The main objective of this article is to analyze the cognitive level of the activities in History textbooks in Spain, England, and Portugal in the transition stage from Primary to Secondary Education (11–13 years), according to the country of origin, typology, and the concepts and disciplinary contents included. The design of this research is quantitative, descriptive, and cross-sectional. The non-probabilistic sample consists of 6,561 activities contained in 27 school textbooks from Spain, England, and Portugal. Descriptive and contrast analyses have been (...) carried out using parametric tests. The results indicate that textbooks from Spain and Portugal mainly include activities situated between a basic and intermediate cognitive level while in England, the cognitive level of activities is medium or high. The ANOVA and TukeyBtests show significant differences between the cognitive level required in the activities and the typology of exercises, the concepts, and historical contents worked on. The activities with higher cognitive level correspond to those of creation and essays, the exercises that work on empathy and historical relevance, and that contain activities of social and economic history. In contrast, the activities with the lowest cognitive level are short questions and objective tests, those that work on first-order concepts (data and concrete facts), and those on the History of Art. The conclusion is that there is a need for a balanced presence of first-order content and historical thinking skills, the application in the classroom of a more active student-centered methodology, and the teachers’ conception of history teaching that prioritizes historical skills. (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

for everyone to handle indiscriminately, since it was something great and holy. 28. They were not wrong, were they? For you are the holy mother who by ...

The prevailing scientific paradigm is that matter is primary and everything, including consciousness can be derived from the laws governing matter. Although the scientific explanation of consciousness on these lines has not been realized, in this view it is only a matter of time before consciousness will be explained through neurobiological activity in the brain, and nothing else. There is an alternative view that holds that it is fundamentally impossible to explain how subjectivity can arise solely out of material processes—“the (...) hard problem of consciousness”—and instead consciousness should be regarded in itself as a primary force in nature. This view attempts to derive, for example, the laws of physics from models of consciousness, instead of the other way around. While as scientists we can understand and have an intuition for the first paradigm, it is very difficult to understand what “consciousness is primary” might mean since it has no intuitive scientific grounding. Here we show that worlds experienced through virtual reality are such that consciousness is a first order phenomenon. We discuss the Interface Theory of Perception which claims that in physical reality perceptions are not veridical and that we do not see the “truth” but that perception is based on evolutionary payoffs. We show that this theory may provide an accurate description of perception and consciousness within VR, and we put forward an experimental study that could throw light on this. We conclude that VR does offer an experimental frame that provides intuition with respect to the idea that “consciousness is first” and what this might mean regarding the perceived world. However, we do not draw any conclusions about the veracity of this notion with respect to physical reality or question the emergence of consciousness from brain function. (shrink)

Decision-making under normative uncertainty requires an agent to aggregate the assessments of options given by rival normative theories into a single assessment that tells her what to do in light of her uncertainty. But what if the assessments of rival theories differ not just in their content but in their structure -- e.g., some are merely ordinal while others are cardinal? This paper describes and evaluates three general approaches to this "problem of structural diversity": structural enrichment, structural depletion, and multi-stage (...) aggregation. All three approaches have notable drawbacks, but I tentatively defend multi-stage aggregation as least bad of the three. (shrink)

Sainz Rodríguez, P. Luis Vives y el Renacimiento en España.--Fontan, A. El latín de Luis Vives.--Jiménez Delgado, J. Nueves aportaciones al epistolario de Juan Luis Vives.--Swift, L. J. Somnium vivis y el Sueño de Escipión.--Etchegaray Cruz, A. Juan Vives, según Erasmo de Rotterdam.--Argudo Sánchez, F. Vives y el humanismo ciceroniano.

Este artículo propone un análisis de los Aforismos sobre religión y deísmo escritos por J. G. Fichte en 1790, poco antes de su conversión a la filosofía kantiana. Sostenemos que este texto no expresa la adhesión de Fichte al determinismo, ni al punto de vista del corazón, ni tampoco se limita a presentar la religión y el deísmo como dos sistemas opuestos. Según nuestra interpretación, Fichte defiende dos tesis. En primer lugar, que la mezcla de ambos sistemas es inaceptable y (...) hay que respetar el límite que existe entre ellos. En segundo lugar, que es imposible sostener ninguno de los dos sistemas, porque necesariamente entran en colisión y dejan al ser humano en una situación de desgarramiento. La conclusión del fragmento es, por lo tanto, la necesidad de buscar una posición superadora, que logre subsanar la escisión. Esa posición superadora será la Doctrina de la ciencia, que modifica los términos del planteo antagónico y logra la reconciliación de la libertad y la filosofía. This article proposes an analysis of the Aphorisms on Religion and Deism written by J. G. Fichte in 1790, shortly before his conversion to the Kantian philosophy. We argue that this text does not express Fichte’s accordance with determinism, or with the point of view of the heart, nor merely present religion and deism as two opposing systems. According to our interpretation, Fichte defends two theses. First, that the mixture of both systems is unacceptable and the limit between them must be respected. Secondly, that it is impossible to affirm neither of them, because they necessarily collide and leave the human being in a situation of scission. The conclusion of the fragment is, therefore, the need to seek a position that overcomes this situation of scission. That position will be the Doctrine of science, which amends the antagonistic terms of the dilemma and achieves the reconciliation between freedom and philosophy. (shrink)

The Ideas and Meditative Practices of Early Buddhism. Tilmann Vetter. E.J. Brill, Leiden 1988. xxxviii, 110 pp. Dfl.42.50.

Two essays on utilitarianism, written from opposite points of view, by J. J. C. Smart and Bernard Williams. In the first part of the book Professor Smart advocates a modern and sophisticated version of classical utilitarianism; he tries to formulate a consistent and persuasive elaboration of the doctrine that the rightness and wrongness of actions is determined solely by their consequences, and in particular their consequences for the sum total of human happiness. In Part II Bernard Williams offers a sustained (...) and vigorous critique of utilitarian assumptions, arguments and ideals. He finds inadequate the theory of action implied by utilitarianism, and he argues that utilitarianism fails to engage at a serious level with the real problems of moral and political philosophy, and fails to make sense of notions such as integrity, or even human happiness itself. This book should be of interest to welfare economists, political scientists and decision-theorists. (shrink)

Some of my best friends are women, but I would not want my sister to marry one of them. Modern-minded persons criticize me for manifesting such out-dated prejudices, and would like to send me to Coventry for a compulsory course of reindoctrination. They may be right. It could conceivably be the case that in due course the Sex Discrimination Act will be tightened up, even to the extent of our recognizing that there are no ‘good reasons why the State should (...) not recognize contracts which are in all respects like marriage, except for the sex of the parties concerned’. We can envisage a society so enlightened that the relations between men and women will be purely platonic and it will be a matter of no concern whether two people are members of the opposite sex or not: or, alternatively, our feelings could be so completely homogenized, that it will make no difference to an emotional relationship whether Leslie and Julian have only one Y-chromosome between them, or two, or none at all. In that event I shall be shown to be wrong, and my critics entitled to erect a monument to female equality on my grave. But I have doubts, and suspect that long after I am dead men will go on falling in love with women and women will continue to find their hearts wooed and won by men. And this fact, if it is a fact, makes a profound difference to our social institutions. I want to follow out the logic of social differentiation, relying as little as I can on putative facts about the differences between the sexes. Scientifically attested knowledge is scarce in this field. Many academics take refuge in a safe suspension of judgment, but this is a craven dereliction of duty. We have yet to develop an adequate theory of knowledge in social matters, and only by thrashing out the apparently telling arguments on this and similar issues can we clear our minds about the nature of social knowledge. Moreover, if those who might argue rationally draw back from doing so, they leave the field clear for others who suffer from fewer inhibitions and fewer scruples. And finally, serious social consequences can follow from public confusion about the logic of a situation, and what things are possible and what desirable. There is a danger that in our attempts to remedy the real wrongs done to women we shall only succeed, as with much modern legislation, in making a bad case worse. (shrink)

The old, mechanistic idea of nature is dying. We are witnessing the shift to a new idea, in which nature is seen as an organic system that includes human beings as one of its components rather than as brutal and ultimately self‐defeating conquistadores.

What obligations do global actors have to prevent terrorism? Is consent required to create an international obligation, or does the correctness of its goals ground its legitimacy? In this paper, I consider these questions with respect to a subset of international law often overlooked: anti-money laundering and combating the financing of terrorism . AML/CFT comprises peaceful response to violence and terrorism, making it a significant component of international justice and diplomacy. First, I present the current legal framework for AML/CFT institutions (...) and identify two conflicting sources of justification: objective value and consent. The fix for this problem, I argue, does not come from either component alone. Objective value cannot provide the sole source of justification because it cannot settle the choice between multiple competing norms that would achieve the same objective goods were we to follow them . Consent cannot provide the sole source of justification (‘the const.. (shrink)

The essay presents Giorgio Agamben’s theory of the paradigm in the first chapter of The Signature of All Things. On Method in order to better understand the well-known use of references to and qoutations from literature in philosophical reasoning and theory. Agamben’s uncommented reference to two short stanzas from Wallace Stevens’ poem “Description without Place”, which he consider the best definition of a paradigmatic ontology, is briefly commented. A gathering of three ‘literary singularities’ from Friedrich Hölderlin/Sophocles, James Joyce, and Samuel (...) Beckett in a suggested paradigm on time is presented as an example of a solely literary way of philosophical thinking. (shrink)

The old, mechanistic idea of nature is dying. We are witnessing the shift to a new idea, in which nature is seen as an organic system that includes human beings as one of its components rather than as brutal and ultimately self‐defeating conquistadores.

J.S. Mill's plural voting proposal in Considerations on Representative Government presents political theorists with a puzzle: the elitist proposal that some individuals deserve a greater voice than others seems at odds with Mill's repeated arguments for the value of full participation in government. This essay looks at Mill's arguments for plural voting, arguing that, far from being motivated solely by elitism, Mill's account is actually driven by a commitment to both competence and participation. It goes on to argue that, for (...) Mill, much of the value of political participation lies in its unique ability to educate the participants. That ability to educate is not, however, a product of participation alone; rather, for Mill, the true educative benefits of participation obtain only when competence and participation work together in the political sphere. Plural voting, then, is a mechanism for allowing Mill to take advantage of the educative benefits that arise from the intersection of competence and participation. (shrink)

European Journal of Philosophy, EarlyView.

Overview -/- Most philosophical explorations of responsibility discuss the topic solely in terms of metaphysics and the "free will" problem. By contrast, these essays by leading philosophers view responsibility from a variety of perspectives—metaphysics, ethics, action theory, and the philosophy of law. After a broad, framing introduction by the volume's editors, the contributors consider such subjects as responsibility as it relates to the "free will" problem; the relation between responsibility and knowledge or ignorance; the relation between causal and moral responsibility; (...) the difference, if any, between responsibility for actions and responsibility for omissions; the metaphysical requirements for making sense of "collective" responsibility; and the relation between moral and legal responsibility. (shrink)

In this paper I consider, in connection with dementia, two views of the person. One view of the person is derived from Locke and Parfit. This tends to regard the person solely in terms of psychological states and his/her connections. The second view of the person is derived from a variety of thinkers. I have called it the situated-embodied-agent view of the person. This view, I suggest, more readily squares with the reality of clinical experience. It regards the person as (...) embedded in a history and culture. The human person is also an embodied agent. I contend that this view encourages a more appropriate approach towards the ethical issues that arise in dementia and towards people with dementia. (shrink)

This article provides an overview of the origins and development of green chemistry. Aiming to contribute to the understanding of green chemistry, basically from a historical point of view, this overview argues that contextual influences and the user friendliness of the term are drivers for the explosive growth of green chemistry. It is observed that political support for its development has been significant, in which the Pollution Prevention Act of 1990 was a formal political starting-point, but informally the origins of (...) green chemistry go back to before 1990. US EPA played an important role in all this, but did not solely contribute to the growth of green chemistry. (shrink)

Atque illo die certe Aricia rediens devertit Clodius ad se in Albanum: quod ut sciret Milo ilium Ariciae fuisse, suspicari tamen debuit eum, etiam si Romam illo die reverti vellet, ad villam suam, quae viam tangeret, deversurum. THIS passage is interesting in that its argument runs counter to the main picture which Cicero had earlier presented of the movements of Milo and Clodius before they met on the Appian Way in January 52 B.C. In an earlier passage Cicero says: ‘Interim (...) cum sciret Clodius–neque enim difficile erat id scire–xiter sollemne, legitimum, necessarium ante diem XIII Kalendas Februarias Miloni esse Lanuvium ad flaminem prodendum, quod erat dictator Lanuvii Milo, Roma subito ipse profectus pridie est, ut ante suum fundum, quod re intellectum est, Miloni insidias conlocaret.’ Cicero remains true to this latter version in all the relevant arguments concerning the motives and movements of Clodius and Milo. Milo had legitimate business at Lanuvium, and hence a legitimate reason for being on the road at the time of the affray; Clodius′ presence is explained by Cicero as due solely to the desire to place an ambush for his enemy at a convenient spot, i.e. in front of his farm, and for this reason he had set out from Rome a day before Milo, when his presence was really required in Rome. (shrink)

Atque illo die certe Aricia rediens devertit Clodius ad se in Albanum: quod ut sciret Milo ilium Ariciae fuisse, suspicari tamen debuit eum, etiam si Romam illo die reverti vellet, ad villam suam, quae viam tangeret, deversurum.THIS passage is interesting in that its argument runs counter to the main picture which Cicero had earlier presented of the movements of Milo and Clodius before they met on the Appian Way in January 52 B.C. In an earlier passage Cicero says: ‘Interim cum (...) sciret Clodius–neque enim difficile erat id scire–xiter sollemne, legitimum, necessarium ante diem XIII Kalendas Februarias Miloni esse Lanuvium ad flaminem prodendum, quod erat dictator Lanuvii Milo, Roma subito ipse profectus pridie est, ut ante suum fundum, quod re intellectum est, Miloni insidias conlocaret.’ Cicero remains true to this latter version in all the relevant arguments concerning the motives and movements of Clodius and Milo. Milo had legitimate business at Lanuvium, and hence a legitimate reason for being on the road at the time of the affray; Clodius′ presence is explained by Cicero as due solely to the desire to place an ambush for his enemy at a convenient spot, i.e. in front of his farm, and for this reason he had set out from Rome a day before Milo, when his presence was really required in Rome. (shrink)

This book takes on two main tasks. The first is to argue that anti-hedonism lies at the center of Plato's critical project in both ethics and politics. Plato sees pleasure and pain as our sole sources of empirical evidence about good and bad. But as sources of evidence they are highly fallible; contrast effects with pain intensify certain pleasures, including most pleasures related to the body and social standing. This leads us to believe that the causes of such pleasures (e.g. (...) food, drink, sex, status) are greater goods than they are, and greater goods than other, more important goods (e.g. virtue, knowledge). As a result, hedonic error produces the belief that vice, including injustice, can be prudent. Hedonic error leads to other misconceptions of virtue as well, such as that wisdom is weak and can be ruled by the passions. These cognitive distortions can only be corrected by reference to some non-hedonic standard, so hedonists reliably fall prey to them. This entire system of attitudes—hedonism and its associated misconceptions of virtue—is widely held and constitutes popular morality. Popular morality's basic source is hedonic error, but it is also transmitted and sustained in society through shame and fear of punishment. However, avoiding shame and punishment requires a sort of double-think: adherents of popular morality must accept certain views that they cannot acknowledge too clearly or too publicly. For example, they must hold that injustice can be prudent and must be willing to wrong out-groups (e.g. another city), but openly acknowledging this same view threatens in-groups (one's own city) by implying willingness to wrong some in the city to benefit a closer in-group (e.g. one's class, clique, or family). // -/- The book's second task is to tackle a seeming outlier to Plato's anti-hedonism: the _Protagoras_, where Socrates appears to defend hedonism. I argue that the _Protagoras_ actually perfectly illustrates Plato's anti-hedonism, as explained above. Protagoras and other sophists think they shape public opinion, but in fact they have internalized popular morality through shame and fear. As a result, Protagoras accepts but refuses to openly endorse three parts of popular morality: that injustice can be prudent (333c), that pleasure is the good (351c-d), and that wisdom is weak and can be ruled by the passions (352c-d). Each time, his concealed view is (aptly!) attributed to "the many". So, when Socrates appears to endorse hedonism in the _Protagoras_, he actually introduces and develops the view as part of his examination of Protagoras' covert ethical commitments. (shrink)

Muddles can be instructive. The clarifying confusion to be examined in this paper is Isaiah Berlin's intelligent vacillation on the issue of whether or not the extent of a person's freedom depends on his desires. Is the amount of freedom an agent possesses determined solely by his objective circumstances or is it also partly a function of his subjective tastes and preferences? In clarifying this question I shall suggest that Berlin has trouble answering it because he almost perceives that interpersonal (...) cardinal measurement of freedom, if possible at all, is possible only on a subjective basis. Yet as Berlin eloquently reminds us measuring freedom according to a subjective metric generates paradox. Whether commonsense ideas of freedom are consistent and reasonable is not purely an academic issue, for we do often make political judgments to the effect that one or another policy, or a movement to one or another form of society, can be expected to reduce or enlarge human freedom. If freedom is not measurable these judgments are merely hortatory. (shrink)

In at least some of their forms, Cost-Benefit techniques for the evaluation of environmental projects and policies treat the preferences of citizens as the sole determinants of the value of outcomes. There are two salient ways in which this supposition might be defended. The first is metaethical and appeals to considerations about how we must understand talk of environmental and other values. The second is political and appeals to considerations about democratic legitimacy and the proper aims of public policy. Metaethical (...) considerations, I argue, are something of a red herring here. Roughly subjectivist understandings of our talk of values may be appealingly metaphysically unassuming, but in their most plausible formulations they do not support a view of preferences as the sole determinants of value. Political considerations, on the other hand, are to be taken very seriously. They offer, however, no straightforward rationale for any crudely preferentialist measure of social value. Findings obtained from the use of cost-benefit techniques might sometimes have a legitimate role as an input into, but not as a substitute for, political deliberation. Questions about the scope and limits of such legitimacy are properly addressed in political and not in metaethical terms. (shrink)

This essay argues that idleness as play and leisure would be recognised as an ideal over game playing in Bernard Suits’ Utopia. Idleness is unaccountably overlooked as an ideal by Suits, as is the problem that his description of game playing is an anachronism, pushing his Utopians into a pre-Utopian condition. There is room for playing games in an idle Utopia but in a less prominent and more restricted role. Idleness as play and leisure is not defended as the sole (...) ideal of Utopian existence though it is possibly that. Rather, it is presented as a compelling and preferable ideal for Suits’ Utopians, thus refuting his claim that game playing is ‘the only possible’ ideal of human existence in Utopia. (shrink)

The nature of linguistic understanding is a much-debated topic. Among the issues that have been discussed, two questions have recently received a lot of attention: (Q1) ‘Are states of understanding direct (i.e. represent solely what is said) or indirect (i.e. represent what is said as being said/asserted)?’ and (Q2) ‘What kind of mental attitude is linguistic understanding (e.g. knowledge, belief, seeming)?’ This paper argues that, contrary to what is commonly assumed, there is no straightforward answer to either of these questions. (...) This is because linguistic understanding cannot be identified with a single mental attitude towards a particular representation. Instead, we should characterize states of linguistic understanding as involving complex representational structures generated by a dual-stream process. The first stream operates on direct representations of what is said, while the second operates on representations of what is said as being said/asserted by a given source. Both these streams feed a situation model, i.e. a complex representation of a state of affairs described by a given piece of discourse. (shrink)

Held at Philadelphia for promoting useful knowledge.

Frege wanted to define the number 1 and the concept of number. What is required of a satisfactory definition? A truly arbitrary definition will not do: to stipulate that the number one is Julius Caesar is to change the subject. One might expect Frege to define the number 1 by giving a description that picks out the object that the numeral '1' already names; to define the concept of number by giving a description that picks out precisely those objects that (...) are numbers. Yet Frege appears to do no such thing. Indeed, when he defends his definitions, he does not argue that they pick out objects that we have been talking about all along-the issue never comes up. The aim of this paper is to explain why. I argue that, on Frege's view, our numerals do not, antecedent to his work, name particular objects. This raises an obvious question: If (like 'Odysseus') the numerals do not name particular objects, how can Frege write (as he does) as if sentences in which numerals appear state truths? One central concern of this paper is exegetical-to answer these questions. But my aim is not solely exegetical. For these questions direct us to something that, I believe, creates only an apparent problem for Frege but an actual problem for many contemporary philosophers: the assumption that singular terms appearing in statements about the world must actually have referents. Another aim of this paper is to suggest that the problem-as well as a solution that can be found in Frege's writings-should be of import to contemporary philosophers. (shrink)

In this article I rebut conservative objections to five phases of embryonic stem cell research. I argue that researchers using existing embryonic stem cell lines are not complicit in the past destruction of embryos because beneficiaries of immoral acts are not necessary morally tainted. Second, such researchers do not encourage the destruction of additional embryos because fertility clinics presently destroy more spare embryos than researchers need. Third, actually harvesting stem cells from slated-to-be-discarded embryos is not wrong. The embryos are not (...) sacrificed for the good of others because they would have been destroyed anyway. Fourth, harvesting stem cells from embryos that are not doomed is morally acceptable, because preserving frozen embryos is futile therapy. Finally, creating embryos solely for the sake of harvesting stem cells from them is morally acceptable because the assumption that embryos have the right to life has very counterintuitive implications. (shrink)

The validity of an entailment has nothing to do with whether or not the components are true, false, necessary, or impossible; it has to do solely with whether or not there is a necessary connection between antecedent and consequent. Hence it is a mistake (we feel) to try to build a sieve which will “strain out” entailments from the set of material or strict “implications” present in some system of truth-functions, or of truth-functions with modality. Anderson and Belnap (1962, p. (...) 47). (shrink)

The fundamental relations that underlie cognitive comparisons—“same” and “different”—can be defined at multiple levels of abstraction, which vary in relational complexity. We compared response times to decide whether or not two sequentially‐presented patterns, each composed of two pairs of colored squares, were the same at three levels of abstraction: perceptual, relational, and system (higher order relations). For both 150 ms and 5 s inter‐stimulus intervals (ISIs), both with and without a masking stimulus, decision time increased with level of abstraction. Sameness (...) at lower complexity levels contributed to decisions based on the higher levels. The pattern of comparison times across levelswas not predictable solely from encoding times. The results indicated that relations at multiple levels of complexity can be abstracted and compared in working memory, with higher complexity levels requiring more processing time. We simulated the impact of relational complexity on response time using Learning and Inference with Schemas and Analogies (LISA), a computational model of relational comparisons based on dynamic binding of elements into roles in a relational working memory. (shrink)

ABSTRACT One of the most perceptive and ambidextrous social commentators of our day, Augustinian scholar Jean Bethke Elshtain furnishes in ever fresh ways through her writings a bridge between the ancient and the modern, between politics and ethics, between timeless moral wisdom and cultural sensitivity. To read Elshtain seriously is to take the study of culture as well as the “permanent things” seriously. But Elshtain is no mere moralist. Neither is she content solely to dwell in the domain of the (...) theoretical. For it is Elshtain the citizen—the creatively engaged and contributing citizen—whom the reader encounters on virtually every page of her writings. But reader beware: Elshtain does not shy away from controversy. At the same time, she is anything but a controversialist. In the essay that follows, several prominent themes that emerge from Elstain's writings—civic responsibility, justice, gender, and war—are considered afresh. Whether one agrees with her positions or not, one is forced to confess in the end that she cares deeply about the common good. And this alone makes her required reading for any engaged citizen of the republic. (shrink)

Alluding to a passage in Plato’s Philebus Paul Ricoeur remarks, "Philosophy’s eminence lies in the art of arranging ordered manifolds". Whatever its general pertinence, this comment certainly applies to Ricoeur’s own work. The Rule of Metaphor, expertly translated from La métaphore vive, presents a multi-faceted approach to problems of metaphor and meaning that justifies the subtitle yet also manages to build up a coherent argument from ideas drawn from a wide variety of sources in philosophy and linguistics.

Traditionally, epistemologists have distinguished between epistemic and pragmatic goals. In so doing, they presume that much of game theory is irrelevant to epistemic enterprises. I will show that this is a mistake. Even if we restrict attention to purely epistemic motivations, members of epistemic groups will face a multitude of strategic choices. I illustrate several contexts where individuals who are concerned solely with the discovery of truth will nonetheless face difficult game theoretic problems. Examples of purely epistemic coordination problems and (...) social dilemmas will be presented. These show that there is a far deeper connection between economics and epistemology than previous appreciated. (shrink)

It is generally accepted that prion infection is due solely to a protein i.e. the protein-only hypothesis. The essential constituent of infectious prions is the scrapie prion protein (PrPSc) which is chemically indistinguishable from the normal, cellular protein (PrPC) but exhibits distinct secondary and tertiary structure. This very unusual feature seems to be in contradiction with a major paradigm of present structural biology stated by Anfinsen: a protein folds to the most stable conformation, this means only one structure.In order to (...) reconcile the results obtained on prions with the biophysics of protein folding, a model is proposed. It is based on the hypothesis that a thermodynamically irreversible step is involved in protein folding. The model is then extended to chaperone-assisted protein folding. It is shown that, under certain conditions, the transitory secondary structure formed during the earlier step of folding could interact with chaperone. Analysis shows that chaperone may help the protein to find correct conformation. On the other hand, analysis reveals the possibility that more than one structure may form from a single polypeptide chain. Under these conditions, the behaviour of chaperones resembles the characteristics of prion diseases. (shrink)