We demonstrate how different normalization techniques in GC‐MS analysis impart unique properties to the data, influencing any biological inference. Using simulations, and empirical data, we compare the most commonly used techniques (Total Sum Normalization ‘TSN’; Median Normalization ‘MN’; Probabilistic Quotient Normalization ‘PQN’; Internal Standard Normalization ‘ISN’; External Standard Normalization ‘ESN’; and a compositional data approach ‘CODA’). When differences between biological classes are pronounced, ESN and ISN provides good results, but are less reliable for more subtly differentiated groups. MN, TSN, and (...) CODA approaches produced variable results dependent on the structure of the data, and are prone to false positive biomarker identification. In contrast, PQN exhibits the lowest false positive rate, though with occasionally poor model performance. Because ESN requires extensive pre‐planning, and offers only mixed reliability, and ISN, TSN, MN, and CODA approaches are prone to introducing artefactual differences, we recommend the use of PQN in GC–MS research. (shrink)

The book roots corruption in the idea of a departure from conventional standards, and thus offers an account not only of its corrosiveness but also of its malleability and controversiality. In the course of a broadranging exploration, it examines various links between private and public corruption, connecting the latter with other social and political structures.

A new collection of essays edited by Michael J. Thompson aims to explicate and defend the humanist values which, according to the authors, were the core of Marx's critique of capitalist society. The text does not aim to provide a political roadmap to building an alternative society in which those values could be realized but rather philosophical analysis of the meaning and implications of those values. While there are sometimes tensions between the philosophical arguments developed in the various essays (...) that make up the text and the traditions of Marxist political practice, the book as a whole certainly proves that the human values of Marx's philosophy are central to his politics and that his emancipatory vision remains relevant, even necessary. (shrink)

In his interesting article, Michael Burke (1996) offers a novel solution to the puzzle of Tibbles, the cat, a solution he says, which is based on Aristotelian essentialism. In what follows I argue that, despite its ingenuity, Burke’s solution can be seen to be too implausible to be accepted once we extend it to a variant of the puzzle Burke himself suggests. The conclusion must be that one of the other solutions to the puzzle must be correct. Or, perhaps, (...) that there is no correct solution and that we should simply (to use a Wittgensteinian turn of phrase) ‘say what we like as long as we are clear about the facts.’. (shrink)

The concepts of time and identity seem at once unproblematic and frustratingly difficult. Time is an intricate part of our experience -- it would seem that the passage of time is a prerequisite for having any experience at all -- and yet recalcitrant questions about time remain. Is time real? Does time flow? Do past and future moments exist? Philosophers face similarly stubborn questions about identity, particularly about the persistence of identical entities through change. Indeed, questions about the metaphysics of (...) persistence take on many of the complexities inherent in philosophical considerations of time. This volume of original essays brings together these two essentially related concepts in a way not reflected in the available literature, making it required reading for philosophers working in metaphysics and students interested in these topics. The contributors, distinguished authors and rising scholars, first consider the nature of time and then turn to the relation of identity, focusing on the metaphysical connections between the two, with a special emphasis on personal identity. The volume concludes with essays on the metaphysics of death, issues in which time and identity play a significant role. This groundbreaking collection offers both cutting-edge epistemological analysis and historical perspectives on contemporary topics. Contributors:_ _Harriet Baber, Lynne Rudder Baker, Ben Bradley, John W. Carroll, Reinaldo Elugardo, Geoffrey Gorham, Mark Hinchliff, Jenann Ismael, Barbara Levenbook, Andrew Light, Lawrence B. Lombard, Ned Markosian, Harold Noonan, John Perry, Harry S. Silverstein, Matthew H. Slater, Robert J. Stainton, Neil A. Tognazzini The hardcover edition does not include a dust jacket. (shrink)

Transformation of the sparrow and the butterfly -- Meeting the gods of poverty in a dream -- The greatest joys of the cicada and its cast-off shell -- The owl's understanding -- The centipede questions the snake -- The toad's way of the gods -- The mysterious technique of the cat -- Afterword by William Scott Wilson.

One recurrent objection to the idea that the right kind of reasons for or against an attitude are object-given reasons for or against that attitude is that object-given reasons for or against belief and disbelief are incapable of explaining certain features of epistemic normativity. Prohibitive balancing, the behaviour of bare statistical evidence, information about future or easily available evidence, pragmatic and moral encroachment, as well as higher-order defeaters, are all said to be inexplicable in terms of those object-given reasons. In (...) this paper, I provide a rebuttal to all these challenges by drawing attention to the object-given reasons for and against the third doxastic state, namely the suspension of judgement. First, I introduce an original picture of how suspension relates to belief and disbelief – as ways of being decided – which yields a novel weighing model of the corresponding reasons. Second, I demonstrate that this new take on doxastic deliberation can accommodate all five features of epistemic normativity. Finally, I extend the weighing model to cover practical deliberation and the suspension of intentions. The resulting theory provides an explanation of why epistemic and practical normativity differ in certain respects in terms of a significant difference between doxastic and conative suspension. (shrink)

Was leistete der Gedanke der selbstandigen Auswahl (Eklektik) in der Geschichte der Philosophie von Aristoteles bis zum 20. Jahrhundert, wo liegen die Anwendungsgebiete, wo seine Grenzen und warum kam der Begriff der Eklektik schon im 18. Jahrhundert zur Bezeichnung unselbstandiger Vermischung herunter? Der Schwerpunkt der umfangreichen Arbeit liegt in der Philosophie und Naturwissenschaft des 17. Jahrhunderts; sie reicht aber bis zur eklektischen Psychotherapie der Gegenwart.

Apophaticism -- the view that God is both indescribable and inconceivable -- is one of the great medieval traditions of philosophical thought about God, but it is largely overlooked by analytic philosophers of religion. This paper attempts to rehabilitate apophaticism as a serious philosophical option. We provide a clear formulation of the position, examine what could appropriately be said and thought about God if apophaticism is true, and consider ways to address the charge that apophaticism is self-defeating. In so doing (...) we draw on recent work in the philosophy of language, touching on issues such as the nature of negation, category mistakes, fictionalism, and reductionism. (shrink)

Michael T. Ferejohn presents a new analysis of Aristotle's theory of explanation and scientific knowledge, in the context of its Socratic roots. Ferejohn shows how Aristotle resolves the tension between his commitment to the formal-case model of explanation and his recognition of the role of efficient causes in explaining natural phenomena.

We provide a new interpretation of Zeno’s Paradox of Measure that begins by giving a substantive account, drawn from Aristotle’s text, of the fact that points lack magnitude. The main elements of this account are (1) the Axiom of Archimedes which states that there are no infinitesimal magnitudes, and (2) the principle that all assignments of magnitude, or lack thereof, must be grounded in the magnitude of line segments, the primary objects to which the notion of linear magnitude applies. Armed (...) with this account, we are ineluctably driven to introduce a highly constructive notion of (outer) measure based exclusively on the total magnitude of potentially infinite collections of line segments. The Paradox of Measure then consists in the proof that every finite or potentially infinite collection of points lacks magnitude with respect to this notion of measure. We observe that the Paradox of Measure, thus understood, troubled analysts into the 1880’s, despite their knowledge that the linear continuum is uncountable. The Paradox was ultimately resolved by Borel in his thesis of 1893, as a corollary to his celebrated result that every countable open cover of a closed line segment has a finite sub-cover, a result he later called the “First Fundamental Theorem of Measure Theory.” This achievement of Borel has not been sufficiently appreciated. We conclude with a metamathematical analysis of the resolution of the paradox made possible by recent results in reverse mathematics. (shrink)

Proponents of zetetic encroachment claim that certain zetetic or inquiry-related considerations can have a bearing on the epistemic rationality of one’s belief formation. Since facts about the interestingness or importance of a topic can be the right kind of reasons for inquisitive attitudes, such as curiosity, and inquisitive attitudes are ways to suspend judgement, these facts also amount to reasons against believing. This mechanism is said to explain several contentious phenomena in epistemology, such as the occurrence of pragmatic encroachment. In (...) this paper, I provide two lines of reasoning against zetetic encroachment. First, on any contrastivist understanding of epistemic reasons, the case in favour of zetetic encroachment loses all its motivational force. Second, the thesis of zetetic encroachment is incompatible with the most promising way to understand degrees of inquisitive attitudes. (shrink)

This article challenges conventional readings of Michel Foucault by examining his fascination with neoliberalism in the late 1970s. Foucault did not critique neoliberalism during this period; rather, he strategically endorsed it. The necessary cause for this approval lies in the broader rehabilitation of economic liberalism in France during the 1970s. The sufficient cause lies in Foucault's own intellectual development: drawing on his long-standing critique of the state as a model for conceptualizing power, Foucault concluded, during the 1970s, that economic liberalism, (...) rather than “discipline,” was modernity's paradigmatic power form. Moreover, this article seeks to clarify the relationship between Foucault's philosophical antihumanism and his assessment of liberalism. Rather than arguing that Foucault's antihumanism precluded a positive appraisal of liberalism, or that the apparent reorientation of his politics in a more liberal direction in the late 1970s entailed a partial retreat from antihumanism, this article contends that Foucault's brief, strategic, and contingent endorsement of liberalism was possible precisely because he saw no incompatibility between antihumanism and liberalism—but only liberalism of the economic variety. Economic liberalism alone, and not its political iteration, was compatible with the philosophical antihumanism that is the hallmark of Foucault's thought. (shrink)

My topic is authenticity in or perhaps as painting, not the authenticity of paintings; I know next to nothing about the problem of verifying claims of authorship. I am interested in another kind of genuineness and fraudulence, the kind at issue when we say of a person that he or she is false, not genuine, inauthentic, lacks integrity, and, especially when we say he or she is playing to the crowd, playing for effect, or is a poseur. These are not (...) quite moral distinctions (no one has a duty to be authentic), but they are robustly normative appraisals, applicable even when such falseness is not a case of straight hypocrisy but of lack of self-knowledge or of self-deceit. (A person can be quite sincere and not realize the extent of her submission to the other’s expectations and demands.) This sort of appraisal also has a long history in post-Rousseauist reflections on the dangers of uniquely modern forms of social dependence, and they are prominent worries in the modern novel. (shrink)

Foundations of Relational Realism presents an intuitive interpretation of quantum mechanics, based on a revised decoherent histories interpretation, structured within a category theoretic topological formalism. -/- If there is a central conceptual framework that has reliably borne the weight of modern physics as it ascends into the twenty-first century, it is the framework of quantum mechanics. Because of its enduring stability in experimental application, physics has today reached heights that not only inspire wonder, but arguably exceed the limits of intuitive (...) vision, if not intuitive comprehension. For many physicists and philosophers, however, the currently fashionable tendency toward exotic interpretation of the theoretical formalism is recognized not as a mark of ascent for the tower of physics, but rather an indicator of sway—one that must be dampened rather than encouraged if practical progress is to continue. -/- In this unique two-part volume, designed to be comprehensible to both specialists and non-specialists, the authors chart out a pathway forward by identifying the central deficiency in most interpretations of quantum mechanics: That in its conventional, metrical depiction of extension, inherited from the Enlightenment, objects are characterized as fundamental to relations—i.e., such that relations presuppose objects but objects do not presuppose relations. The authors, by contrast, argue that quantum mechanics exemplifies the fact that physical extensiveness is fundamentally topological rather than metrical, with its proper logico-mathematical framework being category theoretic rather than set theoretic. -/- By this thesis, extensiveness fundamentally entails not only relations of objects, but also relations of relations. Thus, the fundamental quanta of quantum physics are properly defined as units of logico-physical relation rather than merely units of physical relata as is the current convention. Objects are always understood as relata, and likewise relations are always understood objectively. In this way, objects and relations are coherently defined as mutually implicative. The conventional notion of a history as “a story about fundamental objects” is thereby reversed, such that the classical “objects” become the story by which we understand physical systems that are fundamentally histories of quantum events. -/- These are just a few of the novel critical claims explored in this volume—claims whose exemplification in quantum mechanics will, the authors argue, serve more broadly as foundational principles for the philosophy of nature as it evolves through the twenty-first century and beyond. (shrink)

The contribution deals with the sources of Kant's criticism of the historical knowledge of philosophy. This criticism is an important motif in Kant's thought. Its contents are directed against Wolffianism. Nevertheless it was Christian Wolff who gave Kant the concept of the historical knowledge of philosophy. This concept is of great importance for Wolff, too. It can be traced back to the fight against Aristotelian scholastic philosophy. The reading of the traditional handbooks was criticized early, and the individual's own meditation (...) was challenged. Wolff formulated these intentions in his term: the historical knowledge of philosophy. Christian Thomasius and his followers, on the other hand, continued to criticize learning with the help of the memory, and they demanded the individual's own meditation. From this the slogan 'Selbstdenken' originated. Because of the opposition between the Wolffians and their opponents, for a long time 'self-thinking' and 'historical knowledge of philosophy' were treated side by side and independently of each other. Kant was the first to connect them definitively. He acknowledges the clarity of Wolff's terminology, but fills it up with the old content. (shrink)

Albert of Saxony was one of the great logicians of the Middle Ages, on a par with William Ockham and John Buridan. The Twenty-Five Disputed Questions on Logic treat of central issues in logic, both then and now, such as the nature of meaning, of universals, of truth, and of tense and modality; and the quality and quantity of propositions, the role of negation, and the relations of contradiction and equivalence between them. Dr. Fitzgerald has studied Albert's work extensively, and (...) previously edited the Twenty-Five Disputed Questions from the original manuscripts. This translation makes available for the first time in English this careful and exemplary examination of logical notions by an outstanding medieval thinker.-Stephen Read, University of St. Andrews. (shrink)

This book demonstrates that the important educational developments of the Elizabethan and early Stuart periods, which are often portrayed as new and revolutionary in nature, were in fact the culmination of an evolutionary process more than two centuries old. It also shows that popular literacy was considerably more widespread by the time of Spenser and Shakespeare than most recent studies suggest. The book treats the long period 1348–1648 as a unit by discounting the importance of the year 1485, which marked (...) the end of one dynasty and the beginning of another but had no discernible effect on educational and cultural conditions. Additionally, it argues that the massive changes of the final years of Henry VIII, which momentarily disrupted the universities and the grammar schools of the realm, were beneficial in the long run, since local energies were thereby unleashed and greater public support for educational institutions of all kinds soon materialized. A period of steady growth continued until the 1640s and 1650s, when the bitter experiences of the Civil War and rancorous arguments about the role of the universities and the grammar schools in precipitating the outbreak of hostilities caused the mainstream of public opinion to question the efficacy of advanced education, which increasingly came to be seen as a threat to established values and traditions. Thereafter an era of decline began that lasted until the mid-nineteenth century. Finally, the book treats the important contributions made by both clerics and women during the long period 1348–1648. Although laymen were the greatest beneficiaries of the steady widening of educational opportunity during those three centuries, clerics and women provided most of the funds, without which many fewer colleges, schools, and scholarships for poor boys would have been established. They did so because of their belief that improved education was necessary for the further spread of the Christian message. (shrink)

'Sustainable development ' is analysed as a product of the Modernist tradition, in which social criticism and understanding are legitimized against a background of evolutionary theory, scientific specialization, and rapid economic growth. Within this tradition, sustainable development emphasizes the need to live within ecological limits, but allows the retention of an essentially optimistic idea of progress. However, the inherent contradictions in the concept of sustainable development may lead to rejection of the Modernist view in favour of a new vision of (...) the world in which the authority of science and technology is questioned and more emphasis is placed on cultural diversity. (shrink)

The history of biochemistry and molecular biology is replete with examples of erroneous theories that persisted for considerable lengths of time before they were rejected. This paper examines patterns of dissolution of three such erroneous hypotheses: The idea that nucleic acids are tetrads of the four nucleobases (‘the tetranucleotide hypothesis’); the notion that proteins are collinear with their encoding genes in all branches of life; and the hypothesis that proteins are synthesized by reverse action of proteolytic enzymes. Analysis of these (...) cases indicates that amassed contradictory empirical findings did not prompt critical experimental testing of the prevailing theories nor did they elicit alternative hypotheses. Rather, the incorrect models collapsed when experiments that were not purposely designed to test their validity exposed new facts. (shrink)

The structure of the brain and the nature of evolution suggest that, despite its uniqueness, language likely depends on brain systems that also subserve other functions. The declarative / procedural model claims that the mental lexicon of memorized word- specific knowledge depends on the largely temporal-lobe substrates of declarative memory, which underlies the storage and use of knowledge of facts and events. The mental grammar, which subserves the rule-governed combination of lexical items into complex representations, depends on a distinct neural (...) system. This system, which is composed of a network of specific frontal, basal - ganglia, parietal and cerebellar structures, underlies procedural memory, which supports the learning and execution of motor and cognitive skills, especially those involving sequences. The functions of the two brain systems, together with their anatomical, physiological and biochemical substrates, lead to specific claims and predictions regarding their roles in language. These predictions are compared with those of other neurocognitive models of language. Empirical evidence is presented from neuroimaging studies of normal language processing, and from developmental and adult- onset disorders. It is argued that this evidence supports the DP model. It is additionally proposed that “ language ” disorders, such as specific language impairment and non-fluent and fluent aphasia, may be profitably viewed as impairments primarily affecting one or the other brain system. Overall, the data suggest a new neurocognitive framework for the study of lexicon and grammar. (shrink)

Michael Walzer; Education, Democratic Citizenship and Multiculturalism, Journal of Philosophy of Education, Volume 29, Issue 2, 30 May 2006, Pages 181–189, http.

This paper is an aesthetic analysis of the practice of serpent handling by Christians in the Appalachian region of the United States. The purpose of this analysis is to understand serpent handling's aesthetic relationship to the Pentecostal tradition and exposit the implications of this relationship for the practice's legal status. The first section examines the history and defining characteristics of serpent handling and introduces the controversial problem of whether the practice can be categorized within the Pentecostal movement. The second section (...) argues that serpent handling can be understood as belonging within the broader global Pentecostal tradition through engagement with the Pentecostal aesthetics of Nimi Wariboko. The final section concludes that if serpent handling is legible according to the aesthetic norms of Pentecostalism, a now broadly tolerated religious tradition in the United States, then this necessitates a wholesale reconsideration of antiserpent handling legislation. (shrink)

Much of the debate about identity in recent decades has been about personal identity, and specifically about personal identity over time, but identity generally, and the identity of things of other kinds, have also attracted attention. Various interrelated problems have been at the centre of discussion, but it is fair to say that recent work has focussed particularly on the following areas: the notion of a criterion of identity; the correct analysis of identity over time, and, in particular, the disagreement (...) between advocates of perdurance and advocates of endurance as analyses of identity over time; the notion of identity across possible worlds and the question of its relevance to the correct analysis of de re modal discourse; the notion of contingent identity; the question of whether the identity relation is, or is similar to, the composition relation; and the notion of vague identity. A radical position, advocated by Peter Geach, is that these debates, as usually conducted, are void for lack of a subject matter: the notion of absolute identity they presuppose has no application; there is only relative identity. Another increasingly popular view is the one advocated by Lewis: although the debates make sense they cannot genuinely be debates about identity, since there are no philosophical problems about identity. Identity is an utterly unproblematic notion. What there are, are genuine problems which can be stated using the language of identity. But since these can be restated without the language of identity they are not problems about identity. (For example, it is a puzzle, an aspect of the so-called “problem of personal identity”, whether the same person can have different bodies at different times. But this is just the puzzle whether a person can have different bodies at different times. So since it can be stated without the language of personal “identity”, it is not a problem about identity, but about personhood.) This article provides an overview of the topics indicated above, some assessment of the debates and suggestions for further reading. (shrink)

Michael Luntley provides a lively introduction to the debate over postmodernism. Sympathisers of the postmodernist critique of absolute knowledge have jetisoned concepts of reason,t ruth and self; this abandonment has fuelled their opponents' case against postmodernism. This has led them to ignore the very real problems raised by the postmodernists. Luntley offers a clear and careful exposition of how rational debate survives despite the Enlightenment's failings. _Reason, Truth and Self_ covers many of the key questions of our age: * (...) How rational is science? * Can we really know the truth about ourselves and the world? * What is the nature of the mind? * Can we know the difference between right and wrong? _Reason, Truth and Self_ is ideal for courses in philosophy and the social sciences. (shrink)

Michael Luntley provides a lively introduction to the debate over postmodernism. Sympathisers of the postmodernist critique of absolute knowledge have jetisoned concepts of reason,t ruth and self; this abandonment has fuelled their opponents' case against postmodernism. This has led them to ignore the very real problems raised by the postmodernists. Luntley offers a clear and careful exposition of how rational debate survives despite the Enlightenment's failings. _Reason, Truth and Self_ covers many of the key questions of our age: * (...) How rational is science? * Can we really know the truth about ourselves and the world? * What is the nature of the mind? * Can we know the difference between right and wrong? _Reason, Truth and Self_ is ideal for courses in philosophy and the social sciences. (shrink)

In this article, I consider whether Plantinga, in "Where the Conflict Really Lies," is a friend or an opponent of evolutionary science. First, I consider what sorts of things count as opposing evolutionary science. Second, I highlight three key questions, one having to do with whether God is specially involved in evolutionary history, and the other two having to do with the rationale for the answer to the first question. Third, I examine various answers to these three key questions, including (...) Plantinga’s in Where the Conflict Really Lies, and consider which of them are unfriendly to evolutionary science. I close with a few additional questions for Plantinga. (shrink)