In Powers of Horror,1 the psychoanalyst Julia Kristeva presented the first explicit, elaborated theory of ‘abjection,’ which she defines as the casting off of that which is not of one’s “clean and proper”2 self. According to Kristeva, abjection is a demarcating impulse which establishes the basis of all object relations, and is operative in the Lacanian narrative of subject formation in early childhood via object differentiation. Abjection continues to operate post-Oedipally to prevent the dissolution of the subject by repressing identification (...) with that which is other, and particularly that which is only tenuously other: the abject. Though Kristeva’s theory is braided into problematic Freudian premises, this essay will argue that abjection remains operative independent of the Oedipal model. (shrink)

(2009). Text and deployment of the masochist. Angelaki: Vol. 14, shadows of cruelty sadism, masochism and the philosophical muse – part one, pp. 45-57.

The Common Anatomy Reference Ontology (CARO) is being developed to facilitate interoperability between existing anatomy ontologies for different species, and will provide a template for building new anatomy ontologies. CARO has a structural axis of classification based on the top-level nodes of the Foundational Model of Anatomy. CARO will complement the developmental process sub-ontology of the GO Biological Process ontology, using it to ensure the coherent treatment of developmental stages, and to provide a common framework for the model organism communities (...) to classify developmental structures. Definitions for the types and relationships are being generated by a consortium of investigators from diverse backgrounds to ensure applicability to all organisms. CARO will support the coordination of cross-species ontologies at all levels of anatomical granularity by cross-referencing types within the cell type ontology (CL) and the Gene Ontology (GO) Cellular Component ontology. A complete cross-species CARO could be utilized in other ontologies for cross-product generation. (shrink)

De-Signing Design: Cartographies of Theory and Practice throws new light on the terrain between theory and practice in transdisciplinary discourses of design and art. The collection brings together a selection of essays on spatiality, difference, cultural aesthetics, and identity in the expanded field of place-making and being.

The Plant Ontology (PO) (http://www.plantontology.org) (Jaiswal et al., 2005; Avraham et al., 2008) was designed to facilitate cross-database querying and to foster consistent use of plant-specific terminology in annotation. As new data are generated from the ever-expanding list of plant genome projects, the need for a consistent, cross-taxon vocabulary has grown. To meet this need, the PO is being expanded to represent all plants. This is the first ontology designed to encompass anatomical structures as well as growth and developmental stages (...) across such a broad taxonomic range. While other ontologies such as the Gene Ontology (GO) (The Gene Ontology Consortium, 2010) or Cell Type Ontology (CL) (Bard et al., 2005) cover all living organisms, they are confined to structures at the cellular level and below. The diversity of growth forms and life histories within plants presents a challenge, but also provides unique opportunities to study developmental and evolutionary homology across organisms. (shrink)

The National Center for Biomedical Ontology is a consortium that comprises leading informaticians, biologists, clinicians, and ontologists, funded by the National Institutes of Health (NIH) Roadmap, to develop innovative technology and methods that allow scientists to record, manage, and disseminate biomedical information and knowledge in machine-processable form. The goals of the Center are (1) to help unify the divergent and isolated efforts in ontology development by promoting high quality open-source, standards-based tools to create, manage, and use ontologies, (2) to create (...) new software tools so that scientists can use ontologies to annotate and analyze biomedical data, (3) to provide a national resource for the ongoing evaluation, integration, and evolution of biomedical ontologies and associated tools and theories in the context of driving biomedical projects (DBPs), and (4) to disseminate the tools and resources of the Center and to identify, evaluate, and communicate best practices of ontology development to the biomedical community. Through the research activities within the Center, collaborations with the DBPs, and interactions with the biomedical community, our goal is to help scientists to work more effectively in the e-science paradigm, enhancing experiment design, experiment execution, data analysis, information synthesis, hypothesis generation and testing, and understand human disease. (shrink)

BioPortal is a Web portal that provides access to a library of biomedical ontologies and terminologies developed in OWL, RDF(S), OBO format, Protégé frames, and Rich Release Format. BioPortal functionality, driven by a service-oriented architecture, includes the ability to browse, search and visualize ontologies (Figure 1). The Web interface also facilitates community-based participation in the evaluation and evolution of ontology content.

The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

The Planteome project provides a suite of reference and species-specific ontologies for plants and annotations to genes and phenotypes. Ontologies serve as common standards for semantic integration of a large and growing corpus of plant genomics, phenomics and genetics data. The reference ontologies include the Plant Ontology, Plant Trait Ontology, and the Plant Experimental Conditions Ontology developed by the Planteome project, along with the Gene Ontology, Chemical Entities of Biological Interest, Phenotype and Attribute Ontology, and others. The project also provides (...) access to species-specific Crop Ontologies developed by various plant breeding and research communities from around the world. We provide integrated data on plant traits, phenotypes, and gene function and expression from 95 plant taxa, annotated with reference ontology terms. (shrink)

Vaccine research, as well as the development, testing, clinical trials, and commercial uses of vaccines involve complex processes with various biological data that include gene and protein expression, analysis of molecular and cellular interactions, study of tissue and whole body responses, and extensive epidemiological modeling. Although many data resources are available to meet different aspects of vaccine needs, it remains a challenge how we are to standardize vaccine annotation, integrate data about varied vaccine types and resources, and support advanced vaccine (...) data analysis and inference. To address these problems, the community-based Vaccine Ontology (VO) has been developed through collaboration with vaccine researchers and many national and international centers and programs, including the National Center for Biomedical Ontology (NCBO), the Infectious Disease Ontology (IDO) Initiative, and the Ontology for Biomedical Investigations (OBI). VO utilizes the Basic Formal Ontology (BFO) as the top ontology and the Relation Ontology (RO) for definition of term relationships. VO is represented in the Web Ontology Language (OWL) and edited using the Protégé-OWL. Currently VO contains more than 2000 terms and relationships. VO emphasizes on classification of vaccines and vaccine components, vaccine quality and phenotypes, and host immune response to vaccines. These reflect different aspects of vaccine composition and biology and can thus be used to model individual vaccines. More than 200 licensed vaccines and many vaccine candidates in research or clinical trials have been modeled in VO. VO is being used for vaccine literature mining through collaboration with the National Center for Integrative Biomedical Informatics (NCIBI). Multiple VO applications will be presented. (shrink)

1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

Chris L. Firestone and Nathan Jacobs integrate and interpret the work of leading Kant scholars to come to a new and deeper understanding of Kant's difficult book, Religion within the Boundaries of Mere Reason. In this text, Kant's vocabulary and language are especially tortured and convoluted. Readers have often lost sight of the thinker's deep ties to Christianity and questioned the viability of the work as serious philosophy of religion. Firestone and Jacobs provide strong and cogent grounds for taking (...) Kant's religion seriously and defend him against the charges of incoherence. In their reading, Christian essentials are incorporated into the confines of reason, and they argue that Kant establishes a rational religious faith in accord with religious conviction as it is elaborated in his mature philosophy. For readers at all levels, this book articulates a way to ground religion and theology in a fully fledged defense of Religion which is linked to the larger corpus of Kant's philosophical enterprise. (shrink)

This book examines the transcendental dimension of Kant's philosophy as a positive resource for theology.

While earlier work has emphasized Kant’s philosophy of religion as thinly disguised morality, this timely and original reappraisal of Kant’s philosophy of religion incorporates recent scholarship. In this volume, Chris L. Firestone, Stephen R. Palmquist, and the other contributors make a strong case for more specific focus on religious topics in the Kantian corpus. Main themes include the relationship between Kant’s philosophy of religion and his philosophy as a whole, the contemporary relevance of specific issues arising out of Kant’s (...) philosophical theology, and the relationship of Kant’s philosophy to Christian theology. As a whole, this book capitalizes on contemporary movements in Kant studies by looking at Kant not as an anti-metaphysician, but as a genuine seeker of spirituality in the human experience. (shrink)

In _The Persistence of the Sacred in Modern Thought,_ Chris L. Firestone, Nathan A. Jacobs, and thirteen other contributors examine the role of God in the thought of major European philosophers from the seventeenth to the nineteenth century. The philosophers considered are, by and large, not orthodox theists; they are highly influential freethinkers, emancipated by an age no longer tethered to the authority of church and state. While acknowledging this fact, the contributors are united in arguing that this is (...) only one side of a complex story. To redress the imbalance of attention to secularism among crucial modern thinkers and to consolidate a more theologically informed view of modernity, they focus on the centrality of the sacred in the thought of these philosophers. The essays, each in its own way, argue that the major figures in modernity are theologically astute, bent not on removing God from philosophy but on putting faith and reason on a more sure footing in light of advancements in science and a perceived need to rethink the relationship between God and world. By highlighting and defending the theologically affirmative dimensions of thinkers such as Thomas Hobbes, Gottfried Leibniz, John Locke, Immanuel Kant, F. W. J. Schelling, G. W. F. Hegel, and others, the essayists present a forceful and timely correction of widely accepted interpretations of these philosophers. To ignore or downplay the theological dimensions of the philosophical works they address, they argue, distorts our understanding of modern thought. "Over the past twenty-five years there has been a gradual change in the study of modern philosophy toward recognizing the centrality of our relation to God in the work of most of the major modern thinkers of the period. _The Persistence of the Sacred in Modern Thought_ is a timely and useful collection that has the potential to crystallize this important development in the study of modern philosophy." —_John E. Hare, Yale Divinity School_. (shrink)

Background: The factors influencing parents’ willingness to enroll their children in biobanks are poorly understood. This study sought to assess parents’ willingness to enroll their children, and their perceived benefits, concerns, and information needs under different consent and data-sharing scenarios, and to identify factors associated with willingness. Methods: This large, experimental survey of patients at the 11 eMERGE Network sites used a disproportionate stratified sampling scheme to enrich the sample with historically underrepresented groups. Participants were randomized to receive one of (...) three consent and data-sharing scenarios. Results: In total, 90,000 surveys were mailed and 13,000 individuals responded (15.8% response rate). 5737 respondents were parents of minor children. Overall, 55% (95% confidence interval 50–59%) of parents were willing to enroll their youngest minor child in a hypothetical biobank; willingness did not differ between consent and data-sharing scenarios. Lower educational attainment, higher religiosity, lower trust, worries about privacy, and attitudes about benefits, concerns, and information needs were independently associated with less willingness to allow their child to participate. Of parents who were willing to participate themselves, 25% were not willing to allow their child to participate. Being willing to participate but not willing to allow one’s child to participate was independently associated with multiple factors, including race, lower educational attainment, lower annual household income, public health care insurance, and higher religiosity. Conclusions: Fifty-five percent of parents were willing to allow their youngest minor child to participate in a hypothetical biobank. Building trust, protecting privacy, and addressing attitudes may increase enrollment and diversity in pediatric biobanks. (shrink)

God is a problematic idea in Kant's terms, but many scholars continue to be interested in Kantian theories of religion and the issues that they raise. In these new essays, scholars both within and outside Kant studies analyse Kant's writings and his claims about natural, philosophical, and revealed theology. Topics debated include arguments for the existence of God, natural theology, redemption, divine action, miracles, revelation, and life after death. The volume includes careful examination of key Kantian texts alongside discussion of (...) their themes from both constructive and analytic perspectives. These contributions broaden the scope of the scholarship on Kant, exploring the value of doing theology in consonance or conversation with Kant. It builds bridges across divides that often separate the analytic from the continental and the philosophical from the theological. The resulting volume clarifies the significance and relevance of Kant's theology for current debates about the philosophy of God and religion. (shrink)

In this essay, I reply to the above four critics of In Defense of Kant’s Religion (IDKR). In reply to George di Giovanni, I highlight the interpretive differencesthat divide the authors of IDKR and di Giovanni, and argue that di Giovanni’s atheist reading of Kant does not follow, even granting his premises. In reply to Pamela Sue Anderson, I show that if her reading of Kant is accurate, Kant’s own talk of God becomes empty and contemptible by his own lights, (...) and I then show how her empirical bias prompts a significant misreading of IDKR. In reply to Stephen Palmquist, I expose four fallacious maneuvers in his paper, which comprise the bulk of his essay. And in reply to Michalson, I address a series of minor concerns raised in his essay, and then set the record straight on the motives behind IDKR in general and my own take on Kant’s compatibility (or lack thereof) with Christianity in specific. (shrink)

I contend that Kant’s philosophy, as it stands, is strictly deistic in a strictly epistemic sense, but its own internal theological momentum suggests this epistemic deism may be overcome in the eyes of faith because of ontological considerations surrounding God and God’s work in the world. I sketch six “signposts” in defense of this claim that emerge out of the New Wave. Because these signposts lead directly to two philosophically viable and theologically acceptable roadways for overcoming the charge of deism, (...) I conclude that “maybe” is the best answer to the question “Can the New Wave Baptize Kant’s Deism?”. (shrink)

The standard reading of Kant presumes that 'the moral hypothesis' is a necessary and sufficient condition for understanding his philosophy of religion. This paper opens with the assumption -- taken from one of Kant's last works -- that philosophy and theology must always remain in conflict. Then, by way of an abductive comparison of the positions of Ronald M. Green and John Hick, I demonstrate that the moral hypothesis leads to religious compromises that contradict this assumption. To conclude, I argue (...) that the motif of transformation is syptomatic of the underlying problem and suggest that it be replaced by the motif of transition. (shrink)

Stephen R. Palmquist’s Kant and Mysticism revisits his earlier work on Kant and Swedenborg, arguing that, contrary to standard interpretations, the arguments of Dreams of a Spirit-Seer expand into ‘Critical mysticism’ throughout the Critical philosophy and into the Opus Postumum. Although the beginning portions of Palmquist’s book successfully disturb the standard portrait of Kant as the all-destroyer of metaphysics and religious experience, his argument for critical mysticism is inconclusive. It is impossible to know if his interpretation of the Opus Postumum (...) is more right than its competitors. The conflict of interpretations shows Palmquist’s interpretation to be a hermeneutic impossible possibility. (shrink)

Erasmus's polemical texts against Alberto Pio have been edited in a critical edition with commentary. The Latin texts were made accessible to readers interested in philological, theological and historical issues.

Extending the dialogue on corporate social performance (CSP) as descriptive stakeholder management (Clarkson, Acad Manage Rev 20: 92, 1995), we examine differences in CSP activity between family and nonfamily firms. We argue that CSP activity can be explained by the firm's identity orientation toward stakeholders (Brickson, Admin Sci Quart 50: 576, 2005; Acad Manage Rev 32: 864, 2007). Specifically, individualistic, relational, or collectivistic identity orientations can describe a firm's level of CSP activity toward certain stakeholders. Family firms, we suggest, adopt (...) a more relational orientation toward their stakeholders than nonfamily firms, and thus engage in higher levels of CSP.Further, we invoke collectivistic identity orientation to argue that the higher the level of family or founder involvement within a family firm, the greater the level of CSP toward specific stakeholders. Using social performance rating data from 1991 to 2005, we find that family and nonfamily firms demonstrate notable differences in terms of social initiatives and social concerns. We also find that the level of family and founder involvement is related to the type and frequency of a family firm's social initiatives and social concerns. (shrink)

We investigated people's ability to infer others’ mental states from their emotional reactions, manipulating whether agents wanted, expected, and caused an outcome. Participants recovered agents’ desires throughout. When the agent observed, but did not cause the outcome, participants’ ability to recover the agent's beliefs depended on the evidence they got. When the agent caused the event, participants’ judgments also depended on the probability of the action ; when actions were improbable given the mental states, people failed to recover the agent's (...) beliefs even when they saw her react to both the anticipated and actual outcomes. A Bayesian model captured human performance throughout, consistent with the proposal that people rationally integrate information about others’ actions and emotional reactions to infer their unobservable mental states. (shrink)

The possible integration of genomic sequencing (including whole‐genome and whole‐exome sequencing) into the three contexts addressed in this special report—state‐mandated screening programs, clinical care, and direct‐to‐consumer services—raises related but distinct legal issues. This essay will outline the legal issues surrounding the integration of genomic sequencing into state newborn screening programs, parental rights to refuse and access sequencing for their newborns in clinical and direct‐to‐consumer care, and privacy‐related legal issues attending the use of sequencing in newborns.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Kant and the Divine: From Contemplation to Moral Law by Christopher J. InsoleChris L. FirestoneChristopher J. Insole. Kant and the Divine: From Contemplation to Moral Law. Oxford: Oxford University Press, 2020. Pp. v + 409. Hardback, $110.00.The extent to which the philosophy of Immanuel Kant converges with or diverges from Christian thought has been a hotly debated topic in recent years. Central to that debate has been the (...) resurgence of interest in Kant's classic Religion within the Boundaries of Mere Reason (henceforth, Religion). The most insightful interpretations and applications of Religion, it seems, have utilized resources from a broad range of Kant's writings, emphasizing his philosophy considered as an integrated whole. Christopher Insole's recent monograph—Kant and the Divine: From Contemplation to Moral Law—attempts to redirect this debate with an argument spanning Kant's precritical and critical periods in performing a deep dive on the topic of freedom. On the face of it, the argument is not purely theological or even religious. It revolves, instead, around a metaphysical analysis of freedom, both as exemplified in Kant's writings and relative to his historical predecessors.Key to Insole's proposal is that Kant's critical notion of freedom evolves into something very different than that of his predecessors (on which his early writings depend) and, in its development, decisively "ruptures" with the Christian tradition. Human freedom, on Insole's analysis of Kant, must be "end-setting" and not constrained or directed by any type of external compulsion. This suggests that God cannot be understood to influence freedom causally, or at least not without human conscious and free consent. Numerous writers have thought they spied Christian connections in Kant's notion of freedom, such as the need for divine forgiveness, and even grace, to avoid the absurdum practicum. Insole resists all such attempts as being foreign to the novelty of the mature Kant's reflections on freedom. No external force can be brought to bear as a determining causal influence on human freedom, presumably because an end set before us from outside undermines our ability to set an end for ourselves. God is at best the "all-knowing distributor of happiness" (321) that makes end-setting and the kingdom of ends worthwhile moral pursuits. Insole's express intention is to "show the significance of Kant's denial that God can be our final cause" and that "his philosophical religiosity, understood on its own terms, and as expressed across his whole oeuvre" shows that "Kant cannot easily be called a Christian thinker" at all (2–4).Extricating Kant from Christianity proves to be a monumental task. Insole uses eighteen chapters and more than four hundred pages to make his case. The argument distinguishes itself from other such attempts in its rigorous analytic approach to unpacking the metaphysical underpinnings of issues supposedly at the root of Kant's philosophical theology. The book presents a cumulative case argument for Kant's supposed break with "the Christian theological tradition as he would have received it" (13). Much rests on whether or not this argument is cogent. Kant, according to Insole, is something akin to a theological Platonist and moral Stoic, who attempts to establish a unique form of "philosophical religiosity" (3 and 156). This makes Kant similar to the likes of Augustine and Ambrose, but different in terms of his theological aspirations. Insole casts Kant not as a pure philosopher seeking to understand philosophy relative to the Christian tradition, but rather as a philosophical [End Page 164] theologian bent on showing human freedom, free end-setting, and an ethical community of end-setters to be the exclusive means for attaining the highest good. Although this may sound Pelagian, Insole insists it is not, because "the Pelagian could still regard God as our final cause and efficient cause" (299). In other words, in Insole's interpretation, Kant is a strict philosophical humanist or what theologians might term a hyper-Pelagian.The difficult details of Insole's arguments are important to consider but not easily dealt with in the space provided here. Early in the book, Insole takes his reader on a metaphysical tour of "Divine Ideas" and "God... (shrink)

Human vision supports social perception by efficiently detecting agents and extracting rich information about their actions, goals, and intentions. Here, we explore the cognitive architecture of perceived animacy by constructing Bayesian models that integrate domain‐specific hypotheses of social agency with domain‐general cognitive constraints on sensory, memory, and attentional processing. Our model posits that perceived animacy combines a bottom–up, feature‐based, parallel search for goal‐directed movements with a top–down selection process for intent inference. The interaction of these architecturally distinct processes makes perceived (...) animacy fast, flexible, and yet cognitively efficient. In the context of chasing, in which a predator (the “wolf”) pursues a prey (the “sheep”), our model addresses the computational challenge of identifying target agents among varying numbers of distractor objects, despite a quadratic increase in the number of possible interactions as more objects appear in a scene. By comparing modeling results with human psychophysics in several studies, we show that the effectiveness and efficiency of human perceived animacy can be explained by a Bayesian ideal observer model with realistic cognitive constraints. These results provide an understanding of perceived animacy at the algorithmic level—how it is achieved by cognitive mechanisms such as attention and working memory, and how it can be integrated with higher‐level reasoning about social agency. (shrink)

Cultural influences are pervasive throughout human behaviour, and as human–robot interactions become more common, roboticists are increasingly focusing attention on how to build robots that are culturally competent and culturally sustainable. The current treatment of culture in robotics, however, is largely limited to the definition of culture as national culture. This is problematic for three reasons: it ignores subcultures, it loses specificity and hides the nuances in cultures, and it excludes refugees and stateless persons. We propose to shift the focus (...) of cultural robotics to redefine culture as an emergent phenomenon. We make use of three research programmes in the social and cognitive sciences to justify this definition. Consequently, cultural behaviour cannot be explicitly programmed into a robot, rather, a robot must be designed with the capability to participate in the interactions that lead to the arising of cultural behaviour. In the final part of the paper, we explore which capacities and abilities are the most salient for a robot to do this. (shrink)