Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Mental time travel is defined as projecting the self into the past and the future. Despite growing evidence of the similarities of remembering past and imagining future events, dominant theories conceive of these as distinct capacities. I propose that memory and imagination are fundamentally the same process – constructive episodic simulation – and demonstrate that the ‘simulation system’ meets the three criteria of a neurocognitive system. Irrespective of whether one is remembering or imagining, the simulation system: acts on the same (...) information, drawing on elements of experience ranging from fine-grained perceptual details to coarser-grained conceptual information and schemas about the world; is governed by the same rules of operation, including associative processes that facilitate construction of a schematic scaffold, the event representation itself, and the dynamic interplay between the two ; and is subserved by the same brain system. I also propose that by forming associations between schemas, the simulation system constructs multi-dimensional cognitive spaces, within which any given simulation is mapped by the hippocampus. Finally, I suggest that simulation is a general capacity that underpins other domains of cognition, such as the perception of ongoing experience. This proposal has some important implications for the construct of ‘MTT’, suggesting that ‘time’ and ‘travel’ may not be defining, or even essential, features. Rather, it is the ‘mental’ rendering of experience that is the most fundamental function of this domain-general simulation system enabling humans to re-experience the past, pre-experience the future, and also comprehend the complexities of the present. (shrink)

A Mystical Philosophy contributes to the contemporary resurgence of interest in Spirituality, but from a new direction. Revealing, in an original and provocative study, the mystical contents of the works of famous atheists Virginia Woolf and Iris Murdoch, Donna Lazenby shows how these thinkers' refusal to construe worldviews on available reductive models brought them to offer radically alternative pictures of life which maintain its mysteriousness, and promote a mystical way of knowing. This book makes a daring claim: that a (...) return to 'pure' experience is sufficient to demonstrate, for the contemporary imagination, the irreducibly mystical contents of everyday life: and, therefore, the enduring appropriateness of theological conversations. Lazenby reveals how these atheist thinkers offer crucial spiritual-intellectual advice for our times: a warning against reductive scientific and philosophical models that impoverish our understanding of our selves and the world, and a powerful endorsement of ways of knowing that give art, and a restored concept of contemplation, their consummative place. (shrink)

Dedicated to the late Gerard Béhague, this anthology offers perspectives on the evolving legacy of performance ethnography in socio-musical analysis and reflects the heritage but also contemporary trajectories of Béhague’s scholarly concerns. Prefaced by an essay outlining key developments in the ethnography of performance paradigm, the volume’s seven case studies portray snapshots of musical life in representative communities of the Americas, including the southwestern and Pacific United States, Puerto Rico, Bolivia, Chile, Cuba, and Ecuador. These studies pose anthropological inquiries into (...) the ontology of performance practice, the social power of poetic performativity, and the experience and embodiment of sound in place. (shrink)

This study examines the impact of a social desirability response bias as a personality characteristic (self-deception and impression management) and as an item characteristic (perceived desirability of the behavior) on self-reported ethical conduct. Findings from a sample of college students revealed that self-reported ethical conduct is associated with both personality and item characteristics, with perceived desirability of behavior having the greatest influence on self-reported conduct. Implications for research in business ethics are drawn, and suggestions are offered for reducing the effects (...) of a socially desirable response bias. (shrink)

Donna Quesada had been teaching for about a dozen years when the first signs of burnout hit her. Rather than give in to her frustration, she reached for Buddha's teachings, the Zen wisdom that formed the basis of her own longtime spiritual practice. She survived the semester and gradually rediscovered the joy in her job that had been progressively declining. In this wise and inspirational book, she shares the lessons she learned-lessons that revealed, time and again, that no matter (...) the situation, it's always about getting your head in the right place first. Resolution begins in our own minds. Some days, some semesters, and even some years will be more challenging and more wearisome than others, she warns. But in The Inspired Teacher, Quesada offers a lasting source of encouragement and Zen. Although the book draws from Eastern teachings, the wisdom is for everyone, regardless of personal background, creed, or faith. With elements of The Last Lecture as well as Chicken Soup for the Teacher's Soul, this is the perfect gift for teachers-but also for anyone needing inspiration. (shrink)

Colonial and Postcolonial Linguistics. The scholarly articles assembled in this volume discuss various topics related to languages such as Chamorro, Chuuk, Ewe, Ewondo, Kanuri, Khoekowap, Nauruan, Weskos.

“When Species Meet is a breathtaking meditation on the intersection between humankind and dog, philosophy and science, and macro and micro cultures.” —Cameron Woo, Publisher of Bark magazine In 2006, about 69 million U.S. households had pets, giving homes to around 73.9 million dogs, 90.5 million cats, and 16.6 million birds, and spending over $38 billion dollars on companion animals. As never before in history, our pets are truly members of the family. But the notion of “companion species”—knotted from human (...) beings, animals and other organisms, landscapes, and technologies—includes much more than “companion animals.” In When Species Meet, Donna J. Haraway digs into this larger phenomenon to contemplate the interactions of humans with many kinds of critters, especially with those called domestic. At the heart of the book are her experiences in agility training with her dogs Cayenne and Roland, but Haraway’s vision here also encompasses wolves, chickens, cats, baboons, sheep, microorganisms, and whales wearing video cameras. From designer pets to lab animals to trained therapy dogs, she deftly explores philosophical, cultural, and biological aspects of animal-human encounters. In this deeply personal yet intellectually groundbreaking work, Haraway develops the idea of companion species, those who meet and break bread together but not without some indigestion. “A great deal is at stake in such meetings,” she writes, “and outcomes are not guaranteed. There is no assured happy or unhappy ending—socially, ecologically, or scientifically. There is only the chance for getting on together with some grace.” Ultimately, she finds that respect, curiosity, and knowledge spring from animal-human associations and work powerfully against ideas about human exceptionalism. One of the founders of the posthumanities, Donna J. Haraway is professor in the History of Consciousness Department at the University of California, Santa Cruz. Author of many books and widely read essays, including The Companion Species Manifesto: Dogs, People, and Significant Otherness and the now-classic essay “The Cyborg Manifesto,” she received the J. D. Bernal Prize in 2000, a lifetime achievement award from the Society for Social Studies in Science. (shrink)

Psychoanalysis, History, and Radical Ethics: Learning to Hear explores the importance of listening, being able to speak, and those who are silenced, from a psychoanalytic perspective. In particular, it focuses on those voices silenced either collectively or individually by trauma, culture, discrimination and persecution, and even by the history of psychoanalysis. Drawing on lessons from philosophy and history as well as clinical vignettes, this book provides a comprehensive guide to understanding the role of trauma in creating silence, and the importance (...) for psychoanalysts of learning to hear those silenced voices. (shrink)

What is hermeneutics? -- The suffering stranger and the hermeneutics of trust -- Sandor Ferenczi : the analyst of last resort and the hermeneutics of trauma -- Frieda Fromm-Reichmann : incommunicable loneliness -- D.W. Winnicott : humanitarian without sentimentality -- Heinz Kohut : glimpsing the hidden suffering -- Bernard Brandchaft : liberating the incarcerated spirit.

volume 1. Quantifying diversity and formulating success -- volume 2. Perspectives and exemplary programs.

The study assesses how a social desirability (SD) bias influences the relationship between several independent and dependent variables commonly investigated in ethics research. The effect of a SD bias was observed when a questionnaire was administered under varying conditions of anonymity and with different measurement techniques for the SD construct. Findings reveal that a SD bias is present in the majority of relationships studied, and it most frequently plays a moderating role. While the measure of SD influences the strength and (...) type of relationship, condition of anonymity has relatively little effect on the level of SD. (shrink)

Modest_Witness@Second_Millennium. FemaleMan_Meets_OncoMouse explores the roles of stories, figures, dreams, theories, facts, delusions, advertising, institutions, economic arrangements, publishing practices, scientific advances, and politics in twentieth- century technoscience. The book's title is an e-mail address. With it, Haraway locates herself and her readers in a sprawling net of associations more far-flung than the Internet. The address is not a cozy home. There is no innocent place to stand in the world where the book's author figure, FemaleMan, encounters DuPont's controversial laboratory rodent, OncoMouse. (...) Haraway sees the world of contemporary technoscience as a drama. Information sciences and life sciences are at the center of the dramatic action. Scenes are set in landscapes where maps of human genetic differences are stored in databases, racialized bodies are reconfigured by morphing for photographs in popular magazines, and transgenic mice important to breast cancer research are patented intellectual property. The actors are many, and not all are human. Beginning with the Modest Witness, the key figure in the Science Revolution, Haraway shows us the trouble lurking in race and gender- marked practices for attesting to matters of fact. In later scenes, Haraway explores the kinship relations among the many cyborg creatures produced in the late twentieth-century--in nuclear research, genetic engineering, reproductive technologies, computer-mediated representational practices, and mutations in biological approaches to "race.". (shrink)

This innovative textbook provides a systematic approach to developing practices of perception, reflection and inquiry to facilitate sound ethical action in organizational settings. Now in its second edition, Donna Ladkin's Mastering Ethics in Organizations invites readers to reflect and experiment on ethical behaviors with targeted activities in unique organizational contexts. Key features of the second edition include: A step-by-step approach to developing ethical astuteness Brand new case studies on companies including Volkswagen, Amazon and Boeing Art-based pedagogical material, including unique (...) storytelling approaches through mythology and film Guided and informed discussions about contemporary ethical issues concerning the use of social media, artificial intelligence and human-centred design. Offering curated contextualised insights into the field, this textbook will be ideal reading for MBA business ethics courses, as well as Masters courses in leadership. It will also benefit Continuing Professional Development audiences dealing with ethical situations. (shrink)

Preface : Dear All University Presidents -- Title IX : a crash course -- The state of consent education -- Drinking on campus and sexual misconduct policies -- Hookup culture : expectations of sexual ambivalence -- Men and masculinity : the problematic relationship between men and sex -- A hierarchy of bodies : sexual privilege, gender, shame, and blame -- When culture and sexual ethics are good : preparing ourselves to do necessary work -- Scripting consent : an activist lesson (...) plan -- The only thing stopping us, is us : contending with ongoing academic biases against the personal -- Conclusion : consent requires class. (shrink)

Preface : Dear All University Presidents -- Title IX : a crash course -- The state of consent education -- Drinking on campus and sexual misconduct policies -- Hookup culture : expectations of sexual ambivalence -- Men and masculinity : the problematic relationship between men and sex -- A hierarchy of bodies : sexual privilege, gender, shame, and blame -- When culture and sexual ethics are good : preparing ourselves to do necessary work -- Scripting consent : an activist lesson (...) plan -- The only thing stopping us, is us : contending with ongoing academic biases against the personal -- Conclusion : consent requires class. (shrink)

Engaging and accessible, this book is ideal for anyone looking to teach leadership and organization - from lecturers to human resource professionals and managers alike.'Donna Ladkin gives us an entirely novel and creative approach to thinking about, and importantly, doing and teaching ethics. The book is practice-based in the best sense of the word, using meditation and other attention techniques to enhance awareness, inquiry, and ultimately ethical insight at the personal and organizational levels. It is accessible to students at (...) all levels of learning, with exercises that will generate personal insights. At the same time, it is grounded in a wide range of sources, both philosophical and managerial, that enhance the credibility of its approach. This book will enhance the ethics and the lives of people who read it and practice its approaches.'- Sandra Waddock, Boston College Carroll School of Management, USWith the use of exercises, reflective prompts and case studies, Mastering the Ethical Dimension of Organizations offers a practice-based approach to developing the skills critical to responding ethically to organizational dilemmas. Engagingly and accessibly written by a leading communicator in the field, this book will be essential for postgraduate students of business, management or leadership.Starting from the premise that ethical issues within organizations rarely come 'packaged', this book encourages an understanding of ethics beyond organizational compliance systems or codes of conduct. It argues that our ability to respond ethically requires ethical perception, moral imagination and discernment akin to aesthetic judgment; capabilities it fosters through a clear, programmed approach. (shrink)

It is well known that the difference in performance between valid and invalid trials in the covert orienting paradigm increases as the proportion of valid trials increases. This proportion valid effect is widely assumed to reflect “strategic” control over the distribution of attention. In the present experiments we determine if this effect results from an explicit strategy or implicit learning by probing participant’s awareness of the proportion of valid trials. Results support the idea that the proportion valid effect in the (...) covert orienting paradigm reflects implicit learning not an explicit strategy. (shrink)

The purpose of this study is to explore with more rigor and detail the role of social norms in tax compliance. This study draws on Cialdini and Trost’s (The Handbook of Social Psychology: Oxford University Press, Boston, MA, 1998) taxonomy of social norms to investigate with more specificity this potentially decisive (Alm and McKee, Managerial and Decision Economics, 19:259–275, 1998) influence on tax compliance. We test our research hypotheses regarding the direct and indirect influences of social norms using a hypothetical (...) compliance scenario with 174 experienced taxpayers as participants. Factor analysis of the social norm questions successfully identified four distinct social norm constructs, in line with Cialdini and Trost (1998). Results of the path analysis show that individuals’ standards for behavior/ethical beliefs (personal norms) as well as the expectations of close others (subjective norms) directly influence tax compliance decisions, whereas general societal expectations (injunctive norms) and other individuals’ actual behavior (descriptive norms) have an indirect influence. This shows that social norms have important direct as well as indirect influences on tax compliance behavior. We also investigate a number of attitudinal variables that may be related to social norms and taxpayer compliance. The results of this study further clarify the important role that social norms have with regard to taxpayers’ compliance behavior. (shrink)

Becoming Marxist offers a series of studies that take up the importance of philosophy for the development of an open and critical Marxism.

Donna Haraway's work has transformed the fields of cyberculture, feminist studies, and the history of science and technology. Her subjects range from animal dioramas in the American Museum of Natural History to research in transgenic mice, from gender in the laboratory to the nature of the cyborg. Trained as an historian of science, she has produced a series of books and essays that have become essential reading in cultural studies, gender studies, and the history of science. The Haraway Reader (...) brings together a generous selection of Donna Haraway's work. Included is her "Manifesto for Cyborgs," in which she famously wrote that she "would rather be a cyborg than a goddess." Other selections are taken from her three major works, Primate Visions, Modest Witness , and Simians, Cyborgs and Women , as well as some of her more recent writing on animals. For readers in cultural studies, feminist theory, science studies, and cyberculture, Donna Haraway is one of our keenest observers of nature, science, and the social world. This volume is the best introduction to her thought. (shrink)

Tax compliance is a concern to governments around the world. Prior research (Alm, J. and I. Sanchez: 1995, KYKLOS 48, 3–19) has attributed unexplained inter-country differences in compliance rates to differences in social norms. Economics researchers studying tax compliance in the United States (U.S.) (see for example J. Andreoni et al.: 1998, Journal of Economic Literature 36, 818–860) have called for more attention to social (as opposed to economic) influences on tax compliance. In this study, we extend this prior research (...) by explicitly examining the role of social norms [Cialdini, R. and M. Trost: 1998, The Handbook of Social Psychology (Oxford University Press, New York)] on tax compliance in three different countries. We test our research hypotheses using a hypothetical compliance scenario, which was administered in Australia, Singapore, and the U.S. There were differences in compliance rates and social norms among the three countries. Factor analysis of the social norm questions identified three distinct social norm constructs. Two of these factors were significant in explaining tax compliance behavior. The first and most influential factor was taxpayers’ own personal moral beliefs, along with the beliefs of those close to them (e.g., friends and important others). The second significant factor represented societal views of proper behavior. We conclude that social norms help to explain tax compliance intentions and why tax compliance rates are higher than would be predicted by strictly economic models. (shrink)

This work offers an introduction to one of the most seminal figures in the field of education. In this collection of essays, contemporary authors consider their favorite quotations from John Dewey's works and share how Dewey has impacted their teaching practices. Responses are organized around the themes introduced in the first edition: active learning, the educative experience, critical thinking, inquiry and education, and democratic citizenship, plus a new section on accountability added for the second edition. Quotes and responses are kept (...) deliberately brief as an effective way of inviting readers to reflect on and experience Dewey. This book is a resource for current and aspiring teachers. This thoroughly updated edition also includes online resources for teacher educators. (shrink)

This paper reviews the theoretical underpinnings of phenomenology-related writings which support claims that the self and the social (the ‘I’ and the ‘We’) can plausibly be integrated and nurtured together in education. We begin by analysing contemporary theorising which suggests that reviewing foundational phenomenologists, particularly Husserl and Merleau-Ponty, can lead to greater clarity in understanding and appreciating the intersubjective sense of the self and the social. This perspective is aided by reviewing the reciprocal connections which take place during human action, (...) situational structuring, and reality construction. Building on this review we consider some of the ontological possibilities for a self and social phenomenology to become more central to educational aims. In doing so, we raise rather than unpack in exhaustive detail associated methodological matters in light of their educational implications. If successfully enacted, we perceive considerable benefits for students in being able to directly attend to the properties of their experiences, especially in contexts where new habits are formed and where opportunities arise for self and shared experiences to be reviewed and reflected on by all involved. (shrink)

Revisiting narratives on life that were produced in this age of machinery and war, Donna V. Jones shows how Bergson, Nietzsche, and the poets Leopold Senghor and Aimâe Câesaire fashioned the concept of life into a central aesthetic and ...

Taboo terms offer a playground for linguistic creativity in language after language, and sign languages form no exception. The present paper offers the first investigation of taboo terms in sign languages from a cognitive linguistic perspective. We analyze the linguistic mechanisms that introduce offense, focusing on the combined effects of cognitive metonymy and iconicity. Using the Think Aloud Protocol, we elicited offensive or crass signs and dysphemisms from nine signers. We find that German Sign Language uses a variety of linguistic (...) means to introduce and enhance offense, many of which rely on iconic properties of the taboo sign. In conjunction with cross-linguistically common metonymic word-formation strategies, the degree of visual explicitness of a sign increases its potential to offend. Semantically similar taboo signs based on the same metonymic anchor but differing in their degree of iconicity also differ in offensiveness. This allows for creating dysphemisms and euphemisms via phonological changes to a sign. We further show that embodiment creates modality-enhanced ‘vicarious embarrassment’ in the viewer that results in the respective signs being judged obscene or offensive. Further, lexical blending and non-manual enhancement play a role in the creation of dysphemisms in DGS. Lastly, we propose that iconicity as a cognitive structuring principle of linguistic expressions constrains the possible semantic extensions of iconic taboo terms. (shrink)

Barzykowski and Moulin's view on involuntary autobiographical memory focuses on automatic activation of representations and inhibitory control mechanisms. We discuss how and when a known neural mechanism – pattern completion – may result in involuntary autobiographical memories, the types of cues that may elicit this phenomenon and consider interactions with future-oriented cognition.

This study investigated individual differences in the belief bias effect, which is the tendency to accept conclusions because they are believable rather than because they are logically valid. It was observed that the extent of an individual's belief bias effect was unrelated to a number of measures of reasoning competence. Instead, as predicted by mental models theory, it was related to a person's ability to generate alternative representations of premises: the more alternatives a person generated, the less likely they were (...) to show a belief bias effect. In contrast to belief effects, which were predicted by the number of alternatives generated, scores on logical reasoning tasks were predicted by an individual's understanding of the concept of logical necessity. These two mediating variables, ability to generate alternatives and understanding of logical necessity, were themselves predicted by similar variables, such as cognitive motivation and abstract reasoning ability. Our findings strongly support the mental models interpretation of the belief bias effect, and suggest that individual differences in this effect are associated with a specific ability to generate alternatives, rather than with a general logical competence. (shrink)

Policies promoted and adopted for allocating ventilators during the COVID-19 pandemic have often prioritised healthcare workers or other essential workers. While the need for such policies has so far been largely averted, renewed stress on health systems from continuing surges, as well as the experience of allocating another scarce resource—vaccination—counsel revisiting the justifications for such prioritisation. Prioritising healthcare workers may have intuitive appeal, but the ethical justifications for doing so and the potential harms that could follow require careful analysis. Ethical (...) justifications commonly offered for healthcare worker prioritisation for ventilators rest on two social value criteria: instrumental value, also known as the ‘multiplier effect’, which may preserve the ability of healthcare workers to help others, and reciprocity, which rewards past usefulness or sacrifice. We argue that these justifications are insufficient to over-ride the common moral commitment to value each person’s life equally. Institutional policies prioritising healthcare workers over other patients also violate other ethical norms of the healthcare professions, including the commitment to put patients first. Furthermore, policy decisions to prioritise healthcare workers for ventilators could engender or deepen existing distrust of the clinicians, hospitals and health systems where those policies exist, even if they are never invoked. (shrink)

Previous studies have shown that misperceptions and illusory experiences can occur if sensory stimulation is withdrawn or becomes invariant even for short periods of time. Using a perceptual deprivation paradigm, we created a monotonous audiovisual environment and asked participants to verbally report any auditory, visual or body-related phenomena they experienced. The data (analysed using a variant of interpretative phenomenological analysis) revealed two main themes: (1) reported sensory phenomena have different spatial characteristics ranging from simple percepts to the feeling of immersion (...) in a complex multisensory environment and (2) the active contribution of the perceiver where participants report engaging in exploratory processes even when there is nothing to find. Detailed analysis of the qualitative data further showed that participants who reported more perceptual phenomena were more likely to report internal bodily sensations, move more during the experiment and score higher on the Revised Hallucination Scale than those reporting fewer percepts explicitly linking perceptual deprivation to somatic phenomena. The results demonstrate how the variety of sensory experiences induced by perceptual deprivation can give further insight into the factors mediating conscious awareness and may suggest ways in which the brain imposes meaning on the environment under invariant sensory conditions. (shrink)

The article clarifies the way in which ‘the aesthetic’ is conceptualised in relation to business ethics in order to assess its potential to inform theory building and developmental practices within the business ethics field. A systematic review of relevant literature is undertaken which identifies three ontologically based accounts of the relationship between the aesthetic and business ethics: ‘positive’ ones, ‘negative’ accounts and ‘Postmodern’ renderings. Five epistemologically based approaches are also made explicit: those in which the aesthetic is thought to develop (...) enhanced perceptual discernment, those in which the aesthetic catalyses emotional sensitivity, those in which the aesthetic contributes to imaginative capacity, those in which the aesthetic prompts integrative apprehension and those in which the aesthetic is seen to foster critical reflexivity. The review reveals two key findings: firstly, the dearth of empirically based research to substantiate claims made about the aesthetic’s ability to foster ethical capabilities, which leads to proposals for further research; secondly, the analysis indicates the significance of critical reflexivity both in resolving the apparent dichotomy between ontologically based perspectives asserting the aesthetic’s ability to lead to ethically sound or egregious behaviour, and in underpinning the capacities of perceptual discernment, emotional connectivity, imagination and integrative apprehension which epistemologically based approaches assert the aesthetic can foster. (shrink)