Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community

Bioessays 46 (5):2300223 (2024)
  Copy   BIBTEX


Ageing causes progressive decline in metabolic, behavioural, and physiological functions, leading to a reduced health span. The extracellular matrix (ECM) is the three‐dimensional network of macromolecules that provides our tissues with structure and biomechanical resilience. Imbalance between damage and repair/regeneration causes the ECM to undergo structural deterioration with age, contributing to age‐associated pathology. The ECM ‘Ageing Across the Life Course’ interdisciplinary research network (ECMage) was established to bring together researchers in the United Kingdom, and internationally, working on the emerging field of ECM ageing. Here we report on a consultation at a joint meeting of ECMage and the Medical Research Council / Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing, held in January 2023, in which delegates analysed the key questions and research opportunities in the field of ECM ageing. We examine fundamental biological questions, enabling technologies, systems of study and emerging in vitro and in silico models, alongside consideration of the broader challenges facing the field.



    Upload a copy of this work     Papers currently archived: 92,991

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

Author’s Comments: Economic Foundations for Creative Ageing Policy, Volume II.Andrzej Klimczuk - 2019 - Newsletter of the Research Network Ageing in Europe 24:3--4.
Models of Cognitive Aging.Timothy J. Perfect & Elizabeth A. Maylor (eds.) - 2000 - Oxford University Press UK.
Author’s Comments: Economic Foundations for Creative Ageing Policy, Volume I.Andrzej Klimczuk - 2015 - Newsletter of the Research Network Ageing in Europe 16:5.


Added to PP

11 (#1,165,599)

6 months
11 (#272,549)

Historical graph of downloads
How can I increase my downloads?

Citations of this work

No citations found.

Add more citations

References found in this work

No references found.

Add more references