BackgroundAlthough patient advocates have developed templates for standard consent forms, evaluating patient preferences for first in human (FIH) and window of opportunity (Window) trial consent forms is critical due to their unique risks. FIH trials are the initial use of a novel compound in study participants. In contrast, Window trials give an investigational agent over a fixed duration to treatment naïve patients in the time between diagnosis and standard of care (SOC) surgery. Our goal was to determine the patient-preferred presentation (...) of important information in consent forms for these trials.MethodsThe study consisted of two phases: (1) analyses of oncology FIH and Window consents; (2) interviews of trial participants. FIH consent forms were analyzed for the location(s) of information stating that the study drug has not been tested in humans (FIH information); Window consents were analyzed for the location(s) of information stating the trial may delay SOC surgery (delay information). Participants were asked about their preferred placement of the information in their own trial’s consent form. The location of information in the consent forms was compared to the participants’ suggestions for placement. Results34 [17 FIH; 17 Window] of 42(81%) cancer patients approached participated. 25 consents [20 FIH; 5 Window] were analyzed. 19/20 FIH consent forms included FIH information, and 4/5 Window consent forms included delay information. 19/20(95%) FIH consent forms contained FIH information in the risks section 12/17(71%) patients preferred the same. Fourteen (82%) patients wanted FIH information in the purpose, but only 5(25%) consents mentioned it there. 9/17(53%) Window patients preferred delay information to be located early in the consent, before the “Risks” section. 3/5(60%) consents did this.ConclusionsDesigning consents that reflect patient preferences more accurately is essential for ethical informed consent; however, a one-size fits all approach will not accurately capture patient preferences. We found that preferences differed for FIH and Window trial consents, though for both, patients preferred key risk information early in the consent. Next steps include determining if FIH and Window consent templates improve understanding. (shrink)

The subject of news media ethics has long been in the forefront of multi-media journalism. Doctored quotes, investigative journalism, plagiarism, etc. are frequently debated in newspaper editorials and have become the subject of docu-dramas. These controversies are also frequent fodder for that segment of television news that is cultivated by scandal and consumed by a voracious public.University professor Maclyn McClary's Issues in Journalism is a unique and dynamic book designed to encourage discussion and debate about news media ethics. Whether (...) the dialogue is among classmates, within focus groups, or between friends, this book guarantees animated and thought-provoking communication. What makes this book unique is the author's approach: He has created three journalists who sit around a table and argue the many and often divisive facets of ethics. At the end of each discussion is a series of questions for students and focus-group participants. It is preordained that the diversity of answers will result in lively and educational debate. (shrink)

Expression and truth are traditional opposites in Western thought: expression supposedly refers to states of mind, truth to states of affairs. _Expression and Truth_ rejects this opposition and proposes fluid new models of expression, truth, and knowledge with broad application to the humanities. These models derive from five theses that connect expression to description, cognition, the presence and absence of speech, and the conjunction of address and reply. The theses are linked by a concentration on musical expression, regarded as the (...) ideal case of expression in general, and by fresh readings of Ludwig Wittgenstein’s scattered but important remarks about music. The result is a new conception of expression as a primary means of knowing, acting on, and forming the world. “Recent years have seen the return of the claim that music’s power resides in its ineffability. In _Expression and Truth_, Lawrence Kramer presents his most elaborate response to this claim. Drawing on philosophers such as Wittgenstein and on close analyses of nineteenth-century compositions, Kramer demonstrates how music operates as a medium for articulating cultural meanings and that music matters too profoundly to be cordoned off from the kinds of critical readings typically brought to the other arts. A tour-de-force by one of musicology’s most influential thinkers.”—Susan McClary, _Desire and Pleasure in Seventeenth-Century Music_. (shrink)