A comprehensive look at the intellectual and cultural innovations of the Weimar period During its short lifespan, the Weimar Republic witnessed an unprecedented flowering of achievements in many areas, including psychology, political theory, physics, philosophy, literary and cultural criticism, and the arts. Leading intellectuals, scholars, and critics—such as Hannah Arendt, Walter Benjamin, Ernst Bloch, Bertolt Brecht, and Martin Heidegger—emerged during this time to become the foremost thinkers of the twentieth century. Even today, the Weimar era remains a vital resource for (...) new intellectual movements. In this incomparable collection, Weimar Thought presents both the specialist and the general reader a comprehensive guide and unified portrait of the most important innovators, themes, and trends of this fascinating period. The book is divided into four thematic sections: law, politics, and society; philosophy, theology, and science; aesthetics, literature, and film; and general cultural and social themes of the Weimar period. The volume brings together established and emerging scholars from a remarkable array of fields, and each individual essay serves as an overview for a particular discipline while offering distinctive critical engagement with relevant problems and debates. Whether used as an introductory companion or advanced scholarly resource, Weimar Thought provides insight into the rich developments behind the intellectual foundations of modernity. (shrink)

This collection of recent articles by leading scholars is designed to illuminate one of the greatest and most influential philosophical books of all time. It includes incisive commentary on every major theme and argument in the Meditations, and will be valuable not only to philosophers but to historians, theologians, literary scholars, and interested general readers.

The linguistic foundations of science and technology include many terms that have been borrowed from ancient languages. In the case of terms with origins in the Greek language, the modern meaning can often differ significantly from the original one. Here we use the PubMed database to demonstrate the prevalence of words of Greek origin in the language of modern science, and call for scientists to exercise care when coining new terms.

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS Men Astutely Trained: A History of the Jesuits in the American Cen· tury. By PETER McDONOUGH. New York: Free Press, 1992. xxi +616 pp. $24.95. Last summer in Paris, sitting at one of the sidewalk tables that line the Boulevard S. Germain, a young Jesuit priest just finishing his doc· toral studies narrated some of the horror stories associated these days with " the joh market." Having (...) suffered through my own variation on that theme, I could only share with him the results of my own experi· ence. This novelty in the Jesuit stance provides Peter McDonough with a major theme in his narrative, for he describes the change in the So· ciety " from a rule-governed hierarchy to a role-driven network " (p. 459). He locates this transition in what he calls " the American century," roughly from 1900 to 1965. McDonough's study, an exciting and profitable read, traces the shift from Aquinas to the Age of Aquarius. Especially for an extern (i.e. a non-Jesuit), he has taken on a formidable challenge. Generally well received by the Jesuits, Men Astutely Trained tells how American Catholicism moved from an immigrant church to an upwardly mobile society. In the shifting loyalties, aggravated by the Second Vatican Council, Jesuits and their institutions felt the crunch. Since this innovation, loosely identified with " the democratization of culture," has precipitated the Society of Jesus "into the most serious crisis in its history " (p. xiv), McDonough must do a counterpoint he· tween the inner life and its external expressions. So the saga gains both breadth and depth. Without denigrating the accomplishment, at once earnest and literate, I want to take issue with the hook. As one of my colleagues taught me many years ago, we cannot stimulate discourse if everybody is con· tinually agreeing. First then, I want to comment on the flawed methodology. Next, I will say something about its thesis and conclude with a few reflections on "modernity." For Jesuits of my generation, the work of Malinowski proved normative. The anthropologist spent ten years among the natives who in· habited the Trobriand Islands in Melanesia. It apparently took that long for him to understand the stories and symbols, their myths and rituals. When he put his encyclopedia together, he could describe their institutions and social structures. In short, he worked from the inside out. McDonough, on the other hand, works from the outside in. In my 711 712 BOOK REVIEWS opinion, this represents a major failing in methodology. Two consequences flow from this deficiency. The author is never able to relate the works of the Society to the principal texts of the Society. The Spiritual Exercises, for example, does not rate even a mention. The Constitutions merits a fleeting reference on p. 160. St. Ignatius himself does not appear. Divorced as he is from the principal experience of Jesuits, our author cannot provide an adequate understanding for any of their priorities. This awareness makes his claim to present "the inside of the Society of Jesus" (p. 462) somewhat pretentious. Because he does not have the interior life in focus, many of the readings strike me as unnecessarily cluttered. He has yet to recognize the validity of John Stuart Mill's principle, "No man's synthesis can be greater than his analysis." While he has not left out three-fourths the data, perhaps he has neglected one-half. Secondly, he does not acknowledge Jesuits principally as churchmen. Instead, he makes us look like an acephalous torso. The church-con· nection reveals a major dimension to understanding the Society's coherence and institutions. It does not occur to the author that Jesuit priests are also bound to the universal discipline of the Church as found, for example, in the Codex Juris Canonici (1917). According to the Pio-Benedictine Code, all priests (and not just Jesuits) are expected to recite the breviary, to stay away from politics, and to avoid all "spectacles" including baseball games. Moreover, it is not entirely true to say that Jesuits acted independently of local bishops. Jesuits were able to establish their schools precisely because the local bishop invited them and encouraged the work. The ecclesial dimension becomes especially... (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

This paper replies to Peter Millican (Mind, 2009), who argues that Hume denies the possible existence of causal powers which underlie the regularities that we observe in nature. I argue that Hume's own philosophical views on causal power cannot be considered apart from his mitigated skepticism. His account of the origin of the idea of causal power, which traces it to a subjective impression, only leads to what he calls ‘Pyrrhonian scepticism’. He holds that we can only escape such excessive (...) skepticism by way of a natural judgment based on the association of ideas, which forms the basis of what he calls ‘a legitimate ground of Assent’. (shrink)

What inductive biases must be incorporated into multi-agent artificial intelligence models to get them to capture high-fidelity imitation? We think very little is needed. In the right environments, both instrumental- and ritual-stance imitation can emerge from generic learning mechanisms operating on non-deliberative decision architectures. In this view, imitation emerges from trial-and-error learning and does not require explicit deliberation.

This collection’s basic theme and thesis, explained by Curtis L. Hancock, “A Critique of Social Construct Theory” and “A Counterfeit Choice,” is that the seeds of contemporary relativism were sown by modern philosophy, primarily Descartes himself, its founder. Following a lead from Gilson, these authors pursue the benefits of classical realism and existential Thomism compared with the Cartesian legacy of subjectivism in modern philosophy. Indeed, Peter Redpath, “Why Descartes was not a Philosopher,” explains why Descartes may not be a philosopher (...) at all, if the significance of the term be properly considered as a love of wisdom and a search for true being. As Maritain coined the phrase, he is an “ideosopher,” in pursuit of the effective idea and rhetorical success, not the contemplation of being. Christopher Cullen, “Transcendental Thomism: Realism Rejected,” argues that the attempt by Karl Rahner, Joseph Donceel, and others to absorb the Cartesian and Kantian approach into Thomism has not proved successful. Robert Geis, “Descartes’s Res: An Interactionist Difficulty,” explains how the objectifying of mind as a thing sets up insoluble difficulties; he argues that a more adequate account is found in Aristotle. Donald DeMarco, “Descartes, Mathematics and Music,” traces out the effect in music when the physical is reduced to the mathematical. The imposition of a uniform method leads to a distortion of what musicians do. William J. Fossati, “Maximum Influence from Minimum Abilities: La Mettrie and Radical Materialism,” traces the Cartesian heritage of reductionism through Julien Offroy de Le Mettrie to the most contemporary attempts to explain human beings as mere biological organisms. (shrink)

As John Henry Newman reflected on 'The Idea of a University' more than a century and a half ago, Bradley C. S. Watson brings together some of the nation's most eminent thinkers on higher education to reflect on the nature and purposes of the American university today. Their mordant reflections paint a picture of the American university in crisis. This book is essential reading for thoughtful citizens, scholars, and educational policymakers.

What were Shakespeare's final thoughts on history, tragedy, and comedy? Shakespeare's Last Plays focuses much needed scholarly attention on Shakespeare's "Late Romances." The work--a collection of newly commissioned essays by leading scholars of classical political philosophy and literature--offers careful textual analysis of Pericles, Prince of Tyre, Cymbeline, The Winter's Tale, The Tempest, All is True, and The Two Noble Kinsmen. The essays reveal how Shakespeare's thought in these final works compliments, challenges, fulfills, or transforms previously held conceptions of the playwright (...) and his political-philosophical views. (shrink)

For forty years, Harvey Mansfield has been worth reading. Whether plumbing the depths of MachiavelliOs Discourses or explaining what was at stake in Bill ClintonOs impeachment, MansfieldOs work in political philosophy and political science has set the standard. In Educating the Prince, twenty-one of his students, themselves distinguished scholars, try to live up to that standard. Their essays offer penetrating analyses of Machiavellianism, liberalism, and America., all of them informed by MansfieldOs own work. The volume also includes a bibliography of (...) MansfieldOs writings. (shrink)

With this issue we initiate the policy of expanding the scope of Tulane Studies in Philosophy to include, in addition to the work of members of the department, contributions from philosophers who have earned advanced degrees from Tulane and who are now teaching in other colleges and universities. The Editor THE LOGIC OF OUR LANGUAGE ROBERT L. ARRINGTON Wittgenstein wrote in the Tractatus that "logic is not a body of doctrine, but a mirror-image of the world. " 1 In line (...) with his suggestion that a proposition is a 'picture', Wittgenstein argued that propositions 'show' the logical structure of the real. He was insistent, however, that "the apparent logical form of a proposition need not be its real one. " 2 As a result of this we can misunderstand the structure of fact. Philosophical problems arise just when "the logic of our language is mis understood. " 3 It is common knowledge that much of this view of logic was rejected by Wittgenstein himself in the Philosophical Investi gations. There we are told that language has no ideal or sublime 4 logic which mirrors the structure of the extra-linguistic world. Consequently, inferences from the structure of language to the structure of that extra-linguistic world are invalid. Reality can be 'cut up' in any of a number of ways by language. Wittgenstein adopted a view of philosophy which would render that discipline a non-explanatory, non-critical study of the multiple ways in which language can be used. (shrink)

Pope John Paul II's opposition to the Iraq War was not that it failed to meet the conditions of Just War Theory. Indeed, we cannot tell from what he publicly said whether he thought it met those conditions or not, for he would have opposed it in any case. His thinking was rather that even just and necessary wars always come, as it were, too late, and are never able to solve the problems that made wars just and necessary. (...) He was not trying therefore to enter into the details of Just War Theory. He wanted to subsume the principles of war into the principles of peace and to do so, not by denying justice, but by transcending it with charity. This article shows how this thinking is to be understood and the many means the Pope devised for putting this thinking into practice. (shrink)

A scholarly edition of Essay Concerning Human Understanding by P. H. Nidditch. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.

DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers can freely discuss current and emerging deep brain stimulation technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank IX speakers was that DBS expanded in (...) its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. After collectively sharing our experiences, it was estimated that globally more than 230,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. As such, this year’s meeting was focused on advances in the following areas: neuromodulation in Europe, Asia and Australia; cutting-edge technologies, neuroethics, interventional psychiatry, adaptive DBS, neuromodulation for pain, network neuromodulation for epilepsy and neuromodulation for traumatic brain injury. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

"John Anton introduces the reader to the poetry and poetics of Constantine P. Cavafy from a different perspective. He traces Cavafy's development during the early phases of the poet's creativity, when he was gradually discovering his poetic self, until he finally created his own authentic voice. Autobiographical elements in Cavafy's poems are introduced mainly as guides to explore one aspect of Cavafy's world: how he gradually learned to control the transformation of experience into "work in progress". Professor Anton clearly (...) portrays Cavafy's quality of thought, his originality, the freshness of his imagery and his penetrating commentary on the human condition. The author also provides details of the historical background of ancient Alexandria, which formed one of the key ways whereby Cavafy recreated the city for himself and used it to develop his unique poetic vision."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Book Reviews How Philosophy Uses Its Past. By John Herman Randall, Jr. Foreword by Cornelius Krus~. (The Matehette Lectures, Wesleyan University, 1961; New York and London: Columbia University Press, 1963. Pp. xiv + 106. $3.50.) One could easily characterize this small volume as a minor masterpiece on a major theme. It is an admirable statement from the pen of one of America's leading thinkers in both the history (...) of philosopy and philosophy "proper." Actually the distinction between these two fields of philosophic activity becomes superfluous since Professor Randall has an elaborate theory of his own, whereby to do philosophy and do it well involves, in a serious and inescapable way, competent performance in the history of philosophy. How Philosophy UsesIts Past may have to be read, and I propose here that it should, as the general introduction to Randall's projected three volumes of his monumental The Career of Philosophy, of which only Volume One has been published. The close analyses of specific men and issues presented in the latter work can be seen as the evidence meant to corroborate the thesis asserted in How Philosophy Uses Its Past. In his own words: "It remains true that it is impossible to gain insight into the history of philosophical ideas--into the dimensions of philosophizing--without being led to formulate a philosophy of cultural change" (p. 20). Randall has made in this volume a significant contribution if only by way of focusing his powerful lens on three central issues: (1) how genuine philosophizing is still "metaphysical" thinking; (2) why it is necessary to undertake a thorough investigation of the antecedents leading up to our prevailing philosophies of experience; (3) how to understand the seemingly chaotic situation in our philosophical affairs, under the age-old distinction of the "one and many." In a critical and appreciative article on Lovejoy, Randall stated his reservations toward Lovejoy's "atomistic" conception of intellectual history and proceeded to note that the history of philosophy has a philosophic function iust as philosophy has historical dimensions such that when adequately explored can tell us much about the nature and limits of our own philosophizing.1 A permeative thesis in the volume under review is that to do "history of philosophy" is to do "philosophy." To show how and why Randall believes this to be the case, we must consider in some detail three of his main themes: the redefinition of metaphysics, the broader conception of experience, and the "one and many" aspect of contemporary philosophy. One may go so far as to say that Randall is doing philosophy just as he is formulating a theory of the philosophy, for the sake of responding philosophically to the stated problems. But to respond philosophically is something that one must learn in conjunction with the examination of the historical past of philosophy. Randall thus believes, on the evidence gathered, that philosophy has revealed itself to be "a clarification and criticism of fundamental beliefs involved in all the great enterprises of human culture, science, art, religion, the moral, social and practical activity, when some new idea or some altered experience has impinged upon them and generated intellectual tensions and maladjustments" (pp. 19; 100). This way of understanding philosophy affects his approach to every problem he mentions. Indeed, even the denial of the importance of the history of philosophy is rooted in historical processes which must be understood before the denial can be fully illumined. Without historical knowledge, he argues even our decisions will suffer (p. 14). Randall calls his approach to defining philosophical problems "operational." Accordingly, we do not know whether we have a philosophical problem until a philosophical response has occurred. Looking back from the response to what it was that philosophers responded to, we See Randall's "Arthur O. Lovejoy and the History of Ideas," Philosophy and Phenomenological Research,XXII (1963), 475-479; also book under review, p. 36. [1071 108 HISTORY OF PHILOSOPHY discover that these were problems that emerged "whenever strife of ideas and experiences forced men back to the fundamental assumptions in any field" (p. 18). Briefly put, the response has always been that of analysing, clarifying, criticizing and reconstructing "fundamental assumptions." The problems vary and... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Book Reviews How Philosophy Uses Its Past. By John Herman Randall, Jr. Foreword by Cornelius Krus~. (The Matehette Lectures, Wesleyan University, 1961; New York and London: Columbia University Press, 1963. Pp. xiv + 106. $3.50.) One could easily characterize this small volume as a minor masterpiece on a major theme. It is an admirable statement from the pen of one of America's leading thinkers in both the history (...) of philosopy and philosophy "proper." Actually the distinction between these two fields of philosophic activity becomes superfluous since Professor Randall has an elaborate theory of his own, whereby to do philosophy and do it well involves, in a serious and inescapable way, competent performance in the history of philosophy. How Philosophy UsesIts Past may have to be read, and I propose here that it should, as the general introduction to Randall's projected three volumes of his monumental The Career of Philosophy, of which only Volume One has been published. The close analyses of specific men and issues presented in the latter work can be seen as the evidence meant to corroborate the thesis asserted in How Philosophy Uses Its Past. In his own words: "It remains true that it is impossible to gain insight into the history of philosophical ideas--into the dimensions of philosophizing--without being led to formulate a philosophy of cultural change" (p. 20). Randall has made in this volume a significant contribution if only by way of focusing his powerful lens on three central issues: (1) how genuine philosophizing is still "metaphysical" thinking; (2) why it is necessary to undertake a thorough investigation of the antecedents leading up to our prevailing philosophies of experience; (3) how to understand the seemingly chaotic situation in our philosophical affairs, under the age-old distinction of the "one and many." In a critical and appreciative article on Lovejoy, Randall stated his reservations toward Lovejoy's "atomistic" conception of intellectual history and proceeded to note that the history of philosophy has a philosophic function iust as philosophy has historical dimensions such that when adequately explored can tell us much about the nature and limits of our own philosophizing.1 A permeative thesis in the volume under review is that to do "history of philosophy" is to do "philosophy." To show how and why Randall believes this to be the case, we must consider in some detail three of his main themes: the redefinition of metaphysics, the broader conception of experience, and the "one and many" aspect of contemporary philosophy. One may go so far as to say that Randall is doing philosophy just as he is formulating a theory of the philosophy, for the sake of responding philosophically to the stated problems. But to respond philosophically is something that one must learn in conjunction with the examination of the historical past of philosophy. Randall thus believes, on the evidence gathered, that philosophy has revealed itself to be "a clarification and criticism of fundamental beliefs involved in all the great enterprises of human culture, science, art, religion, the moral, social and practical activity, when some new idea or some altered experience has impinged upon them and generated intellectual tensions and maladjustments" (pp. 19; 100). This way of understanding philosophy affects his approach to every problem he mentions. Indeed, even the denial of the importance of the history of philosophy is rooted in historical processes which must be understood before the denial can be fully illumined. Without historical knowledge, he argues even our decisions will suffer (p. 14). Randall calls his approach to defining philosophical problems "operational." Accordingly, we do not know whether we have a philosophical problem until a philosophical response has occurred. Looking back from the response to what it was that philosophers responded to, we See Randall's "Arthur O. Lovejoy and the History of Ideas," Philosophy and Phenomenological Research,XXII (1963), 475-479; also book under review, p. 36. [1071 108 HISTORY OF PHILOSOPHY discover that these were problems that emerged "whenever strife of ideas and experiences forced men back to the fundamental assumptions in any field" (p. 18). Briefly put, the response has always been that of analysing, clarifying, criticizing and reconstructing "fundamental assumptions." The problems vary and... (shrink)

This book taps the best American thinkers to answer the essential American question: How do we sustain our experiment in government of, by, and for the people? Authored by an extraordinary and politically diverse roster of public officials, scholars, and educators, these chapters describe our nation's civic education problem, assess its causes, offer an agenda for reform, and explain the high stakes at risk if we fail.

© Copyright 2015, Mary Ann Liebert, Inc..Signal transducer and activator of transcription factor 3 is hyperactivated in head and neck squamous cell carcinomas. Cumulative evidence indicates that IL-6 production by HNSCC cells and/or stromal cells in the tumor microenvironment activates STAT3 and contributes to tumor progression and drug resistance. A library of 94,491 compounds from the Molecular Library Screening Center Network was screened for the ability to inhibit interleukin-6 -induced pSTAT3 activation. For contractual reasons, the primary high-content screening campaign was (...) conducted over several months in 3 distinct phases; 1,068 primary HCS actives remained after cytotoxic or fluorescent outliers were eliminated. One thousand one hundred eighty-seven compounds were cherry-picked for confirmation; actives identified in the primary HCS and compounds selected by a structural similarity search of the remaining MLSCN library using hits identified in phases I and II of the screen. Actives were confirmed in pSTAT3 IC50 assays, and an IFNγ-induced pSTAT1 activation assay was used to prioritize selective inhibitors of STAT3 activation that would not inhibit STAT1 tumor suppressor functions. Two hundred three concentration-dependent inhibitors of IL-6-induced pSTAT3 activation were identified and 89 of these also produced IC50s against IFN-γ-induced pSTAT1 activation. Forty-nine compounds met our hit criteria: they reproducibly inhibited IL-6-induced pSTAT3 activation by ≥70% at 20 μM; their pSTAT3 activation IC50s were ≤25 μM; they were ≥2-fold selective for pSTAT3 inhibition over pSTAT1 inhibition; a cross target query of PubChem indicated that they were not biologically promiscuous; and they were ≥90% pure. Twenty-six chemically tractable hits that passed filters for nuisance compounds and had acceptable drug-like and ADME-Tox properties by computational evaluation were purchased for characterization. The hit structures were distributed among 5 clusters and 8 singletons. Twenty-four compounds inhibited IL-6-induced pSTAT3 activation with IC50s ≤20 μM and 13 were ≥3-fold selective versus inhibition of pSTAT1 activation. Eighteen hits inhibited the growth of HNSCC cell lines with average IC50s ≤ 20 μM. Four chemical series were progressed into lead optimization: the guanidinoquinazolines, the triazolothiadiazines, the amino alcohols, and an oxazole-piperazine singleton. (shrink)

Paper edition (unseen), $14.95. Annotation copyright by Book News, Inc., Portland, OR.

Fifteen years ago, Peter Singer published Animal Liberation: A New Ethics for Our Treatment of Animals. In it, he proposed to end “the tyranny of humans over nonhuman animals” by “thinking through, carefully, and consistently, the question of how we ought to treat animals” (p. ix). On this anniversary of the book's publication, a critical analysis shows that the logic he presents, though popularly appealing, is philosophically flawed. Though influential in slowing and in some cases stopping biomedical research involving animals, (...) the animal rights movement in the United States has yet to offer a clear and compelling argument for the equlity of species. (shrink)