Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

New agrifood technologies are often difficult to grasp for the public, which may lead to resistance or even rejection. Insight into which technology features determine public acceptability of the technology could offer guidelines for responsible technology development. This paper systematically assesses the relative importance of specific technology features for consumer response in the agrifood domain in two consecutive studies. Prominent technology features were selected from expert judgment and literature. The effects of these features on consumer evaluation were tested in a (...) consumer study. Fictitious technologies were used to avoid any uncontrollable contextual influences that existing new technologies may evoke. Results show that technologies that were seen as more natural and newer were perceived less risky, more beneficial, and were evaluated more positively. Technologies applied to food were judged to be more beneficial, but also more risky than those applied to non-food. Technologies used in the production process were perceived to be less risky and evaluated more positively than those used in the product. Technologies owned by the market leader were perceived to be more beneficial, and evaluated more positively than those that were freely available. In a next study, effects of the technology features on consumer response were tested for existing new agrifood technologies. This study replicated the results for perceived naturalness, perceived newness, and place in the production process where the technology is applied. However, in contrast to the first study, we did not find an effect of application area and technology ownership. (shrink)

v. 1. General introduction, the works on logic -- v. 2. The metaphysics, semantics in Aristotle's strategy of argument.

Paperback. This volume is a new interpretation of Plato's earlier and later Theory of Ideas, starting from a detailed analysis of the dialogue, The Sophist.The way in which Plato announces his novel Metaphysics has been puzzling scholars for a long time. Did Plato really introduce Change into the Transcendent World and thus abandon his Theory of Unchangeable Forms?Many of Plato's commentators have claimed that the use of modern techniques of logico-semantical analysis can be a valuable aid in unravelling this problem, (...) as well as other difficulties Plato raised and attempted to solve. In this commentary, Plato's own logico-semantical approach to metaphysical problems is followed. (shrink)

One of the most controversial issues that divided Islamic philosophers and theologians during the Middle Ages was whether human beings would have a spiritual or bodily existence after death. The idea of a world of image was conceived as a solution, suggesting that there exists a world of non-physical bodies, beyond our earthly existence. This world may be reached in sleep, in meditation or after death.From the embryonic conception by Ibn Sina, to the radical rethinking by Suhrawardi and Shahrazuri into (...) a sophisticated system, L. W. C. van Lit unravels the history of this idea. Using a distant reading approach for measuring the transmission, he further shows how the idea remained relevant for Muslim thinkers through the centuries, up until today. (shrink)

The strong connection between the two and its development into the Middle Ages form a major subject of this volume.Other themes featuring in this book are Plato ...

v. 1. On the twelfth century theories of fallacy.--v. 2. The origin and early development of the theory of supposition.

Building on the recent scholarship of Bonnie Kent, Christian Trottmann, and especially L.M. de Rijk, this volume gathers together studies by other specialists on Odonis, covering his ideas in economics, logic, metaphysics, ethics, natural ...

Wijsgerige bezinning op de rol en betekenis van religie in het debat over normen en waarden.

Professor de Rijk's interest here is in the views on reality put forward by the medieval thinkers from Boethius to William of Ockham, but especially in the 12th-14th centuries, the period from Abelard onwards.Theology was naturally a key influence, but sematic theories - the philosophical theories on how terms signify, or how a name has its meaning and how this is affected by its context - were fundamental as the starting point of ontological speculation. The categories formulated in order to (...) differentiate various types of context and their impact on the semantics of the verb esse, 'to be', and its related forms. De Rijk's aim is to understand how these medieval thinkers interpreted reality according to their own semantic views, and to see how their own particular concerns - for instance William of Ockham's application of the 'principle of parsimony' to ontology - shaped the nature of their thought. (shrink)

New agrifood technologies are often difficult to grasp for the public, which may lead to resistance or even rejection. Insight into which technology features determine public acceptability of the technology could offer guidelines for responsible technology development. This paper systematically assesses the relative importance of specific technology features for consumer response in the agrifood domain in two consecutive studies. Prominent technology features were selected from expert judgment and literature. The effects of these features on consumer evaluation were tested in a (...) consumer study. Fictitious technologies were used to avoid any uncontrollable contextual influences that existing new technologies may evoke. Results show that technologies that were seen as more natural and newer were perceived less risky, more beneficial, and were evaluated more positively. Technologies applied to food were judged to be more beneficial, but also more risky than those applied to non-food. Technologies used in the production process were perceived to be less risky and evaluated more positively than those used in the product. Technologies owned by the market leader were perceived to be more beneficial, and evaluated more positively than those that were freely available. In a next study, effects of the technology features on consumer response were tested for existing new agrifood technologies. This study replicated the results for perceived naturalness, perceived newness, and place in the production process where the technology is applied. However, in contrast to the first study, we did not find an effect of application area and technology ownership. (shrink)

L. M. de Rijk, born at Hilversum (Nederland) November, 6 1924, is Professor Emeritus of Ancient and Medieval Philosophy at the University of Leiden, and Honorary Professor at the University of Maastricht. A complete bibliography of his writings up to 1999 is available in: Maria Kardaun and Joke Spruyt (eds.) - The winged chariot. Collected essays on Plato and Platonism in honour of L. M. de Rijk - Leiden, Brill, 2000. pp. XV-XXVI. I made some corrections, updated the bibliography and (...) omitted the publications in Dutch. (shrink)

Past and recent historiography on the fifteenth-century Wegestreit described early Parisian Albertism as an intellectual trend internal to the Arts Faculty and almost exclusively identified with the figure of Johannes de Nova Domo. Although historical documents hinted at the existence of a more established school, no further evidence could be provided. In this contribution we focus on the manuscript Brussel, Koninklijke Bibliotheek van België, ms. 760, which contains a commentary to the Sentences given at Paris by Lambertus de Monte, (...) albertista magnus, around 1423. This previously unnoticed source turns out to be the first important witness of the presence of Albertism in the Faculty of Theology at Paris, and testifies to a significant reception and development of the ideas of Johannes de Nova Domo. Moreover, the manuscript evinces an interesting constellation of marginalia, some of which bear traces of unknown works of the Albertist Heymericus de Campo. The article aims to present the source from a textual and material perspective, insofar as it investigates also some peculiar aspects of the history of the manuscript. The codex came from the Augustinian Canons’ Convent of Korsendonk, where it was partially copied, as we discovered, by the erudite Johannes de Meehrout. (shrink)