religion in modern society. This book will be of great interest to students and scholars in theology, religious studies and philosophy, as well as to all those already familiar with Habermas' work. (shrink)