The Planteome project provides a suite of reference and species-specific ontologies for plants and annotations to genes and phenotypes. Ontologies serve as common standards for semantic integration of a large and growing corpus of plant genomics, phenomics and genetics data. The reference ontologies include the Plant Ontology, Plant Trait Ontology, and the Plant Experimental Conditions Ontology developed by the Planteome project, along with the Gene Ontology, Chemical Entities of Biological Interest, Phenotype and Attribute Ontology, and others. The project also provides (...) access to species-specific Crop Ontologies developed by various plant breeding and research communities from around the world. We provide integrated data on plant traits, phenotypes, and gene function and expression from 95 plant taxa, annotated with reference ontology terms. (shrink)

La philosophie cartésienne, en dépit des efforts souvent tentés pour l'exposer suivant une dialectique unilinéaire, n'est point à strictement parler, un système. On la nommerait assez bien, un pluralisme, en ce sens que son contenu ne se laisse ni dériver d'un seul principe ni enfermer dans une seule formule. Pluralisme cohérent, faudrait-il ajouter : non seulement parce que les oppositions qui s'y révèlent ne sont pas (quoi qu'on en ait dit) de formelles contradictions, mais surtout parce que chacun des termes (...) opposés n'y a été admis qu'en vertu d'une même attitude d'esprit, la docilité à l'évidence. Se plier en toutes choses à ce qu'on voit ; l'enregistrer comme on le voit, à quelque ordre qu'il appartienne, sans y rien mêler de sa sensibilité propre : voilà l'attitude cartésienne, telle qu'elle se manifeste dans la théorie de la méthode, comme aussi dans le Cogito et dans les démarches qui en procèdent. C'est l'attitude empirique, au sens premier et authentique du mot : ceux-là seuls répugnent à en convenir que des associations invétérées conduisent toujours à confondre empirique et sensualiste. En sorte que, si nous voulons à toute force caractériser la philosophie de Descartes par un nom, le nom qui lui siérait le mieux serait, tout paradoxe à part, celui d'empirisme - empirisme radical et intégral. (shrink)

Le. Jansénisme. Convient-il, dans une Histoire des Religions, de consacrer un chapitre au « jansénisme » ? On pourrait se le demander. Car tous ceux qui ont coutume d'être appelés « Jansénistes » s'accordent à répudier ce nom de « secte ...

Background The prioritization protocols for accessing adult critical care in the extreme pandemic context contain tiebreaker criteria to facilitate decision-making in the allocation of resources between patients with a similar survival prognosis. Besides being controversial, little is known about the public acceptability of these tiebreakers. In order to better understand the public opinion, Quebec and Ontario’s protocols were presented to the public in a democratic deliberation during the summer of 2022. Objectives (1) To explore the perspectives of Quebec and Ontario (...) citizens regarding tiebreakers, identifying the most acceptable ones and their underlying values. (2) To analyze these results considering other public consultations held during the pandemic on these criteria. Methods This was an exploratory qualitative study. The design involved an online democratic deliberation that took place over two days, simultaneously in Quebec and Ontario. Public participants were selected from a community sample which excluded healthcare workers. Participants were first presented the essential components of prioritization protocols and their related issues (training session day 1). They subsequently deliberated on the acceptability of these criteria (deliberation session day 2). The deliberation was then subject to thematic analysis. Results A total of 47 participants from the provinces of Quebec (n = 20) and Ontario (n = 27) took part in the online deliberation. A diverse audience participated excluding members of the healthcare workforce. Four themes were identified: (1) Priority to young patients - the life cycle - a preferred tiebreaker; (2) Randomization - a tiebreaker of last resort; (3) Multiplier effect of most exposed healthcare workers - a median acceptability tiebreaker, and (4) Social value – a less acceptable tiebreaker. Conclusion Life cycle was the preferred tiebreaker as this criterion respects intergenerational equity, which was considered relevant when allocating scarce resources to adult patients in a context of extreme pandemic. Priority to young patients is in line with other consultations conducted around the world. Additional studies are needed to further investigate the public acceptability of tiebreaker criteria. (shrink)

© Copyright 2015, Mary Ann Liebert, Inc..Signal transducer and activator of transcription factor 3 is hyperactivated in head and neck squamous cell carcinomas. Cumulative evidence indicates that IL-6 production by HNSCC cells and/or stromal cells in the tumor microenvironment activates STAT3 and contributes to tumor progression and drug resistance. A library of 94,491 compounds from the Molecular Library Screening Center Network was screened for the ability to inhibit interleukin-6 -induced pSTAT3 activation. For contractual reasons, the primary high-content screening campaign was (...) conducted over several months in 3 distinct phases; 1,068 primary HCS actives remained after cytotoxic or fluorescent outliers were eliminated. One thousand one hundred eighty-seven compounds were cherry-picked for confirmation; actives identified in the primary HCS and compounds selected by a structural similarity search of the remaining MLSCN library using hits identified in phases I and II of the screen. Actives were confirmed in pSTAT3 IC50 assays, and an IFNγ-induced pSTAT1 activation assay was used to prioritize selective inhibitors of STAT3 activation that would not inhibit STAT1 tumor suppressor functions. Two hundred three concentration-dependent inhibitors of IL-6-induced pSTAT3 activation were identified and 89 of these also produced IC50s against IFN-γ-induced pSTAT1 activation. Forty-nine compounds met our hit criteria: they reproducibly inhibited IL-6-induced pSTAT3 activation by ≥70% at 20 μM; their pSTAT3 activation IC50s were ≤25 μM; they were ≥2-fold selective for pSTAT3 inhibition over pSTAT1 inhibition; a cross target query of PubChem indicated that they were not biologically promiscuous; and they were ≥90% pure. Twenty-six chemically tractable hits that passed filters for nuisance compounds and had acceptable drug-like and ADME-Tox properties by computational evaluation were purchased for characterization. The hit structures were distributed among 5 clusters and 8 singletons. Twenty-four compounds inhibited IL-6-induced pSTAT3 activation with IC50s ≤20 μM and 13 were ≥3-fold selective versus inhibition of pSTAT1 activation. Eighteen hits inhibited the growth of HNSCC cell lines with average IC50s ≤ 20 μM. Four chemical series were progressed into lead optimization: the guanidinoquinazolines, the triazolothiadiazines, the amino alcohols, and an oxazole-piperazine singleton. (shrink)

En publiant en 1965 Le Péché et la durée de l’ange, le P. Guérard des Lauriers, o. p. (1898-1989) offrait une contribution majeure à un débat qui divisait les thomistes. En 1946 en effet, la parution de Surnaturel du P. de Lubac avait remis en cause, textes de Thomas d’Aquin à l’appui, la thèse de l’impeccabilité naturelle de l’ange, jusqu’alors (presque) unanimement reçue dans l’École thomiste. Deux interprétations de Thomas d’Aquin polarisèrent alors le débat : la raison de la peccabilité (...) de l’ange est à rechercher ou bien dans son élévation à l’ordre surnaturel ( De malo, q. 16, a. 4), ou bien dans la structure même de la créature angélique ( Summa theologiae I a Pars, q. 63, a. 1). Servi par une herméneutique renouvelée des textes de Thomas sur la peccabilité de l’ange, et fort d’un redéploiement d’une doctrine thomiste de la liberté, articulée dans sa double dimension de spécification et d’exercice, Guérard établit que le fondement de la liberté des créatures spirituelles – et donc leur peccabilité – se situe au cœur de leur constitution métaphysique, dans la distinction réelle entre nature et personne, sans qu’intervienne nécessairement la distinction des ordres naturel et surnaturel. Son analyse pénétrante et novatrice le conduit à mettre au jour une structure du libre arbitre, laquelle intègre et unit sans confusion les deux ordres de réalité engagés dans l’acte libre : le métaphysique et le moral. Il offre ainsi une contribution de premier plan à l’élaboration d’une philosophie contemporaine de la liberté, attestant par-là la fécondité de la tradition thomiste. (shrink)

Rigid designators for concrete objects and for properties -- On the coherence of the distinction -- On whether the distinction assigns to rigidity the right role -- A uniform treatment of property designators as singular terms -- Rigid appliers -- Rigidity - associated arguments in support of theoretical identity statements: on their significance and the cost of its philosophical resources -- The skeptical argument impugning psychophysical identity statements: on its significance and the cost of its philosophical resources -- The skeptical (...) argument further examined: on resources, allegedly overlooked, for confirming psychological identities. (shrink)

Considering the persisting disagreement between the common sense philosophers and the sceptics, it seems that they are faced with a deep epistemic disagreement. Taking stock from Wittgenstein’s On Certainty, one generally thinks that deep epistemic disagreements cannot be rationally resolved. Hinge epistemology, inherited from Wittgenstein, is also considered as an illuminating detour to understand common sense epistemology. But is there really a deep epistemic disagreement between the common sense philosophers and the sceptics? Could it not be considered that they share (...) a common background? If so, is the rational resolution of their disagreement logically possible? What rational means can common sense use to convince someone of the privileged status of an epistemic principle? Relying on Reid’s, Alston’s and Lynch’s arguments, I show that common sense epistemology is a more promising approach than hinge epistemology, because it is driven by an optimism about reason in the solving of deep epistemic disagreements. (shrink)

The pivotal problem of comorbidity research lies in the psychometric foundation it rests on, that is, latent variable theory, in which a mental disorder is viewed as a latent variable that causes a constellation of symptoms. From this perspective, comorbidity is a (bi)directional relationship between multiple latent variables. We argue that such a latent variable perspective encounters serious problems in the study of comorbidity, and offer a radically different conceptualization in terms of a network approach, where comorbidity is hypothesized to (...) arise from direct relations between symptoms of multiple disorders. We propose a method to visualize comorbidity networks and, based on an empirical network for major depression and generalized anxiety, we argue that this approach generates realistic hypotheses about pathways to comorbidity, overlapping symptoms, and diagnostic boundaries, that are not naturally accommodated by latent variable models: Some pathways to comorbidity through the symptom space are more likely than others; those pathways generally have the same direction (i.e., from symptoms of one disorder to symptoms of the other); overlapping symptoms play an important role in comorbidity; and boundaries between diagnostic categories are necessarily fuzzy. (shrink)

Les noms sous-spécifiés, qui peuvent apparaitre dans une construction spécificationnelle, de la forme Leur ambition a été d’innover, sont par ailleurs souvent des prédicats régissant des arguments, dans une phrase élémentaire de la forme Ils ont eu l’ambition d’innover, où Nss est le prédicat accompagné d’un verbe support et de ses arguments N0 et N1. Nous avons étudié des noms entrant à la fois dans les deux constructions et avec le même sens, et trouvé trois cas de figure. Avec des (...) noms tels que ambition, et ont presque le même sens. Dans d’autres entrées, telles que souvenir et preuve, les deux constructions ne sont pas équivalentes : l’attribut phrastique de est absent de, tandis que l’argument N1 de peut apparaitre comme complément de nom du Nss sujet dans, et spécifie souvent le thème du propos contenu dans l’attribut phrastique de. Enfin, d’autres noms tels que embarras ne sont pas des Nss typiques car l’attribut phrastique de y joue un rôle causal ; il n’a pas le même contenu que N1. Ainsi, dans les types souvenir/preuve et embarras, est à analyser comme une combinaison de plusieurs phrases élémentaires. (shrink)

The building of a global model of carcinogenesis is one of modern biology’s greatest challenges. The traditional somatic mutation theory is now supplemented by a new approach, called the Tissue Organization Field Theory. According to TOFT, the original source of cancer is loss of tissue organization rather than genetic mutations. In this paper, we study the argumentative strategy used by the advocates of TOFT to impose their view. In particular, we criticize their claim of incompatibility used to justify the necessity (...) to definitively reject SMT. First, we note that since it is difficult to build a non-ambiguous experimental demonstration of the superiority of TOFT, its partisans add epistemological and metaphysical arguments to the debate. This argumentative strategy allows them to defend the necessity of a paradigm shift, with TOFT superseding SMT. To do so, they introduce a notion of incompatibility, which they actually use as the Kuhnian notion of incommensurability. To justify this so-called incompatibility between the two theories of cancer, they move the debate to a metaphysical ground by assimilating the controversy to a fundamental opposition between reductionism and organicism. We show here that this argumentative strategy is specious, because it does not demonstrate clearly that TOFT is an organicist theory. Since it shares with SMT its vocabulary, its ontology and its methodology, it appears that a claim of incompatibility based on this metaphysical plan is not fully justified in the present state of the debate. We conclude that it is more cogent to argue that the two theories are compatible, both biologically and metaphysically. We propose to consider that TOFT and SMT describe two distinct and compatible causal pathways to carcinogenesis. This view is coherent with the existence of integrative approaches, and suggests that they have a higher epistemic value than the two theories taken separately. (shrink)

Philon d'Alexandrie, un philosophe juif contemporain de Jésus et de saint Paul et le principal témoin de la théologie de la Diaspora, éclaire les multiples visages de sa foi religieuse à l'aide de la philosophie grecque, au cours de ses abondants commentaires sur la Loi de Moïse. Il est très proche du monde de pensée de saint Paul, de l'Épître aux Hébreux et de saint Jean, c'est-à-dire du milieu où s'est développé le christianisme. L'auteur, Jean Laporte, élève de l'Institut (...) catholique de Paris et professeur à l'université Notre-Dame d'Indiana (USA), s'est fixé pour but d'étudier la doctrine eucharistique de Philon sous ses différents aspects : les termes et images qui l'expriment, son lien intime avec le culte du temple, les problèmes cosmologiques, anthropologiques et spirituels liés à l'œuvre de la création et de la restauration de l'homme. Le travail révèle la richesse de l'Eucharistie philonienne et contribue indirectement à éclairer les bases de l'Eucharistie chrétienne. (shrink)

Systems biology is today such a widespread discipline that it becomes difficult to propose a clear definition of what it really is. For some, it remains restricted to the genomic field. For many, it designates the integrated approach or the corpus of computational methods employed to handle the vast amount of biological or medical data and investigate the complexity of the living. Although defining systems biology might be difficult, on the other hand its purpose is clear: systems biology, with its (...) emerging subfields systems medicine and systems pharmacology, clearly aims at making sense of complex observations/experimental and clinical datasets to improve our understanding of diseases and their treatments without putting aside the context in which they appear and develop. In this short review, we aim to specifically focus on these new subfields with the new theoretical tools and approaches that were developed in the context of cancer. Systems pharmacology and medicine now give hope for major improvements in cancer therapy, making personalized medicine closer to reality. As we will see, the current challenge is to be able to improve the clinical practice according to the paradigm shift of systems sciences. (shrink)

In this paper, I address the charge that the category species should be abandoned in biological work. The widespread appeal to species in scientific discourse provides a presumption in favor of the category’s usefulness, but a defeasible presumption. Widely acknowledged troubles attend species: these troubles might render the concept unusable by showing that ‘species’ is equivocal or meaningless or in some similar way fatally flawed. Further, there might be better alternatives to species. I argue that the presumption in favor of (...) species is not defeated on these scores. Troubles attending species, which arise on account of contextual variation attending the use of ‘species’, do not indicate that the concept is unusable. And alternatives to the use of ‘species’, which have been proposed in connection with rank-free systematics and in connection with conservation efforts, fail to provide a proper replacement for species. (shrink)

This paper is devoted to computer modelling of the development and regeneration of multicellular biological structures. Some species are able to regenerate parts of their body after amputation damage, but the global rules governing cooperative cell behaviour during morphogenesis are not known. Here, we consider a simplified model organism, which consists of tissues formed around special cells that can be interpreted as stem cells. We assume that stem cells communicate with each other by a set of signals, and that the (...) values of these signals depend on the distance between cells. Thus the signal distribution characterizes location of stem cells. If the signal distribution is changed, then the difference between the initial and the current signal distribution affects the behaviour of stem cells—e.g. as a result of an amputation of a part of tissue the signal distribution changes which stimulates stem cells to migrate to new locations, appropriate for regeneration of the proper pattern. Moreover, as stem cells divide and form tissues around them, they control the form and the size of regenerating tissues. This two-level organization of the model organism, with global regulation of stem cells and local regulation of tissues, allows its reproducible development and regeneration. (shrink)

Large sets of elements interacting locally and producing specific architectures reliably form a category that transcends the usual dividing line between biological and engineered systems. We propose to call them morphogenetically architected complex systems. While taking the emergence of properties seriously, the notion of MACS enables at the same time the design of operational means that allow controlling and even, paradoxically, programming this emergence. To demonstrate our claim, we first show that among all the self-organized systems studied in the field (...) of Artificial Life, the specificity of MACS essentially lies in the close relation between their emergent properties and functional properties. Second, we argue that to be a MACS a system does not need to display more than weak emergent properties. Third, since the notion of weak emergence is based on the possibility of simulation, whether computational or mechanistic via machines, we see MACS as good candidates to help design artificial self-architected systems but also harness and redesign living ones. (shrink)

Lindquist et al. present a strong case for a constructionist account of emotion. First, we elaborate on the ramifications that a constructionist account of emotions might have for psychiatric disorders with emotional disturbances as core elements. Second, we reflect on similarities between Lindquist et al.'s model and recent attempts at formulating psychiatric disorders as networks of causally related symptoms.

In this article we present a new kind of computing device that uses biochemical reactions networks as building blocks to implement logic gates. The architecture of a computing machine relies on these generic and composable building blocks, computation units, that can be used in multiple instances to perform complex boolean functions. Standard logical operations are implemented by biochemical networks, encapsulated and insulated within synthetic vesicles called protocells. These protocells are capable of exchanging energy and information with each other through transmembrane (...) electron transfer. In the paradigm of computation we propose, protoputing, a machine can solve only one problem and therefore has to be built specifically. Thus, the programming phase in the standard computing paradigm is represented in our approach by the set of assembly instructions that directs the wiring of the protocells that constitute the machine itself. To demonstrate the computing power of protocellular machines, we apply it to solve a NP-complete problem, known to be very demanding in computing power, the 3-SAT problem. We show how to program the assembly of a machine that can verify the satisfiability of a given boolean formula. Then we show how to use the massive parallelism of these machines to verify in less than 20 min all the valuations of the input variables and output a fluorescent signal when the formula is satisfiable or no signal at all otherwise. (shrink)

This article examines women who have been antinuclear activists at the Three Mile Island nuclear power plant for two decades. Qualitative interviews focus on their perceived transformations over time that are based on gender and everyday experiences. They perceive gender as both a barrier and a facilitator to activism, even after 20 years. Women describe their technological education as one strategy to overcome the barrier of gender. On the other hand, they consider the gendered role of motherhood as a primary (...) catalyst for action. In addition, they discuss individual everyday experiences focused on the health concerns for family members that influenced their political activity. Over time, women linked personal transformations with increased political understanding and involvement. (shrink)

The majority of commentators agree on one thing: Our network approach might be the prime candidate for offering a new perspective on the origins of mental disorders. In our response, we elaborate on refinements (e.g., cognitive and genetic levels) and extensions (e.g., to Axis II disorders) of the network model, as well as discuss ways to test its validity.

Présentation des articles qui suivent : invoquer le sens commun, ce n’est pas supposer un abandon de la philosophie et de la raison, mais faire droit à une conception ajustée de la rationalité humaine. Les articles ici réunis s’inscrivent dans l’approche du sens commun comme instance régulatrice.

According to the received tradition, the language used to to refer to natural kinds in scientific discourse remains stable even as theories about these kinds are refined. In this illuminating book, Joseph LaPorte argues that scientists do not discover that sentences about natural kinds, like 'Whales are mammals, not fish', are true rather than false. Instead, scientists find that these sentences were vague in the language of earlier speakers and they refine the meanings of the relevant natural-kind terms to (...) make the sentences true. Hence, scientists change the meaning of these terms, This conclusions prompts LaPorte to examine the consequences of this change in meaning for the issue of incommensurability and for the progress of science. This book will appeal to students and professional in the philosophy of science, the philosophy of biology and the philosophy of language. (shrink)

This book arose out of a conference organised by the Fay Gale Centre for Research on Gender at The University of Adelaide honouring Carol Bacchi's work and is intended to make that work accessible to a range of audiences. - from the ...

The Enzymatic control reactions model was presented within the scope of fractional calculus. In order to accommodate the usual initial conditions, the fractional derivative used is in Caputo sense. The methodologies of the three analytical methods were used to derive approximate solution of the fractional nonlinear system of differential equations. Two methods use integral operator and the other one uses just an integral. Numerical results obtained exhibit biological behavior of real world problem.

RÉSUMÉLe mot «migrants» n'existait pas dans la langue des Hellènes; ils étaient plus familiers avec le vocable de l'exil et de l'asile. D'ailleurs, l'exil ne saurait se penser sans son corollaire, l'asile, comme le citoyen antique sans le barbare et la démocratie sans la tyrannie. À travers une métaphore située au carrefour de la fiction historique, de la philosophie politique et de la psychanalyse, cet article propose une réflexion sur l'exil comme condition fondamentale du sujet. L'exil est d'origine, car la (...) langue de l'enfance, la langue dite maternelle est d'abord une langue étrangère. L'exil intime porte la marque d'une universalité qui fonde l'expérience subjective.ABSTRACTThe word ‘migrants’ did not exist in the language of the Hellenes; they were more familiar with the terms ‘exile’ and ‘political asylum.’ Indeed, exile cannot be thought of without its corollary, political asylum, as the Ancient citizen cannot be thought of without the barbarian, and democracy without tyranny. Through a metaphor located at the crossroads of historical fiction, political philosophy and psychoanalysis, this article offers a reflection on exile as a fundamental condition of the subject. Exile is originary because the language of childhood, the so-called mother tongue, is originally a foreign language. Intimate exile bears the mark of a universality that founds subjective experience. (shrink)

In the past decades, reductionism has dominated both research directions and funding policies in clinical psychology and psychiatry. The intense search for the biological basis of mental disorders, however, has not resulted in conclusive reductionist explanations of psychopathology. Recently, network models have been proposed as an alternative framework for the analysis of mental disorders, in which mental disorders arise from the causal interplay between symptoms. In this target article, we show that this conceptualization can help explain why reductionist approaches in (...) psychiatry and clinical psychology are on the wrong track. First, symptom networks preclude the identification of a common cause of symptomatology with a neurobiological condition; in symptom networks, there is no such common cause. Second, symptom network relations depend on the content of mental states and, as such, feature intentionality. Third, the strength of network relations is highly likely to depend partially on cultural and historical contexts as well as external mechanisms in the environment. Taken together, these properties suggest that, if mental disorders are indeed networks of causally related symptoms, reductionist accounts cannot achieve the level of success associated with reductionist disease models in modern medicine. As an alternative strategy, we propose to interpret network structures in terms of D. C. Dennett's (1987) notion ofreal patterns, and suggest that, instead of being reducible to a biological basis, mental disorders feature biological and psychological factors that are deeply intertwined in feedback loops. This suggests that neither psychological nor biological levels can claim causal or explanatory priority, and that a holistic research strategy is necessary for progress in the study of mental disorders. (shrink)

We generally consider that we should not believe on the basis of insufficient evidence. Yet there are many beliefs which are deprived of adequate epistemic evidence. In such cases, James recommends the “subjective method” which allows us to hold beliefs for practical reasons. This pragmatist move is rejected by evidentialists who think that beliefs must be grounded on adequate epistemic evidence. My contention is that Reid’s approach to irresistible beliefs we do not hold for epistemic reasons offers a persuasive means (...) to escape the contemporary stalemate between evidentialism and pragmatism. Are we rational in holding beliefs for which we don’t possess sufficient epistemic evidence? Reid and James subscribe to a permissivist ethics of belief, according to which we are allowed to hold a belief even if we cannot show its epistemic credentials. Yet I show that the abandonment of the stringent evidentialist requirement (which is tied to a form of internalism) does not necessarily commit one to a pure form of pragmatism (which offers practical reasons instead of epistemic ones). If Reid proposes arguments built on a pragmatist line, he does not reject the evidentialist demand per se, only its internalist form. Moreover, in his view, immediate beliefs are carried by a kind of instinctive epistemic trust. On the whole, pragmatism and common sense do not defend the same kind of epistemic permissivism. (shrink)

The field of synthetic biology is looking forward engineering framework for safely designing reliable de-novo biological functions. In this undertaking, Computer-Aided-Design environments should play a central role for facilitating the design. Although, CAD environment is widely used to engineer artificial systems the application in synthetic biology is still in its infancy. In this article we address the problem of the design of a high level language which at the core of CAD environment. More specifically the Gubs language is a specification (...) language used to describe the observations of the expected behaviour. The compiler appropriately selects components such that the observation of the synthetic biological function resulting to their assembly complies to the programmed behaviour. (shrink)

Supposons un sceptique qui doute qu’il ait deux mains. Je montre tout d’abord que si on le compare au fou, cela coupe court à toute tentative de le comprendre. La raison en est non pas qu’il ne partage pas les mêmes croyances-charnières que nous, mais qu’il n’effectue aucun partage entre des croyances-charnières et des croyances susceptibles d’être révisées. Puis je propose un autre modèle à partir duquel le discours d’un sceptique peut apparaître comme intelligible : le modèle de la compréhension (...) interculturelle. Dans ce cadre, un sceptique n’est intelligible que s’il adhère à un système partagé de distribution entre des croyances-charnières et des croyances révisables, quand bien même il n’a pas les mêmes croyances-charnières que nous. (shrink)

What are the conditions under which one biological object is a part of another biological object? This paper answers this question by developing a general, systematic account of biological parthood. I specify two criteria for biological parthood. Substantial Spatial Inclusionrequires biological parts to be spatially located inside or in the region that the natural boundary of t he biological whole occupies. Compositional Relevance captures the fact that a biological part engages in a biological process that must make a necessary contribution (...) to a condition that is minimally sufficient to one or more of the characteristic behaviors of the biological whole. Instead of emphasizing the diversity of part-whole relations in the biological world, this paper asks what biological part-whole relations have in common and what constrains their existence, in general. After presenting the two criteria for biological parthood I discuss in how far my account can cope with hard cases (e.g., redundant parts) and I reveal the merits and limits of monism. (shrink)

Quiconque veut croire de manière appropriée devrait obéir à la règle de l’évidence qui veut que l’on croie que p si et seulement si l’on a des raisons suffisantes de croire qu’il est vrai que p. En tout autre cas, le doute s’impose. Pourtant, il existe des croyances qui ne respectent pas cette règle : les principes du sens commun. Même si nous croyons en eux sans disposer de raisons suffisantes pour attester de leur vérité, cette attitude n’est pas intellectuellement (...) illégitime. Ainsi, nous sommes en droit de croire que nos pouvoirs intellectuels sont fiables, à défaut de disposer de raisons suffisantes, et même en dépit de raisons de douter. Nous n’avons pas à choisir entre la suspension du jugement et la thèse fidéiste selon laquelle les principes du sens commun relèvent de la foi, conçue comme étant distincte des croyances. L’idée de Reid que les principes du sens commun sont des croyances authentiques en lesquelles nous avons confiance ou foi permet d’échapper à ce dilemme : la foi n’est pas une réponse au doute, un saut qu’on décide de faire faute de mieux. C’est une foi primitive, sans laquelle on ne peut pas évaluer l’évidence. Il en résulte que 1) une telle foi peut être conservée en dépit de raisons de douter, car elle n’est pas acquise du fait de raisons et 2) la compatibilité avec les principes du sens commun est une règle doxastique qui a priorité sur la règle de l’évidence. (shrink)

The classic model of blood pressure regulation by Guyton et al. set a new standard for quantitative exploration of physiological function and led to important new insights, some of which still remain the focus of debate, such as whether the kidney plays the primary role in the genesis of hypertension. Key to the success of this model was the fact that the authors made the computer code freely available and eventually provided a convivial user interface for exploration of model behavior (...) on early microcomputers. Ikeda et al. developed an offshoot of the Guyton model targeting especially the regulation of body fluids and acid–base balance; their model provides extended renal and respiratory functions and would be a good basis for further extensions. In the interest of providing a simple, useable version of Ikeda et al.’s model and to facilitate further such extensions, we present a practical implementation of the model of Ikeda et al., using the ODE solver Berkeley Madonna. (shrink)

How is hope to be found amid the ethical and political dilemmas of modern life? Writer and philosopher Mary Zournazi brought her questions to some of the most thoughtful intellectuals at work today. She discusses "joyful revolt" with Julia Kristeva, the idea of "the rest of the world" with Gayatri Spivak, the "art of living" with Michel Serres, the "carnival of the senses" with Michael Taussig, the relation of hope to passion and to politics with Chantal Mouffe and Ernesto Laclau. (...) A dozen stimulating minds weigh in with their visions of a better social and political order. The result is a collaboration - of writing, of thinking, and of politics - that demonstrates more clearly than any single-authored project could how ideas encountering one another can produce the vision needed for social change. (shrink)