We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

In Planned Parenthood v. Casey the Court argued that the Fourteenth Amendment protected “choices central to personal dignity and autonomy”. In...

D'où vient cette réalité historique particulière qu'est la morale protestante? C'est pour répondre à cette question que les deux premières parties de ce livre sont consacrées à une présentation des sources de l'éthique protestante, celles de la Réforme du 16e siècle (Luther et Calvin), et celles du puritanisme anglais. On découvrira à ce propos le lien étroit du protestantisme et de la modernité, pour le meilleur (démocratie) et pour le pire (utilistarisme). Dès lors, la question de l'avenir d'un tel lien (...) se pose et deux enjeux prioritaires sont ici mis en évidence : comment, dans une société sécularisée, faire valoir l'importance et la valeur d'une morale de conviction théologique? Comment, face à des phénomènes de retour régressif d'une religiosité irrationnelle, maintenir l'exigence d'une relation positive entre foi et raison, sagesse éthique et intelligences? Comment rester à la fois solidaire et critique de notre culture? Enfin l'auteur propose trois engagements spécifiques par quoi le protestantisme pourra prendre utilement sa part au débat contemporain sur la morale nécessaire à notre société actuelle. (shrink)

Reaching into our own time, _Crisis and the Apocalypse of Man_ confronts the disintegration of traditional sources of meaning and the correlative attempt to generate new sources of order from within the self. Voegelin allows us to contemplate the crisis in its starkest terms as the apocalypse of man that now seeks to replace the apocalypse of God. The totalitarian upheaval that convulsed Voegelin's world, and whose aftermath still defines ours, is only the external manifestation of an inner spiritual turmoil. (...) Its roots have been probed throughout the eight volumes of _History of Political Ideas,_ but its emergence is marked by the age of Enlightenment. In our postmodern era, discussions of the collapse of the "enlightenment project" have become commonplace. Voegelin compels us to follow the great-souled individuals who sought to go from disintegration of the present toward evocations of order for the future. Such thinkers as Comte, Bakunin, and Marx suffered through the crisis and fully understood the need for a new outpouring of the spirit. They resolved to supply the deficiency themselves. As a consequence they launched us irrevocably on the path of the apocalypse of man. One of the great merits of Voegelin's analysis is his exposition of the pervasive character of this crisis. It is not confined to the megalomaniacal dreamers of a revolutionary apocalypse; rather, echoes of it are found in the more moderate Enlightenment preoccupation with progress to be attained through application of the scientific method. Faith in the capacity of instrumental reason to answer the ultimate questions of human existence defined men such as Voltaire, Helvétius, Diderot, D'Alembert, and Condorcet. It remains the authoritative faith of our world today, Voegelin argues, demonstrated by our continuing inability to step outside the parameters of the Enlightenment. Are we condemned, then, to oscillate between the rational incoherence of a science that never delivers on its promises and a now discredited revolutionary idealism that wreaks havoc in practice? This is the question toward which Voegelin's final volume points. While not direct, his response is evident everywhere. _Crisis and the Apocalypse of Man_ could have been written only by a man who had reached his own resolution of the crisis. (shrink)

This paper attempts to shed light on Kant’s notion of autonomy in his moral philosophy by considering the extent to which he presents a similar doctrine in his theoretical philosophy, where he strikingly claims (e.g., in the Prolegomena) that the understanding prescribes laws to nature. It argues that even though there are important points of difference between the cases of theoretical legislation of the laws of nature and autonomy in moral philosophy, their extensive parallels make a strong, even if not (...) definitive case in favor of the Prolegomena forming at least an important part of the explanation of the emergence of autonomy in the Groundwork. In addition, the comparison proves instructive insofar as it reveals deep structural parallels between Kant’s theoretical and practical philosophy regarding his conception of laws. (shrink)

Luther's struggle with the forces and influences of late medieval culture for what he believed contributed to the birth of a new age.

Je m’oppose ici à la théorie « structurale » de la sensation développée par Kurt Koffka dans les années 1920, et reprise notamment par Merleau-Ponty, qui en fait le centre théorique des analyses de la psychologie de la forme. Je commence donc par examiner cette théorie et les faits sur lesquels elle repose, en montrant notamment, à l’aide de la méréologie husserlienne, qu’ils ne peuvent paraître corroborer une théorie structurale de la sensation que si l’on confond « abstraire » et (...) « séparer réellement » une qualité de son contexte. Il s’agit par là plus largement de montrer l’impossibilité, en fait comme en droit, de toute philosophie de la perception qui chercherait à réduire les sensations ou « qualia » à des prédicats relationnels. Je convoque alors William James à l’appui de ces conclusions, en rappelant qu’il avait déjà montré contre les théories néo-hégéliennes de son époque l’illégitimité de leur prétention à se réclamer de faits psychologiques similaires, et qu’il avait soutenu contre eux une théorie de la connaissance par accointance et de l’absoluité ontologique des qualités sensorielles que je cherche à reprendre à mon compte. (shrink)

Any future-oriented work, whether of academic or policy kind, needs a vision of the future, however vague. It is well known that such predictions are bound to be wrong, at least on the margin. The question is how to minimise that threat and make reliable assumptions. In this chapter we discuss a strategy of hypothetical retrospection. By imagining a future state of the world that is radically different from the present, we scrutinise hidden assumptions and suppositions taken for granted in (...) philosophical and policy visions of the future. More specifically, we discuss one example from political philosophy, which is John Rawls’s theorising about justice between generations, and three examples from policy, which are all from a Swedish context. We highlight some of the assumptions made in these disparate works, such as economic growth and acceptance of inequality. With the use of Tim Mulgan’s thought experiment of a ‘broken world’, where there are not enough resources to meet everyone’s basic needs, we, as it were, retrospectively assess the embedded assumptions. The main ambition is not to suggest that they are wrong from this perspective, but that the optimism they exhibit is not beyond doubt. (shrink)

My starting point is that discussions in philosophy about the ontology of technical artifacts ought to be informed by classificatory practices in engineering. Hence, the heuristic value of the natural-artificial distinction in engineering counts against arguments which favour abandoning the distinction in metaphysics. In this chapter, I present the philosophical equipment needed to analyse classificatory practices and then present a case study of engineering practice using these theoretical tools. More in particular, I make use of the Collectivist Account of Technical (...) Artifacts (CAT) according to which there are different classificatory practices for natural, artificial, and social objects. I demonstrate that in the community studied, artificial kinds are marked by distinctive classificatory practices. The presence of these distinctive classificatory practices in engineering with regard to artificial kinds should inform discussions about the ontology of technical artifacts just as the distinctive classificatory practices in natural science inform discussions about natural kinds. (shrink)

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and (...) made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

By endorsing the use of a vaccine that makes the experience of puffing on a cigarette deeply distasteful, Lieber and Millum have taken the first few tentative steps into a future filled with medical interventions that manipulate individual preferences. It is tempting to embrace the careful arguments of “Preventing Sin” and celebrate the possibility that the profound individual and social costs of smoking will finally be tamed. Yet there is something unsettling about the possibility that parental discretion may be on (...) the cusp of a radical expansion, one that involves a new and unexplored approach to behavior modification. (shrink)

Research on the perception of silence has led to insights regarding its positive effects on individuals. We conducted a series of studies during which individuals were exposed to several minutes of silence in different contexts. Participants were introduced to different social and environmental settings, either in a seminar room at a university or in a city garden, alone or in a group. Instructions across studies varied, as participants were exposed to real waiting situations, were asked to just think and to (...) explicitly experience the time interval without further instructions or following a session of Depth Relaxation Music Therapy (DRMT)/ Hypnomusictherapy (HMT). Silence was judged to significantly increase relaxation, improve mood states, and alter the perception of time and the orientation towards the present moment. We controlled for influences of trait variables, such as impulsivity, mindfulness, daydreaming, and time perspective. Findings empirically demonstrate that exposure to silence can be effective in therapeutic and educational contexts to promote relaxation and well-being. (shrink)

Explores the wealth of evidence for the reality of the human biofield. Looks at how energy therapies are now gaining acceptance due to irrefutable proof of their effectiveness for everything from PTSD to phantom limb pain. Examines the power of group energetics and team chemistry. Explains how the builders of Stonehenge and other sacred sites harnessed Earth energy and explores the subtle energetics of crop circles.

The history of ancient chemistry has been virtually ignored. I examine the foundations of the chemical theories of the Peripatetics and Stoics, in an attempt to glean the motivations for their chemical theories, and how these theories relate to their greater natural philosophies. This involves a detailed examination of ancient theories of mixture. I attempt to relate Aristotle's theory of mixture to his theories of substantial change, the elements and matter. This entails a rejection of the notion of prime matter, (...) and a reevaluation of the status of the contrarieties. I also look at the understudied fourth book of the Meteorologica, which sheds new light on Aristotle's theory of matter. I then turn to Alexander of Aphrodisias, and his development of Aristotle's theory. Next I consider the Stoic theory of body, and how doxographers have misinterpreted this theory. While offering a radically new interpretation of the Stoic theory of mixture, much of Stoic natural philosophy is reconstructed, including their theory of categories and qualities. In the end a Stoic theory free from obvious paradox is presented. (shrink)

Susan M. Turner has argued that the use of animal analogs ought to be considered categorically unethical on deontological, or rights-grounds, and that some but not all animal analogs are unethical on utilitarian grounds. I claim, on the contrary, that the use of most, if not all animal analogs can be justified from both the utilitarian and animal rights perspectives. Indeed, I believe that a convincing case is to be made for the thesis that animal analogs ought to be promoted (...) actively, on ethical grounds. I hold this to be true of both food and clothing replacement analogs, although I agree with Turner’s categorical condemnation of secondhand animal skin. I also hold that the general question of the preference for animal analogs over their original flesh and skin-based inspirations raises important questions about the relationship between ethics and aesthetics. I examine these in sympathy with the moderate aestheticist claims that some degree of distinction between these two spheres of value is desirable, and that the sublimation of powerful and problematical urges is normally preferable to their suppression. (shrink)