Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

We study behind-the-scenes investor activism promoting environmental, social, and governance improvements by means of a proprietary dataset of a large international, socially responsible activist fund. We examine the activist’s target selection, forms of engagement, impact on ESG performance, drivers of success, and effects on the targets’ operations and value creation. Target firms are typically large and visible, perform well, and have high liquidity and low ESG performance. Engagement induces ESG rating adjustments: firms with poor ex ante ESG ratings experience a (...) ratings increase after complying with the activist’s demands, whereas firms with high ex ante ESG ratings experience a ratings decrease following the revelation of their ESG problems. Activism that is focused on environmental and social issues is more likely to succeed if targets are ESG-sensitive. Successful engagements boost targets’ sales. Risk-adjusted excess stock returns of successful engagements outperform those of unsuccessful engagements by 2.7%. Results are especially strong for firms with low ex ante ESG scores. Specifically, targeted firms in the lowest ex ante ESG quartile outperform matched peers by 7.5% in the year after the end of the engagement. Our results thus suggest that the activism regarding corporate social responsibility generally improves ESG practices and corporate sales and is profitable to the activist. Taken together, we provide direct evidence that ethical investing and strong financial performance, both from the activist’s and the targeted firm’s perspective, can go hand-in-hand together. (shrink)

In his famous clarification Kant claimed that philosophy of Fichte is „nothing more or less than mere logic". In contrast with this interpretation Fichte from the beginning agreed with Kant and Reinhold on the fact that philosophy and logic are different from each other moreover the classical principles of logic can not be the principles of philosophy as well. However according to Fichte Reinhold did not succeed in explaining the relationship between philosophy and logic sufficiently. Hence Fichte proceeding from the (...) detailed critique of Reinhold laid in Review of Aenesidemus gives a new concept for the principles of both logic and philosophy. Accordingly in Foundations of the Entire Science of Knowledge he building upon this idea chooses such principle of the logic that possesses material validity and special content to be the absolutely primordial axiom of the science of knowledge. As we have seen the differences from the logic conception of Kant and Reinhold we can conceive better the meaning of the sentence from Fichte: “Everything to which the proposition ‘A = A’ is applicable, has reality, insofar as that proposition is applicable to it.” – This is one of the sentences dragged away from the context could provoked Kant’s ire reasonably.In seiner berühmten Erklärung äußerte Kant, die Wissenschaftslehre sei „nichts mehr oder weniger als bloße Logik“. Dieser Meinung widerspricht Fichtes Selbstinterpretation, weil er von Anfang an mit Kant und Reinhold darin einig war, dass sich Philosophie und Logik voneinander unterscheiden, und die klassischen Prinzipien der Logik nicht als Grundsätze der Philosophie gelten können. Nach seiner Auffassung gelingt es allerdings Reinhold nicht, das Verhältnis von Logik und Philosophie befriedigend zu klären. Ausgehend von einer gründlichen Kritik an Reinhold in der Rezension des Aenesidemus führt Fichte eine neue Konzeption vom Verhältnis der Grundsätze der Logik und der Philosophie ein. In der Grundlage der gesamten Wissenschaftslehre wählt er einen mit realer Gültigkeit und besonderem Inhalt ausgestatteten Grundsatz der Logik zum absolut ersten Grundsatz der Wissenschaftslehre. Betrachtet man die Veränderungen der Kantschen und Reinholdschen Logikauffassung, wird es verständlicher, wenn Fichte schreibt: „Alles, worauf der Satz A = A anwendbar ist, hat, inwiefern derselbe darauf anwendbar ist, Realität“–einer von vielen Sätzen, die aus dem Kontext herausgenommen mit Fug und Recht Kants Missfallen ausgelöst haben könnten. (shrink)

In this paper, I introduce a prominent classical scholar, József Balogh, whose work can be read as a significant contribution to the historiography of ancient, and in some sense modern, philosophy. Following a summary biography, I sketch the relevance of Balogh''s interpretation of Augustine. I draw some analogies between his and Eric Havelock''s treatment of the problems in ancient philosophy, and argue that the obvious similarities between them have a common origin, namely the perspective of the orality/literacy chasm which both (...) treated, in connection with their research into Augustine and Plato, as crucial. Subsequently, I show how the problem of reading aloud, which Balogh was the first to treat systematically, has acquired significance in some current debates in philosophy. (shrink)

Words can mean different things to different people. This can be problematic, mainly for those working together in a bureaucratic institution, such as the secret service. Shared, certified, explicit and codified definitions offer a counter to subjective, solitary and/or culturally dominant definitions. It’s true that codified secrecy terms for secret services can be seen to involve a number of political, cultural, subcultural “languages”, but if words come from unclassified or declassified files, memorandums and/or records, one needs a deep understanding of (...) the secret services. A remarkable feature of this bureaucratic language is the evolving nature of, certain “keywords” as important signifiers of historical transformation. Thus, the changes in the language of the secret services depends at least as much on the internal changes of the secret services as on the transformation in the external political-social environment. In spite of the confusion of Hungarian secret services in the revolutions of 1918–1919 and the disintegration of the Austrian-Hungarian Monarchy, in the early 1920’s became a stable system. Between the two World Wars, the Hungarian State Police directed by the Ministry of Internal Affairs, the Military Intelligence and Counter-Espionage directed by the Ministry of Defence, and the Hungarian Royal Gendarmerie directed by both of the Ministries had their own operational service. This structure existed unchanged until 1945. Simultaneously with the forward advance of the soviet troops, government began to re-establish the former system of the secret services in the eastern part of the country. After WWII, in 1946, the “State-protection Department” as political police became independent from the police. However, from the beginning, they remained under the control of the Communist Party. After 1950, the State Security Authority provided special services for the MIA and the Military Political Directorate of the MoD. After quashing the revolution in 1956, in the spring of 1957, the MIA Political Investigation Department was established which—with slight modifications—kept the structure created during the “state protection era”. The MIA III. The State-Protection General Directorate was established in 1962. The reorganization was finalized in the middle of the 1960’s, which resulted in the new system, which—with the structure of Directorates—became the ultimate structure of the state secret police until the abolishment of the MIA General Directorate III in January 1990. These organizational transformations were largely the result of exogenous historical-political changes. Moreover, each new period had a major impact on the organizational communication, language use and vocabulary of the secret services. This study seeks to interpret these historical transformations. (shrink)

A piliscsabai Pázmány Péter Katolikus Egyetem oktatója, Hankovszky Tamás (két kivételtől eltekintve) az utóbbi évtizedben megjelent publikációiból állította össze tanulmánykötetét. A filozófiai, teológiai és irodalmi ihletésű írásokat mindenekelőtt "az Istennel való találkozás" keresztény hite fűzi egybe, és persze a filozófiatörténész szerző preferenciái (Pilinszky, Camus, Mauriacimon Weil, Dosztojevszkij). "Minden találkozás olyan partnereket követel, akik szabadon megnyílnak egymásnak, de nem oldódnak fel egymásban, akik a másik közelségére vágynak, mégis megőrzik a köztük lévő távolságot, mert a dialógust keresik, és a dialógus lételeme a (...) különbözőség. Ám az ember csak azért különbözik a másik embertől és Istentől, hogy kapcsolatba léphessenek" - olvasható az ismertetőben. Mivel Hankovszky professzor a találkozásban és a párbeszédben látja az élet értelmét és végső célját, a kötet kívül áll azon a misztikát is felölelő monista hagyományon, amely az Istennel való minél teljesebb egyesülésre, Isten és ember egységére törekszik, és a vele való párbeszédet, a kölcsönös megszólítást pusztán a cél felé vezető út első lépésének tekinti. Azonban éppen azért áll kívül ezen az ősi és tiszteletreméltó hagyományon, hogy dialógust folytasson vele, és így teljesebben érthesse meg Isten és ember viszonyát, valamint megtalálja benne a földi lét, a művészet és a kultúra igazi helyét. A szakkönyvtárak anyagába ajánlható kötetet rövidítés- és irodalomjegyzék, valamint az esszék és tanulmányok első megjelenési helyeinek listája teszi teljessé. (shrink)

Reviewer gives a survey of the new phylogenetic theory of language recently published by Prof. Dr. G. Révész, founder and director of the Laboratory for experimental psychology of the University of Amsterdam ). The starting-point of the theory is the conception of "contact", defined by the author as the innate trend to be together or to co-operate, common to all socially living beings. This "theory of contact" is developed by the author in different directions and gives rise to the distinction (...) 1. of three degrees of communication: cry , call and word , 2. of three periods in the development of language: a pre-phase , a primevalphase and a final phase and 3. of three main functions of language: impelling , indication and interrogation , and leads to the conclusion that most probably the oldest form of human intercourse was restricted to the function of impelling . Prof. R. lays great stress on the in his opinion unsurmountable barrier between human and animal forms of communication. (shrink)

Wish-fulfilment as a singular means of satisfying ineluctable desire is a pivotal concept in classical psychoanalysis. Freud argued that it was the thread that united dreams, daydreams, phantasy, omnipotent thinking, neurotic and some psychotic symptoms such as hallucinations and delusions, art, myth, and religious illusions. The concept's theoretical exploration has been largely neglected within psychoanalysis since, but contemporary philosophers have recognised it as providing an explanatory model for much of the kind of irrational behaviour so problematic for psychiatry, social psychology (...) and the philosophy of mind. Although critically neglected in contemporary psychological and psychoanalytic thought, the concept remains clinically fundamental, under different labels: it encompasses the processes of omnipotent phantasy, symbolic or substitutive satisfaction, actualisation in transference and acting out, symptom formation and defenses such as projective identification. Wish-fulfilment can be shown to be a specifically psychoanalytic compartment of a common-sense psychological theory of action that illuminates not just clinical material but also the paradoxes of irrationality – such as weakness of will and self-deception – that preoccupy philosophers. The first half of this book develops a comprehensive and novel theory of wish-fulfilment, explores its radical implications for the structure of mind, and locates it against the backdrop of both contemporary psychoanalytic and philosophical thought. In the second half, the book applies the theory to illuminate important features of self-deception and delusion, religion, insanity defences, creative writing and the exclusion of mind and intention in the biological drift of modern psychiatry. The book will be essential to philosophers of mind, psychoanalysts, psychiatrists, psychologists, social theorists, and students in these disciplines; as well as readers interested in understanding how the mind works in mental illness, self-deception, religion, and creative writing. (shrink)

The present work investigates the memory accessibility of linguistically focused elements and the representation of the alternatives for these elements in Working Memory and in delayed recognition memory in the case of the Hungarian pre-verbal focus construction. In two probe recognition experiments we presented preVf and corresponding focusless neutral sentences embedded in five-sentence stories. Stories were followed by the presentation of sentence probes in one of three conditions: the probe was identical to the original sentence in the story, the focused (...) word was replaced by a semantically related word and the target word was replaced by a semantically unrelated but contextually suitable word. In Experiment 1, probes were presented immediately after the stories measuring WM performance, while in Experiment 2, blocks of six stories were presented and sentences were probed with a 2-minute delay measuring delayed recognition memory performance. Results revealed an advantage of the focused element in immediate but not in delayed retrieval. We found no effect of sentence type on the recognition of the two different probe types in WM performance. However, results pertaining to the memory accessibility of focus alternatives in delayed retrieval showed an interference effect resulting in a lower memory performance. We conclude that this effect is indirect evidence for the enhanced activation of focus alternatives. The present work is novel in two respects. First, no study has been conducted on the memory representation of focused elements and their alternatives in the case of the structurally marked Hungarian pre-verbal focus construction. Second, to our knowledge, this is the first study that investigates the focus representation accounts for WM and delayed recognition memory using the same stimuli and same measured variables. Since both experiments used exactly the same stimulus set, and they only differed in terms of the timing of recognition probes, the principle of ceteris paribus fully applied with respect to how we addressed our research question regarding the two different memory systems. (shrink)

First published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

This article shows that the various regimes of “real socialism” uniformly failed to transcend the horizon of capitalism. They have remained class societies based on wage labour, commodity production, a money economy and welfare systems fed by redistribution. At the same time, they present peculiar features that are different from other versions of “state capitalism.” Traditional elites were annihilated, private property of capital in the hands of individuals or autonomous groups was prohibited, and the advantages accruing to leading positions were (...) not inherited, although equality in income was very modest. The main political invention of “real socialism” was the Party, a unique institution unlike any other, grounded in theory, but an institution of the state, over the executive, which had unprecedented powers of mobilisation and cultural influence. It had to be intellectual in character, as the system was steered through the Plan which was, in the final analysis, a text. The changes of 1989 took place partly mediated by the Party, partly against its rule. The successor regimes are conspicuously political owing to the nature of the adversary. (shrink)

An evolutionary theory of socialization suggests that children from father-absent families will mature earlier, and form less-stable pair bonds, compared with those from father-present families. Using a sample of about 1,000 persons the recent study focuses on elements of father-absent children’s behavior that could be better explained by a Darwinian approach than by rival social science theories. As a result of their enhanced interest in male competition, father-absent boys were found to engage in rule-breaking behavior more intensively than father-present boys. (...) Compared with father-present children, adolescents from widowed households (both boys and girls) showed a higher intensity of various kinds of noncompliant behavior, which can be linked to their earlier maturation. School attendance, age at marriage, and marital success proved to be influenced by the children’s early family experiences, governed by adapted evolutionary strategies. Father-absent daughters conceived more children than those whose fathers were present during their childhood. As evolutionary theory predicts, reproductive behavior of individuals from divorced households differed from that of individuals who grew up in widowed households. Finally, the strong correlation found between spontaneous abortion/stillbirths and family arrangement indicates that father absence has certain direct impacts on the neurohormonal processes of child development. (shrink)

Explores the impact of Enlightenment philosophers in Scotland on the development of sociology The first collection to look at the significance of the Scottish Enlightenment for sociological thought, this book explores how and what sociological ideas were developed during this period. It also analyses how the ideas of the Scottish Enlightenment would emerge and develop in subsequent traditions of sociology. Scottish Enlightenment thinkers developed and refined a descriptive-explanatory approach and methodology to explore social and economic processes, an approach that was (...) different from the normative and justificatory aspirations of 17th- and 18th-century social and political philosophies. This distinct contribution of the Scottish Enlightenment is frequently overlooked, even if some of its central figures - Adam Ferguson, David Hume, Adam Smith, to name but three - are acknowledged as important forerunners of contemporary social sciences. This book offers both a synoptic perspective on individual contributions and a connective view of theoretical achievements that are otherwise typically treated in isolation. Tamás Demeter is Professor of Philosophy at the Corvinus University of Budapest and Senior Research Fellow at the HUN-REN Research Centre for the Humanities, Budapest. (shrink)

It is essential for social robots to fit in the human society. In order to facilitate this process we propose to use the family dog’s social behaviour shown towards humans as an inspiration. In this study we explored dogs’ low level social monitoring in dog-human interactions and extracted individually consistent and context dependent behaviours in simple everyday social scenarios. We found that proximity seeking and tail wagging were most individually distinctive in dogs, while activity, orientation towards the owner, and exploration (...) were dependent on the context and/or the activity of the owner. The functional analogues of these dog behaviours can be implemented in social robots of different embodiments in order to make them acceptable and more believable for humans. Keywords: dog-owner interaction; social robotics; low-level social monitoring; greeting behaviour; individually distinctive behaviours. (shrink)

In Opticks, Newton notes that by following the method of analysis and synthesis, ’the bounds of moral philosophy will also be enlarged’. Hume’s Treatise fulfills this vision, albeit with significant caveats. The chapter argues: 1) Hume’s affinity with Newton is primarily methodological, and Hume’s project is closer to the Queries of Opticks than to the Principia. 2) For Hume, moral philosophy is an experimental study of moral beings qua moral beings which results in ‘an anatomy of the mind’ embodying an (...) epistemic ideal closer to Scottish philosophical chemistry than to any kind of mechanical philosophy. 3) Hume primarily inquires into qualitatively different active principles of human nature that explain why humans function as they do. 4) The knowledge that Hume’s project offers can be used normatively. 5) Thus, in Hume’s hands the boundaries of moral philosophy are enlarged. Yet, being entirely secular, it was not what Newton had envisioned. (shrink)

The aim of this study is an analysis of the possible adaptive consequences of delivery of low birth weight infants. We attempt to reveal the cost and benefit components of bearing small children, estimate the chance of the infants’ survival, and calculate the mothers’ reproductive success. According to life-history theory, under certain circumstances mothers can enhance their lifetime fitness by lowering the rate of investment in an infant and/or enhancing the rate of subsequent births. We assume that living in a (...) risky environment and giving birth to a small infant may involve a shift from qualitative to quantitative production of offspring. Given high infant mortality rates, parents will have a reproductive interest in producing a relatively large number of children with a smaller amount of prenatal investment. This hypothesis was tested among 650 Gypsy and 717 non-Gypsy Hungarian mothers. Our study has revealed that 23.8% of the Gypsy mothers had low birth weight (<2,500 g) children, whose mortality rate is very high. These mothers also had more spontaneous abortions and stillbirths than those with normal weight children. As a possible response to these reproductive failures, they shortened birth spacing, gaining 2–4 years across their reproductive lifespan for having additional children. Because of the relatively short interbirth intervals, by the end of their fertility period, Gypsy mothers with one or two low birth weight infants have significantly more children than their ethnic Hungarian counterparts. They appear to compensate for handicaps associated with low birth weights by having a larger number of closely spaced children following the birth of one or more infants with a reduced probability of survival. The possible alternative explanations are discussed, and the long-term reproductive benefits are estimated for both ethnic groups. (shrink)

I begin with a diagnosis. Present-day scholarly work on the Scottish Enlightenment is bifurcated: it is either focused on the areas of moral philosophy or of natural philosophy, broadly construed in both cases. The aspiration to combine these inquiries is rare and unsystematic. This paper makes a case for the need and possibility of a perspective that conceives moral and natural inquiry as integrated enterprises in the period. It also suggests that potentially useful interpretive devices can be adopted from the (...) historiography of science and philosophy, as well as science studies. (shrink)

Introduction -- The Marx project : a brief overview -- Origins of totalitarianism : ideology and terror -- The tradition -- First pillar : "labor is the creator of man" : on labor, necessity, and loneliness -- Third pillar : the eleventh thesis on Feuerbach -- Second pillar : violence is the midwife of history -- Die Aufhebung : as the state withers a new politics arises and philosophy fades away.

To establish Optimality Theory as a framework in anthropology, or as a general model of higher human cognition, researchers have to demonstrate OT is convincing in a number of ways. This commentary summarizes some of them including factorial typologies, exact formulation of candidate sets and constraints, and computational plausibility.

(1996). The emergence of the global culture and the global moral system: The global bio‐social system as the reference system of the human rights. World Futures: Vol. 46, No. 1, pp. 47-51.

In the present paper I sketch three genres of sociology of knowledge and trace their roots to Marx and Marxist literature while reconstructing two causal and one hermeneutic strand in this context. While so doing the main focus is set on György Lukács and György Márkus and their interpretation of Marx’s contribution to sociologically minded theories of knowledge. As a conclusion I point out that Marx-inspired sociologies of knowledge are more sensitive to the relation of larger-scale social and historical processes (...) than to the actual practices of knowledge production, and that recent developments in science studies tend to integrate larger- and smaller-scale sociological sensitivities. (shrink)

Some of the key primary source texts central to the history of British feminism are now being made available in the six volumes of Sources of British Feminism . These anthologies are intended to signal a tribute to the collective and collaborative efforts of writers whose work has effected profound social and political change. Writings compiled here include socialist manifestoes, miscellaneous pamphlets, personal reminiscences, full length biographies, histories of the various movements and impassioned treatises on the cause of women's rights (...) by leading advocates like Mary Astell, Barbara Bodichon and Emmeline Pankhurst. (shrink)

This study aims to clarify the relationship between nature and God in Pascalian thought. This relationship is based on the concept of unity. In a letter of 1648, Pascal wrote that God is present in nature through the ontological and formal unity of things which represents perfect divine unity. A few years later, through his mathematical research, Pascal discovered the principle of double infinity which he considered to be the essential attribute of nature. The unity of nature is defined as (...) the omnipresence of double infinity in nature. However, these two interpretations of unity are mutually exclusive because double infinity destroys all ontological and formal unity in things. The question is how Pascal maintains the relationship between nature and God if the principle of double infinity destroys formal unity in nature. The paper argues that the presence of the double infinite in nature does not destroy the relationship of resemblance and representation between nature and God but makes it more complex. The double infinite does not represent God in nature directly but is inscribed in things as the image of the hidden God. (shrink)