This article presents a review of the literature, summarizes current initiatives, and provides a heuristic for assessing the effectiveness of a range of institutional review board collaborative strategies that can reduce the regulatory burden of ethics review while ensuring protection of human subjects, with a particular focus on international research. Broad adoption of IRB collaborative strategies will reduce regulatory burdens posed by overlapping oversight mechanisms and has the potential to enhance human subjects protections.

The primary purpose of Institutional Review Boards (IRBs) is to protect the rights and welfare of human research participants. Evaluation and measurement of how IRBs satisfy this purpose and other important goals are open questions that demand empirical research. Research on IRBs, and the Human Research Protection Programs (HRPPs) of which they are often a part, is necessary to inform evidence-based practices, policies, and approaches to quality improvement in human research protections. However, to date, HRPP and IRB engagement in empirical (...) research about their own activities and performance has been limited. To promote engagement of HRPPs and IRBs in self-reflective research on HRPP and IRB quality and effectiveness, barriers to their participation need to be addressed. These include: extensive workloads, limited information technology systems, and few universally accepted or consistently measured metrics for HRPP/irb quality and effectiveness. Additionally, institutional leaders may have concerns about confidentiality. Professional norms around the value of participating in this type of research are lacking. Lastly, obtaining external funding for research on IRBs and HRPPs is challenging. As a group of HRPP professionals and researchers actively involved in a research consortium focused on IRB quality and effectiveness, we identify potential levers for supporting and encouraging HRPP and IRB engagement in research on quality and effectiveness. We maintain that this research should be informed by the core principles of patient- and community-engaged research, in which members and key stakeholders of the community to be studied are included as key informants and members of the research team. This ensures that relevant questions are asked and that data are interpreted to produce meaningful recommendations. As such, we offer several ways to increase the participation of HRPP professionals in research as participants, as data sharers, and as investigators. (shrink)

As the first of its kind this collection draws together cutting edge scholarship in the field, focusing on the theory and practice of yoga in contemporary times ...

Yoga is hugely popular around the world today, yet until now little has been known of its roots. This book collects, for the first time, core teachings of yoga in their original form, translated and edited by two of the world's foremost scholars of the subject. It includes a wide range of texts from different schools of yoga, languages and eras: among others, key passages from the early Upanisads and the Mahabharata, and from the Tantric, Buddhist and Jaina traditions, with (...) many pieces in scholarly translation for the first time. Covering yoga's varying definitions across systems, models of the esoteric and physical bodies, and its most important practices, such as posture, breath control, sensory withdrawal and meditation, Roots of Yoga is a unique and essential source of knowledge. (shrink)

This article describes a qualitative study of models of ethics consultation used by ethics consultants in Canada. We found four different models used by Canadian ethics consultants whom we interviewed, and one sub-variant. We describe the lone ethics consultant model, the hub-and-spokes sub-variant of this model; the ethics committee model; the capacity-building model; and the facilitated model. Previous empirical studies of ethics consultation describe only two or three of these models.

COVID-19 is unique in that it is the first global pandemic occurring amidst a crowded information environment that has facilitated the proliferation of misinformation on social media. Dangerous misleading narratives have the potential to disrupt ‘official’ information sharing at major government announcements. Using an interrupted time-series design, we test the impact of the announcement of the first UK lockdown on short-term trends of misinformation on Twitter. We utilise a novel dataset of all COVID-19-related social media posts on Twitter from the (...) UK 48 hours before and 48 hours after the announcement. We find that while the number of tweets increased immediately post announcement, there was no evidence of an increase in misinformation-related tweets. We found an increase in COVID-19-related bot activity post-announcement. Topic modelling of misinformation tweets revealed four distinct clusters: ‘government and policy’, ‘symptoms’, ‘pushing back against misinformation’ and ‘cures and treatments’. (shrink)

In this contribution to the Common Knowledge symposium “Fuzzy Studies,” the authors, all of whom work in the field of science, technology, and society, begin from the assumption that, as Bruno Latour has put it, “we have never been modern.” They accept the STS thesis that, while modern practices purport to be entirely rational and coherent, on closer inspection they turn out to be as much noncoherent as coherent. This article poses the question of what forms “noncoherences” take and how (...) they are managed. The basic argument is that there is a range of styles of noncoherence or “modes of syncretism.” In small case studies, the authors identify six such modes or styles, which they term denial, domestication, separation, care, conflict, and collapse. Given that consistency and coherence seem less important now than they were once taken to be — and given that the conditions of possibility for purity are, in any case, in decline — this list and its supporting case studies, while not meant to be definitive, are offered as a way of understanding how practices that do not cohere may still function and fit together admirably. (shrink)

The Dutch microbiologist/biochemist Albert Jan Kluyver was an early proponent of the idea of biochemical unity, and how that concept might be demonstrated through the careful study of microbial life. The fundamental relatedness of living systems is an obvious correlate of the theory of evolution, and modern attempts to construct phylogenetic schemes support this relatedness through comparison of genomes. The approach of Kluyver and his scientific descendants predated the tools of modern molecular biology by decades. Kluyver himself is poorly recognized (...) today, yet his influence at the time was profound. Through lens of today however, it has been argued that the focus by Kluyver and others to create taxonomic and phylogenetic schemes using morphology and biochemistry distorted and hindered progress of the discipline of microbiology, because of a perception that the older approaches focused too much on a reductionist worldview. This essay argues that in contrast the careful characterization of fundamental microbial metabolism and physiology by Kluyver made many of the advances of the latter part of the twentieth century possible, by offering a framework which in many respects anticipated our current view of phylogeny, and by directly and indirectly training a generation of scientists who became leaders in the explosive growth of biotechnology. (shrink)

Put briefly: perhaps the entire evolution of the spirit is a question of the body; it is the history of the development of a higher body that emerges into our sensibility. The organic is rising to yet higher levels. Our lust for knowledge of nature is a means through which the body desires to perfect itself. Or rather: hundreds of thousands of experiments are made to change the nourishment, the mode of living and of dwelling in the body; consciousness and (...) evaluations in the body, all kinds of pleasure and displeasure, are signs of these changes and experiments. In the long run, it is not a question of man at all: he is to be overcome (Nietzsche 1967: 358). (shrink)

Contemporary theories of Virtue Ethics are often presented as being in opposition to Kantian Ethics and Consequentialism. It is argued that Virtue Ethics takes as fundamental the question, “What sort of character would a virtuous person have?” and that Kantian Ethics and Consequentialism take as fundamental the question, “What makes an action right?” I argue that this opposition is misconceived. The opposition is rather between Virtue Ethics and Kantian Ethics on the one hand and Consequentialism on the other. The former (...) two are concerned with, respectively, the development of a virtuous character and a good will, whereas Consequentialism is essentially a doctrine that just provides a justification of the right option without specifying how this is to be achieved. Furthermore, I show that Consequentialism, interpreted as a justificatory doctrine, is both an impoverished doctrine and one that cannot be enriched by taking a “pick and mix” approach to other ethical theories in the way that Consequentialists advocate. I argue that there is at least one reason to prefer Kantian Ethics: Kantian Ethics necessarily avoids the objection of selfcenteredness, whereas the avoidance of this objection is only contingent in the case of Virtue Ethics. (shrink)

Contemporary theories of Virtue Ethics are often presented as being in opposition to Kantian Ethics and Consequentialism. It is argued that Virtue Ethics takes as fundamental the question, “What sort of character would a virtuous person have?” and that Kantian Ethics and Consequentialism take as fundamental the question, “What makes an action right?” I argue that this opposition is misconceived. The opposition is rather between Virtue Ethics and Kantian Ethics on the one hand and Consequentialism on the other. The former (...) two are concerned with, respectively, the development of a virtuous character and a good will, whereas Consequentialism is essentially a doctrine that just provides a justification of the right option without specifying how this is to be achieved. Furthermore, I show that Consequentialism, interpreted as a justificatory doctrine, is both an impoverished doctrine and one that cannot be enriched by taking a “pick and mix” approach to other ethical theories in the way that Consequentialists advocate. I argue that there is at least one reason to prefer Kantian Ethics: Kantian Ethics necessarily avoids the objection of selfcenteredness, whereas the avoidance of this objection is only contingent in the case of Virtue Ethics. (shrink)

In this study, Canadian healthcare ethics consultants describe their use of ethics decision-making frameworks. Our research finds that ethics consultants in Canada use multi-purpose ethics decision-making frameworks, as well as targeted frameworks that focus on reaching an ethical resolution to a particular healthcare issue, such as adverse event reporting, or difficult triage scenarios. Several interviewees mention the influence that the accreditation process in Canadian healthcare organizations has on the adoption and use of such frameworks. Some of the ethics consultants we (...) interviewed also report on their reluctance to use these tools. Limited empirical work has been done previously on the use of ethics decision-making frameworks. This study begins to fill this gap in our understanding of the work of healthcare ethics consultants. (shrink)

Background: Randomized controlled trials have been criticized for their inability to identify and differentiate the causal mechanisms that generate the outcomes they measure. One solution is the development of realist trials that combine the empirical precision of trials' outcome data with realism's theoretical capacity to identify the powers that generate outcomes. Main Body: We review arguments for and against this position and conclude that critical realist trials are viable. Using the example of an evaluation of the educational effectiveness of virtual (...) reality simulation, we explore whether Partial Least Squares Structural Equation Modelling can move statistical analysis beyond correlational analysis to support realist identification of the mechanisms that generate correlations. Conclusion: We tentatively conclude that PLS-SEM, with its ability to identify ‘points of action’, has the potential to provide direction for researchers and practitioners in terms of how, for whom, when, where and in what circumstances an intervention has worked. (shrink)

In this paper we present a modal logic framework to reason about the expertise of information sources. A source is considered an expert on a proposition φ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\varphi $$\end{document} if they are able to correctly refute φ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\varphi $$\end{document} in any possible world where φ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\varphi $$\end{document} is false. Closely connected with expertise is a notion of (...) soundness of information: φ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\varphi $$\end{document} is said to be “sound” if it is true up to lack of expertise of the source. That is, any statement logically weaker than φ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\varphi $$\end{document} on which the source has expertise must in fact be true. This is relevant for modelling situations in which sources make claims beyond their domain of expertise. Particular attention is paid to the connection between expertise and knowledge: we show that expertise and soundness admit precise interpretations in terms of S4 and S5 epistemic logic, under certain conditions. We go on to extend the framework to multiple sources, defining two notions of collective expertise. These also have epistemic interpretations via distributed and common knowledge from multi-agent epistemic logic. On the technical side, we give several sound and complete axiomatisations of various classes of expertise models. (shrink)

This book details the underlining philosophical approaches to ethical theories and how these can be used to structure an approach to day-to-day ethical issues, and thereby resolve them. It provides an understanding of the ethical theories which underpin decisions in health care by first laying the foundation with a philosophical framework and then going on to develop this into an examination of contemporary health care dilemmas and professional issues. Not available in the U.S.

In this article I shall be supporting two main claims. The first is that the essence of the difference between particularism and generalism lies in where they locate ethical correctness. The second is that generalism, although to be preferred to particularism, is not the final resting place for ethical correctness. Ultimately, ethical correctness resides in ethical theories that provide the rationale for generalism. Particularism is presented as a theory that allows attention to be paid to specific cases and shows a (...) sensitivity to the particular case. Generalism, with its appeal to moral principles, is supposed to lack this sensitivity to specific cases. I argue that although this might be true of subsumptive generalism, it is not true of what I call judgmental generalism. This latter type of generalism retains an appeal to moral principles while requiring sensitivity to the particular case. I consider Kantian ethics as an example of this sort of generalism. Furthermore, I support the claim that this judgmental generalism is to be preferred to particularism. I argue against a prominent form of particularism, put forward by Jonathan Dancy, based on an appeal to the holism of reasons. This doctrine involves the claim that the value of a complex whole is not necessarily identical with the value of its parts. I show that Dancy’s discussion of this involves inconsistencies and also appears to incorporate subsumptive generalism. This statement of particularism is ultimately incoherent. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Henry James—Aristotle's Ally, An Exclusive Pact?Jane SingletonIMany claims are advanced for the importance of narrative art works in philosophy. This paper will concentrate on one specific thesis put forward by Martha Nussbaum about the relationship between certain works of literature and moral philosophy. Although Nussbaum explores many roles for narrative artworks in philosophy,1 I shall concentrate on those works where she argues for a close connection between the novels (...) of Henry James and Aristotle's ethics. These are Love's Knowledge,2 where other authors other than James are also considered, and "Exactly and Responsibly: A Defense of Ethical Criticism," an article that formed part of a debate with Richard Posner and Wayne Booth in 1997 and 1998 in Philosophy and Literature.3 It is this latter work that provides the central thesis to be considered.I argue that there are least four possible attributes or combinations of them that Nussbaum might be suggesting are present in James's novels when she claims that James is an ally of Aristotle. My claim will be that James can only be regarded as an ally of Aristotle with respect to some of these attributes. It is a second question to determine precisely how the legitimate attributes isolated in James's novels are to be used to provide an ally for Aristotle's ethics. I shall claim that in any sense in which it is legitimate to regard James as an ally of Aristotle, he could also be regarded as an ally of a generalist theory. This is an important point to emphasise since Nussbaum explicitly enlists James as an ally of Aristotle because of the normative primacy that he gives to the particular. I shall use Kant's theory as an example of a generalist theory. Henry [End Page 61] James, I argue, can be an ally of both Aristotle and Kant but both can adopt an isolationist policy.IIThe specific thesis put forward by Nussbaum in 1998 is as follows:My claim is that in order to investigate this Aristotelian ethical view fully and fairly, we need to turn to texts in which the case for that sort of rationality is made out in a powerful and convincing way—and this cannot be done if we confine ourselves to works written in the abstract style characteristic of most contemporary theory... Aristotle's conception is much more dependent on "allies" who will make out the force of such obscure claims as the claim that "the discernment rests with perception," and that correct action "lies in a mean." Because Aristotle's conception leaves so much to particularized contextual judgment, one cannot well assess the conception without studying complex examples of such particularized judgment; and of course Aristotle's text does not supply such material. I claim that Henry James is a powerful ally of Aristotle, and one whom Aristotle badly needs if he is to convince us of his claims.("ER," pp. 347–48)It is the clarification and discussion of this that provides my point of departure. I shall then consider the four possible characteristics of James's novels that I have isolated. These are: exemplars of good choice, illustrations of the direction of thought to follow for the discernment of the particular, vehicles for developing imagination and sources that enable us to develop an understanding of and engagement of emotions. In each case I shall consider how, if at all, these characteristics enable James to be an ally of either Aristotle or Kant.IIINussbaum's thesis is limited to the late novels of James. "I assert that there is a distinctive type of ethical view... that requires literary works of a very specific type, primarily exemplified by the late novels of James, for its complete investigation" ("ER," p. 348). These include The Wings of the Dove (1902), The Ambassadors (1903), and The Golden Bowl (1904). I shall use examples from each of these although, as Posner notes, The Wings of The Dove, is one book that Nussbaum does not discuss in the article.4 [End Page 62]What attributes or characteristics do these late novels of James possess? They all have in common... (shrink)

New Approaches to Monetary Economics brings together presentations of innovative research in the field of monetary economics. Much of this research develops and applies approaches to modelling financial intermediation, aggregate fluctuations, monetary aggregation and transactions-motivated monetary equilibrium. The contents of this volume comprise the proceedings of the second in a conference series entitled International Symposia in Economic Theory and Econometrics. This conference was held in 1985 at the IC2 Institute at the University of Texas at Austin. The symposia in this (...) series are sponsored by the IC2 Institute and the RGK Foundation. New Approaches to Monetary Economics, edited by Professors William A. Barnett and Kenneth J. Singleton, consists of five parts. Part I examines transactions-motivated monetary holding in general equilibrium; Part II, financial intermediation; Part III, monetary aggregation theory, Part IV, issues in aggregate fluctuation; and Part V, theoretical issues in the foundations of monetary economics and macroeconomics. (shrink)

A useful guide to best practice including reviews of the latest and most helpful tests available. In Part One, contributors discuss the theory of reading assessment including issues such as screening, legal aspects, memory and visual problems, computer based assessment and the dyslexias. Part Two contains the review section where experts give comprehensive reviews of named tests.

We examine the possible role played by field angular momentum in two systems of vastly different sizes: (i) the nucleon and (ii) highly magnetic white dwarf stars. For the nucleon we study the restrictions on the nucleon's structure that arise from the requirement that the total field angular (spin, orbital and field angular momentum) should satisfy the standard angular momentum commutation relationship. For the magnetic white dwarfs we argue that the magnetic field may alter the statistics of some fraction of (...) the white dwarf's electrons from fermionic to bosonic. This would effect the stars structure, giving it a smaller than expected radius, and a lower than expected temperature. In some extreme cases one could imagine that this effect could lead to the collapse of the white dwarf into a neutron star despite being below the Chandreshekar limit. (shrink)

Kant starts the Groundwork of the Metaphysics of Morals by emphasizing the importance of separating the a priori or rational part of moral philosophy from the a posteriori or empirical aspects. Indeed, he reserves the term moral philosophy for the rational part. He writes ‘ethics … the empirical part might be given the special title practical anthropology, the term moral philosophy being properly used to refer just to the rational part’. Throughout his writings in both theoretical and practical philosophy the (...) distinction between what is a priori and what is a posteriori is given paramount importance. We need to separate that which has its source a priori from its application to, for example human beings. (shrink)

The nucleon spin problem raises experimental and theoretical questions regarding the contribution of the orbital angular momentum of the quarks to the total spin of the nucleon. In this article we examine the commutation relationships of various operators that contribute to the total angular momentum of the nucleon. We find that the sum of the orbital plus gluon field angular momenta should satisfy the angular momentum commutators, at least up to the one-loop level. This, requirement on the sum of these (...) operators imposes a non-trivial restriction on the form of the color electric and magnetic fields. This is similar to the magnetic monopole/electric charge system where it is only the sum of the orbital plus field angular momentum that satisfies the correct commutation relationships. (shrink)