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  1. Principled Mechanistic Explanations in Biology: A Case Study of Alzheimer's Disease.Sepehr Ehsani - manuscript
    Following an analysis of the state of investigations and clinical outcomes in the Alzheimer's research field, I argue that the widely-accepted 'amyloid cascade' mechanistic explanation of Alzheimer's disease appears to be fundamentally incomplete. In this context, I propose that a framework termed 'principled mechanism' (PM) can help with remedying this problem. First, using a series of five 'tests', PM systematically compares different components of a given mechanistic explanation against a paradigmatic set of criteria, and hints at various ways of making (...)
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  2. The Ethics of Hippocampal Prosthesis as a Potential Future Treatment for Alzheimer’s Disease.Matt Schuler - manuscript
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  3. An Ethical Argument for Ending Human Trials of Amyloid-Lowering Therapies in Alzheimer’s Disease.Timothy Daly, Karl Herrup & Alberto J. Espay - forthcoming - American Journal of Bioethics Neuroscience.
    Given the past two decades of over 40 failed trials of amyloid-lowering therapies in Alzheimer’s Disease (AD), many of which succeeded in lowering amyloid as designed, we present an ethical argument for emptying the drug pipeline of tests of amyloid-lowering agents so as to end the historical dominance of the amyloid-reducing therapeutic approach in AD.
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  4. Quality of life: The family and Alzheimer's disease.Mary Guerriero Austrom & Hugh C. Hendrie - forthcoming - Journal of Palliative Care.
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  5. Hospice and Alzheimer disease: a study in access and simple justice.Bruce Jennings - forthcoming - Hastings Center Report.
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  6. Ethics of Early Intervention in Alzheimer’s Disease.Alex McKeown, Gin S. Malhi & Ilina Singh - forthcoming - American Journal of Bioethics Neuroscience:1-18.
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  7. Dementia Prevention Guidelines Should Explicitly Mention Deprivation.Timothy Daly - 2024 - American Journal of Bioethics Neuroscience 15 (1):73-76.
    The brain requires sustained interaction with a rich physical and social environment to stay healthy. Individuals without access to such enabling environments and who instead live and grow in disabling environments tend to have greater risk of developing dementia. But research and policymaking as regards dementia risk reduction have so far focused almost exclusively on the role of how individuals’ health behaviors change their risk profile. This exclusive focus on “lifestyle” is both ethically problematic and therapeutically inadequate. I highlight a (...)
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  8. Narrating Experiences of Alzheimer's Through the Arts: Phenomenological and Existentialist Experiences of the Living Body.Ana Paula Barbosa-Fohrmann - 2023 - Bielefeld: Transcript.
    While Alzheimer's might be associated with a difficulty to express oneself, Ana Paula Barbosa-Fohrmann addresses this topic by examining experiences with Alzheimer's based on narratives. In this original contribution, she studies the nexus of life stories, subjectivity, fragmentation, and fiction. The philosophical basis of this research is phenomenology from the end of the 19th century to the middle of the 20th century, specifically that of Husserl and above all that of Merleau-Ponty. This work also draws on Proust's and Camus' literature (...)
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  9. Alzheimer’s, Advance Directives, and Interpretive Authority.Charles L. Barzun - 2023 - Journal of Medicine and Philosophy 48 (1):50-59.
    Philosophers have debated whether the advance directives of Alzheimer’s patients should be enforced, even if patients seem content in their demented state. The debate raises deep questions about the nature of human autonomy and personal identity. But it tends to proceed on the assumption that the advance directive’s terms are clear, whereas in practice they are often vague or ambiguous, requiring the patient’s healthcare proxy to make difficult judgment calls. This practical wrinkle raises its own, distinct but related, philosophical question: (...)
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  10. Avoiding the Premature Introduction of Psychedelic Medicines in Alzheimer’s Disease and Related Disorders.Adrian Carter, Myfanwy Graham, Wayne Hall, Michaela Barber & John Gardner - 2023 - American Journal of Bioethics Neuroscience 14 (2):129-131.
    Peterson et al. (2023) identify two potential uses of psychedelic drugs in Alzheimer’s disease and related disorders (AD/ADRD). The first is to treat depression and anxiety that commonly occur afte...
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  11. The Accelerated Approval of Aducanumab Invites a Rethink of the Current Model of Drug Development for Alzheimer's Disease.Timothy Daly & Stéphane Epelbaum - 2023 - American Journal of Bioethics Neuroscience 14 (3):332-335.
    It is a tale of two Pfizers. In 2018 they abandoned research into the leading cause of dementia, Alzheimer’s Disease (AD) (Hawkes 2018). In 2021, they developed the first vaccine for Covid-19 to re...
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  12. Publishing the Biotechnical Futures of Alzheimer’s Disease.James Rupert Fletcher - 2023 - American Journal of Bioethics Neuroscience 14 (2):124-126.
    In “Journeying to Ixtlan,” Peterson and colleagues (2023) evaluate some of the potential ethical implications of treating Alzheimer’s disease (AD) with psychedelic medicines. In this commentary, I...
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  13. Project DECIDE, part II: decision-making places for people with dementia in Alzheimer’s disease: supporting advance decision-making by improving person-environment fit.Julia Haberstroh, Heiko Ullrich, Anna Theile-Schürholz, Irene Schmidtmann, Andreas Reif, Aoife Poth, David Prvulovic, Nathalie Pfeiffer, Frank Oswald, Tanja Müller, Gregor Lindl, Boris Knopf, Jonas Karneboge, Tarik Karakaya, Ingmar Hornke, Martin Grond, Daniel Garmann, Simon Forstmeier, Stefanie Baisch, Christina Abele & Janina Florack - 2023 - BMC Medical Ethics 24 (1):1-11.
    BackgroundThe UN Convention on the Rights of Persons with Disabilities, and the reformed guardianship law in Germany, require that persons with a disability, including people with dementia in Alzheimer’s disease (PwAD), are supported in making self-determined decisions. This support is achieved through communication. While content-related communication is a deficit of PwAD, relational aspects of communication are a resource. Research in supported decision-making (SDM) has investigated the effectiveness of different content-related support strategies for PwAD but has only succeeded in improving understanding, (...)
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  14. A Disembodied Dementia: Graphic Medicine and Illness Narratives.Sarah B. Kovan & Derek R. Soled - 2023 - Journal of Medical Humanities 44 (2):227-244.
    The dominant discourse on dementia promotes a view that as individuals progress with the disease, they experience a neurological decline causing a loss of self. This notion, grounded in a Cartesian representation of selfhood, associates a loss of self as directly related to cognition. This paper presents an alternative anthropological framework, embodied selfhood, that challenges this representation. It then examines a potential tool, graphic medicine, to translate this theory into caregiving practice. Through analyzing three graphic novels—Wrinkles, Tangles, and Aliceheimer’s—this paper (...)
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  15. Mild Cognitive Impairment in Relation to Alzheimer’s Disease: An Investigation of Principles, Classifications, Ethics, and Problems.Joseph Lee - 2023 - Neuroethics 16 (2):1-18.
    Mild Cognitive Impairment (MCI) is a diagnostic category indicating cognitive impairment which does not meet diagnostic criteria for dementia such as Alzheimer’s disease. There are public health concerns about Alzheimer’s disease (AD) prompting intervention strategies to respond to predictions about the impacts of ageing populations and cognitive decline. This relationship between MCI and AD rests on three interrelated principles, namely, that a relationship exists between AD and MCI, that MCI progresses to AD, and that there is a reliable system of (...)
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  16. Caregiver Burden and the Impact of Diagnostic Disclosure of Dementia: Why Primary Care Physicians Have a Moral Responsibility to Disclose.Noelle Ohanesian - 2023 - Journal of Clinical Ethics 34 (2):128-137.
    Currently, the number of individuals affected by Alzheimer’s disease is rapidly increasing, expected to reach 14 million in the United States within 30 years. In spite of this impending crisis, less than 50 percent of primary care physicians disclose the diagnosis of dementia to their patients. This failure negatively impacts not only patients but also caregivers, whom dementia patients require to help them meet their needs and who often serve as important decision makers, either as surrogates or as designated healthcare (...)
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  17. Journey to Narayama: Cultural Complexities, Psychedelics and Dementia.Reina Ozeki-Hayashi & Dominic J. C. Wilkinson - 2023 - American Journal of Bioethics Neuroscience 14 (2):145-147.
    In their target article, Peterson et al. discuss the intriguing prospect of using psychedelics as a treatment for patients with Alzheimer’s Disease and Related Dementias (AD/ADRD) (Peterson et al....
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  18. Journeying to Ixtlan: Ethics of Psychedelic Medicine and Research for Alzheimer’s Disease and Related Dementias.Andrew Peterson, Emily A. Largent, Holly Fernandez Lynch, Jason Karlawish & Dominic Sisti - 2023 - American Journal of Bioethics Neuroscience 14 (2):107-123.
    In this paper, we examine the case of psychedelic medicine for Alzheimer’s disease and related dementias (AD/ADRD). These “mind-altering” drugs are not currently offered as treatments to persons with AD/ADRD, though there is growing interest in their use to treat underlying causes and associated psychiatric symptoms. We present a research agenda for examining the ethics of psychedelic medicine and research involving persons living with AD/ADRD, and offer preliminary analyses of six ethical issues: the impact of psychedelics on autonomy and consent; (...)
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  19. The Road to Ixtlan in Neuro-Degenerative Diseases Is Paved with Palliative Cobblestones.Christopher Poppe & Manuel Trachsel - 2023 - American Journal of Bioethics Neuroscience 14 (2):134-136.
    While the developers of the “Ixtlan Basic Kit” promise a curative treatment taking advantage of increased neuroplasticity for targeting the underlying neurological causes of Alzheimer's disease and...
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  20. Barriers and Facilitators to the Equitable Access of Psychedelic Medical Care and Research in Alzheimer’s Disease and Related Dementias.Kaila A. Rudolph - 2023 - American Journal of Bioethics Neuroscience 14 (2):136-138.
    Dementia is an ever-growing public health concern with significant impact on the quality of life of older adults and their families (Aranda et al. 2021). Research continues to investigate treatment...
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  21. Preclinical Disease or Risk Factor? Alzheimer’s Disease as a Case Study of Changing Conceptualizations of Disease.Maartje H. N. Schermer - 2023 - Journal of Medicine and Philosophy 48 (4):322-334.
    Alzheimer’s Disease (AD) provides an excellent case study to investigate emerging conceptions of health, disease, pre-disease, and risk. Two scientific working groups have recently reconceptualized AD and created a new category of asymptomatic biomarker positive persons, who are either said to have preclinical AD, or to be at risk for AD. This article examines how prominent theories of health and disease would classify this condition: healthy or diseased? Next, the notion of being “at risk”—a state somewhere in-between health and disease—is (...)
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  22. Psychedelic Research for Dementia Risks Perpetuating Structural Failures and Inadequacies in Aged Care.Hojjat Soofi & Cynthia Forlini - 2023 - American Journal of Bioethics Neuroscience 14 (2):131-134.
    Peterson et al. (2023) outline a broad ethics agenda for imminent research on psychedelic agents for Alzheimer’s disease and related dementias (AD/ADRD) by acknowledging the therapeutic promise of...
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  23. A Review of Scientific Ethics Issues Associated with the Recently Approved Drugs for Alzheimer’s Disease. [REVIEW]Bor Luen Tang & Nicole Shu Ling Yeo-Teh - 2023 - Science and Engineering Ethics 29 (1):1-18.
    Alzheimer’s disease (AD), the devastating and most prevailing underlying cause for age-associated dementia, has no effective disease-modifying treatment. The last approved drug for the relief of AD symptoms was in 2003. The recent approval of sodium oligomannate (GV-971, 2019) in China and the human antibody aducanumab in the USA (ADUHELM, 2021) therefore represent significant breakthroughs, albeit ones that are fraught with controversy. Here, we explore potential scientific ethics issues associated with GV-971 and aducanumab’s development and approval. While these issues may (...)
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  24. On Reminding and Forgetting: Care about Moral Responses in the Case of Alzheimer’s Disease.Adriana Wierzba - 2023 - Studia Philosophica Wratislaviensia 17 (4):29-44.
    In this article, caring, remembering and sharing memory are presented as moral responses, the case study being Alzheimer’s disease (AD). Memory connects memories and images, while care connects individuals, which is an ethical issue. When a person’s memory is lost, the care of others becomes the only thread connecting them to the world. AD deprives a person of memories, body control, makes it impossible to remember, communicate, move, recognize the environment, and disrupts consciousness. Caring for a patient with a neurodegenerative (...)
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  25. Project DECIDE, part 1: increasing the amount of valid advance directives in people with Alzheimer’s disease by offering advance care planning—a prospective double-arm intervention study.Stefanie Baisch, Christina Abele, Anna Theile-Schürholz, Irene Schmidtmann, Frank Oswald, Tarik Karakaya, Tanja Müller, Janina Florack, Daniel Garmann, Jonas Karneboge, Gregor Lindl, Nathalie Pfeiffer, Aoife Poth, Bogdan Alin Caba, Martin Grond, Ingmar Hornke, David Prvulovic, Andreas Reif, Heiko Ullrich & Julia Haberstroh - 2022 - BMC Medical Ethics 23 (1):1-12.
    BackgroundEverybody has the right to decide whether to receive specific medical treatment or not and to provide their free, prior and informed consent to do so. As dementia progresses, people with Alzheimer’s dementia (PwAD) can lose their capacity to provide informed consent to complex medical treatment. When the capacity to consent is lost, the autonomy of the affected person can only be guaranteed when an interpretable and valid advance directive exists. Advance directives are not yet common in Germany, and their (...)
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  26. Unfathomed Dangers from Aluminum — Alzheimer’s? Autism? Multiple Sclerosis?Henry Bauer - 2022 - Journal of Scientific Exploration 35 (4).
    That aluminum is fatally toxic is beyond doubt, demonstrated by mass human poisoning at Camelford in Cornwall in Britain in 1988 (chapter 18) and by occasional fish kills (p. 49). Aluminum may also be a contributing factor in a number of human diseases, in particular those involving brain and nerves (p. 124) — autism, Alzheimer’s disease (AD) (chapter 14), Parkinson’s disease, multiple sclerosis. Aluminum salts used in kidney dialysis may be responsible for dialysis-related encephalopathy (pp. 38, 79). Aluminum adjuvants in (...)
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  27. Digital phenotyping and the (data) shadow of Alzheimer's disease.Natassia Brenman, Alessia Costa & Richard Milne - 2022 - Big Data and Society 9 (1).
    In this paper, we examine the practice and promises of digital phenotyping. We build on work on the ‘data self’ to focus on a medical domain in which the value and nature of knowledge and relations with data have been played out with particular persistence, that of Alzheimer's disease research. Drawing on research with researchers and developers, we consider the intersection of hopes and concerns related to both digital tools and Alzheimer's disease using the metaphor of the ‘data shadow’. We (...)
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  28. The value of privacy for people with dementia.Eike Buhr & Mark Schweda - 2022 - Ethik in der Medizin 34 (4):591-607.
    Definition of the problemThe concept of privacy has been astonishingly absent in the discussion about dementia care. In general, questions of privacy receive a lot of attention in nursing ethics; however, when it comes to dementia care, hardly any systematic ethical debate on the topic can be found. It almost seems as though people with dementia had lost any comprehensible interest in privacy and no longer had any private sphere that needed to be considered or protected. However, this not only (...)
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  29. Enfermedad de Alzheimer, musicoterapia y la intervención del trabajo social.María Ángeles Cuadrado Cenzual, Gloria Peláez Escribá de Balaguer & Aurora Castillo Charfolet - 2022 - Human Review. International Humanities Review / Revista Internacional de Humanidades 11 (2):1-11.
    A través del presente trabajo se aborda el papel de la musicoterapia en la enfermedad de alzheimer (EA) desde el ámbito del trabajo social. Para ello, se lleva a cabo una revisión bibliográfica y se identifican conceptos claves como musicoterapia, EA e intervención del trabajo social. La información recogida lleva a considerar la musicoterapia como tratamiento coadyuvante en la enfermedad de Alzheimer a través de áreas como la integración social, la autoestima, la comunicación o la reducción del estrés. Por ello, (...)
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  30. Embryo Research Ethics.Robert George & Christopher Tollefsen - 2022 - In Tomas Zima & David N. Weisstub (eds.), Medical Research Ethics: Challenges in the 21st Century. Springer Verlag. pp. 3-15.
    Robert George and Christopher Tollefsen argue that human beings have fundamental dignity and basic rights (“human rights”) in virtue of the kind of entity they are—creatures bearing a rational nature. The indicia of a rational nature are the basic natural capacities—which obtain from the point a rational creature comes into existence—for thinking, deliberating, and choosing, whether or not these capacities are immediately exercisable. All human beings, including those who are asleep, or under general anesthesia, or who are in deep comas (...)
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  31. Fear of Dementia and the Obligation to Provide Aggregate Research Results to Study Participants.Mackenzie Graham, Francesca Farina, Craig W. Ritchie, Brian Lawlor & Lorina Naci - 2022 - Cambridge Quarterly of Healthcare Ethics 31 (4):498-505.
    A general obligation to make aggregate research results available to participants has been widely supported in the bioethics literature. However, dementia research presents several challenges to this perspective, particularly because of the fear associated with developing dementia. The authors argue that considerations of respect for persons, beneficence, and justice fail to justify an obligation to make aggregate research results available to participants in dementia research. Nevertheless, there are positive reasons in favor of making aggregate research results available; when the decision (...)
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  32. The ethics of disease-modifying drugs targeting Alzheimer disease: response to our commentators.Erik Gustavsson, Pauline Raaschou, Gerd Lärfars, Lars Sandman & Niklas Juth - 2022 - Journal of Medical Ethics 48 (3):193-193.
    In Gustavsson et al,1 we discussed the ethical issues that arise when identifying the relevant population for disease-modifying drugs targeting Alzheimer disease. More specifically, we focused on novel immunotherapies aimed at amyloid β and tau, two relevant biomarkers. The commentaries to our paper2 3 acknowledge our conclusion: screening for AD involve ethical costs that cannot be justified unless a drug with clinically relevant effect becomes available. Since Aduhelm is the only immunotherapy targeting AD currently approved by the Food and Drug (...)
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  33. Preserving narrative identity for dementia patients: Embodiment, active environments, and distributed memory.Richard Heersmink - 2022 - Neuroethics 15 (8):1-16.
    One goal of this paper is to argue that autobiographical memories are extended and distributed across embodied brains and environmental resources. This is important because such distributed memories play a constitutive role in our narrative identity. So, some of the building blocks of our narrative identity are not brain-bound but extended and distributed. Recognising the distributed nature of memory and narrative identity, invites us to find treatments and strategies focusing on the environment in which dementia patients are situated. A second (...)
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  34. Development and Psychometric Evaluation of Family Caregivers’ Hardiness Scale: A Sequential-Exploratory Mixed-Method Study.Lida Hosseini, Hamid Sharif Nia & Mansoureh Ashghali Farahani - 2022 - Frontiers in Psychology 13.
    ObjectiveCaring for patients with Alzheimer’s disease is a stressful situation and an overwhelming task for family caregivers. Therefore, these caregivers need to have their hardiness empowered to provide proper and appropriate care to these older adults. From the introduction of the concept of hardiness, few studies have been conducted to assess the hardiness of caregivers of patients with AD. Presumably, one reason for this knowledge gap is the lack of a proper scale to evaluate hardiness in this group. This study (...)
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  35. A Comparison of Caregiver Burden for Different Types of Dementia: An 18-Month Retrospective Cohort Study.Wen-Chien Huang, Ming-Che Chang, Wen-Fu Wang & Kai-Ming Jhang - 2022 - Frontiers in Psychology 12.
    BackgroundThis study aimed to elucidate the influence of dementia etiologies on the degree of caregiver burden and determine which factors predict a high caregiving burden.MethodsThis 18-month retrospective cohort study enrolled 630 patients and their caregivers from the Dementia Center of Changhua Christian Hospital. The care team performed face-to-face interviews every 6 months, for 18 months from when a diagnosis of dementia was made. The primary outcome was the change in Zarit Burden Interview scores. Generalized estimating equations were used for the (...)
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  36. Aesthetic Preference for Negatively-Valenced Artworks Remains Stable in Pathological Aging: A Comparison Between Cognitively Impaired Patients With Alzheimer's Disease and Healthy Controls.Elisabeth Kliem, Michael Forster & Helmut Leder - 2022 - Frontiers in Psychology 13.
    BackgroundDespite severe cognitive dysfunction in Alzheimer's disease, aesthetic preferences in AD patients seem to retain some stability over time, similarly to healthy controls. However, the underlying mechanisms of aesthetic preference stability in AD remain unclear. We therefore aimed to study the role of emotional valence of stimuli for stability of aesthetic preferences in patients with AD compared to cognitively unimpaired elderly adults.MethodsFifteen AD patients score 12–26) without visual impairment and/or psychiatric disorder, as well as 15 healthy controls without cognitive impairment (...)
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  37. Pure Tone Audiometry and Hearing Loss in Alzheimer's Disease: A Meta-Analysis.Susanna S. Kwok, Xuan-Mai T. Nguyen, Diana D. Wu, Raksha A. Mudar & Daniel A. Llano - 2022 - Frontiers in Psychology 12.
    An association between age-related hearing loss and Alzheimer's Disease has been widely reported. However, the nature of this relationship remains poorly understood. Quantification of hearing loss as it relates to AD is imperative for the creation of reliable, hearing-related biomarkers for earlier diagnosis and development of ARHL treatments that may slow the progression of AD. Previous studies that have measured the association between peripheral hearing function and AD have yielded mixed results. Most of these studies have been small and underpowered (...)
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  38. Making Art at the End of the World: Reimagining Feminist Bioethics through Research-Creation.Caitlin Leach - 2022 - International Journal of Feminist Approaches to Bioethics 15 (1):123-128.
    My mother died within the first few months of the pandemic. Her sudden and rapid decline from Alzheimer's disease is difficult to separate from the COVID-19 restrictions put in place by her nursing home just two months prior. We went from visiting her daily to not at all, then to a strictly enforced twenty-minute hospice visit to say goodbye. After her passing, and still amidst the pandemic, I could not write. The conventional methods and outputs of bioethics inquiry felt impossible.Making (...)
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  39. Alzheimer’s Disease and the Invisible Person: The Missing Patient Voice.Garson Leder & Arthur R. Derse - 2022 - American Journal of Bioethics 22 (7):87-90.
    There are at least three related issues that need to be resolved in this case: Who should be the patient’s medical decision-maker?, Should the patient be treated and possibly admitted?, and...
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  40. Altered dynamic intrinsic brain activity of the default mode network in Alzheimer’s disease: A resting-state fMRI study.Zhengluan Liao, Wangdi Sun, Xiaozheng Liu, Zhongwei Guo, Dewang Mao, Enyan Yu & Yan Chen - 2022 - Frontiers in Human Neuroscience 16.
    ObjectiveStatic regional homogeneity based on the resting-state functional magnetic resonance imaging has been used to study intrinsic brain activity in Alzheimer’s disease. However, few studies have examined dynamic ReHo in AD. In this study, we used rs-fMRI and dReHo to investigate the alterations in dynamic IBA in patients with AD to uncover dynamic imaging markers of AD.MethodIn total, 111 patients with AD, 29 patients with mild cognitive impairment, and 73 healthy controls were recruited for this study ultimately. After the rs-fMRI (...)
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  41. Alzheimer’s disease: history, ethics and medical humanities in the context of assisted suicide. [REVIEW]Thomas Horst Loew, Joachim Demling & Birgit Braun - 2022 - Philosophy, Ethics, and Humanities in Medicine 17 (1):1-7.
    IntroductionDementia diseases, especially Alzheimer’s disease (AD), are of considerable importance in terms of social policy and health economics. Moreover, against the background of the current Karlsruhe judgement on the legalisation of assisted suicide, there are also questions to be asked about medical humanities in AD.MethodologyRelevant literature on complementary forms of therapy and prognosis was included and discussed.ResultsCreative sociotherapeutic approaches (art, music, dance) and validating psychotherapeutic approaches show promise for suitability and efficiency in the treatment of dementia, but in some cases (...)
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  42. Hippocampal morphological atrophy and distinct patterns of structural covariance network in Alzheimer’s disease and mild cognitive impairment.Dawei Miao, Xiaoguang Zhou, Xiaoyuan Wu, Chengdong Chen & Le Tian - 2022 - Frontiers in Psychology 13:980954.
    Elucidating distinct morphological atrophy patterns of Alzheimer’s disease and its prodromal stage, namely, mild cognitive impairment helps to improve early diagnosis and medical intervention of AD. On that account, we aimed to obtain distinct patterns of voxel-wise morphological atrophy and its further perturbation on structural covariance network in AD and MCI compared with healthy controls. T1-weighted anatomical images of matched AD, MCI, and HCs were included in this study. Gray matter volume was obtained using voxel-based morphometry and compared among three (...)
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  43. “Ready for What?”: Timing and Speculation in Alzheimer’s Disease Drug Development.Richard Milne & Natassia F. Brenman - 2022 - Science, Technology, and Human Values 47 (3):597-622.
    “Readiness cohorts” are an innovation in clinical trial design to tackle the scarcity of time and people in drug studies. This has emerged in response to the challenges of recruiting the “right” research participants at the “right time” in the context of precision medicine. In this paper, we consider how the achievement of “readiness” aligns temporalities, biologies, and market processes of pharmaceutical innovation: how the promise of “willing bodies” in research emerges in relation to intertwined economic and biological time imperatives. (...)
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  44. Item-Level Story Recall Predictors of Amyloid-Beta in Late Middle-Aged Adults at Increased Risk for Alzheimer’s Disease.Kimberly D. Mueller, Lianlian Du, Davide Bruno, Tobey Betthauser, Bradley Christian, Sterling Johnson, Bruce Hermann & Rebecca Langhough Koscik - 2022 - Frontiers in Psychology 13.
    BackgroundStory recall tests have shown variable sensitivity to rate of cognitive decline in individuals with Alzheimer’s disease biomarkers. Although SR tasks are typically scored by obtaining a sum of items recalled, item-level analyses may provide additional sensitivity to change and AD processes. Here, we examined the difficulty and discrimination indices of each item from the Logical Memory SR task, and determined if these metrics differed by recall conditions, story version, lexical categories, serial position, and amyloid status.Methodsn = 1,141 participants from (...)
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  45. The capacity to designate a surrogate is distinct from decisional capacity: normative and empirical considerations.Mark Navin, Jason Adam Wasserman, Devan Stahl & Tom Tomlinson - 2022 - Journal of Medical Ethics 48 (3):189-192.
    The capacity to designate a surrogate is not simply another kind of medical decision-making capacity. A patient with DMC can express a preference, understand information relevant to that choice, appreciate the significance of that information for their clinical condition, and reason about their choice in light of their goals and values. In contrast, a patient can possess the CDS even if they cannot appreciate their condition or reason about the relative risks and benefits of their options. Patients who lack DMC (...)
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  46. Challenges of anticipation of future decisions in dementia and dementia research.Julia Perry - 2022 - History and Philosophy of the Life Sciences 44 (4):1-29.
    Anticipation of future decisions can be important for individuals at risk for diseases to maintain autonomy over time. For future treatment and care decisions, advance care planning is accepted as a useful anticipation tool. As research with persons with dementia seems imperative to develop disease-modifying interventions, and with changing regulations regarding research participation in Germany, advance research directives (ARDs) are considered a solution to include persons with dementia in research in an ethically sound manner. However, little is known about what (...)
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  47. Brain Atrophy and Clinical Characterization of Adults With Mild Cognitive Impairment and Different Cerebrospinal Fluid Biomarker Profiles According to the AT(N) Research Framework of Alzheimer’s Disease.Miguel Ángel Rivas-Fernández, Mónica Lindín, Montserrat Zurrón, Fernando Díaz, José Manuel Aldrey-Vázquez, Juan Manuel Pías-Peleteiro, Laura Vázquez-Vázquez, Arturo Xosé Pereiro, Cristina Lojo-Seoane, Ana Nieto-Vieites & Santiago Galdo-Álvarez - 2022 - Frontiers in Human Neuroscience 16.
    IntroductionThis study aimed to evaluate, in adults with mild cognitive impairment, the brain atrophy that may distinguish between three AT biomarker-based profiles, and to determine its clinical value.MethodsStructural MRI was employed to evaluate the volume and cortical thickness differences in MCI patients with different AT profiles, namely, A−T−−: normal AD biomarkers; A+T−−: AD pathologic change; and A+T++: prodromal AD. Sensitivity and specificity of these changes were also estimated.ResultsAn initial atrophy in medial temporal lobe areas was found in the A+T−− and (...)
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  48. Voluntary Registries to Support Improved Interaction Between Police and People Living with Dementia.Heather M. Ross, Diana M. Bowman & Jessica M. Wani - 2022 - Journal of Law, Medicine and Ethics 50 (2):348-363.
    This paper provides an overview of the societal impact of a rising dementia population and examines the legal and ethical implications posed by voluntary registries as a community-oriented solution to improve interactions between law enforcement and individuals with dementia. It provides a survey of active voluntary registries across the United States, with a focus on Arizona, which has the highest projected growth for individuals living with dementia in the country.
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  49. Classification of Alzheimer's Disease Using Convolutional Neural Networks.Lamis F. Samhan, Amjad H. Alfarra & Samy S. Abu-Naser - 2022 - International Journal of Academic Information Systems Research (IJAISR) 6 (3):18-23.
    Brain-related diseases are among the most difficult diseases due to their sensitivity, the difficulty of performing operations, and their high costs. In contrast, the operation is not necessary to succeed, as the results of the operation may be unsuccessful. One of the most common diseases that affect the brain is Alzheimer’s disease, which affects adults, a disease that leads to memory loss and forgetting information in varying degrees. According to the condition of each patient. For these reasons, it is important (...)
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  50. Moving in Semantic Space in Prodromal and Very Early Alzheimer's Disease: An Item-Level Characterization of the Semantic Fluency Task.Aino M. Saranpää, Sasa L. Kivisaari, Riitta Salmelin & Sabine Krumm - 2022 - Frontiers in Psychology 13.
    The semantic fluency task is a widely used clinical tool in the diagnostic process of Alzheimer's disease. The task requires efficient mapping of the semantic space to produce as many items as possible within a semantic category. We examined whether healthy volunteers and patients with early Alzheimer's disease take advantage of and travel in the semantic space differently. With focus on the animal fluency task, we sought to emulate the detailed structure of the multidimensional semantic space by utilizing word2vec-method from (...)
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