Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Håkon Evju demonstrates how history and historical writing were at the centre of debates over monarchy and monarchical reform politics in Denmark-Norway during the Enlightenment.

Concepts in Action focuses on what to do with theoretical concepts, rather than providing conveyed definitions. The book covers a variety of examples what to do, how to think, in order to develop and use concepts in the social sciences.

The article investigates how national and international measures to protect wolves turned the whole of Norway into a field of study for wildlife biologists, and how the extensiveness of this “field” prompted a transformation in the methods employed to count and monitor wolves. As it was not possible to conduct traditional field studies throughout the whole of Norway, the biologists constructed an extensive infrastructure, which I have termed a “counting complex,” in order to count wolves from a distance. The article (...) identifies three decisive periods in the construction of this complex: the 1960s, the 1980s, and the first decade of the new millennium. During the first two periods, biologists used the infrastructure to mobilize ordinary people’s observations; they did this by first searching through newspaper notes, then enrolling people more directly through local committees of game management. However, the public’s observations often turned out to be unreliable, and, in the 2000s, molecular biologists helped to incorporate genetic techniques into the counting complex. By using the infrastructure to mobilize wolf scat, rather than observations, and by constructing DNA profiles for individual wolves, the molecular biologists enabled research that I have termed “nationwide field studies in absentia.” The article argues that the biologists’ main motive for constructing and refining the counting complex was to make wolves amenable to government, as they considered this a vital premise for the successful practice of protecting wolves. The increased intensity in monitoring in the last period, however, was also driven by international conventions and detailed regulations. (shrink)

Rec. av Håkon Witt Andersen et al., Aemula Lauri: The Royal Norwegian Society of Sciences and Letters, 1760–2010.

Le présent article revient sur l’expression en vieil islandais vargr í véum (« loup dans les sanctuaires »). En comparant différents récits de tels loups, notamment le mythe de l’enchaînement de Fenrir, l’article montre que plutôt qu’une vieille catégorie préchrétienne dénotant le sacrilège, l’expression doit être comprise comme un moyen discursif servant à marginaliser son objet. Elle devait ainsi s’avérer utile pour des auteurs médiévaux et donc chrétiens au moment où ceux-ci pensaient des problèmes tels que les hiérarchies sociales ou (...) encore la centralisation de l’état. (shrink)

The Tristan legend is the quintessential love story of the Middle Ages. From the formative period of its courtly branch, the only extant complete version is Tristrams saga ok Ísöndar (1226). King Hákon of Norway commissioned this and other romances to convince his aristocratic warriors to give up the kinship society ethos of heroic love that directed them to rape their enemies’ women. Courtly love sacralized female consent, yet critics have struggled to make sense of which purposes courtliness served. This (...) evolutionary reading of Tristrams saga reveals how courtly love not only functioned as an ideological bridge be­tween mating regimes, but also embodied proto-WEIRD psychology, the impersonal pro­sociality of the new mobile, educated, and transculturally inclusive European individual-as described by Henrich (2020). This ethos would evolve to become the morality of modernity. How it was disseminated exemplifies how fiction can help communities find provisional solutions to problems that cannot be solved definitely. (shrink)

The Tristan legend is the quintessential love story of the Middle Ages. From the formative period of its courtly branch, the only extant complete version is Tristrams saga ok Ísöndar (1226). King Hákon of Norway commissioned this and other romances to convince his aristocratic warriors to give up the kinship society ethos of heroic love that directed them to rape their enemies’ women. Courtly love sacralized female consent, yet critics have struggled to make sense of which purposes courtliness served. This (...) evolutionary reading of Tristrams saga reveals how courtly love not only functioned as an ideological bridge be­tween mating regimes, but also embodied proto-WEIRD psychology, the impersonal pro­sociality of the new mobile, educated, and transculturally inclusive European individual-as described by Henrich (2020). This ethos would evolve to become the morality of modernity. How it was disseminated exemplifies how fiction can help communities find provisional solutions to problems that cannot be solved definitely. (shrink)