BackgroundAlthough patient advocates have developed templates for standard consent forms, evaluating patient preferences for first in human (FIH) and window of opportunity (Window) trial consent forms is critical due to their unique risks. FIH trials are the initial use of a novel compound in study participants. In contrast, Window trials give an investigational agent over a fixed duration to treatment naïve patients in the time between diagnosis and standard of care (SOC) surgery. Our goal was to determine the patient-preferred presentation (...) of important information in consent forms for these trials.MethodsThe study consisted of two phases: (1) analyses of oncology FIH and Window consents; (2) interviews of trial participants. FIH consent forms were analyzed for the location(s) of information stating that the study drug has not been tested in humans (FIH information); Window consents were analyzed for the location(s) of information stating the trial may delay SOC surgery (delay information). Participants were asked about their preferred placement of the information in their own trial’s consent form. The location of information in the consent forms was compared to the participants’ suggestions for placement. Results34 [17 FIH; 17 Window] of 42(81%) cancer patients approached participated. 25 consents [20 FIH; 5 Window] were analyzed. 19/20 FIH consent forms included FIH information, and 4/5 Window consent forms included delay information. 19/20(95%) FIH consent forms contained FIH information in the risks section 12/17(71%) patients preferred the same. Fourteen (82%) patients wanted FIH information in the purpose, but only 5(25%) consents mentioned it there. 9/17(53%) Window patients preferred delay information to be located early in the consent, before the “Risks” section. 3/5(60%) consents did this.ConclusionsDesigning consents that reflect patient preferences more accurately is essential for ethical informed consent; however, a one-size fits all approach will not accurately capture patient preferences. We found that preferences differed for FIH and Window trial consents, though for both, patients preferred key risk information early in the consent. Next steps include determining if FIH and Window consent templates improve understanding. (shrink)

The word “emotion” has named a psychological category and a subject for systematic enquiry only since the 19th century. Before then, relevant mental states were categorised variously as “appetites,” “passions,” “affections,” or “sentiments.” The word “emotion” has existed in English since the 17th century, originating as a translation of the French émotion, meaning a physical disturbance. It came into much wider use in 18th-century English, often to refer to mental experiences, becoming a fully fledged theoretical term in the following century, (...) especially through the influence of two Scottish philosopher-physicians, Thomas Brown and Charles Bell. This article relates this intellectual and semantic history to contemporary debates about the usefulness and meaning of “emotion” as a scientific term. (shrink)

Conciliationism is the family of views that rationality requires agents to reduce confidence or suspend belief in p when acknowledged epistemic peers (i.e. agents who are (approximately) equally well-informed and intellectually capable) disagree about p. While Conciliationism is prima facie plausible, some have argued that Conciliationism is not an adequate theory of peer disagreement because it is self-undermining. Responses to this challenge can be put into two mutually exclusive and exhaustive groups: the Solution Responses which deny Conciliationism is self-undermining and (...) attempt to provide arguments which demonstrate this; and the Skeptical Responses which accept that Conciliationism is self-undermining but attempt to mitigate this result by arguing this is either impermanent and/or not very worrisome. I argue that, by Conciliationism’s own lights, both kinds of responses (almost certainly) fail to save Conciliationism from being self-undermining. Thus, Conciliationism is (almost certainly) permanently self-undermining. This result is significant because it demonstrates that Conciliationism is likely hopeless: there is likely nothing that can save Conciliationism from this challenge. I further argue that Conciliationism, like any view, should be abandoned if it is (almost certainly) hopeless. (shrink)

'Altruism' was coined by the French sociologist Auguste Comte in the early 1850s as a theoretical term in his 'cerebral theory' and as the central ideal of his atheistic 'Religion of Humanity'. In The Invention of Altruism, Thomas Dixon traces this new language of 'altruism' as it spread through British culture between the 1850s and the 1900s, and in doing so provides a new portrait of Victorian moral thought. Drawing attention to the importance of Comtean positivism in setting the (...) agenda for debates about science and religion, this volume challenges received ideas about both Charles Darwin and Herbert Spencer as moral philosophers. Darwin saw sympathy and love, not only selfishness and competition, throughout the natural world. Spencer was the instigator of an Anti-Aggression League and an advocate of greater altruism in Britain's dealings with the 'lower races'. It also sheds light on the rise of popular socialism in the 1880s, on the creation of the idealist 'altruist' in novels of the 1890s, and on the individualistic philosophies of Friedrich Nietzsche, Oscar Wilde, and G. E. Moore - authors considered by some to be representative of fin de siècle 'egomania.' This wide-ranging study in the history of ideas is highly relevant to contemporary debates about altruism, evolution, religion, and ethics. (shrink)

In this major study, Professor Kitching builds on recent scholarship on Marx and Wittgenstein to provide an incisive, readable account and critique of the whole of Marx's work. He presents the philosophical, economic, and political Marx as one thinker, and argues that the key to understanding Marx is his commitment to a 'philosophy of praxis'. This sees thought as just part of that purposive activity (or praxis) which distinguishes human beings from other creatures. This is the first book to analyse (...) all of Marx's thought from a Wittgenstein perspective; in doing so, it clarifies and deepens our understanding of Marx. (shrink)

A first in English, this book engages with the ways in which Hegel and Sartre answer the difficult questions: What is it to be human? What place do we have in the world? How should we live? What can we be?

Discusses a number of pressing social issues, including nuclear weapons, radiation in the food supply, technological disasters, cancer, and other diseases traced to toxic chemicals in the air and water.

For most of the history of prejudice research, negativity has been treated as its emotional and cognitive signature, a conception that continues to dominate work on the topic. By this definition, prejudice occurs when we dislike or derogate members of other groups. Recent research, however, has highlighted the need for a more nuanced and “inclusive” (Eagly 2004) perspective on the role of intergroup emotions and beliefs in sustaining discrimination. On the one hand, several independent lines of research have shown that (...) unequal intergroup relations are often marked by attitudinal complexity, with positive responses such as affection and admiration mingling with negative responses such as contempt and resentment. Simple antipathy is the exception rather than the rule. On the other hand, there is mounting evidence that nurturing bonds of affection between the advantaged and the disadvantaged sometimes entrenches rather than disrupts wider patterns of discrimination. Notably, prejudice reduction interventions may have ironic effects on the political attitudes of the historically disadvantaged, decreasing their perceptions of injustice and willingness to engage in collective action to transform social inequalities.These developments raise a number of important questions. Has the time come to challenge the assumption that negative evaluations are inevitably the cognitive and affective hallmarks of discrimination? Is the orthodox concept of prejudice in danger of side-tracking, if not obstructing, progress towards social justice in a fuller sense? What are the prospects for reconciling a prejudice reduction model of change, designed to get people to like one another more, with a collective action model of change, designed to ignite struggles to achieve intergroup equality? (shrink)

In this collection of essays Gavin Kitching argues that the whole project of a 'science of society' is radically misconceived - the pursuit of an objective that ...

The Cartesian arguments for external world skepticism are usually considered to be significant for at least two reasons: they seem to present genuine paradoxes and that providing an adequate response to these arguments would reveal something epistemically important about knowledge, justification, and/or our epistemic position to the world. Using only premises and reasoning the skeptic accepts, I will show that the most common Cartesian argument for external world skepticism leads to a previously unrecognized self-undermining dilemma: it either leads to a (...) reductio ad absurdum, or to avoid this reductio the skeptic must accept that this argument is epistemically idle—it does not provide any support for external world skepticism. Either way, this Cartesian argument cannot legitimately threaten or even call into question our beliefs about the external world. And thus, either way, this Cartesian argument for external world skepticism is not epistemically significant—it is not a genuine paradox and adequately responding to it need not reveal anything epistemically important. (shrink)

ABSTRACT This paper [1] is a defence of a modified version of Jane English's model of filial obligations based on adult children's friendship with their parents. Unlike the more traditional view that filial obligations are a repayment for parental sacrifices, the friendship model puts filial duties in the appealing context of voluntary, loving relationships. Contrary to English's original statement of this view, which is open to the charge of tolerating filial ingratitude, the friendship model can generate obligations to help our (...) parents even if we are no longer friendly with them. Joseph Kupfer has pointed out several ways in which parent‐child relationships differ from peer friendships; but his arguments do not preclude our enjoying a type of friendship with our parents. In response to Christina Hoff Sommers, who objects that feelings of friendship toward our parents are too flimsy a ground for filial duties, the friendship model can provide a plausible, robust account of filial obligations. As for adult children who have never formed friendships with their loving, caring parents, and refuse to give them much‐needed assistance, they can be criticised by moral considerations independent of but compatible with the friendship model. (shrink)

Big Data has been variously defined in the literature. In the main, definitions suggest that Big Data possess a suite of key traits: volume, velocity and variety, but also exhaustivity, resolution, indexicality, relationality, extensionality and scalability. However, these definitions lack ontological clarity, with the term acting as an amorphous, catch-all label for a wide selection of data. In this paper, we consider the question ‘what makes Big Data, Big Data?’, applying Kitchin’s taxonomy of seven Big Data traits to 26 datasets (...) drawn from seven domains, each of which is considered in the literature to constitute Big Data. The results demonstrate that only a handful of datasets possess all seven traits, and some do not possess either volume and/or variety. Instead, there are multiple forms of Big Data. Our analysis reveals that the key definitional boundary markers are the traits of velocity and exhaustivity. We contend that Big Data as an analytical category needs to be unpacked, with the genus of Big Data further delineated and its various species identified. It is only through such ontological work that we will gain conceptual clarity about what constitutes Big Data, formulate how best to make sense of it, and identify how it might be best used to make sense of the world. (shrink)

Cybernetic-Existentialism: Freedom, Systems, and Being-for-Others in Contemporary Art and Performance offers a unique discourse and an original aesthetic theory. It argues that fusing perspectives from the philosophy of Existentialism with insights from the 'universal science' of cybernetics provides a new analytical lens and deconstructive methodology to critique art. In this study, Steve Dixon examines how a range of artists' works reveal the ideas of Existentialist philosophers including Kierkegaard, Camus, de Beauvoir and Sartre on freedom, being and nothingness, eternal recurrence, (...) the absurd, and being-for-others. Simultaneously, these artworks are shown to engage in complex explorations of concepts proposed by cyberneticians including Wiener, Shannon, and Bateson on information theory and 'noise', feedback loops, circularity, adaptive ecosystems, autopoiesis, and emergence. Dixon's ground-breaking book demonstrates how fusing insights and knowledge from these two fields can throw new light on pressing issues within contemporary arts and culture, including authenticity, angst and alienation, homeostasis, radical politics, and the human as system. (shrink)

We give an overview of the practice of developing and using complex climate models, as seen from experiences in a major climate modelling center and through participation in the Coupled Model Intercomparison Project. We discuss the construction and calibration of models; their evaluation, especially through use of out-of-sample tests; and their exploitation in multi-model ensembles to identify biases and make predictions. We stress that adequacy or utility of climate models is best assessed via their skill against more naïve predictions. The (...) framework we use for making inferences about reality using simulations is naturally Bayesian, and has many points of contact with more familiar examples of scientific epistemology. While the use of complex simulations in science is a development that changes much in how science is done in practice, we argue that the concepts being applied fit very much into traditional practices of the scientific method, albeit those more often associated with laboratory work. (shrink)

Cohen’s (2023) mapping exercise of possible bioethical issues emerging from the use of ChatGPT in medicine provides an informative, useful, and thought-provoking trigger for discussions of AI ethic...

While many have argued that moral disagreement poses a challenge to moral knowledge, the precise nature of this challenge is controversial. Indeed, in the moral epistemology literature, there are many different versions of ‘the’ argument from moral disagreement to moral scepticism. This paper contributes to this vast literature on moral disagreement by arguing for two theses: 1. All (or nearly all) moral disagreement arguments share an underlying structure; and, 2. All moral disagreement arguments that satisfy this underlying structure cannot establish (...) moral scepticism because this underlying structure leads to a previously unrecognized reductio ad absurdum. In short, I argue that this reductio argument (very likely) refutes all versions of the moral disagreement to moral scepticism argument in one fell swoop. (shrink)

Thomas Brown (1778-1820) is the third member, after Thomas Reid and Dugald Steward, traditionally associated with the Scottish School of Common Sense. This collection makes this major thinker's work available in a modern scholarly edition.

Virtual Futures explores the ideas that the future lies in its ability to articulate the consequences of an increasingly synthetic and virtual world. New technologies like cyberspace, the internet, and Chaos theory are often discussed in the context of technology and its potential to liberate or in terms of technophobia. This collection examines both these ideas while also charting a new and controversial route through contemporary discourses on technology; a path that discusses the material evolution and the erotic relation between (...) humans and machines. Virtual Futures brings together diverse fields such as cyberfeminism, materialist philosophy, postmodern fiction, computing culture and performance art, with essays by Sadie Plant, Stelarc and Manuel de Landa (to name a few). The collection heralds the death of humanism and the ride of posthuman pragmatism. The contested zone of debate throughout these essays is the notion of the posthuman, or the possibility of the cyborg as the free human. Viewed by some writers as a threat to human life and humanism itself, others in the collection describe the posthuman as a critical perspective that anticipates the next step in evolution: the integration or synthesis of humans and machines, organic life and technology. This view of technology and information is heavily influenced by Anglo American literature, especially cyberpunk, Pynchon and Ballard, as well as the materialist philosophies of Freud, Deleuze, and Haraway, Virtual Futures provides analyses by both established theorists and the most innovative new voices working in conjunction between the arts and contemporary technology. (shrink)

_Virtual Futures_ explores the ideas that the future lies in its ability to articulate the consequences of an increasingly synthetic and virtual world. New technologies like cyberspace, the internet, and Chaos theory are often discussed in the context of technology and its potential to liberate or in terms of technophobia. This collection examines both these ideas while also charting a new and controversial route through contemporary discourses on technology; a path that discusses the material evolution and the erotic relation between (...) humans and machines. _Virtual Futures_ brings together diverse fields such as cyberfeminism, materialist philosophy, postmodern fiction, computing culture and performance art, with essays by Sadie Plant, Stelarc and Manuel de Landa. The collection heralds the death of humanism and the ride of posthuman pragmatism. The contested zone of debate throughout these essays is the notion of the posthuman, or the possibility of the cyborg as the free human. Viewed by some writers as a threat to human life and humanism itself, others in the collection describe the posthuman as a critical perspective that anticipates the next step in evolution: the integration or synthesis of humans and machines, organic life and technology. This view of technology and information is heavily influenced by Anglo American literature, especially cyberpunk, Pynchon and Ballard, as well as the materialist philosophies of Freud, Deleuze, and Haraway, _Virtual Futures_ provides analyses by both established theorists and the most innovative new voices working in conjunction between the arts and contemporary technology. (shrink)

This paper explores the embedding of data producing technologies in people's everyday lives and practices. It traces how repeated encounters with digital data operate to naturalise these entities, while often blindsiding their agentive properties and the ways they get implicated in processes of exploitation and governance. I propose and develop the notion of ‘data doxa’ to conceptualise the way in which digital data – and the devices and platforms that stage data – have come to be perceived in Western societies (...) as normal, necessary and enabling. The ‘data doxa’ concept also accentuates the enculturation of many individuals into a data sharing habitus which frames digital technologies in simplistic terms as panaceas for the problems associated with contemporary life, figures of progress and convenience, and mediums of knowledge, pleasure and identity. I suggest that three types of data-based relations contribute to the formation of this doxic sensibility: fetishisation, habit and enchantment. Each of these relations come to mediate public understandings of digital devices and the data they generate, obscuring the multifaceted nature and hidden depths of data and their propensity to double up as technologies of exposure and discipline. As a result of this situation, imaginative educational programs and revamped regulatory frameworks are urgently needed to inform individuals about the contribution of data to the leveraging of value and power in today's digital economies, but also to protect them from experiencing data-based harms. (shrink)

This book explores the diverse understandings of the archaeological record in both historical and contemporary perspective, while also serving as a guide to reassessing current views. Gavin Lucas argues that archaeological theory has become both too fragmented and disconnected from the particular nature of archaeological evidence. The book examines three ways of understanding the archaeological record - as historical sources, through formation theory, and as material culture - then reveals ways to connect these three domains through a reconsideration of (...) archaeological entities and archaeological practice. Ultimately, Lucas calls for a rethinking of the nature of the archaeological record and the kind of history and narratives written from it. (shrink)

Today’s bodies are akin to ‘walking sensor platforms’. Bodies either host, or are the subjects of, an array of sensing devices that act to convert bodily movements, actions and dynamics into circulative data. This article proposes the notions of ‘disembodied exhaust’ and ‘embodied exhaustion’ to conceptualise processes of bodily sensorisation and datafication. As the material body interfaces with networked sensor technologies and sensing infrastructures, it emits disembodied exhaust: gaseous flows of personal information that establish a representational data-proxy. It is this (...) networked actant that progressively structures how embodied subjects experience their daily lives. The significance of this symbiont medium in determining the outcome of interplays between networked individuals and audiences necessitates that it is carefully contrived. The article explores the nature and function of the data-proxy, and its impact on social relations. Drawing on examples that depict individuals engaging with their data-proxies, the article suggests that managing a virtual presence is analogous to a work relation, demanding diligence and investment. But it also shows how the data-proxy operates as a mode of affect that challenges conventional distinctions made between organic and inorganic bodies, agency and actancy, mortality and immortality, presence and absence. (shrink)

This paper identifies and examines the possible contributions that emerging fields of study, particularly feminist public health, can make to enhancing and expanding trans/feminist theory and practice. A feminist public-health approach that is rooted in a tradition of political economy, social justice and equity studies, and an anti-oppression orientation, provides one of the most comprehensive "toolboxes" of perspectives, theoretical frameworks, methods, practices, processes, and strategies for trans-oriented scholars and activists.

Historians of science have often presented the inter-war period as a time when British scientific communities radically questioned existing scholarship on ‘race’. The ascendancy of genetics, and the perceived need to challenge Nazi ‘racial’ theory have been highlighted as pivotal issues in shaping this British revision of ‘racial’ ideas. This article offers a detailed analysis of British scientific thinking in the inter-war period. It questions whether historians have exaggerated or oversimplified the prevalence of anti-‘racial’ reform. It uses a wide range (...) of scientific writings to consider issues of continuity and change in ‘racial’ thinking in mainstream British scientific communities. The article probes the relationship between science and politics, focusing on the extent to which ideological factors affected both the scientific agenda and conclusions as regards ‘racial’ issues. Far from dismissing the idea that events in the inter-war period triggered changes in the way in which British scientists dealt with ‘race’, the article argues that the seeds of the post-Second World War international scientific rejection of ‘race’ were sown in inter-war Britain amid considerable ambivalence and discord.We must remember that the investigator, whether a biologist, an economist, or a sociologist, is himself a part of history, and that if he ever forgets he is a part of history he will deceive his audience and deceive himself.J. B. S. Haldane, Heredity and Politics, 1938. (shrink)

In the wake of two decades in which postmodern theory has become very popular in university humanities and social science departments around the world, Gavin Kitching claims that postmodernism is causing harm to students intellectually. Postmodern theory has engaged the hearts and heads of the brightest students because of its apparent political and social radicalism. Yet Kitching writes: “At the heart of postmodernism is very poor, deeply confused, and misbegotten philosophy. As a result even the very best students who (...) fall under its sway produce radically incoherent ideas about language, meaning, truth, and reality.” This is not another conservative attack on postmodern theory. Rather, it is a carefully considered analysis from a dedicated university teacher who is convinced that we have gone terribly astray. He analyzes why typical postmodern theoretical approaches simply aren’t effective tools for dealing with the realities of people and their activities, and he describes the philosophical confusion that lies at the heart of the problem. He also demonstrates the political implications for students, their universities, and society when students learn to use poorly constructed arguments as the basis of their writing. _The Trouble with Theory _is essential reading for all students writing a thesis in the humanities and the social sciences and for their teachers. (shrink)

This article examines the discourses that are used by the British press to represent obesity in its coverage of coronavirus disease 2019 (COVID-19). Obesity is understood to be a risk factor for COVID-19, with people with obesity being more likely to die from the virus. This study adopts a corpus-based approach to Critical Discourse Studies and utilises a novel approach to keyword analysis, based on comparing analysis corpora against two reference corpora in order to yield keywords that are, in this (...) case, characteristic compared to general coverage of both COVID-19 and obesity. It is argued that the context of the pandemic has produced a range of discourses around obesity that are more stigmatising than usual in both the tabloids and the broadsheets, with people with obesity being construed, for example, in especially fatalistic terms and as being responsible for the problems facing the country’s healthcare system. At the same time, the pandemic context also seems to have given rise to some more positive changes to press coverage of obesity, with race-related health disparities receiving more focus than usual and the right-leaning press being more likely to critique the Conservative Government than it usually is, resulting in an arguably more balanced style of reporting. (shrink)

Psychonarratology is an approach to the empirical study of literary response and the processing of narrative. It draws on the empirical methodology of cognitive psychology and discourse processing as well as the theoretical insights and conceptual analysis of literary studies, particularly narratology. The present work provides a conceptual and empirical basis for this interdisciplinary approach that is accessible to researchers from either disciplinary background. An integrative review is presented of the classic problems in narratology: the status of the narrator, events (...) and plot, characters and characterization, speech and thought, and focalization. For each area, Bortolussi and Dixon critique the state of the art in narratology and literary studies, discuss relevant work in cognitive psychology, and provide a new analytical framework based on the insight that readers treat the narrator as a conversational participant. Empirical evidence is presented on each problem, much of it previously unpublished. (shrink)

Philippa Foot is one of the most original and widely respected philosophers of our time; her work has exerted a lasting influence on the development of moral philosophy. In tribute to her, twelve leading philosophers from both sides of the Atlantic have contributed essays exploring the various topics in moral philosophy to which she has made a distinctive contribution--virtue ethics, naturalism, non-cognitivism, relativism, categorical requirements, and the role of rationality in morality.

This volume provides an authoritative, up-to-date survey of theories of infant development.

South Africa has a long history of orality deeply embedded in the archival memory of the ‘Other’ or the history of the poor and oppressed. Their untold stories, undocumented histories with displacing identities are how the historical ‘Other’ has been perceived by colonialism and the apartheid regime. The ‘Other’ or primary oral communities in the context of this article can be seen by a name, a face and a particular identity, namely, indigenous people. This article will engage the work of (...) Finnegan on what is ‘Orality – if anything’. The term ‘orality’, as a conceptual tool, can help us to widen our horizons and attention to forms of human creativity and imagination which was neglected or unnoticed by scholars. Orality has forced scholars to ask new questions on what is the meaning of ‘text’ and encouraged and challenge scholars in orality and literacy research with a new analysis of what we thought we already knew. The article engages oral and written research and how it can assist in understanding the discourse of the ‘Other’ and the power relation in reconstructing and re-ordering of their social universe through collective memory, songs, rituals, satire, drama and political protest which at large was perceived by the apartheid era and Western colonisers as savage, uncivilised and barbaric. The oral discourse of the ‘Other’ has become part of the power struggles politically and educationally in South Africa. Orality has further reshaped the Christian discourse in South Africa and Africa as the poor and oppressed find new power in a discourse of metaphysics of presence of the Gospel through preaching and bearing witness of their new encounter spiritually. (shrink)

Unless one is a pacifist there is little difficulty in theory in ethically justifying a country’s entitlement to produce or to purchase, or even to market, weapons for the preservation of internal order or external peace. In practice, however, the international arms industry gives considerable cause for ethical misgivings, which are here explored. “It is difficult to escape from the notion that the primary factor behind the international sale of arms is the generation of profits. If companies are left unchecked, (...) there is considerable evidence that companies will exploit commercial opportunities to the detriment of ethical considerations.”. (shrink)

Alain Badiou’s theoretical work maintains an ambiguous relation to Marx’s critique of political economy. In seemingly refusing the Marxian analytical strategy of displacement and referral across the fields of politics and economy, Badiou is frequently seen to be lacking a rigorous theoretical grasp of capitalism itself. In turn, this is often seen as a consequence of his understanding of political subjectivity. But the origins of this ‘lack’ of analysis of the social relation called ‘capital’ in his work can also be (...) investigated by means of a detour into the economic writings of theUnion des communistes de France marxiste-léniniste, the political organisation in which Badiou played a leading rôle throughout the 1970s in particular. By excavating this theoretical work of the 1970s, we can identify more precisely the historical and political reasons behind Badiou’s ambiguous relation to Marx and specifically to Marx’s systematic grasp of the logic of capital. This excavation will consequently lead us to a reflection on the limits and openings in Badiou’s thought for the Marxian critique of political economy. (shrink)