Ever since Greek antiquity "disembodied knowledge" has often been taken as synonymous with "objective truth." Yet we also have very specific mental images of the kinds of bodies that house great minds--the ascetic philosopher versus the hearty surgeon, for example. Does truth have anything to do with the belly? What difference does it make to the pursuit of knowledge whether Einstein rode a bicycle, Russell was randy, or Darwin flatulent? Bringing body and knowledge into such intimate contact is occasionally seen (...) as funny, sometimes as enraging, and more often just as pointless. Vividly written and well illustrated, Science Incarnate offers concrete historical answers to such skeptical questions about the relationships between body, mind, and knowledge. Focusing on the seventeenth century to the present, Science Incarnate explores how intellectuals sought to establish the value and authority of their ideas through public displays of their private ways of life. Patterns of eating, sleeping, exercising, being ill, and having (or avoiding) sex, as well as the marks of gender and bodily form, were proof of the presence or absence of intellectual virtue, integrity, skill, and authority. Intellectuals examined in detail include René Descartes, Isaac Newton, Charles Darwin, and Ada Lovelace. Science Incarnate is at once very funny and deeply serious, addressing issues of crucial importance to present-day discussions about the nature of knowledge and how it is produced. It incorporates much that will interest cultural and social historians, historians of science and medicine, philosophers, sociologists, and anthropologists. (shrink)

Theories of familial, racial, and national degeneration in the late nineteenth and early twentieth centuries have been explored by historians in the context of social and moral pathology. At the same time nerve degeneration was studied in the post mortem room and in the laboratory but links to the broader ideology of degeneration have not been investigated by scholars. This paper joins these domains by examining the concept of Wallerian degeneration. It argues that various discourses—including those of the laboratory scientist, (...) the clinician, and the social theorist—employed the term degeneration, and these discourses frequently overlapped demonstrating that degeneration was a ubiquitous fact of Victorian and Edwardian nature. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Robert Maxwell Young's first book Mind, Brain and Adaptation in the Nineteenth Century, written from 1960 to 1965, still merits reading as a study of the naturalization of mind and its relation to social thought in Victorian Britain. I examine the book from two perspectives that give the volume its unique character: first, Young's interest in psychology, which he considered should be used to inform humane professional practices and be the basis of social reform; second, new approaches to the history (...) of scientific ideas. I trace Young's intellectual interests to the Yale Philosophy Department, the Cambridge Department of Experimental Psychology and a new history and philosophy of science community. Although Young changed his political outlook and historiography radically after 1965, he always remained faithful to ideas about thought and practice described in Mind, Brain. (shrink)