The translocation of proteins across membranes is a central problem in biology. Regardless of the system in question, delivering proteins across a given membrane relies on many of the same basic themes. At the same time, however, each membrane translocation system, beit signal‐gated or signal‐assembled, makes use of components unique to that system. The latest findings on protein translocation across a variety of biological membranes have been presented in a recent review article.1 BioEssays 25:1154–1157, 2003. © 2003 Wiley Periodicals, Inc.

Do human beings ever act freely, and if so what does freedom mean? Is everything that happens antecedently caused, and if so how is freedom possible? Is it right, even for God, to punish people for things that they cannot help doing? This volume presents the famous seventeenth-century controversy in which Thomas Hobbes and John Bramhall debate these questions and others. The complete texts of their initial contributions to the debate are included, together with selections from their subsequent replies to (...) one another and from other works of Hobbes, in a collection that offers an illuminating commentary on issues still of concern to philosophers today. The volume is completed by a historical and philosophical introduction that explains the context in which the debate took place. (shrink)

This new volume in the successful Oxford Readings in Philosophy series presents a selection of the best recent articles on the main topics in Locke's philosophy. These include: innate ideas, ideas and perception, primary and secondary qualities, free will, substance, personal identity, language, essence, knowledge, and belief. The authors include some of the world's leading Locke scholars, and their essays exemplify the best - and most accessible - recent scholarship on Locke, making the volume essential for students and specialists.

This symposium comprises five papers on Locke's theory of sense perception. The authors are John Rogers, Gideon Yaffe, Lex Newman, Tom Lennon, and Martha Bolton. There are also comments on the papers, both individually and as a group, by Vere Chappell. In addition to Locke's view of perception, the papers deal with the nature of Lockean ideas and with the question whether Locke is committed to skepticism regarding the external world. The authors (and the commentator) disagree in their readings of (...) Locke on these issues, but most maintain--and some argue--that he holds a representative theory of perception, and that he is not an external-world skeptic. (shrink)

This book analyzes recent artistic and activist projects in order to conceptualize the new roles and goals of a critical theory and practice of art and photography. Vered Maimon argues that current artistic and activist practices are no longer concerned with the "politics of representation" and the critique of the spectacle, but with a "politics of rights" and the performative formation of shared yet highly contested public domains. The book thus offers a critical framework in which to rethink the (...) artistic, the activist, and the political under globalization. The primary focus is on the ways contemporary artists and activists examine political citizenship as a paradox where subjects are struggling to acquire rights whose formulation rests on attributes they allegedly don't have; while the universal political validity of these rights presupposes precisely the abstraction of every form of difference, rights for all. The book will be of interest to scholars working in art history, contemporary art, photography theory, visual culture, cultural studies, critical theory, political theory, human rights, and activism. (shrink)

Considering the absence of any ancient systematic approach to the reading of the novel, this paper turns to ancient dream hermeneutics as a valuable field of reference that can provide the theoretical framework for studying the ancient novel within its own cultural context. In introducing dream interpretation as one of the ancient novel's creative sources, this essay focuses on Apuleius' Metamorphoses. It explores the dream logic in Apuleius' novel by turning to such authorities as Heraclitus, Plato, Cicero, Artemidorus, and Macrobius, (...) whose characterization of the phenomenon of dreaming sheds light on specific narratological trtaits of the Metamorphoses. It argues that the lower dream category, the insomnium , provides a notion of textuality that can clarify the traditional status of the Metamorphoses as a marginal work of art. In contrast to divinely sent symbolic dreams, it is primarily the insomnium—conceived as a by-product of the lower functions of the soul—that lends psychological force to Apuleius' fiction. (shrink)

This text is the introduction to V. Amit & N. B. Salazar, Pacing Mobilities. Timing, Intensity, Tempo & Duration of Human Movements, New York/Oxford, Berghahn, 2020, 202 p. It is also available on Berghahn publisher website.

This article aims to deepen and extend theoretical understanding of mobility by exploring some of the mechanisms by which it operates. It introduces the concept and practices of ‘tacking’ as a frame for examining the creative processes of navigation and improvisation through which people approach and reflect on the irregularities and uncertainties of their everyday rounds, enacted or otherwise narrated as spatial biography – lives conceived in mobile-spatial terms. ‘Tacking’ also travels beyond this frame of reference, i.e. it is ‘good (...) to think with’ across different substantive contexts of social interaction. Tacking suggests ongoing adjustment and modification that respond to shifting circumstances and may create new facts on the ground, which elicit further adjustments. (shrink)

Turning the attention to the temporal as well as the more familiar spatial dimensions of mobility, this volume focuses on the momentum for and temporal composition of mobility, the rate at which people enact or deploy their movements as well as the conditions under which these moves are being marshalled, represented and contested. This is an anthropological exploration of temporality as a form of action, a process of actively modulating or responding to how people are moving rather than the more (...) usual focus in mobility studies on where they are heading. (shrink)

We focus on the question of how expertise as conceived by the Stoics interacts with the content of impressions. In Section 1, we situate the evidence concerning expert perception within the Stoic account of cognitive development. In Section 2, we argue that the content of rational impressions, and notably of expert impressions, is not exhausted by the relevant propositions. In Section 3, we argue that expert impressions are a subtype of kataleptic impressions which achieve their level of clarity and distinctness (...) due to the contribution of expertise. In Section 4, we argue that the expertise in living well not only allows the wise person to assent correctly but also affects the content of her impressions. We suggest that these two models – one’s attitude toward an impression being informed by expertise, and one’s impressions being affected by expertise – might characterize distinct stages of cognitive development. Stoic wisdom is not only a matter of the way one assents to one’s impressions but also a matter of the condition of one’s soul and, consequently, of the kinds of impressions one even entertains. Expertise offers a model of how cognitive and discriminatory improvement through practice and effort can transform the non-wise into the wise. A reading on which the content of impressions is not exclusively propositional illuminates a further aspect of this transformation. If the same propositions are accessible through impressions with different non-propositional content, we can account for cases in which the novice and the expert entertain the same proposition. (shrink)

Professor Duncan Vere lays before us the idealised guidelines used for recruiting volunteers on which to try and test new medicines. He points out that if these were followed rigidly, few, if any volunteers would be found for this vital work. Inducements are used, but the size of these determines whether society deems it right or wrong. However, the aim is to help and advise volunteers of the need for such tests and the risks involved and therefore the information leaflet (...) reprinted as part of the article indicates how the drug testers are attempting to encourage volunteers in as ethical a way as possible. To abandon human tests with new drugs may be unethical. A balance is sought. (shrink)

In Principles I. 53, Descartes states what appears to be an important metaphysical principle: P1: Each substance has one principal property, which constitutes its nature and essence, and to which all its other properties are referred (AT VIIIA 25; CSM I 210).1 Marleen Rozemond calls this Descartes's "Attributes Premise", and it leads directly, as she points out, to Cartesian Dualism, the doctrine that a human mind and a human body, even when they belong to the same human being, are distinct (...) substances (Rozemond forthcoming). (shrink)

(2005). Learning From Descartes, Via Bennett. British Journal for the History of Philosophy: Vol. 13, No. 1, pp. 139-147. doi: 10.1080/0960878042000317636.

This paper was first presented at the London Medical Group's Annual Conference entitled Death: the last taboo held in February 1980. Dr Vere comments on the evidence of research done by him and his colleagues on the pain and discomfort suffered by patients who are dying and are in hospital. He contrasts this with the situation in hospices, analyses the differences, and attributes much of the unnecessary pain suffered in hospitals to attitudes of staff, as well as to a reluctance (...) by relatives to allow patients with terminal pain to die at home. He deprecates the tendency in hospitals to separate 'curing' and 'caring' and suggests that sometimes the best help involves 'doing' less, not more. (shrink)

The concept of vocal charisma has changed in the past decades from something that people have to something that people do, thereby stimulating research on how vocal charisma can be created and improved. Broadening the perspective on vocal charisma beyond the speaker’s performance itself to the context of the speech, we conducted acoustic-prosodic analyses of public speeches of two prominent Israelian politicians – Benjamin Netanyahu and Benny Gantz. The speech material consisted of 311–516 prosodic phrases per politician from the election (...) campaigns 2019–2020 and, crucially, was balanced so as to include an equal number of pre- and post-election speeches. Results show a superiority of Netanyahu over Gantz in almost all facets of vocal charisma, although Gantz caught up over time. Moreover, unlike Gantz, Netanyahu showed a strong adaptation of his vocal charisma patterns to before- and after-election contexts. Scrutinizing this versatility difference, an additional perception experiment with 42 listeners and excerpts from the two politicians’ speeches was carried out. Results show that Netanyahu’s speech excerpts were, unlike those of Gantz, mainly rated as more charismatic in those contexts in which they were performed. Gantz’ post-election speech excerpts, by contrast, were primarily rated as not fitting into that context, i.e., as unfolding their charisma better in a pre-election context. Moreover, listeners also rated Netanyahu as overall more charismatic than Gantz. The combined production and perception evidence suggests the relevance of context in the evaluation and interpretation of vocal charisma signals. (shrink)

In Hellenistic philosophy, one can find contrasting evaluations of the argumentative use of merely conceivable states of affairs. On the one hand, Epicureans discard any proposal that has no plausibility from the point of view of someone in possession of the relevant expertise. On the other hand, Sceptics regularly invoke views which one might conceivably hold, irrespective of the view’s epistemic credentials or whether or not it has or has ever had actual proponents. Since thought experiments often introduce scenarios involving (...) merely conceivable but non-actual states of affairs, the positions of Epicureans and Sceptics regarding conceivability can be transposed into different attitudes towards the method of thought experiments. (shrink)

It has been argued that Pyrrhonists will have trouble acquiescing in the religious practices of their compatriots, since those practices depend on beliefs that are supposedly eliminated by suspension of judgement. According to this objection ..., the Sceptic’s religious behaviour will be inescapably disingenuous. As a way out of this predicament, some interpreters have suggested that the sort of religion that Sextus was familiar with did not require the kind of belief that is subjected to Sceptical examination. This, however, acquits (...) Sextus of the charge of insincerity at the price of taking religious behaviour to be a culturally contingent exception to, rather than a standard case of, Pyrrhonian conduct. Another worry concerns the fixity of Sextus’ philosophical agenda. The argument in PH 3 concludes that, if one goes by what dogmatic philosophers have to say, one will be forced to think that god is inconceivable. By contrast, the first part of the M 9 section on theology argues not for suspension of judgement across the board, but only for the more modest claim that several noteworthy explanations of the emergence of religious belief are unsatisfactory. Insofar as this is the case, M 9 fails to live up to the standard set by PH 3, a failure due either to authorial incompetence or to a difference in philosophical objective. If that is the case, then the two discussions cannot be read as successful examples of the same philosophical outlook. In this paper, I argue for a comprehensive reading of Sextus’ take on religious matters that responds to these worries. In the first half of the paper, I present the two caveats as formulating a uniform agenda concerning theology (Section 1) which is further consistent with the Pyrrhonian stance as presented in PH 1 (Section 2). I show not only that Sextan Sceptics are able to engage in ordinary religious practices, but also that they can do so whether or not their cultural environment takes these practices to depend on holding dogmatic beliefs. In the second half of the paper, I argue by way of a detailed analysis that both PH 3 and M 9 are intended to motivate suspension of judgement about highly specific dogmatic tenets, and while their sources and targets might change, their intended outcome remains the same. The argument in PH 3, often understood as a sort of ‘master argument’ aimed at disarming a broad theistic consensus, depends in fact on peculiar commitments concerning the nature of inquiry (Section 3). The conceptual section of M 9 incorporates explicitly dogmatic—and quite plausibly Epicurean—material in order to argue for suspension of judgement about yet another issue, namely, the question of the natural or conventional origin of the concept of god (Section 4). (shrink)

Pyrrhonian inquiry responds to the hope of intellectual tranquillity, and aims at the achievement and maintenance of said tranquillity. According to the Tranquillity Charge, philosophical inquiry aims at the truth; hence, insofar as Pyrrhonian inquiry aims at tranquillity, it does not qualify as philosophical inquiry. Furthermore, Pyrrhonian philanthropy rests on the Partisan Premise, i.e. the claim that all philosophers aim at the removal of psychological disturbance. I show that the origin-story of Pyrrhonism evades the Tranquillity Charge, and that the Partisan (...) Premise is not as partisan as it seems. Unlike previous attempts, my reconstruction preserves all tranquillity-related features of Sextan Pyrrhonism. (shrink)

The 'playful affirmation', as Uziel Awret calls it, turns into a joyful affirmation of a theoretical challenge in a philosophical space set up by the many questions concerning the nature of consciousness. This is especially because the 'Las Meninas and the search for self-representation' (Awret, this volume) has been written in the spirit of an interplay between different modes and approaches, and also the different philosophical traditions, for dealing with the 'enigma' it presents. Bringing Velasquez's Las Meninas into the bigger (...) picture of consciousness studies means a change in methodological perspective. Not only does it support the idea so dear to the tradition of phenomenology and philosophical hermeneutics of claiming back the truth value for the experience of work of art, but the author also succeeds in showing the relevance of this 'truth' to recent theoretical approaches to problems of representationalism and self-representation (like those of David Rosenthal, Robert Van Gulick, Bruce Mangan and Uriah Kriegel, for example). (shrink)

The evidence concerning the existence of Epicurean gods has invited ever-growing attention, and has resulted in discussions of increasing sophistication. I aim to provide a roadmap to this controversy, and to argue for the following three claims. First, in the debate concerning ‘realist’ and ‘idealist’ readings of the Epicurean thesis that gods exist, there is no principled way of deciding which one to favour without having to compromise on some aspect of a minimally Epicurean position. Second, positing an innate disposition (...) to form the concept of god is not going to carry the day for an ‘idealist’ reading, though it does capture an important insight about the ethical orientation of the Epicurean theory. Third, in accor- dance with this ethical orientation, we have reason to suspect that Epicurus was genuinely uninterested in what the correct ontological position might be. (shrink)

In Against the Musicologists (Math. 6), Sextus uses two types of arguments against musicology. Some would argue that a science of music – does not contribute to a happy life, while others deny that such a science has ever been established. Since the respective beliefs that musicology exists and that it benefits those who have mastered it are fine specimens of dogmatism, all Sextus has to do is to set the naysayers and the believers against each other in good Pyrrhonian (...) fashion. If their accounts balance each other out, he can go on to suggest that reasonable inquirers will suspend judgement as to the truth about these matters, while leaving everyday musical practice intact. Against the Musicologists thus lends itself to being read as an attempt to display the Sceptical capacity to motivate suspension of judgement in a specific domain where the Sceptic has detected dogmatic belief. -/- In what follows, I develop a reading of the treatise along these lines. In Section 5.1, I argue that Sextus’ polemical engagement with philosophical musicology sits well with the project of the treatise to which it belongs, and with a plausible understanding of his philosophical position as presented in the Outlines of Pyrrhonism (Pyr.). Then I turn to the two kinds of arguments that are contrasted by Sextus as being ‘more dogmatic’ and ‘more aporetic’ in spirit. After their brief presentation in Section 5.2, explaining the nature of their contrast by pointing to the diverging agendas that they originally served, I give an overview of both as ultimately aiming at epochē in Sections 5.3 and 5.4. Finally, in Section 5.5, I push back against readings that take the treatise to present a deviation from the suspensive outlook. (shrink)

Each volume of this series of companions to major philosophers contains specially commissioned essays by an international team of scholars, together with a substantial bibliography, and will serve as a reference work for students and non-specialists. One aim of the series is to dispel the intimidation such readers often feel when faced with the work of a difficult and challenging thinker. The essays in this volume provide a systematic survey of Locke's philosophy informed by the most recent scholarship. They cover (...) Locke's theory of ideas, his philosophies of body, mind, language, and religion, his theory of knowledge, his ethics, and his political philosophy. There are also chapters on Locke's life and subsequent influence. New readers and non-specialists will find this the most convenient, accessible guide to Locke currently available. (shrink)

Locke was a libertarian: he believed in human freedom. To be sure, his conception of freedom was different from that of many philosophers who call themselves libertarians. Some such philosophers maintain that an agent is free only if her action is uncaused; whereas Locke thought that all actions have causes, including the free ones. Some libertarians hold that no action is free unless it proceeds from a volition that is itself free; whereas Locke argued that free volition, as opposed to (...) free action, is an impossibility. On the other hand, Locke agrees with the typical professed libertarian that free actions depend on volitions - or, as he often puts it, that an agent is free only with respect to the actions she wills, to those that are voluntary. And he also refuses to make voluntariness sufficient for freedom, whereby a free action is merely one that is willed. The free agent, Locke insists, must also be able or have been able to do something other than she does or did. Thus both Locke and the libertarian professor require indifference as well as spontaneity for freedom. But Locke’s freedom is not contra-causal; and he denies that it extends to volition. In this paper I want to focus on just this last component of Locke’s view of freedom: that freedom in willing, far from being required for free agency, is not even possible. I call this ‘the thesis of volitional determinism’. Locke presents an argument for this thesis in the Essay, but scholars have never paid much attention to it: I want to examine it. (shrink)