Over 300 years ago the father of microscopy, Antonie van Leeuwenhoek, observed dried rotifers “coming back to life” upon rehydration. Since then, scientists have been fascinated by the enduring mystery of how certain organisms survive losing essentially drying out completely. Historically sugars, such as the disaccharide trehalose, have been viewed as major functional mediators of desiccation tolerance. However, some desiccation tolerant organisms do not produce this sugar, hinting that additional mediators, and potentially novel mechanisms exist. It has become apparent that (...) a common theme among such organisms is the production and use of intrinsically disordered proteins to mediate survival in this dry state. However, the basic biology of these proteins – which unlike globular proteins lack persistent three-dimensional structure – is poorly understood, as are the functional mechanisms utilized by these enigmatic proteins that allow them to mediate desiccation tolerance. We purpose that probing the biochemical and biophysical nature of stress-related IDPs will provide mechanistic insights into these fascinating proteins. Remarkably, organisms from every kingdom of life can survive losing nearly all their intracellular water. A hallmark of desiccation tolerance is the use of intrinsically disordered proteins, but how IDPs contribute to tolerance is poorly understood. Here, we discuss possible mechanisms and avenues for studying these enigmatic proteins. (shrink)

Crutchfield and Redinger argue that consciousness-altering chemical restraints are less “liberty-intrusive” (or as we will sometimes put it, just less “intrusive”) than physical restraints. Physica...

Most approaches to iterated belief revision are accompanied by some motivation for the use of the proposed revision operator (or family of operators), and typically encode enough information in the epistemic state of an agent for uniquely determining one-step revision. But in those approaches describing a family of operators there is usually little indication of how to proceed uniquely after the first revision step. In this paper we contribute towards addressing that deficiency by providing a formal framework which goes beyond (...) the first revision step in two ways. First, the framework is obtained by enriching the epistemic state of an agent starting from the following intuitive idea: we associate to each world x two abstract objects x⁺ and x⁻, and we assume that, in addition to preferences over the set of worlds, we are given preferences over this set of objects as well. The latter can be considered as meta-information encoded in the epistemic state which enables us to go beyond the first revision step of the revision operator being applied, and to obtain a unique set of preferences over worlds. We then extend this framework to consider, not only the revision of preferences over worlds, but also the revision of this extended structure itself. We look at some desirable properties for revising the structure and prove the consistency of these properties by giving a concrete operator satisfying all of them. Perhaps more importantly, we show that this framework has strong connections with two other types of constructions in related areas. Firstly, it can be seen as a special case of preference aggregation which opens up the possibility of extending the frame-work presented here into a full-fledged framework for preference aggregation and social choice theory. Secondly, it is related to existing work on the use of interval orderings in a number of different contexts. (shrink)

Widespread tax evasion and avoidance have recently led to both significant reforms of international tax governance and increased attention from theorists of global tax justice. Against the background of an analysis of the double challenge of effectiveness and distribution facing the taxation of multinational enterprises, this paper puts forward a taxonomy of recent contributions of the tax justice literature. This taxonomy not only opens up an original angle of interpretation on global tax justice, but also provides a vantage point from (...) which to evaluate recent reforms by the Organisation for Economic Co-operation and Development. (shrink)

Industrial emissions of greenhouse gases are significant contributors to climate change, which poses a grave threat to social and economic systems. Our understanding of what might drive firms to reduce their emissions of these gases, however, is incomplete, and it is not clear that the knowledge gained from other environmental issues will readily apply to these emissions. We argue and find that indicators of environmental injustice previously shown to relate to toxic pollutants, for example, are poor predictors of greenhouse gas (...) emissions. Instead, we show that the degree of belief in and concern about climate change in a local community is a significant predictor of the facility’s rate of emission improvements. Furthermore, we find that beliefs at both the facility and headquarter communities influence emission reduction, and that those effects are substitutes for each other. (shrink)

Since the 19th century, innocence has been a hallmark of childhood. The innocence of children is seen as both a sanctity worth defending and a feature that excuses the unavoidable mistakes of adolescence. While beneficial in many settings, notions of childhood innocence are often entangled with values judgements. Inherent in innocence is the notion that that which we are innocent of is undesirable. Further, attributing innocence to some implies the tolerability of blame for others. This has unique implications in a (...) medical setting. This essay explores the implications of espousing the innocence of paediatric patients. Ultimately, because attribution of innocence is both prone to bias and rooted in the same framework as blame, it degrades patient-centred care and compromises the patient–provider relationship. I argue that avoiding such characterisations may allow providers to more effectively promote paediatric health. (shrink)

This article describes the development, implementation, and evaluation of a complex methotrexate ethics case used in teaching a Pharmacy Law and Ethics course. Qualitative analysis of student reflective writings provided useful insight into the students’ experience and comfort level with the final ethics case in the course. These data demonstrate a greater student appreciation of different perspectives, the potential for conflict in communicating about such cases, and the importance of patient autonomy. Faculty lessons learned are also described, facilitating adoption of (...) this methotrexate ethics case by other healthcare profession educators. (shrink)

David Hilbert sought to secure the epistemic foundations of mathematics by providing consistency proofs of axiomatized mathematical theories from within the finite standpoint. This standpoint requires concrete constructions without reference to completed infinities. In 1938, Gerhardt Gentzen proved the consistency of first-order Peano Arithmetic relying on the well-ordering of certain ordinal notations. This was thought by Gentzen and Paul Bernays to be finitistically acceptable. However, a finitistically acceptable proof of the relevant well-ordering was not available until Gaisi Takeuti’s proof in (...) 1978. Beginning with the proposition that Takeuti’s proof conforms to the finite standpoint, this chapter explores the limits of a finitism based on the methods of Gentzen and Takeuti. It is argued that the upper limit is the Feferman-Schütte ordinal, and thus that finitism may be extended to strong subsystems of second-order arithmetic-systems strong enough to provide a theory of the ordinals for which Gentzen employed notations. (shrink)

Abstract:This essay explores key values of John Lachs's work, especially freedom, diversity, and human flourishing, when applied to the history of the philosophy of education as well as to the practical problems of policy and implementation today in American schools. I consider the importance and tensions involved in these values in the thinking of Plato, Jean-Jacques Rousseau, and John Dewey. Next, I examine necessary and then avoidable challenges of operationalizing freedom and diversity in schools, especially in tensions with recent policy (...) initiatives that threaten freedom and diversity for human flourishing. The aim here is to note the central importance of the values that Lachs has long championed, while attending also to the risks and dangers that misunderstanding and narrow thinking pose about them when applied to American public schools. Ultimately, I argue that while advocacy for liberty sometimes raises profound problems in the sphere of public education, democratic education is enriched immeasurably when it enables and empowers freedom to pursue diverse forms of flourishing. (shrink)

This edited collection includes contributions from expert philosophers of law and considers the work of one of the most important legal philosophers of our time, Professor Gerald J Postema. The chapters dig deep into important camps of Postema's rich theoretical project including: - the value of the rule of law; - the ideal of integrity in adjudication; - his works on analogical reasoning; - the methodology of jurisprudence; - dialogues with Ronald Dworkin, Joseph Raz, Frederick Schauer and HLA Hart. It (...) includes an original article by Professor Postema, in which he develops his conception of the rule of law and replies to some objections to previous works, and an interview in which he provides a fascinating and unique insight into his philosophy of law. (shrink)

Socrates' moral psychology is widely thought to be 'intellectualist' in the sense that, for Socrates, every ethical failure to do what is best is exclusively the result of some cognitive failure to apprehend what is best. Until publication of this book, the view that, for Socrates, emotions and desires have no role to play in causing such failure went unchallenged. This book argues against the orthodox view of Socratic intellectualism and offers in its place a comprehensive alternative account that explains (...) why Socrates believed that emotions, desires and appetites can influence human motivation and lead to error. Thomas C. Brickhouse and Nicholas D. Smith defend the study of Socrates' philosophy and offer an alternative interpretation of Socratic moral psychology. Their novel account of Socrates' conception of virtue and how it is acquired shows that Socratic moral psychology is considerably more sophisticated than scholars have supposed. (shrink)

When do people say that they are moved, and does this experience constitute a unique emotion? We review theory and empirical research on being moved across psychology and philosophy. We examine feeling labels, elicitors, valence, bodily sensations, and motivations. We find that the English lexeme being moved typically (but not always) refers to a distinct and potent emotion that results in social bonding; often includes tears, piloerection, chills, or a warm feeling in the chest; and is often described as pleasurable, (...) though sometimes as a mixed emotion. While we conclude that it is a distinct emotion, we also recommend studying it in a more comprehensive emotion framework, instead of using the ambiguous vernacular term being moved as a scientific term. (shrink)

Though not often discussed as such, Gore Vidal's Myra Breckinridge is a work of queer utopianism. Myra herself is an entrancing figure—a self-created goddess who is determined to save humanity by abolishing gender itself. That her efforts ultimately fail is a testament to the queerness of her utopianism. Using Lee Edelman's discussion of “reproductive futurism” and José Esteban Muñoz's insights into the queerness of utopianism, this article analyzes the ways in which Myra Breckinridge channels both hopeful and destructive urges as (...) a way of imagining a counter-narrative to the human catastrophe represented by the atomic bomb and the threat of overpopulation. (shrink)

Thomas Brickhouse and Nicholas Smith offer a comprehensive historical and philosophical interpretation of, and commentary on, one of Plato's most widely read works, the Apology of Socrates. Virtually every modern interpretation characterizes some part of what Socrates says in the Apology as purposefully irrelevant or even antithetical to convincing the jury to acquit him at his trial. This book, by contrast, argues persuasively that Socrates offers a sincere and well-reasoned defense against the charges he faces. First, the authors establish (...) a consensus of ancient reports about Socrates ' moral and religious principles and show that these prohibit him from needlessly risking the condemnation of the jury. Second, they consider each specific claim made by Socrates in the Apology and show how each can be construed as an honest effort to inform the jurors of the truth and to convince them of his blamelessness. The arguments of this book are informed by a critical review of the scholarly literature and careful attention to the philosophy expressed in Plato's other early dialogues. (shrink)

Codes of ethics exist in many, if not the majority, of all large U.S. companies today. But how the impact of these written codes affect managerial attitudes and behavior is still not clearly documented or explained. This study takes a step in that direction by proposing that attention should shift from the codes themselves as the sources of ethical behavior to the persons whose behavior is the focus of these codes. In particular, this study investigates the role of code familiarity (...) as a factor impacting the influence of an ethics code on manager behavior. Data collected from 286 executives from companies in the direct selling industry are used to test hypotheses (1) that the perceived usefulness of ethics codes is positively related to the degree of familiarity with the code, and (2) that ethical climate as assessed by managers is positively related to the code''s perceived usefulness. Both hypotheses are supported, and their implications and further research directions are discussed. (shrink)

This article argues that Carol Gilligan's research in moral development psychology, work which claims that women speak about ethics in a "different voice" than men do, is applicable to business ethics. This essay claims that Gilligan's "ethic of care" provides a plausible explanation for the results of two studies that found men and women handling ethical dilemmas in business differently. This paper also speculates briefly about the management implications of Gilligan's ideas.

The major point of contention among the philosophers and mathematicians who have written about the independence results for the continuum hypothesis (CH) and related questions in set theory has been the question of whether these results give reason to doubt that the independent statements have definite truth values. This paper concerns the views of G. Kreisel, who gives arguments based on second order logic that the CH does have a truth value. The view defended here is that although Kreisel's conclusion (...) is correct, his arguments are unsatisfactory. Later sections of the paper advance a different argument that the independence results do not show lack of truth values. (shrink)

When making decisions, humans can observe many kinds of information about others' activities, but their effects on performance are not well understood. We investigated social learning strategies using a simple problem-solving task in which participants search a complex space, and each can view and imitate others' solutions. Results showed that participants combined multiple sources of information to guide learning, including payoffs of peers' solutions, popularity of solution elements among peers, similarity of peers' solutions to their own, and relative payoffs from (...) individual exploration. Furthermore, performance was positively associated with imitation rates at both the individual and group levels. When peers' payoffs were hidden, popularity and similarity biases reversed, participants searched more broadly and randomly, and both quality and equity of exploration suffered. We conclude that when peers' solutions can be effectively compared, imitation does not simply permit scrounging, but it can also facilitate propagation of good solutions for further cumulative exploration. (shrink)

The cross-fruition between analytical philosophy and continental philosophical traditions has stimulated a wide-ranging debate about the role of philosophy and the use of argument and reason in culture. Through a discussion of salient themes in the analytical tradition, in the work of the later Wittgenstein, and in critical theory,Transformative Philosophy articulates a novel conception of philosophy as a transformative care for self and others.

"Displaying a masterful grasp of the texts, the author shows how otherness forces itself upon the existentialist Sartre, gradually constraining him to modify his understanding of consciousness as omnipotent. The issue is Sartre’s discovery of the social and its conceptual assimilation into his individualistic, consciousness-oriented philosophy." —Thomas R. Flynn "This very successful and accessible scholarly book... is simultaneously a succinct and clear overview of Sartre’s philosophical works.... and a fresh consideration of Sartre’s body of work." —Choice "Busch’s admirably clear (...) and compact discussion is essential reading for Sartre scholars, since it powerfully addresses many issues dividing them... " —Ethics "... a useful overview of the evolution of Sartre’s thought... " —Review of Politics "... a thought provoking reassessment of Sartre's philosophical career." —Man and World "... succinct, richly documented survey... " —International Studies in Philosophy. (shrink)

Back to Kant is a study of the rise of the neo-Kantian movement from its origins in the 1850s to its academic preeminence in the years before World War I. Thomas E. Willey describes early neo-Kantianism as a reaction of scientists and scientific philosophers against both the then discredited Hegelianism and Naturphilosophie of the preceding era and the simplistic and deterministic scientific materialism of the 1850s. "Back to Kant" was the slogan of a revolt against theories of knowledge which (...) seemed inadequate to recent discoveries in thermodynamics, physiology, optics and other fields. Because Immanuel Kant was the philosopher who placed Newtonian physics on new epistemological foundations and demonstrated the possibility of universal scientific truth, he was the right thinker for a generation of scholars living through a new scientific revolution in Germany and dissatisfied with both speculative idealism and crude materialism. The second wave of neo-Kantians continued to discuss problems of scientific epistemology in the 1880s and after, but they also showed a keen interest in political and social matters, attempting to bridge liberalism and socialism with Kantian ethics. Neo-Kantians had to face questions of socialism, the place of the working class in society, the phenomenon of social welfare, the challenge of political democracy. Willey uses the biographical approach to develop the relationship between unity and diversity in the movement, and to underscore the importance of personality in history. While individual dissertations and monographs have been written on various thinkers and schools within neo-Kantianism, this is the first wide-ranging history of the entire phenomenon. Willey observes that the movement did succeed in reasserting ethical values and in separating humanistic studies from the methods of physical science. He also discusses the possibility that a wider acceptance of neo-Kantian ideals among bourgeois intellectuals and socialist leaders might have reduced class antagonisms and sustained a stronger feeling of community between Germany and the West. (shrink)

Ranging from his early treatises, the ’Monologion’ (a work written to show his monks how to meditate on the divine essence) and the ’Proslogion’ (best known for its advancement of the so-called ontological argument for the existence of God), to his three philosophical dialogues on metaphysical topics such as the relationship between freedom and sin, and late treatises on the Incarnation and salvation, this collection of Anselm’s essential writings will be of interest to students of the history of philosophy and (...) theology as well as to anyone interested in examining what Anselm calls "the reason of faith." (publisher). (shrink)

The technical results presented here on continuity and approximate implication are obviously incomplete. In particular, a syntactic characterization of approximate implication is highly desirable. Nevertheless, I believe the results above do show that the theory has considerable promise for application to the areas mentioned at the top of the paper.Formulation and defense of realist interpretations of science, for example, require approximate truth because we hardly ever have evidence that a particular scientific theory corresponds perfectly with a portion of the real (...) world. Realists need to assert, then, that evidence for a theory is evidence for its approximate truth, not its truth (see [3] and [18]). Approximate truth is, however, a vague notion, and specification of quantity terms and of a sense of approximation are needed to make precise applications of it. Suitability of both vocabulary and sense of approximation depend on the subject matter, and their selection is a partly empirical matter that raises complex issues. In light of the number of common inferences which are not continuous, realists also need to be concerned about indiscriminate use of deductive logic to derive consequences from approximately true theories. These issues will be considered further in a future paper.Approximate truth also has potential application in areas of artificial intelligence that require inference from inaccurate data. In the ‘qualitative’ physical theories of de Kleer and Brown [6], for example, ‘qualitative’ values are derived by partitioning the real numbers into regions. Inferences leading from inside to outside a region must be identified and avoided, and approximate implication and continuity may prove useful in doing this. More generally, growing use of predicate logic as a programming language invites application of the theory of approximate truth as a symbolic substitute for numerical evaluation of computation errors. This too will be the subject of a future paper. (shrink)

In one of the most disputed passages of Greek literature Plato in the Republic, 7. 528e–530c prescribes astronomy as the fourth study in the education of the Guardians. But what sort of astronomy? According to one school of thought it is a purely speculative study of bodies in motion having no relation to the celestial objects that we see. While this interpretation has rejoiced the hearts of Plato's detractors, who regard him as an obstacle to the progress of science, it (...) has dismayed his admirers. Another school of thought holds that what Plato meant was that astronomers must get to know the real motions of the heavenly bodies as opposed to their apparent motions as seen by us on earth. The opposed interpretations may be set out in the following representative citations from Sir Thomas Heath and John Burnet. (shrink)

Scottish philosopher Thomas Brown held the chair of moral philosophy at the University of Edinburgh. He was distinguished for his work in the philosophy of mind and causation, and was a founder member of the Edinburgh Review. At the beginning of the nineteenth century, controversy arose over John Leslie being appointed to the chair of mathematics at the university. City ministers opposed him because he defended Hume's view of causation, which was seen as being incompatible with the existence of (...) God. In 1805 Brown wrote a pamphlet, Observations on the Nature and Tendency of the Doctrine of Mr. Hume Concerning the Relation of Cause and Effect, which among other things aimed to show that Hume's theory was compatible with belief in God. This book, first published in 1818, is the third edition of that original pamphlet, which grew to become a thorough examination of the philosophy of causation. (shrink)

Background Community advisory boards have expanded beyond high-income countries and play an increasing role in low- and middle-income country research. Much research has examined CABs in HICs, but less is known about CABs in LMICs. The purposes of this scoping review are to examine the creation and implementation of CABs in LMICs, including identifying frequently reported challenges, and to discuss implications for research ethics. Methods We searched five databases for publications describing or evaluating CABs in LMICs. Two researchers independently reviewed (...) articles for inclusion. Data related to the following aspects of CABs were extracted from included publications: time, country, financial support, research focus, responsibilities, and challenges. Thematic analyses were used to summarize textual data describing challenges. Results Our search yielded 2005 citations, 83 of which were deemed eligible for inclusion. Most studies were published between 2010 and 2017. Upper-middle-income countries were more likely to have studies describing CABs, with South Africa, China, and Thailand having the greatest numbers. The United States National Institutes of Health was the main source of financial support for CABs. Many CABs focused on HIV research. Thirty-four studies reported how CABs influenced the informed consent process for clinical trials or other aspects of research ethics. CAB responsibilities were related to clinical trials, including reviewing study protocols, educating local communities about research activities, and promoting the ethical conduct of research. Challenges faced by CABs included the following: incomplete ethical regulations and guidance; limited knowledge of science among members of communities and CABs; unstable and unbalanced power relationships between researchers and local communities; poor CAB management, including lack of formal participation structures and absence of CAB leadership; competing demands for time that limited participation in CAB activities; and language barriers between research staff and community members. Several challenges reflected shortcomings within the research team. Conclusions Our findings examine the formation and implementation of CABs in LMICs and identify several ethical challenges. These findings suggest the need for further ethics training among CAB members and researchers in LMICs. (shrink)

The International Society of Krishna Consciousness, commonly known as the Hare Krishna Movement, has disseminated a flurry of antievolutionist media since its inception in 1966. Such communications frequently co-opt arguments employed by Christian creationists and Intelligent Design theorists. At the same time, however, there are indications that a scattering of ISKCON publications have articulated relatively ambiguous, less oppositional statements about evolutionary theory. This article reconsiders ISKCON's Darwin-skepticism by appraising recent, largely unexamined Hare Krishna publications, as well as responses to evolutionary (...) theory expressed by ISKCON's founder, A. C. Bhaktivedanta, and his immediate Vaishnava forerunners. The analysis reveals that, although the majority of contemporary ISKCON materials are vehemently opposed to evolution, some leading voices demonstrate less combative, cautiously accommodating stances. These cases are suggestive of complexities in ISKCON's responses to evolution, both past and present, which are not necessarily encapsulated in the terms Vedic creationism or antievolutionism. (shrink)

In this paper we offer a reconstruction of Anselm’s account of freedom that resolves various apparent inconsistencies. The linchpin of this account is the definition of freedom. Anselm argues that the power to preserve rectitude for its own sake requires the power to initiate an action of which the agent is the ultimate cause, but it does not always require that alternative possibilities be available to the agent. So while freedom is incompatible with coercion and external causal determination, an agent (...) can, under certain circumstances, act freely even though he cannot act otherwise than he does. (shrink)

Nineteenth-century spiritism was a blend of religious elements, the philosophy of mind, science and popular science and contacts with extraterrestrials were a commonplace phenomenon during spiritistic séances. Using the example of Carl du Prel I show how his comprehensive mystic philosophy originated in a theory of extraterrestrial life. Carl du Prel used a Darwinian and monistic framework, theories of the unconscious and a Neo-Kantian epistemology to formulate a philosophy of astronomy and extraterrestrial life. He claimed that the mechanism of Darwinian (...) selection is responsible for the distribution of stars and the orbits of the planets. In his speculations on the nature of extraterrestrial life he used the concept of organ projection to argue that technical solutions on earth will be realized organically on other planets and claimed that superior extraterrestrials have quantitatively and qualitatively different senses and thus different forms of intuition. A comparison with Camille Flammarion, spiritist and populariser of astronomy, demonstrates the contextual complexities of spiritism. In contrast to du Prel’s sober Neo-Kantian philosophical speculations, Flammarion was a late proponent of a French esoteric tradition that was rooted in romantic socialism, painted grand cosmological vistas and emphasized reincarnation. I put forward the hypothesis that current discourses on extraterrestrial life are affected by the spiritist tradition mainly through the ‘Golden Age’ science fiction literature of the 1940s and 50s and its successors. However, neither Carl du Prel nor Camille Flammarion contributed significantly to this tradition, which is mainly shaped by the psychical research of J. B. Rhine.Keywords: Spiritism; Carl du Prel; Camille Flammarion; Organ projection; Science fiction. (shrink)