Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Modern ecological risks associated with the anthropological crisis of nature, leading to the paradoxes of the ecological state of humanity, are analyzed. It is substantiated that the unlimited use of natural resources causes a misbalance between human actions and the riches of nature. The question of the necessity of exploring the man-nature relation in the context of humanistic revolution is raised; it allows us to perceive the relation to nature as caring which includes such existential elements as agreement, tolerance, respect, (...) and care. We are discussing an alternative view of the relationship between man and nature in anthropologies of exploitation and violence. It is necessary to realize the value of nature precisely in its ontological intentionality and not because it is valuable solely in terms of utilitarianism and pragmatism. It is determined that over-technological human activity has led to catastrophic changes in large natural areas, destruction of natural water resources, and global warming, which threatens the biosphere and may lead to fundamental changes in the state of nature. The assumption is made that it is impossible to exclude the situation on the existence of the threat of catastrophe between man and nature; at that, the human search for the options of communication and preservation of nature and man, and their anthropological characteristics becomes expedient. (shrink)

The Book of Historical Documents is an ancient Chinese written monument, a collection of addresses of the ruler to the subjects and of the subjects to the rulers. The philosophical meaning of Shu jing is that it mentions or refers to the issues of a broad ideological order. These brief references either gave life to philosophical ideas, or later, after appropriate interpretation, were used by the philosophers to authoritatively confirm their thoughts. The first complete Russian translation of Shu jing was (...) done by Archimandrite Daniil in the early 40s of the 19th century. The translation was undertaken, first and primarily, as a teaching material assigned to students of the Chinese Language Cathedra at the Kazan Imperial University. This cathedra was first one established in Russia and the second one in Europe. Archimandrite Daniel was its first head in 1837-1844. Unfortunately, the translator have never had a chance to publish his work. Sivillov for the first time in Russian and European Sinology used a purely Chinese commented edition of The Book. The canonical text used by Sivillov and later his followers was considered and understood through the prism of modern Neoconfucianism, which, in comparison with ancient and early medieval Confucianism, reinterpreted and significantly enriched the philosophical meaning of the Shu jing. In some points of understanding of the Neoconfucian interpretation of the ancient text, Archimandrite Daniil was not only ahead of, but also more successful than his later colleagues. The text of the previously unpublished Shu jing Chapter III Da Yu mo Russian translation by archimandrite Daniil is attached. (shrink)

Recent challenges to Chomsky's poverty of the stimulus thesis for language acquisition suggest that children's primary data may carry “indirect evidence” about linguistic constructions despite containing no instances of them. Indirect evidence is claimed to suffice for grammar acquisition, without need for innate knowledge. This article reports experiments based on those of Reali and Christiansen (2005), who demonstrated that a simple bigram language model can induce the correct form of auxiliary inversion in certain complex questions. This article investigates the nature (...) of the indirect evidence that supports this learning, and assesses how reliably it is available. Results confirm the original finding for one specific sentence type but show that the model's success is highly circumscribed. It performs poorly on inversion in related constructions in English and Dutch. Because other, more powerful statistical models have so far been shown to succeed only on the same limited subset of cases as the bigram model, it remains to be seen whether stimulus richness can be substantiated more generally. (shrink)