Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

This volume is dedicated to Barbara Skarga -- her works, profile and biography. It is a unique character in the Polish intellectual life, but also virtually unknown abroad, except a meager milieu of her reeadership in France. Dubbed 'the first lady of Polish philosophy' for a good reason, she contributed not only to [the] shape of Polish philosophy but to the style of public debate too. The problem areas initiating her philosophy stemmed from the group of scholars called the (...) Warsaw school of history of ideas' with its flagship names such as Leszek Kolakowski, Brinisław Baczko, or Andrzej Walicki. On the other hand, her output originates from the extraordinary and dramatic events of her life. The philosophical outpout of Barbara Skarga is thus a proof of continuity and longevity of an important tradition of the 20th century Polish Philosophy. (shrink)

After identifying points of agreement between Karl Rahner and Hans Urs von Balthasar on topics raised by Dr. Sain’s essay, this response raises questions about the deeper foundations of the substantial differences between them. It suggests that the appeal to contrast in their starting-points (Goethe versus Kant) as an explanation is not adequate and suggests lines of further inquiry which might be pursued further.

Interview with Renaud Barbaras, conducted on May 18, 2011.

Mitchell: Could we begin by discussing the problem of public art? When we spoke a few weeks ago, you expressed some uneasiness with the notion of public art, and I wonder if you could expand on that a bit.Kruger: Well, you yourself lodged it as the “problem” of public art and I don’t really find it problematic inasmuch as I really don’t give it very much thought. I think on a broader level I could say that my “problem” is with (...) categorization and naming: how does one constitute art and how does one constitute a public? Sometimes I think that if architecture is a slab of meat, then so-called public art is a piece of garnish laying next to it. It has a kind of decorative function. Now I’m not saying that it always has to be that way—at all—and I think perhaps that many of my colleagues are working to change that now. But all too often, it seems the case.Mitchell: Do you think of your own art, insofar as it’s engaged with the commercial public sphere—that is, with advertising, publicity, mass media, and other technologies for influencing a consumer public—that it is automatically a form of public art? Or does it stand in opposition to public art?Kruger: I have a question for you: what is a public sphere which is an uncommercial public sphere? Barbara Kruger is an artist who works with words and pictures. W. J. T. Mitchell, editor of Critical Inquiry, is Gaylord Donnelly Distinguished Professor of English and art at the University of Chicago. (shrink)

RésuméLes auteurs traduisent et commentent un passage du Kitāb al-āṯār al-bāqiya concernant l'hydrologie. Ce passage révèle comment al-Bīrūnī comprenait les régimes fluviaux, le comportement physique de l'eau, et quelques phénomènes naturels spéciaux. Al-Bīrūnī ne se contente pas d'une discussion sur la prévision météorologique et les régimes fluviaux saisonniers du Tigre, de l'Euphrate, de l'Oxus et du Nile. Il défend surtout le principe qu'en l'absence de force externe, l'eau se meut vers le bas. Ce faisant, le savant du Khwarezm touche à (...) l'origine de la salinité des mers et au fonctionnement des machines à syphon hydraulique, et il décrit un phénomène artificiel, qu'il rejette comme résultant d'observations erronées, mais qu'on pourrait reconnaître comme un cas de saut hydraulique. De plus, ce passage renseigne sur ce qu'al-Bīrūnī comprenait du caractère inhabitable des régions sub-équatoriales, de la possibilité du vide, et du cycle de l'eau. (shrink)

Individual objects have potentials: paper has the potential to burn, an acorn has the potential to turn into a tree, some people have the potential to run a mile in less than four minutes. Barbara Vetter provides a systematic investigation into the metaphysics of such potentials, and an account of metaphysical modality based on them. -/- In contemporary philosophy, potentials have been recognized mostly in the form of so-called dispositions: solubility, fragility, and so on. Vetter takes dispositions as her (...) starting point, but argues for and develops a more comprehensive conception of potentiality. She shows how, with this more comprehensive conception, an account of metaphysical modality can be given that meets three crucial requirements: Extensional correctness: providing the right truth-values for statements of possibility and necessity; formal adequacy: providing the right logic for metaphysical modality; and semantic utility: providing a semantics that links ordinary modal language to the metaphysics of modality. -/- The resulting view of modality is a version of dispositionalism about modality: it takes modality to be a matter of the dispositions of individual objects. This approach has a long philosophical tradition going back to Aristotle, but has been largely neglected in contemporary philosophy. In recent years, it has become a live option again due to the rise of anti-Humean, powers-based metaphysics. The aim of Potentiality is to develop the dispositionalist view in a way that takes account of contemporary developments in metaphysics, logic, and semantics. (shrink)

How does thinking affect doing? There is a widely held view that thinking about what you are doing, as you are doing it, hinders performance. Once you have acquired the ability to putt a golf ball, play an arpeggio on the piano, or parallel-park, reflecting on your actions leads to inaccuracies, blunders, and sometimes even utter paralysis--that's what is widely believed. But is it true? After exploring some of the contemporary and historical manifestations of the idea, Barbara Gail Montero (...) develops a theory of expertise which emphasizes the role of the conscious mind in expert action. She aims to dispel various myths about experts who proceed without any understanding of what guides their action, and she analyzes research in both philosophy and psychology that is taken to show that conscious control and explicit monitoring of one's movements impedes well practiced skills. Montero explores a wide range of real-life examples of optimal performance, in sports, the performing arts, healthcare, the military, and other fields, and draws from psychology, neuroscience, and literature to offer a refreshing and persuasive view of expertise, according to which expert action generally is and ought to be thoughtful, effortful, and reflective. (shrink)

The series Studien zur deutschen Literatur (Studies in German Literature) presents outstanding analyses of German-speaking literature from the early modern period to the present day. It particularly embraces comparative, cultural and historical-epistemological questions and serves as a tradition-steeped forum for innovative literary research. All submitted manuscripts undergo a double peer-review process. Please contact the editor Marcus B hm (marcus.boehm at] degruyter.com) for further information regarding manuscript submission and subsidies.

my comments focus on jane addams's methode of ethical deliberation, as understood through Dr. Fischer's detailed explication, especially as offered in chapter 2, "An Evolutionary Method of Ethical Deliberation." As Fischer points out, this explication is of one iteration of Jane Addams's method, a particularized response to how Jane Addams believed the settlement residents should respond to the many labor strikes in Chicago during the 1890s. I offer my comments from the perspective of both a scholar, seeking to better apply (...) Addams's insights to my own work, and an educator, seeking to better integrate Addams's work into my teaching. My hope is to flesh out more clearly my own understanding and, in so doing... (shrink)

Is the neurophysiology of pain all there is to pain? How do words and mental pictures come to represent things in the world? Do computers think, and if so, are their thought processes significantly similar to our thought processes? Or is there something distinctive about human thought thatprecludes replication in a computer? These are some of the puzzles that motivate the philosophical discipline called "philosophy of mind," a central area of philosophy.This Very Short Introduction introduces the philosophy of mind, and (...) looks at some of the most interesting and important topics in this fascinating field, including the mind-body problem and dualism. Barbara Montero also discusses minds other than our own, and the problems associated with definingconsciousness in animals, aliens and machines. Considering these and other such thorny issues such as physicalism and intentionality, she demonstrates how questions of the philosophy of mind also infiltrate disciplines outside of philosophy, including psychology, neuroscience, economics,evolutionary biology, and linguistics. As she observes, most everyone, at some time or another, has ruminated over the relation between mind and matter.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, andenthusiasm to make interesting and challenging topics highly readable. (shrink)

Barbara Maria Stafford is at the forefront of a growing movement that calls for the humanities to confront the brain’s material realities. In _Echo Objects,_ she argues that humanists should seize upon the exciting neuroscientific discoveries that are illuminating the underpinnings of cultural objects. In turn, she contends, brain scientists could enrich their investigations of mental activity by incorporating phenomenological considerations—particularly the intricate ways that images focus intentional behavior and allow us to feel thought. As a result, _Echo Objects_ (...) is a stunningly broad exploration of how complex images—or patterns that compress space and time—make visible the invisible ordering of human consciousness. Stafford demonstrates, for example, how the compound formats of emblems, symbols, collage, and electronic media reveal the brain’s grappling to construct mental objects that are redoubled by prior associations. In contrast, she shows that findings in evolutionary biology and the neurosciences are providing profound opportunities for understanding aesthetic conundrums such as the human urge to imitate and the role of narrative and nonnarrative representation. Ultimately, she makes an impassioned plea for a common purpose—for the acknowledgement that, at the most basic level, these separate projects belong to a single investigation. “Heroic.... The larger message of Stafford’s intense, propulsive prose is unassailable. If we are to get much further in the great puzzle of ‘binding’—how the perception of an image, the will to act on intention, or the forging of consciousness is assembled from the tens of thousands of neurons firing at any one moment in time—then there needs to be action on all fronts.”—_Science_. (shrink)

This book presents the most important problems of reference and considers their solution. It presupposes no technical knowledge, presents analyses from first principles, illustrates every stage with examples, and is written with verve and clarity. This is the ideal introduction to reference for students of linguistics and philosophy of language.

The study of word meanings promises important insights into the nature of the human mind by revealing what people find to be most cognitively significant in their experience. However, as we learn more about the semantics of various languages, we are faced with an interesting problem. Different languages seem to be telling us different stories about the mind. For example, important distinctions made in one language are not necessarily made in others. What are we to make of these cross-linguistic differences? (...) How do they arise? Are they created by purely linguistic processes operating over the course of language evolution? Or do they reflect fundamental differences in thought? In this sea of differences, are there any semantic universals? Which categories might be given by the genes, which by culture, and which by language? And what might the cross-linguistic similarities and differences contribute to our understanding of conceptual and linguistic development? The kinds of mapping principles, structures, and processes that link language and non-linguistic knowledge must accommodate not just one language but the rich diversity that has been uncovered. The integration of knowledge and methodologies necessary for real progress in answering these questions has happened only recently, as experimental approaches have been applied to the cross-linguistic study of word meaning. In Words and the Mind, Barbara Malt and Phillip Wolff present evidence from the leading researchers who are carrying out this empirical work on topics as diverse as spatial relations, events, emotion terms, motion events, objects, body-part terms, causation, color categories, and relational categories. By bringing them together, Malt and Wolff highlight some of the most exciting cross-linguistic and cross-cultural work on the language-thought interface, from a broad array of fields including linguistics, anthropology, cognitive and developmental psychology, and cognitive neuropsychology. Their results provide some answers to these questions and new perspectives on the issues surrounding them. (shrink)