Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Gyorgy Tamas works in the philosophy of logic, that difficult interdisciplin ary region wherein the notion of categories is both basic and subtle. To understand ways of thinking, to understand patterns of whatever is real, to recognize what is possible and to reject the nonsensical and the impossible is to comprehend the categories. This was a in thought and in fact, recurring motive of European thought from the earliest self-aware beginnings, and Tamas knows that history well, as his (...) critical respect demonstrates. Ancient, medieval, and modern thinkers appear in this book, set forth in their own words; and likewise we see that Tamas has built upon the historians and commentators, upon the pioneering historical investigation of the categories by Trendelenburg a century ago and by Bochenski in our days. Tamas has two principal goals here: to investigate the logic, which is to say the structure and the relations, of the philosophical categories; and to set forth the logic of thought which may then be based upon the critically established system of categories obtained by that investigation. Ancillary but of striking value is his style of historical relevance which enables the reader to engage in a discussion that is both analytically sharp and developmentally insightful. Furthermore, Tamas draws upon his contem porary colleagues with similar critical respect: Lukasiewicz, Quine, Patzig, Menne, Tavanets and others. (shrink)

Tamas Demeter presents a clear and compelling new perspective of Hume’s methodology and conceptual structure in David Hume and the Culture of Scottish Newtonianism. Hume, he argues, is a Newtonian of the Scottish tradition, but not the mechanical kind that is modeled after the Principia. Instead, Hume should be understood as a kind of European Enlightenment “vitalist.” As a result, his work reflects the more organic methodology that defines Newton’s Opticks.

Reviewer gives a survey of the new phylogenetic theory of language recently published by Prof. Dr. G. Révész, founder and director of the Laboratory for experimental psychology of the University of Amsterdam (see notes under)). The starting-point of the theory is the conception of "contact", defined by the author as the innate trend to be together or to co-operate, common to all socially living beings. This "theory of contact" is developed by the author in different directions and gives rise to (...) the distinction 1. of three degrees of communication: cry (Zuruf), call (Anruf) and word (Wort) ("Dreistufentheorie"), 2. of three periods in the development of language: a pre-phase (Vorphase), a primevalphase (Frühphase) and a final phase (Vollphase ("Dreiphasentheorie") and 3. of three main functions of language: impelling (Aufforderung), indication (Mitteilung) and interrogation (Frage) ("Dreifunktionstheorie"), and leads to the conclusion that most probably the oldest form of human intercourse was restricted to the function of impelling ("Imperativsprache"). Prof. R. lays great stress on the in his opinion unsurmountable barrier between human and animal forms of communication. (shrink)

We study behind-the-scenes investor activism promoting environmental, social, and governance improvements by means of a proprietary dataset of a large international, socially responsible activist fund. We examine the activist’s target selection, forms of engagement, impact on ESG performance, drivers of success, and effects on the targets’ operations and value creation. Target firms are typically large and visible, perform well, and have high liquidity and low ESG performance. Engagement induces ESG rating adjustments: firms with poor ex ante ESG ratings experience a (...) ratings increase after complying with the activist’s demands, whereas firms with high ex ante ESG ratings experience a ratings decrease following the revelation of their ESG problems. Activism that is focused on environmental and social issues is more likely to succeed if targets are ESG-sensitive. Successful engagements boost targets’ sales. Risk-adjusted excess stock returns of successful engagements outperform those of unsuccessful engagements by 2.7%. Results are especially strong for firms with low ex ante ESG scores. Specifically, targeted firms in the lowest ex ante ESG quartile outperform matched peers by 7.5% in the year after the end of the engagement. Our results thus suggest that the activism regarding corporate social responsibility generally improves ESG practices and corporate sales and is profitable to the activist. Taken together, we provide direct evidence that ethical investing and strong financial performance, both from the activist’s and the targeted firm’s perspective, can go hand-in-hand together. (shrink)

Words can mean different things to different people. This can be problematic, mainly for those working together in a bureaucratic institution, such as the secret service. Shared, certified, explicit and codified definitions offer a counter to subjective, solitary and/or culturally dominant definitions. It’s true that codified secrecy terms for secret services can be seen to involve a number of political, cultural, subcultural “languages”, but if words come from unclassified or declassified files, memorandums and/or records, one needs a deep understanding of (...) the secret services. A remarkable feature of this bureaucratic language is the evolving nature of, certain “keywords” as important signifiers of historical transformation. Thus, the changes in the language of the secret services depends at least as much on the internal changes of the secret services as on the transformation in the external political-social environment. In spite of the confusion of Hungarian secret services in the revolutions of 1918–1919 and the disintegration of the Austrian-Hungarian Monarchy, in the early 1920’s became a stable system. Between the two World Wars, the Hungarian State Police directed by the Ministry of Internal Affairs, the Military Intelligence and Counter-Espionage directed by the Ministry of Defence, and the Hungarian Royal Gendarmerie directed by both of the Ministries had their own operational service. This structure existed unchanged until 1945. Simultaneously with the forward advance of the soviet troops, government began to re-establish the former system of the secret services in the eastern part of the country. After WWII, in 1946, the “State-protection Department” as political police became independent from the police. However, from the beginning, they remained under the control of the Communist Party. After 1950, the State Security Authority provided special services for the MIA and the Military Political Directorate of the MoD. After quashing the revolution in 1956, in the spring of 1957, the MIA Political Investigation Department was established which—with slight modifications—kept the structure created during the “state protection era”. The MIA III. The State-Protection General Directorate was established in 1962. The reorganization was finalized in the middle of the 1960’s, which resulted in the new system, which—with the structure of Directorates—became the ultimate structure of the state secret police until the abolishment of the MIA General Directorate III in January 1990. These organizational transformations were largely the result of exogenous historical-political changes. Moreover, each new period had a major impact on the organizational communication, language use and vocabulary of the secret services. This study seeks to interpret these historical transformations. (shrink)

Up till this day one cannot find much scholarship which situates Hume in the context of early modern natural philosophy. Tamás Demeter's new book, David Hume and the Culture of Scottish Newtonianism, does a spectacular job in filling this gap. His monograph is the most comprehensive pursuit to understand Hume's place in the Newtonian tradition of natural philosophy. Demeter specifies Hume's place both in the context of Newtonian moral philosophy and Newtonian chemistry and physiology.

Review of "Mental Fictionalism: Philosophical Explorations" by Tamás Demeter, Ted Parent, and Adam Toon.

Introduction -- The Marx project : a brief overview -- Origins of totalitarianism : ideology and terror -- The tradition -- First pillar : "labor is the creator of man" : on labor, necessity, and loneliness -- Third pillar : the eleventh thesis on Feuerbach -- Second pillar : violence is the midwife of history -- Die Aufhebung : as the state withers a new politics arises and philosophy fades away.

The paper contrasts Robert Brandom’s account of rationality with that of Daniel Dennett. It argues that neither of them is tenable, and sketches an alternative outlook that avoids the problems. In spite of their fundamental differences, both Brandom and Dennett employ a robust, i.e. explanatory and predictive notion of rationality, and for different reasons they both fail to offer a plausible theory supporting it. The lesson offered here is that rationality should not be treated alongside other norms prescribing behaviour, as (...) it cannot be accounted for in the same terms. Instead of ascribing rationality a robust role in a philosophical understanding of behaviour, it should be assigned a more modest one: its function should be located not in the context of explaining and predicting behaviour, but in the context of narratives folk psychological interpretation offers. (shrink)

It is essential for social robots to fit in the human society. In order to facilitate this process we propose to use the family dog’s social behaviour shown towards humans as an inspiration. In this study we explored dogs’ low level social monitoring in dog-human interactions and extracted individually consistent and context dependent behaviours in simple everyday social scenarios. We found that proximity seeking and tail wagging were most individually distinctive in dogs, while activity, orientation towards the owner, and exploration (...) were dependent on the context and/or the activity of the owner. The functional analogues of these dog behaviours can be implemented in social robots of different embodiments in order to make them acceptable and more believable for humans. Keywords: dog-owner interaction; social robotics; low-level social monitoring; greeting behaviour; individually distinctive behaviours. (shrink)

This book attempts to elucidate Japanese religious experiences by presenting an innovative interpretation of the oldest existing text of Japanese myth, the Kojiki. Iwasawa offers new insights into Japanese mythology regarding the relationship between the human and the divine.

First published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

Wish-fulfilment as a singular means of satisfying ineluctable desire is a pivotal concept in classical psychoanalysis. Freud argued that it was the thread that united dreams, daydreams, phantasy, omnipotent thinking, neurotic and some psychotic symptoms such as hallucinations and delusions, art, myth, and religious illusions. The concept's theoretical exploration has been largely neglected within psychoanalysis since, but contemporary philosophers have recognised it as providing an explanatory model for much of the kind of irrational behaviour so problematic for psychiatry, social psychology (...) and the philosophy of mind. Although critically neglected in contemporary psychological and psychoanalytic thought, the concept remains clinically fundamental, under different labels: it encompasses the processes of omnipotent phantasy, symbolic or substitutive satisfaction, actualisation in transference and acting out, symptom formation and defenses such as projective identification. Wish-fulfilment can be shown to be a specifically psychoanalytic compartment of a common-sense psychological theory of action that illuminates not just clinical material but also the paradoxes of irrationality – such as weakness of will and self-deception – that preoccupy philosophers. The first half of this book develops a comprehensive and novel theory of wish-fulfilment, explores its radical implications for the structure of mind, and locates it against the backdrop of both contemporary psychoanalytic and philosophical thought. In the second half, the book applies the theory to illuminate important features of self-deception and delusion, religion, insanity defences, creative writing and the exclusion of mind and intention in the biological drift of modern psychiatry. The book will be essential to philosophers of mind, psychoanalysts, psychiatrists, psychologists, social theorists, and students in these disciplines; as well as readers interested in understanding how the mind works in mental illness, self-deception, religion, and creative writing. (shrink)

Unethical behavior in organizations has garnered more and more attention in the last decades but most of the scholarly work has used a static approach relying on methodological individualism and a mechanistic worldview when studying this topic. The process of moral disengagement and organizational culture have been linked to the prevalence of unethical behavior earlier, but this paper uses a complexity-informed systems perspective to explore the dynamic relationship of these concepts and aims to improve our understanding of the often unnoticeable, (...) step-by-step process through which organizational cultures can become conducive to unethical behavior. Organizations are conceptualized as complex adaptive systems in which transformative and stabilizing processes based on feedback loops take place continuously. It is discussed how these processes can lead to a phase transition driving organizations towards a state where unethical behavior is the general norm. The process is illustrated through real-life examples. (shrink)

It is essential for social robots to fit in the human society. In order to facilitate this process we propose to use the family dog’s social behaviour shown towards humans as an inspiration. In this study we explored dogs’ low level social monitoring in dog-human interactions and extracted individually consistent and context dependent behaviours in simple everyday social scenarios. We found that proximity seeking and tail wagging were most individually distinctive in dogs, while activity, orientation towards the owner, and exploration (...) were dependent on the context and/or the activity of the owner. The functional analogues of these dog behaviours can be implemented in social robots of different embodiments in order to make them acceptable and more believable for humans. Keywords: dog-owner interaction; social robotics; low-level social monitoring; greeting behaviour; individually distinctive behaviours. (shrink)

Artificial Culture" is an examination of the articulation, construction, and representation of "the artificial" in contemporary popular cultural texts, especially science fiction films and novels. The book argues that today we live in an artificial culture due to the deep and inextricable relationship between people, our bodies, and technology at large. While the artificial is often imagined as outside of the natural order and thus also beyond the realm of humanity, paradoxically, artificial concepts are simultaneously produced and constructed by human (...) ideas and labor. The artificial can thus act as a boundary point against which we as a culture can measure what it means to be human. Science fiction feature films and novels, and other related media, frequently and provocatively deploy ideas of the artificial in ways which the lines between people, our bodies, spaces and culture more broadly blur and, at times, dissolve. Building on the rich foundational work on the figures of the cyborg and posthuman, this book situates the artificial in similar terms, but from a nevertheless distinctly different viewpoint. After examining ideas of the artificial as deployed in film, novels and other digital contexts, this study concludes that we are now part of an artificial culture entailing a matrix which, rather than separating minds and bodies, or humanity and the digital, reinforces the symbiotic connection between identities, bodies, and technologies. "--Provided by publisher. (shrink)

A piliscsabai Pázmány Péter Katolikus Egyetem oktatója, Hankovszky Tamás (két kivételtől eltekintve) az utóbbi évtizedben megjelent publikációiból állította össze tanulmánykötetét. A filozófiai, teológiai és irodalmi ihletésű írásokat mindenekelőtt "az Istennel való találkozás" keresztény hite fűzi egybe, és persze a filozófiatörténész szerző preferenciái (Pilinszky, Camus, Mauriacimon Weil, Dosztojevszkij). "Minden találkozás olyan partnereket követel, akik szabadon megnyílnak egymásnak, de nem oldódnak fel egymásban, akik a másik közelségére vágynak, mégis megőrzik a köztük lévő távolságot, mert a dialógust keresik, és a dialógus lételeme a (...) különbözőség. Ám az ember csak azért különbözik a másik embertől és Istentől, hogy kapcsolatba léphessenek" - olvasható az ismertetőben. Mivel Hankovszky professzor a találkozásban és a párbeszédben látja az élet értelmét és végső célját, a kötet kívül áll azon a misztikát is felölelő monista hagyományon, amely az Istennel való minél teljesebb egyesülésre, Isten és ember egységére törekszik, és a vele való párbeszédet, a kölcsönös megszólítást pusztán a cél felé vezető út első lépésének tekinti. Azonban éppen azért áll kívül ezen az ősi és tiszteletreméltó hagyományon, hogy dialógust folytasson vele, és így teljesebben érthesse meg Isten és ember viszonyát, valamint megtalálja benne a földi lét, a művészet és a kultúra igazi helyét. A szakkönyvtárak anyagába ajánlható kötetet rövidítés- és irodalomjegyzék, valamint az esszék és tanulmányok első megjelenési helyeinek listája teszi teljessé. (shrink)

The Hungarian health care system is scheduled to undergo dramatic structural changes, emphasizing preventive medicine, health education, and competition among providers. Keywords: cost control, health care reform, health education, Hungary, market system, preventive medicine CiteULike Connotea Del.icio.us What's this?