We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

ABSTRACT The emergence of the coronavirus disease 2019 pandemic has wide-ranging implications for the field of professional psychology. As clinical practice has rapidly adapted to ensure continuity of care, doctoral students have encountered unique opportunities for ethics-related competency development across practicum training settings. This article discusses the relevant American Psychological Association Ethics Code standards and additional ethical considerations facing trainees as they navigate their foundational clinical experiences and develop as professional psychologists in light of a pandemic.

An ethics primer for nurses and nursing students that advances a vision for a holistic Christian notion of health and explores what Christian faith means, on a practical level, for the practice of nursing.

Veganic agriculture, often described as farming that is free of synthetic and animal-based inputs, represents an alternative to chemical-based industrial agriculture and the prevailing alternative, organic agriculture, respectively. Despite the promise of veganic methods in diverse realms such as food safety, environmental sustainability, and animal liberation, it has a small literature base. This article draws primarily on interviews conducted in 2018 with 25 veganic farmers from 19 farms in the United States to establish some baseline empirical research on this farming (...) community. Its qualitative perspectives illuminate farmer perceptions of and experiences with veganic growing, including definitions, knowledge acquisition, values, and challenges. Results highlight a lack of agreement about the meaning of veganic agriculture in terms of allowable inputs and scope. Participants have drawn on a wide array of veganic and non-veganic resources to ascend their veganic production learning curves, also relying on experimentation and trial-and-error. Their farming is motivated by a diversity of real and perceived benefits, most notably consistency with veganism, food safety advantages, and plant and soil health benefits. Veganic product sourcing and the dearth of veganic agriculture-specific resources present considerable challenges to farmers. The article briefly discusses possibilities for developing veganic agriculture in the United States, such as through a US-based certification system and farmers’ associations, based on considerations of the trajectory of the US organic farming movement and veganic developments in Europe. Finally, the article suggests the importance of expanded research into soil health and fertility in plant-based systems to support practicing and potential veganic farmers. (shrink)

Prior to statistical mechanics and especially before the advent of the new quantum mechanics, it was traditionally held, following in the main the Kantian philosophy, that the task of science is to attain a unique quantitative representation of reality. It was thought—and with justifiable zeal—that a scientific discipline is exact to the extent to which a mathematical pattern yielding quantitative relations can be applied to its subject matter. This view was based on the implicit assumptions that functional relatedness conducive to (...) quantitative evaluation is bound to reveal the most generic, and hence, the most essential traits of events. (shrink)

This discussion seeks to highlight the ability of poetry to combat loneliness, a growing public health problem with significant negative health outcomes that potentially impact millions of Americans. We argue that poetry can play a very relevant role and have an impact in medicine. Through a brief literature review of previous studies on poetry in medicine, we demonstrate that poetry can not only combat loneliness but can also play important roles in helping patients, physicians, and other healthcare professionals/providers. Because of (...) the COVID-19 pandemic, we believe now is the perfect opportunity to utilize poetry because the benefits can be experienced even in solitude, which is why this is such a timely and pertinent issue today. (shrink)

In this article, I argue that Heidegger’s political failures haunt Arendt’s complex “phenomenology of thinking,” and, in the words of Richard Bernstein, “Arendt’s most novel and striking thesis—that there is an intrinsic connection between our ability or inability to think and evil—depends on discriminating the thinking that may prevent catastrophes from the thinking that does not.” The key to doing so, I suggest, is to attend more closely to Arendt’s persistent use of the language of stabilization, orientation, and navigation: in (...) other words, how we “take our bearings” in a world of perpetual change and motion. The ability to locate oneself in relation to the world is a recurrent theme in Arendt’s writings, and the metaphors of orientation appear frequently in her attempts to understand totalitarianism and Heidegger’s turn to National Socialism. Whereas most theorists collapse the idea of “taking our bearings” into judging, I argue that the activity of orientation should be theorized in its own right. As such, I explore the disorientation experienced during the traversal between thinking and acting via a close reading of Heidegger’s “Conversation on a Country Path About Thinking.” My reading illustrates how certain elements of the world, crucial to maintaining our bearings, fade from view while one is thinking. I conclude by discussing representative thinking as an explicitly political mode of thought that escapes some of the difficulties inherent in pure thinking—showing how it shores up those elements of the world that enable us to take our bearings. (shrink)

It is too often forgotten that even the most “objective” science such as physics is but a description, interpretation and ordering of physical reality from a selected point of view.In founding terrestial dynamics, Galileo, the father of modern experimental physics, selected concepts that could be given exact mathematical definitions and cast in a form conducive to quantitative results. The qualitative aspects of observed phenomena, such as the color of an accelerated body, and the ultimate cause of motion—a purely metaphysical problem—do (...) not enter into the mathematical dynamical system of Galileo. (shrink)

With the advent of the relativity theory science has entered a transformative period in which previous certainties are undergoing critical scrutiny and renovation. Critical movements in science arise at periods of its history when its foundations are brought into question. True it is that natural philosophers still regard science as a growing body of propositions dealing with natural events enabling them to find the structural laws of the external world. But this “external world” about them changes in significance, interpretation, and (...) meaning as new epoch-making theories are propounded and experimental verification of some of their consequences tend to give them scientific plausibility. (shrink)