In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...) domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. (shrink)

Infection by a temperate phage can lead to death of the bacterial cell, but sometimes these phages integrate into the bacterial chromosome, offering the potential for a more long-lasting relationship to be established. Here we define three major ecological and evolutionary benefits of temperate phage for bacteria: as agents of horizontal gene transfer, as sources of genetic variation for evolutionary innovation, and as weapons of bacterial competition. We suggest that a coevolutionary perspective is required to understand the roles of (...) temperate phages in bacterial populations. The dual personality of temperate phages – as infectious lytic phages or prophages integrated within the bacterial genome – creates a complex interaction with bacterial hosts. Although potentially lethal, prophages confer a multitude of benefits for the host, suggesting the potential for both conflict and collaboration which must be viewed from a coevolutionary perspective that considers both host and phage fitness interests. (shrink)

Two general features of metameric patterning in Drosophilaare considered: (1) maintenance of a constant number of metameres (segments or parasegments) in the face of variation in length of the embryo; (2) expression of pattern by on‐off switchings of particular genes, with only three or four rows of cells to each element of pattern. For each of these features, the general strategic question is raised: could reaction‐diffusion theory account for this? In both cases, it is answered affirmatively. For the second feature, (...) this review contains some hitherto unpublished computer simulations by one of us (K. Y. T.), illustrating that a reaction‐diffusion mechanism can be transformed into a patterned switching mechanism by nothing more than compartmenting of the diffusion region. For the scale of three compartments to one pattern repeat unit (representing three rows of cells to a segment) the switching pattern predicted by computation is two‐off to one‐on. This resembles the pattern of expression of the engrailed gene, posteriorly localized in each segment. (shrink)

Recent work by Jaegwon Kim and others suggest that functionalism leaves mental properties causally inefficacious in some sense. I examine three lines of argument for this conclusion. The first appeals to Occam's Razor; the second appeals to a ban on overdetermination; and the third charges that the kind of response I favor to these arguments forces me to give up "the homogeneity of mental and physical causation". I show how each argument fails. While I concede that a positive theory of (...) mental causation is desirable, there is no reason to think that functionalism renders such a theory unattainable. (shrink)

Poetic and dramatic readings of selected Platonic dialogues show the fallacy of the philosophical and political positions usually attributed to Plato. Dialogues dealt with include Apology, Meno, Ion, Republic, Theaetetus, Euthyphro, Laws.

The Ethical Journalist gives aspiring journalists the tools they need to make responsible professional decisions. Provides a foundation in applied ethics in journalism Examines the subject areas where ethical questions most frequently arise in modern practice Incorporates the views of distinguished print, broadcast and online journalists, exploring such critical issues as race, sex, and the digitalization of news sources Illustrated with 24 real-life case studies that demonstrate how to think in 'shades of gray' rather than 'black and white' Includes questions (...) for class discussion and guides for putting important ethical concepts to use in the real world Accompanying website includes model course schedules, discussion guides, PowerPoint slides, sample quiz and exam questions and links to additional readings online: www.wiley.com/go/foreman. (shrink)

Attentional focus is an area that has garnered considerable attention in the sport psychology and motor performance literature. This is unsurprising given that attentional focus has been directly linked to performance outcomes and is susceptible to coaching input. While research has amassed supporting benefits of an external focus of attention on motor performance using verbal instruction, other studies have challenged the notion that an EFA is more beneficial than an internal focus of attention for sport-related performance. Further, it is unclear (...) what type of instructions may serve to direct an athlete to an EFA and, in particular, if coaching can utilize imagery to orient an athlete toward an EFA. In the present exploratory study, we evaluate the effectiveness of instruction to improve free-throw shooting performance with an emphasis on an EFA brought about by implementing techniques borrowed from the imagery literature. This was tested relative to an alternate approach with an IFA induced through an emphasis on technique, devised to more closely resemble input typical of coach-to-athlete instruction. Twenty-five male and female university basketball players completed both conditions in a fully counterbalanced within-subject design. Results confirmed that participants in the EFA imagery condition had greater shooting accuracy than in the IFA technique condition. The study provides initial evidence that EFA coaching can borrow from imagery techniques, though future research should elucidate the underlying mechanisms of the effect. (shrink)

Tyler Cowen's ?Why Keynesianism Triumphed? proposed that only Keynesian economists have presented a successful explanation for the Great Depression of 1929?1933 and the continuing slow and intermittent recovery of the rest of the 1930s. This paper examines recent scholarship on the 1930s and finds that there is increasing doubt about the validity of Keynesian explanations, lending credence to both older and recent scholarship that vindicates free?market views of why the Depression happened and why the recovery was so slow and uneven.

Theological and secular concepts ofstewardship evolved markedly in the 20thcentury. During this period of evolution, theAmerican Country Life Association through itschurch, academic, farm organization, andgovernmental affiliations, served as a bridgingand bonding agent in developing the stewardshipidea. As in any evolutionary process, thestewardship concept was subjected to a broadarray of influences and characterized bynotable highlights such as the Lynn Smithcritique of the Judaeo-Christian ethic, theman-in-nature statement of Douglas John Hall,and the environmental concerns of ecologistsand philosophers of the post-Rachel Carson era.Some gains (...) have been made in understanding theplace of humans in nature, but the stewardshipidea continues as work in process. (shrink)

In a very literarily complicated setting, Frater Taciturnus sets a remark about Hamlet not being a Christian tragedy. After unpeeling that literary setting and noting that Taciturnus' remark aims more at Jacob Börne than at Shakespeare, the paper shows how Frater Taciturnus' remark calls into question the religious project of a certain danish author. For, Taciturnus' primary concern is to show that religious drama is not possible, or at least "ought not be." This general law applies to Hamlet as well, (...) and if Shakespeare was attempting a religious drama he a) shouldn't have because such a thing is essentially undramatizable, and b) failed because he did not begin (which would be possible) by showing the hero's religious presuppositions. Frater Taciturnus himself has given considerable thought to the extent and the manner in which the religious can be represented; in fact the letter to the reader is his proof of how perfectly his own narrative, "Guilty/Not Guilty," was constructed with precisely these problems in mind. The play is not the thing that Taciturnus is really interested in, nor is he interested in the playwright's intentions, he considers that the play's the thing that catches out Börne's misunderstanding of the religious, and it is this field—in particular, that area where the religious life and literary art intersect, that is the brother's interest and forte. But if Taciturnus is correct in his criticism of Börne, it should be impossible for S. Kierkegaard to produce a religious authorship as well. (shrink)

Restructured health care reimbursement systems and new requirements for nonprofit hospitals are transforming the U.S. health system, creating opportunities for enhanced integration of public health and health care goals. This article explores the role of public health practitioners and lawyers in this moment of transformation. We argue that the population perspective and structural strategies that characterize public health can add value to the health care system but could get lost in translation as changes to tax requirements and payment systems are (...) rapidly implemented. We urge public health leaders to take a more active role in hospital assessments of community health needs and evaluation of the patient outcomes for which providers are accountable. (shrink)

This paper explicates the relationship of innate corruption and natural goodness in Kant's Religion against a background of mistaken arguments and interpretations by Goethe, Allison, and Gordon Michalson, among others. It also argues that the only argument that can be given for the claim of innate moral corruption is a kind of ad hominem; it shows that Kant is giving such an argument, and argues that that argument is valid in its place. It concludes by saying that if this explication (...) is true then it is a mistake to read Kant as a despiser of the body. (shrink)

The authors find it more useful to payattention to relationships than to boundaries.By focusing attention on bounded, individualpsychological issues, the metaphor ofboundaries can distract helping professionalsfrom thinking about inequities of power. Itoversimplifies a complex issue, inviting us toignore discourses around gender, race, class,culture, and the like that support injustice,abuse, and exploitation. Making boundaries acentral metaphor for ethical practice can keepus from critically examining the effects ofdistance, withdrawal, and non-participation.The authors describe how it is possible toexamine the practical, moral, and ethicaleffects (...) of our participation in relationshipsby focusing on just relationships rather thanon boundaries. They give illustrations andclinical examples of relationally-focusedethical practices that derive from a narrativeapproach to therapy. (shrink)

This paper brings Lyotard into connection with the discussions of Socrates in REPUBLIC concerning general libidinal economy and its relation to the logos in human beings. Since desire is always the desire to be amoral -- not to recognize the person as subject, but rather recognizing it as a market for the capital gain of desire, it is to be suspected that desire within the subject is the cause of so-called differends between subjects. This is what Republic is about.

This paper answers the questions ‘what is the Merchant of Venice?’ and ‘how may it accomplish its purpose?’ I argue that the usual treatments of this play are inadequate and show how the play is a comedy through which the passions appropriate for the good human being are engendered. What is raised and ridiculed are our own temptations to lesser joys and less sweet uses mimetically roused in us by the action and characters of the play. What is whetted but (...) left unsatisfied is our higher love for justice. Thus the play provides a catharsis (purification) of desire and sympathy. (shrink)

Agrarianism in America assumes manyforms, in part because of the varied sources ofruralistic values, some evolving from times beforenationhood. Views expressed are sometimes anti-city,other times pro-rural. The Jeffersonian perspective isrevealed in three forms, two by historians, one by aphilosopher. They agree that Jefferson was animportant figure in America's land system, but theydiffer markedly in their uses of Jeffersonian valuesabout agriculture, land, and rural life. The essayconcludes with a basis for “new agrarianism” basedmore on land than agriculture as enterprise.

This paper attempts to explicate the philosophical and theological premisses involved in Fr. Paneloux’s second sermon in Camus’ The Plague. In that sermon Fr. Paneloux says that the suffering of children is our bread of affliction. The article shows where one must start in order to get to that point, and what follows from it. Whether or not the argument given should be called a theodicy or a reductio ad absurdum of religious belief is an open question for a philosopher, (...) but the argument is shown to cohere with the traditional belief in God’s omnipotent goodness. (shrink)

The first half of Plato’s Hippias Major exhibits the interfacing of the first teacher (Socrates) with the first version of a post-colonial, multi-cultural information technology system (Hippias). In this interface the purposes, results, and values of two contradictory types of operating system for educational servicing units are exhibited to, and can be discovered by, anyone who is not an information technologist.

This paper's aim is threefold. First, I wish to show that there is an analogy in section nine that arises out of the interaction of the interlocutors; this analogy is, or has, a certain comic adequatic to the traditional (e.g. Aquinas's) arguments about proofs for the existence of God. Second, Philo's seemingly inconsequential example of the strange necessity of products of 9 in section nine is a perfected analogy of the broken arguments actually given in that section, destroying Philo's earlier (...) arguments. Finally, I raise the question of the designer's intent in creating such a humourous piece. (shrink)

Plato’s dialogues are self-defined as works of mimetic art, and the ancients clearly consider mimesis as working naturally before reason and beneath it. Such aview connects with two contemporary ideas—Rene Girard’s idea of the mimetic basis of culture and neurophysiological research into mirror neurons. Individualityarises out of, and can collapse back into our mimetic origin. This para-rational notion of mimesis as that in which and by which all our knowledge is framed requires we not only concern ourselves with Socrates’s arguments (...) and distinctions, but also see how the dramatic interaction of the characters is working (or not) on/in the characters, and consider how watching the interaction, hearing the parables and myths, and thinking through the arguments and interactions is meant to effect us. That Plato creates mimeses means he aims at passional conversion not merely argumentative worth, since mimesis aims to (and does) work on the passions. (shrink)

This paper is not so much a reading of Shakespeare's play as reading through As You Like It to the kinds of resolution and catharsis that can exist in comedy. We will find two kinds of resolution and catharsis, and within each kind two sub-types. We will then read through the figures of the play and the catharses available in it to the kinds of culture that need or can use each type of catharsis.

Kant's famous statement (from the first Critique) that he found it necessary to deny knowledge in order to make room for faith acknowledges a religious or theological telos to the entire critical project. This article outlines a series of relations of 'knowledge' to 'faith' in the architectonic repetitions with variation that plays from the first Critique through the Religion. Various deployments of 'truth' at each stage presume a kind of 'faith' or trust all the way along. These deployments are shown (...) to follow a pattern which echoes that set out in Northrop Frye's understanding of literary modes descending from myth to romance to high and low mimetic and ending in the ironic. These modes describe realms of possibility and necessity, and their nesting in Frye's explication of literature is shown to be itself an echo of more formal theories of Tarski and Godel. (shrink)

Why would an empiricist look at a poem? And if he did, what could he find? This paper begins with Hume's programmatic statement for literary renewal based on the empirical principles set forth in the first Enquiry, and raises the question about the worth of poetry according to those principles. There is little "abstract reasoning concerning quantity or number, or experimental reasoning concerning matter of fact and existence" in poetry and so "commit it to the flames." The second Enquiry allows (...) that since disputation among men is based on the passions, poetry might have a place as a means to speak to the affections, to inforce particular sophistries close to our hearts. The second half of the paper defends poetry on grounds opposed to the premises of empirical science. Specifically, whereas in science knowledge is power, in the arts knowledge is suffering, or,where science aims at mastery and ownership, poetry relates us to that in being which is not ours. This view is explicated by use of King Lear. (shrink)

In Augustine's Confessions we can find two arguments against drama. One of them is entirely Platonic, echoing the problems raised in Republic 2 and 3 that representations of evil encourage moral turpitude. The other, which can be found in Republic 10, is much more visible in Confessions, and Augustine is more perspicuous than Plato in laying out the difficulty; it has to do with the immoral effect of suffering grief at staged sufferings, where we are moved neither to escape the (...) suffering nor to aid the sufferer, but to enjoy the suffering. Socrates had pointed out that letting suffering have free rein in us, as we do at a play, corrupts even the better sort of man (605c), but Augustine shows us that even the self-control we might exercise at a play is morally questionable. Like the arguments in Republic, Augustine's anti-poetic arguments raise serious problems about the status of the text in which they are found. The problems raised are both logical, on a par with the self-referential problems of Russell's theory of types, and moral, for the books themselves have the culpable nature each wishes to cast out from the republic and the soul: their narratives include representations of evil, and Augustine's book--if not Plato's--stages a suffering at the reading of which we might well be grieved. (shrink)

This paper aims at interpreting (primarily) the first six chapters of Aristotle’s Poetics in a way that dissolves many of the scholarly arguments conceming them. It shows that Aristotle frequently identifies the object of his inquiry by opposing it to what is other than it (in several different ways). As a result aporiai arise where there is only supposed to be illuminating exclusion of one sort or another. Two exemplary cases of this in chapters 1-6 are Aristotle’s account of mimesis (...) as other than enunciative speech (speech that makes truth claims, or representation) and his account of the final cause of tragedy in itself as plot, vis a vis its final cause as regards the audience, which is katharsis. Confusions arising from failure to see the otherness of representation and katharsis leads to an overly intellectualist understanding of the purpose of tragedy. (shrink)

This paper argues that Monologion and Proslogion though distinguishable are not really separable. They are distinct as "the way in" and "the way when one is in" but "the way in" reveals itself as a discovery of already being in; thus these ways are distinct in act, but not in being. Monologion moves from imaginary ignorance to real reverence, while Proslogion begins within reverence to achieve understanding.

An anthology of contemporary readings in analytic aesthetics, this reference reflects the relationships among the central aesthetic concerns of recent years. Providing a new perspective on the contemporary philosophy of art, this volume examines the challenge of Postmodernism and how it may or may not affect the future of analytic aesthetics... offers a case study of the progress that has been made in handling the problem of expression in the arts... reconceptualizes the concepts of the art work, its properties, and (...) our experience and evaluation of it -- to take into account an expanding cultural, sociological contextualization, i.e., art as a culturally emergent product of social institutions and conventions... features several readings organized around clusters of writers discussing each other's ideas and proposals, including: Beardsley, Dickie, and Blizek -- Wolterstorff, Levinson, and Bender -- Stolnitz and Dickie -- Beardsley, Margolis, and Novitz -- and Sibley and Dickie. Suitable for professionals in the art industry and anyone interested in the philosophy or aesthetics of art. (shrink)

This paper is a response to the preceding papers. It is maintained that American business is failing to live up to its obligations to society. One reason for this is acceptance of what De George calls the Myth of Amoral Business. Businessmen believe that morality is either not applicable to business or that business has a special morality of its own. Several arguments are advanced to show why this is not true. A second reason business is failing to fulfill its (...) obligations is that egoism seems to be an essential feature of capitalism. Harrington believes that this should be changed, but that attempts to change it are bringing about a more collectivist society. Kirk sees no need for change because he believes capitalism the best possible economic system. It is argued in reply that they are both mistaken because their analyses are based on outmoded ideologies which impede rather than aid us in solving problems caused by the irresponsibility of business. (shrink)