This case is about a study of burn patients that included a request to the IRB for a waiver of consent for perianal specimen collection–a request which ultimately was not approved by a reviewing IR...

We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

Anthropologists now openly acknowledge that social anthropology can no longer fulfill its traditional aim of providing holistic, objective representations of people of "exotic" cultures. After Writing Culture asks what theoretical and practical role contemporary anthropology can play in our increasingly unpredictable and complex world. With fourteen articles written by well-known anthropologists, the work explores some of the directions in which contemporary anthropology is moving, following the questions raised by the "writing culture" debates of the 1980s. Some of the chapters cover: (...) the concept of caste in Indian society, Scottish ethnography, how dreams are culturally conceptualized, representations of the family, theme parks and the anthropologist in Japan, people's place in the landscape of Northern Australia, and representing the identity of the New Zealand Maori. (shrink)

People can imagine their future selves without taking future-focused action. Identity-based motivation theory explains why. Hoerl & McCormack outline how. Present-focused action prevails because future “me” feels irrelevant to the choices facing current “me” unless future “me” is experienced as occurring now or as linked to current “me” via if-then simulations. This entails reasoning in time and about time.

Population-level biomedical research offers new opportunities to improve population health, but also raises new challenges to traditional systems of research governance and ethical oversight. Partly in response to these challenges, various models of public involvement in research are being introduced. Yet, the ways in which public involvement should meet governance challenges are not well understood. We conducted a qualitative study with 36 experts and stakeholders using the World Café method to identify key governance challenges and explore how public involvement can (...) meet these challenges. This brief report discusses four cross-cutting themes from the study: the need to move beyond individual consent; issues in benefit and data sharing; the challenge of delineating and understanding publics; and the goal of clarifying justifications for public involvement. The report aims to provide a starting point for making sense of the relationship between public involvement and the governance of population-level biomedical research, showing connections, potential solutions and issues arising at their intersection. We suggest that, in population-level biomedical research, there is a pressing need for a shift away from conventional governance frameworks focused on the individual and towards a focus on collectives, as well as to foreground ethical issues around social justice and develop ways to address cultural diversity, value pluralism and competing stakeholder interests. There are many unresolved questions around how this shift could be realised, but these unresolved questions should form the basis for developing justificatory accounts and frameworks for suitable collective models of public involvement in population-level biomedical research governance. (shrink)

This second edition represents a wide-ranging critical introduction to the psychology of Carl Jung, one of the founders of psychoanalysis. Including two new essays and thorough revisions of most of the original chapters, it constitutes a radical assessment of his legacy. Andrew Samuels' introduction succinctly articulates the challenges facing the Jungian community. The fifteen essays set Jung in the context of his own time, outline the current practice and theory of Jungian psychology and show how Jungians continue to question (...) and evolve his thinking and apply it to aspects of modern culture and psychoanalysis. The volume includes a full chronology of Jung's life and work, extensively revised and up to date bibliographies, a case study and a glossary. It is an indispensable reference tool for both students and specialists, written by an international team of Jungian analysts and scholars from various disciplines. (shrink)

Is a human more conscious than an octopus? In the science of consciousness, it’s oftentimes assumed that some creatures (or mental states) are more conscious than others. But in recent years, a number of philosophers have argued that the notion of degrees of consciousness is conceptually confused. This paper (1) argues that the most prominent objections to degrees of consciousness are unsustainable, (2) examines the semantics of ‘more conscious than’ expressions, (3) develops an analysis of what it is for a (...) degreed property to count as degrees of consciousness, and (4) applies the analysis to various theories of consciousness. I argue that whether consciousness comes in degrees ultimately depends on which theory of consciousness turns out to be correct. But I also argue that most theories of consciousness entail that consciousness comes in degrees. (shrink)

This paper examines the idea of "objective phenomenology," or a way of understanding the phenomenal character of conscious experiences that doesn’t require one to have had the kinds of experiences under consideration. My central thesis is that structural facts about experience—facts that characterize purely how conscious experiences are structured—are objective phenomenal facts. I begin by precisifying the idea of objective phenomenology and diagnosing what makes any given phenomenal fact subjective. Then I defend the view that structural facts about experience are (...) objective. I also argue that structural facts about experience, despite being objective, nevertheless still give rise to an explanatory gap. (shrink)

How should politicians act? When should they try to lead public opinion and when should they follow it? Should politicians see themselves as experts, whose opinions have greater authority than other people's, or as participants in a common dialogue with ordinary citizens? When do virtues like toleration and willingness to compromise deteriorate into moral weakness? In this innovative work, Andrew Sabl answers these questions by exploring what a democratic polity needs from its leaders. He concludes that there are systematic, (...) principled reasons for the holders of divergent political offices or roles to act differently. Sabl argues that the morally committed civil rights activist, the elected representative pursuing legislative results, and the grassroots organizer determined to empower ordinary citizens all have crucial democratic functions. But they are different functions, calling for different practices and different qualities of political character. To make this case, he draws on political theory, moral philosophy, leadership studies, and biographical examples ranging from Everett Dirksen to Ella Baker, Frances Willard to Stokely Carmichael, Martin Luther King Jr. to Joe McCarthy. Ruling Passions asks democratic theorists to pay more attention to the "governing pluralism" that characterizes a diverse, complex democracy. It challenges moral philosophy to adapt its prescriptions to the real requirements of democratic life, to pay more attention to the virtues of political compromise and the varieties of human character. And it calls on all democratic citizens to appreciate "democratic constancy": the limited yet serious standard of ethical character to which imperfect democratic citizens may rightly hold their leaders--and themselves. (shrink)

A Physicalist Manifesto is a full treatment of the comprehensive physicalist view that, in some important sense, everything is physical. Andrew Melnyk argues that the view is best formulated by appeal to a carefully worked-out notion of realization, rather than supervenience; that, so formulated, physicalism must be importantly reductionist; that it need not repudiate causal and explanatory claims framed in non-physical language; and that it has the a posteriori epistemic status of a broad-scope scientific hypothesis. Two concluding chapters argue (...) in detail that contemporary science provides no significant empirical evidence against physicalism and some considerable evidence for it. Written in a brisk, candid and exceptionally clear style, this 2003 book should appeal to professionals and students in philosophy of mind, metaphysics and philosophy of science. (shrink)

A satisfactory theory of linguistic communication must explain how it is that, through the interpersonal exchange of auditory, visual, and tactile stimuli, the communicative preconditions for the acquisition of testimonial knowledge regularly come to be satisfied. Without an account of knowledge-yielding communication this success condition for linguistic theorizing is left opaque, and we are left with an incomplete understanding of testimony, and communication more generally, as a source of knowledge. This paper argues that knowledge-yielding communication should be modelled on knowledge (...) itself. It is argued that knowledge-yielding communication occurs iff interlocutors coordinate on truth values in a non-lucky and non-deviant way. This account is able to do significant explanatory work: it sheds light on the nature of referential communication, and it allows us to capture, in an informative way, the sense in which interlocutors must entertain similar propositions in order to communicate successfully. (shrink)

What is the true calling of the intellectual? In this provocative new book, Andrew Shanks presents a distinctive fresh answer. The Other Calling is a systematic riposte both to the elitism of philosophy in the heritage of Plato, and to the typical individualism of Plato's philosophic opponents. Here, instead, intellectual integrity is identified with a form of priesthood. Asserts that intellectuals are critical to bringing together the common aspirations of a community Offers a strikingly original approach to the moral (...) and political aspects of theology’s relationship with philosophy, exploring the perspectives of both disciplines Draws on the work and thought of Christians, Muslims, Hindus, Buddhists, Agnostics, and Atheists Argues for a new, religiously multicultural “priesthood of all thinkers”, considering how once, all intellectuals were as a matter of course also priests Published in the new and prestigious Illuminations series. (shrink)

In this paper I argue that the enkratic principle in its classic formulation may not be a requirement of rationality. The investigation of whether it is leads to some important methodological insights into the study of rationality. I also consider the possibility that we should consider rational requirements as a subset of a broader category of agential requirements.

Paracelsus was a transmutational alchemist: For most of his career, he believed that one metal could be turned into another. In an alchemical text, the De renovatione et restauratione, he explored the theoretical foundations of transmutation and hinted at recipes for bringing it about. He proposed that from plants, gems, metals, and minerals might be prepared a class of marvelous medicaments, which he called prima entia (first entities). Each primum ens had particular uses, but the entia were all supposed to (...) be able to revitalize the human body and cleanse it of disease. Certain entia could also transmute metals. The De renovatione et restauratione affirmed the metaphysical centrality, in goldmaking and medicine alike, not just of purification or alteration but of renewal and transformation. It expressed the author’s eschatological excitement at God’s works of wonder, whether within or above nature. (shrink)

Introduction: Reason, ethics, and animals -- Part I: Making the rational case -- Why animal suffering matters morally -- How we minimize animal suffering and how we can change -- Part II: Three practical critiques -- First case: Hunting with dogs -- Second case: Fur farming -- Third case: Commercial sealing -- Conclusion: Re-establishing animals and children as a common cause and six objections considered.

This chapter explores the ethical dimensions of diplomatic efforts to form a global agreement on climate change. It offers a brief historical background on the core multilateral climate negotiation body, the United Nations Framework Convention on Climate Change, and highlights some contentious moral elements of these negotiations. In particular, it explores the complex ways in which the principle of “common but differentiated responsibilities” has driven debates on how burdens for mitigation, adaptation, and finance should be distributed between developed and developing (...) countries. It then considers the transformation in these climate negotiations since 2009, including the move toward a bottom-up architecture as part from the Copenhagen Accord to the Paris Agreement. Finally, it assesses the current state of climate diplomacy in relation to broader diplomatic priorities, arguing that climate diplomacy must be elevated alongside other top-tier foreign policy issues today in order to eventually achieve some level of climate stability. (shrink)

How is it that a speaker _S_ can at once make it obvious to an audience _A_ that she intends to communicate some proposition _p_, and yet at the same time retain plausible deniability with respect to this intention? The answer is that _S_ can bring it about that _A_ has a high justified credence that ‘_S_ intended _p_’ without putting _A_ in a position to know that ‘_S_ intended _p_’. In order to achieve this _S_ has to exploit a (...) sense in which communication can be lottery-like. After defending this view of deniability I argue that it compares favorably to a rival account recently developed by Dinges and Zakkou (Mind, https://doi.org/10.1093/mind/fzac056, 2023 ). (shrink)

Raanan Gillon is a noted defender of the four principles approach to healthcare ethics. His general position has always been that these principles are to be considered to be both universal and prima facie in nature. In recent work, however, he has made two claims that seem to present difficulties for this view. His first claim is that one of these four principles, respect for autonomy, has a special position in relation to the others: he holds that it is first (...) among equals. We argue that this claim makes little sense if the principles are to retain their prima facie nature. His second claim is that cultural variation can play an independent normative role in the construction of our moral judgments. This, he argues, enables us to occupy a middle ground between what he sees as the twin pitfalls of moral relativism and moral imperialism. We argue that there is no such middle ground, and while Gillon ultimately seems committed to relativism, it is some form of moral imperialism that will provide the only satisfactory construal of the four principles as prima facie universal moral principles. (shrink)

This is a discussion of the state of discussion on pragmatic reasons for belief.

ABSTRACT Pettigrove’s paper argues strongly and effectively against a proportionality principle grounded on a univocal scale of value, and argues in favour of a kind of virtue ethics that is focused exclusively on the characteristic and non-univocal attitudes of the subject. In my critique, however, I point out that not all proponents of value ethics adhere to the proportionality principle and that the radical shift from object to subject has risks that were highlighted in a book by C. S. Lewis, (...) The Abolition of Man. I also point out that Pettigrove in fact treats ‘I love you’ and ‘I forgive you’ substantively in terms of a first-person act in which any relationship-enabling response by the second person is accidental. On this account, there seems to be an underlying ethical challenge, namely that the Pettigrovian valuers are in reality isolated, cut off from relationships based on genuine union with second persons. (shrink)

This book is about the link between animal abuse and human violence.

Recent policy in relation to clinical research proposals in the UK has distinguished between two types of review: scientific and ethical. This distinction has been formally enshrined in the recent changes to research ethics committee structure and operating procedures, introduced as the UK response to the EU Directive on clinical trials. Recent reviews and recommendations have confirmed the place of the distinction and the separate review processes. However, serious reservations can be mounted about the science/ethics distinction and the policy of (...) separate review that has been built upon it. We argue here that, first, the science/ethics distinction is incoherent, and, second, that RECs should not only be permitted to consider a study’s science, but that they have anobligation do so. (shrink)

An examination, by a diverse field of experts, of Pickering's mangle theory and its applicability (or lack thereof) beyond the limited cases he presented in the ...

This essay considers Kant’s theory of modality in light of a debate in contemporary modal metaphysics and modal logic concerning the Barcan formulas. The comparison provides a new and fruitful perspective on Kant’s complex and sometimes confusing claims about possibility and necessity. Two central Kantian principles provide the starting point for the comparison: that the possible must be grounded in the actual and that existence is not a real predicate. Both are shown to be intimately connected to the Barcan formulas, (...) and Kant’s views on what he distinguishes as three different kinds of modality are then considered in light of this connection. (shrink)

Nicolas Malebranche is one of the most important philosophers of the 17th Century after Descartes. A pioneer of Rationalism, he was one of the first to champion and to further Cartesian ideas. Andrew Pyle places Malebranche's work in the context of Descartes and other philosophers, and also in its relation to ideas about faith and reason. He examines the entirety of Malebranche's writings, including the famous The Search After Truth , which was admired and criticized by both Leibniz and (...) Locke. Pyle presents an integrated account of Malebranche's central theses, occasionalism and 'vision in God', before exploring and assessing Malebranche's contribution to debates on physics and biology, and his views on the soul, self-knowledge, grace, and the freedom of the will. This penetrating and wide-ranging study will be of interest to not only philosophers, but also to historians of science and philosophy, theologians, and students of the Enlightenment or 17th Century thought. (shrink)

An important advance in normativity research over the last decade is an increased understanding of the distinction, and difference, between normativity and rationality. Normativity concerns or picks out a broad set of concepts that have in common that they are, put loosely, guiding. For example, consider two commonly used normative concepts: that of a normative reason and that of ought. To have a normative reason to perform some action is for there to be something that counts in favour of performing (...) that action. Likewise with ought, when there is sufficient evidence for something, one ought to believe it (at least under normal circumstances). Not all guidance need be directed towards a specific state or a specific action. Subject to the requirements of normativity, too, are relations. It is commonly believed, for example, that we ought not to hold contradictory beliefs.1 At least some of the requirements that concern relations amongst an agent’s mental states are, or seem, distinctive. Agents who fail to satisfy these requirements are considered, at least to some degree, irrational. On many current views, being irrational is distinct in some way from not being how one ought to be; rationality is a concept distinct from normativity. Much of the literature on this topic over the last decade stems from attempts to capture the characteristic features of the requirements of rationality. Two influential views in particular did much to set the agenda. The first of these two was put forward John Broome.2 His view, the particulars of which I shall discuss in more detail below, is that the requirements of rationality could be expressed using a normative relation, which he calls a ‘normative requirement’. Normative requirements are conditionals governed by an all-thingsconsidered ought. In the case of rationality, the conditional is made up entirely of mental states.. (shrink)

The mystery of Aquinas's virtue ethics -- The gifts as second-personal dispositions -- Virtues and the second-person perspective -- The fruition of the virtues and gifts -- Conclusions and implications.

This paper argues that underlying social biases are able to affect the processes underlying linguistic interpretation. The result is a series of harms systematically inflicted on marginalised speakers. It is also argued that the role of biases and stereotypes in interpretation complicates Miranda Fricker's proposed solution to epistemic injustice.

One of the key achievements of critical realism has been to expose the modernist myth of universal reason, which holds that authentic knowledge claims must be objectively ‘pure’, uncontaminated by the subjectivity of local place, specific time and particular culture. Wright aims to address the lack of any substantial and sustained engagement between critical realism and theological critical realism with particular regard to: (a) the distinctive ontological claims of Christianity; (b) their epistemic warrant and intellectual legitimacy; and (c) scrutiny of (...) the primary source of the ontological claims of Christianity, namely the historical figure of Jesus of Nazareth. As such, it functions as a prolegomena to a much needed wider debate, guided by the under-labouring services of critical realism, between Christianity and various other religious and secular worldviews. This important new text will help stimulate a debate that has yet to get out of first gear. This book will appeal to academics, graduate and post-graduate students especially, but also Christian clergy, ministers and informed laity, and members of the general public concerned with the nature of religion and its place in contemporary society. (shrink)

From ancient times to the present, the discovery and presentation of new proofs of previously established theorems has been a salient feature of mathematical practice. Why? What purposes are served by such endeavors? And how do mathematicians judge whether two proofs of the same theorem are essentially different? Consideration of such questions illuminates the roles that proofs play in the validation and communication of mathematical knowledge and raises issues that have yet to be resolved by mathematical logicians. The Appendix, in (...) which several proofs of the Fundamental Theorem of Arithmetic are compared, provides a miniature case study. (shrink)

In this chapter, I present and explore various arguments for skepticism that are related to memory. My focus will be on the aspects of the arguments that are unique to memory, which are not shared, for example, by the more often explored skeptical arguments related to perception. -/- Here are some interesting upshots. First, a particular problem for justifiably concluding that one's memory is reliable is that any reasoning in favor of this conclusion will either result in epistemically circularity or (...) not be sufficient to justify the conclusion. Second, since many beliefs stored in memory do not appear to be based on evidence, it might also appear to follow that they are not justified. Third, although many stored memory beliefs are not based on stored memory experiences in the same way that perceptual beliefs are based on perceptual experiences, skeptical scenarios loom just as problematically for memory beliefs as they do for perceptual beliefs. (shrink)

Literature cultivates "deep selves" for whom books matter because they take over from religion fundamental questions about the meaning of existence. This volume embraces and questions this perspective, while also developing a "new humanist' critical vocabulary which specifies, and therefore opens to debate, the human significance of literature.

Organized across national boundaries and with millions of supporters worldwide, transnational environmental activist groups such as Greenpeace, the World Wildlife Fund, and Friends of the Earth play a central role in the way the world addresses environmental issues. This book provides the most systematic and theoretically informed study to date of the strategies these organizations use to advance global environmental protection. Based on case studies of three transnational groups, it argues that in addition to lobbying governments, activists operate within and (...) across societies to effect widespread change. They work through transnational social, economic, and cultural networks to alter corporate practices, educate vast numbers of people, pressure multilateral development banks, and shift standards of good conduct. Wapner argues that because this activity takes place outside the formal arena of inter-state politics, environmental activists practice "world civic politics"; they politicize global civil society. The theoretical import of this book is to bring the practice of world civic politics into sharp relief and generalize its significance beyond environmental affairs to explain the efforts of all NGOs in world politics. (shrink)

The obligations of organisations associated with policy formation and implementation of international mass public health programmes are explored. Lines of responsibility are considered to become unclear because of the large number of agencies associated with such programmes. A separation of the relevant obligations among the bodies responsible for the formulation and those responsible for the implementation of the policies is suggested. The continuing oral polio vaccine campaign against poliomyelitis in India is used to illustrate the general argument. Although the aim (...) of the programme is legitimate and laudable, unnecessary harm is currently being caused to some children as a result of elements of the policy and this should be rectified immediately. Such mass programmes should take care to ensure that people are not unnecessarily sacrificed in the drive to attain the desirable ends of the policy. (shrink)

The Report of the Ad Hoc Adivisory Group on the Operation of NHS Research Ethics Committees has resulted in a strange mixture of the timid, the revolutionary, and the bizarre.The Report of the Ad Hoc Advisory Group on the Operation of NHS Research Ethics Committees is a curious document.1 The remit of the review was focused on the workings and effectiveness of NHS research ethics committees and the multicentre committees ). The Group was primarily set up in response to a (...) series of complaints from medical researchers about the new research governance regime in the UK as a result of the Clinical Trials Directive2 and the Governance Arrangements for NHS Research Ethics Committees.3 The opportunity was also taken to consider the role of research ethics committees in a wider context, and take account of recent developments in relation to the ethics review of social care research,4 student projects,5 as well as recent legislation such as the Human Tissue Act,6 and the Mental Capacity Act.7 However, the resulting report is a strange mixture of the timid, the revolutionary, and the bizarre.A good example of the report’s timidity is its reluctance to propose fundamental change to the process of review or seriously limit the type of research that requires REC review. To its credit AHAG does suggest that some research ‘especially surveys and many studies on NHS staff, could normally be conducted safely without a requirement for REC review’ .1 This is, of course, to be welcomed. However, the report ultimately seems dismissive of the general complaint from researchers that the current process is inappropriately uniform. For example, in section 3.2, it is argued that the ‘common perception that the NHS REC system is dominated …. (shrink)

Some postcolonial theorists argue that the idea of a single system of belief known as "Hinduism" is a creation of nineteenth-century British imperialists. Andrew J. Nicholson introduces another perspective: although a unified Hindu identity is not as ancient as some Hindus claim, it has its roots in innovations within South Asian philosophy from the fourteenth to seventeenth centuries. During this time, thinkers treated the philosophies of Vedanta, Samkhya, and Yoga, along with the worshippers of Visnu, Siva, and Sakti, as (...) belonging to a single system of belief and practice. Instead of seeing such groups as separate and contradictory, they re-envisioned them as separate rivers leading to the ocean of Brahman, the ultimate reality. Drawing on the writings of philosophers from late medieval and early modern traditions, including Vijnanabhiksu, Madhava, and Madhusudana Sarasvati, Nicholson shows how influential thinkers portrayed Vedanta philosophy as the ultimate unifier of diverse belief systems. This project paved the way for the work of later Hindu reformers, such as Vivekananda, Radhakrishnan, and Gandhi, whose teachings promoted the notion that all world religions belong to a single spiritual unity. In his study, Nicholson also critiques the way in which Eurocentric concepts—like monism and dualism, idealism and realism, theism and atheism, and orthodoxy and heterodoxy—have come to dominate modern discourses on Indian philosophy. (shrink)