Summary While historians have dealt with the origins of the concept of drug receptors in the work of Paul Ehrlich (1854–1915) and John N. Langley (1852–1925) as well as with some of its applications in modern pharmaceutical research, the history of the receptor theory as such has been neglected. Discussing major developments and conceptual changes in receptor theory between about 1910 and 1960 (including relevant contributions by A. V. Hill, A. J. Clark, J. H. Gaddum, E. J. Ariëns and (...) others), this paper attempts to fill this gap in historiography. It provides a case study of the unfolding of research under a new paradigm, but it considers also contemporary criticism and scepticism. By the early 1960s, quantitative investigations of drug action and interpretations of the experimental findings in terms of the receptor concept had become constitutive of the emerging field of ‘molecular pharmacology’. Even then, however, receptors were still hypothetical entities. (shrink)

This stimulating collection of essays in ethics eschews the simple exposition and refinement of abstract theories. Rather, the author focuses on everyday moral issues, often neglected by philosophers, and explores the deeper theoretical questions which they raise. Such issues are: Is it wrong to tell a lie to protect someone from a painful truth? Should one commit a lesser evil to prevent another from doing something worse? Can one be both autonomous and compassionate? Other topics discussed are servility, weakness of (...) will, suicide, obligations to oneself, snobbery, and environmental concerns. A feature of the collection is the contrast of Kantian and utilitarian answers to these problems. The essays are crisply and lucidly written and will appeal to both teachers and students of philosophy. (shrink)

In the first chapter of his Knowledge and Lotteries, John Hawthorne argues that thinkers do not ordinarily know lottery propositions. His arguments depend on claims about the intimate connections between knowledge and assertion, epistemic possibility, practical reasoning, and theoretical reasoning. In this paper, we cast doubt on the proposed connections. We also put forward an alternative picture of belief and reasoning. In particular, we argue that assertion is governed by a Gricean constraint that makes no reference to knowledge, and that (...) practical reasoning has more to do with rational degrees of belief than with states of knowledge. (shrink)

The type identity theory, according to which types of mental state are identical to types of physical state, fell out of favour for some years but is now being considered with renewed interest. Many philosophers are critically re-examining the arguments which were marshalled against it, finding in the type identity theory both resources to strengthen a comprehensive, physicalistic metaphysics and a useful tool in understanding the relationship between developments in psychology and new results in neuroscience. This volume brings together leading (...) philosophers of mind, whose essays challenge in new ways the standard objections to type identity theory, such as the multiple realizability objection and the modal argument. Other essays show how cognitive science and neuroscience are lending new support to type identity theory and still others provide, extend and improve traditional arguments concerning the theory's explanatory power. (shrink)

The modal account of luck is the predominant account of luck in epistemology and ethics. In the first half of this paper, I discuss three possible interpretations of the modal account and raise objections to each. I then raise an objection to all plausible versions of the modal account, that is, that whether an event is lucky or the extent to which it is a matter of luck will depend on what initial conditions or features of the event one holds (...) constant across nearby possible worlds. However, there is often reasonable disagreement about what the relevant initial conditions of an event are, and the modal account of luck has no means of determining which description of the event is correct. As such, the modal account is subject to a kind of reference class problem, and the view cannot actually tell us the extent to which certain events are a matter of luck. (shrink)

Many philosophers, psychologists, and medical practitioners believe that killing is no worse than letting die on the basis of James Rachels's Bare-Difference Argument. I show that his argument is unsound. In particular, a premise of the argument is that his examples are as similar as is consistent with one being a case of killing and the other being a case of letting die. However, the subject who lets die has both the ability to kill and the ability to let die (...) while the subject who kills lacks the ability to let die. Modifying the latter example so that the killer has both abilities yields a pair of cases with morally different acts. The hypothesis that killing is worse than letting die is the best explanation of this difference. (shrink)

There are two main accounts of what it is for external objects to be presented in visual experience. According to particularism, particular objects are built into the representational contents of experiences. Existentialism is a quite different view. According to existentialism, the representational contents of perceptual experiences are general rather than particular, in the sense that the contents can be fully captured by existentially quantified statements. The present paper is a defense of existentialism. It argues that existentialism is much better equipped (...) than particularism to explain the contents of hallucinations, and it defends existentialism against three objections. (shrink)

Reports of the Intergovernmental Panel on Climate Change (IPCC) employ an evolving framework of calibrated language for assessing and communicating degrees of certainty in findings. A persistent challenge for this framework has been ambiguity in the relationship between multiple degree-of-certainty metrics. We aim to clarify the relationship between the likelihood and confidence metrics used in the Fifth Assessment Report (2013), with benefits for mathematical consistency among multiple findings and for usability in downstream modeling and decision analysis. We discuss how our (...) proposal meshes with current and proposed practice in IPCC uncertainty assessment. (shrink)

For any essential property God has, there is an ability He does not have. He is unable to bring about any state of affairs in which He does not have that property. Such inabilities seem to preclude omnipotence. After making trouble for the standard responses to this problem, I offer my own solution: God is not omnipotent. This may seem like a significant loss for the theist. But I show that it is not. The theist may abandon the doctrine that (...) God is omnipotent without scaling back the extent of His power and without denying that He has all perfections. (shrink)

Most areas of philosopher Edmund Husserl’s thought have been explored, but his views on logic, mathematics, and semantics have been largely ignored. These essays offer an alternative to discussions of the philosophy of contemporary mathematics. The book covers areas of disagreement between Husserl and Gottlob Frege, the father of analytical philosophy, and explores new perspectives seen in their work.

This is a new edition of T. H. Green's Prolegomena to Ethics (1883), a classic of modern philosophy, in which Green sets out his perfectionist ethical theory. In addition to the text of the Prolegomena itself, this new edition provides an introductory essay, a bibliographical essay, and an index. Brink's extended editorial introduction examines the context, themes, and significance of Green's work and will be of special interest to readers working on the history of ethics, ethical theory, political philosophy, and (...) nineteenth century philosophy. (shrink)

Visual experience is shaped by a number of factors that are independent of the external objects that we perceive—factors like lighting, angle of view, and the sensitivities of photoreceptors in the retina. This paper seeks to catalog, analyze, and explain the fluctuations in visual phenomenology that are due to such factors.

In an important and widely cited paper, Zerilli, Knott, Maclaurin, and Gavaghan (2019) argue that opaque AI decision makers are at least as transparent as human decision makers and therefore the concern that opaque AI is not sufficiently transparent is mistaken. I argue that the concern about opaque AI should not be understood as the concern that such AI fails to be transparent in a way that humans are transparent. Rather, the concern is that the way in which opaque AI (...) is opaque is very different than the way in which humans are opaque. What matters is the degree to which the opaque processes of a class of decision makers are stable, uniform, and safe. The degree to which such processes have these features in humans is higher than the degree to which such processes have these features in opaque AI. And therefore we should require AI to be more transparent than humans. (shrink)

I present a counterexample to Kirk-Giannini’s Dilemmatic Theory of gaslighting.

The modal account of luck is the predominant account of luck in epistemology and ethics. In the first half of this paper, I discuss three possible interpretations of the modal account and raise objections to each. I then raise an objection to all plausible versions of the modal account, that is, that whether an event is lucky or the extent to which it is a matter of luck will depend on what initial conditions or features of the event one holds (...) constant across nearby possible worlds. However, there is often reasonable disagreement about what the relevant initial conditions of an event are, and the modal account of luck has no means of determining which description of the event is correct. As such, the modal account is subject to a kind of reference class problem, and the view cannot actually tell us the extent to which certain events are a matter of luck. (shrink)

It is often assumed that all lucky events are significant. The thought is that a chancy event such as winning the lottery is lucky for you in part because it affects your interests or well-being. But whether you win an Absurdist Raffle in which there are no prizes, is, intuitively, not a matter of luck. This is because this event—even if chancy—is not significant for any subject. However, a few philosophers have recently claimed not only that luck does not necessarily (...) involve a significance condition but that we should not view luck involving claims in terms of significance. After reviewing the literature on this topic, I argue that lucky events are significant. A significance condition is necessary to distinguish between different kinds of luck: practical, epistemic, and moral. All lucky events are significant and chancy, but they can be significant for subjects in different ways. For example, an event is epistemically lucky for you if it is epistemically significant and chancy, but such events need not affect your practical interests or moral standing. Furthermore, I argue that events that are chancy but not significant should be thought of in terms of chance and not luck. (shrink)

If moral properties lacked causal powers, would moral skepticism be true? I argue that it would. Along the way I respond to various arguments that it would not.

Philosophical Issues, Volume 30, Issue 1, Page 175-191, October 2020.

Abstract:The standard, Bayesian account of rational belief and decision is often argued to be unable to cope properly with severe uncertainty, of the sort ubiquitous in some areas of policy making. This paper tackles the question of what should replace it as a guide for rational decision making. It defends a recent proposal, which reserves a role for the decision maker’s confidence in beliefs. Beyond being able to cope with severe uncertainty, the account has strong normative credentials on the main (...) fronts typically evoked as relevant for rational belief and decision. It fares particularly well, we argue, in comparison to other prominent non-Bayesian models in the literature. (shrink)

This paper presents quantitative data on altruistic cooperation during food acquisition by Ache foragers. Cooperative activities are defined as those that entail a cost of time and energy to the donor but primarily lead to an increase in the foraging success of the recipient. Data show that Ache men and women spend about 10% of all foraging time engaged in altruistic cooperation on average, and that on some days they may spend more than 50% of their foraging time in such (...) activities. The most time-consuming cooperative activity for both sexes is helping during the pursuit of game animals, a pattern that is probably linked to the widespread sharing of game by Ache foragers. Cooperative food acquisition and subsequent food redistribution in hunter-gatherer societies are critical behaviors that probably helped shape universal, evolved, cooperative tendencies that are well illustrated in modern experimental economics. (shrink)

Theological schools are well situated to create intentional cultures for the purpose of spiritual formation. Indeed, most schools of theology have this goal as an essential part of their mission as well as a requirement for continued accreditation. And yet, the measurement of spiritual formation over time is fraught with challenges. This article seeks to address some of these challenges by means of developing a meta-theory of positive change/growth which would eventually serve as a theoretical basis for the development of (...) a generalizable and reliable measurement tool. (shrink)

We propose an Analogy Principle in the context of Unary Inductive Logic and characterize the probability functions which satisfy it. In particular in the case of a language with just two predicates the probability functions satisfying this principle correspond to solutions of Skyrmsʼ ‘Wheel of Fortune’.

The computational genomics community has come increasingly to rely on the methodology of creating annotations of scientific literature using terms from controlled structured vocabularies such as the Gene Ontology (GO). We here address the question of what such annotations signify and of how they are created by working biologists. Our goal is to promote a better understanding of how the results of experiments are captured in annotations in the hope that this will lead to better representations of biological reality through (...) both the annotation process and ontology development, and in more informed use of the GO resources by experimental scientists. (shrink)

I defend a solution to the puzzle of petitionary prayer based on some ideas of Aquinas, Gregory the Great, and contemporary desert theorists. I then address a series of objections. Along the way broader issues about the nature of desert, what is required for an action to have a point, and what is required for a puzzle to have a solution are discussed.

Many philosophers and members of the public think it is wrong to procreate. If one wants children, it is permissible to adopt. But procreation is allegedly impermissible because there is some respect in which adoption is better than procreation. I show that such objections are unsound.

Berkeley argues that our ideas cannot represent external objects, because only an idea can resemble an idea. But he does not offer any argument for the claim that an idea can represent only what it resembles - a premise essential to his argument. I argue that this gap can be both historically explained and filled by examining the debates between Cartesians and sceptics in the late seventeenth century. Descartes held that representation involves two relations between an idea and its object (...) ? resemblance and causation ? and that these relations are very closely linked to each other. I look at variations upon this claim in later Cartesians, especially Desgabets and Régis. I also examine the critics who attacked this claim, especially Huet, Foucher, and Du Hamel, who developed arguments similar to Berkeley's but concluded that (Cartesian) representation is simply impossible. I also argue that Malebranche, although an adherent of the Cartesian theory of intentionality, used a modified version of this argument to argue for his claim that ideas do not exist in the mind at all. These thinkers, and especially Malebranche, provide the context in which we should understand Berkeley. (shrink)

Epistemic accounts of luck define luck’s chanciness condition relative to a subject’s epistemic position. This could be put in terms of a subject’s evidence or knowledge about whether the event will occur. I argue that both versions of the epistemic account fail. In §2, I give two types of counterexamples to the evidence-based approach. In §3, I argue—contrary to the knowledge-based view—that an event can be a matter of good or bad luck for a subject even if she knows that (...) it will occur. In §4, I argue that epistemic accounts cannot explain some instances of constitutive luck. Because of these problems, luck’s chanciness condition cannot be adequately defined in epistemic terms. (shrink)

Timothy Hsiao asks a good question: Why believe animals deserve moral consideration? His answer is that we should not. He considers various other answers and finds them wanting. In this paper I consider an answer Hsiao has not yet discussed: We should accept a conservative view about how to form beliefs. And such a view will instruct us to believe that animals deserve moral consideration. I think conservatives like Hsiao do best to answer his question in a way that upholds (...) the moral status of animals. Since my answer is one Hsiao has not yet addressed, it is compatible with the main points he makes against various other motivations in his many papers on this topic. So my paper should be understood as an invitation to Hsiao to consider another answer. (shrink)

I have taken a Kantian approach to the issue of pornography and degradation. My thesis is that by perpetuating derogatory myths about womankind, for the sake of financial gain, the pornography industry treats the class of women as a means only, and not as composed of individuals who are ends in themselves. It thus de-grades all women, as members of this class, imputing to them less than full human status.

This article examines some philosophical questions about knowledge of modality, including how we determine whether a proposition is necessary or contingent and what procedures to use for recognizing possibility. It maintains that virtually anything is conceivable, and that conceivability is therefore incapable of providing a reliable test for possibility. Whether a conceivable state of affairs is genuinely possible depends on whether it is compatible with the class of necessary truths. But this means that we must have some independent way of (...) recognizing necessity. The article explains that independent access to necessity in terms of the hypothesis that various modal truths constitute an implicit definition of necessity. To a large extent, our knowledge of necessity derives from our grasp of this definition. The article also criticizes Cartesian modal arguments for dualism, and raises an objection to the view that metaphysical necessity can be reductively explained in terms of subjunctive conditionals. (shrink)

This contrasts Kant's view of conscience, and its merits, with alternative views. These alternatives are a popular religious view, a social relativist conception, and Joseph Butler's philosophical account. Kant's view avoids the epistemological problems of the first view, but accepts its idea that conscience is often experienced as an unsolicited voice. Kant denies the metaethical scepticism of social relativists, but agrees with them that conscience expresses a dissonance between our acts and our moral beliefs rather than an independent perception of (...) what is truly right or wrong. Kant agrees with Butler that reason, in due reflection, is the source of justified moral beliefs, but he distinguishes moral reasoning and judgement about what acts are permissible from conscience, which is an inner forum in which a verdict of innocence or guilt is pronounced on the basis of the moral beliefs that we already have. (shrink)

It is a matter of contention whether or not a general explanatory framework for the biological sciences would be of scientific value, or whether it is even achievable. In this paper we suggest that both are the case, and we outline proposals for a framework capable of generating new scientific questions. Starting with one clear characteristic of biological systems – that they all have the potential to make mistakes - we aim to describe the nature of this potential and the (...) common processes that lie behind it. Given that under most circumstances biological systems function effectively, an examination of different kinds of mistake-making provides pointers to mechanisms that must exist to make failure uncommon. This in turn informs a framework for systematic enquiry, which in this paper we apply to the haemostatic system, but which we believe could be applied to any system across biology. (shrink)

We discuss how the law and scholars have approached three questions. First, what acts count as acts of entrapment? Secondly, is entrapment a permissible method of law-enforcement and, if so, in what circumstances? Thirdly, what must criminal courts do, in response to the finding that an offence was brought about by an act of entrapment, in order to deliver justice? While noting the contrary tendency, we suggest that the first question should be addressed in a manner that is neutral about (...) the answers to the other two. On the second question, we summarize various arguments about the permissibility of entrapment, while remaining largely neutral about their merits. With regard to the third question, we summarize the approaches to entrapment in various jurisdictions, and we note some patterns, across the jurisdictions here surveyed, concerning shifts from one sort of entrapment remedy to another. (shrink)

This paper takes under consideration a piece by Roger Crisp in which he questions what the problem of moral luck can teach us about COVID-19 lockdown rule-breakers. Taking the position that although such rule-breakers might seem to be new examples of moral luck, Crisp ends up denying the existence of moral luck and argues that moral luck is an outdated notion in so far as it relies on other questionable aspects of morality, that is, retributivist punishment and blame. Although the (...) author agrees with Crisp that pandemic rule-breaker cases are putative examples of resultant moral luck, he proposes that Crisp has misconstrued what moral luck is and the paper examines in detail what he sees as the numerous problems with Crisp’s claims. The author concludes that Crisp’s analysis of pandemic rule-breaking does not shed any new light on the moral luck debate, and the difficult questions of luck, moral responsibility, and desert are not so easily resolved. -/- . (shrink)