Elevations in brain stimulation reward (BSR) thresholds have been observed in rats undergoing nicotine withdrawal and have been proposed as a sensitive measure of the negative affective state associated with nicotine withdrawal. mGluR are presynaptic autoreceptors that decrease glutamate release when stimulated. The aim of this study was to examine the role of glutamate neurotransmission in nicotine dependence. The mGluR agonist LY314582 (2.5–7.5 mg/kg) precipitated nicotine withdrawal as measured by elevations in BSR thresholds in nicotine-treated rats but not in controls. (...) It was hypothesized that LY314582 precipitated nicotine withdrawal by decreasing glutamatergic tone at postsynaptic glutamate receptors. Therefore, the effects of MPEP (0.5–2 mg/kg), an mGluR antagonist, and MK-801 (0.01–1 mg/kg), an NMDA receptor antagonist, were examined. MPEP elevated BSR thresholds by an equal magnitude in control and nicotine-treated rats. At low doses, MK-801 (0.01–0.2 mg/kg) lowered BSR thresholds to a similar extent in control and nicotine-treated rats. At higher doses, MK-801 (0.25–1 mg/kg) disrupted performance in nicotine-treated and control rats. These data indicate that mGluR and NMDA receptors regulate BSR in opposite directions in non-dependent animals, and chronic nicotine treatment does not alter these effects. Most importantly, the data demonstrate that the mGluR is involved in nicotine dependence, but mGluR and NMDA receptors do not mediate mGluR actions in nicotine dependence. (shrink)

Hypocretin regulates brain reward function and cocaine consumption in rats. The hypocretinergic (Hcrt) system is implicated in energy homeostasis, feeding and sleep regulation. Hypocretinergic cell bodies are located in the lateral hypothalamus (LH) and project throughout the brain. The aim of the present studies was to investigate the role of the Hcrt system in regulating brain reward function and the reinforcing properties of cocaine in rats. Intracranial self-stimulation (ICSS) thresholds provide an accurate measure of brain reward function in rats. Here (...) we show that a single injection of Hcrt-1 (5 µg icv) induced persistent, long-lasting elevations in ICSS thresholds in drug-naïve rats. Indeed, Hrct-1 elevated ICSS thresholds for 36 h, with peak elevations between 6 and 12 hours after injection. Hrct-1-induced threshold elevations were attenuated by an antibody known to neutralize the binding of hcrt-1 to its receptors. Taken together, these observations suggest that Hrct-1 negatively regulates brain reward function in rats. Because Hrct-1 negatively regulates brain reward function, we hypothesized that it may attenuate the increased brain reward function usually observed after cocaine consumption, and thereby alter cocaine self-administration behavior. A daily injection of Hrct-1 (1 µg icv), for 4 consecutive days, slightly increased cocaine self-administration (0.25 mg/infusion) in rats. Overall, these data demonstrate that Hrct-1 negatively regulates brain reward function, and as such may indirectly alter cocaine self-administration. Given the well-established role of hypocretin neurons in regulating feeding behavior and sleep, we hypothesize that hypocretinergic regulation of brain reward function may provide a mechanism by which appropriate and competing behaviors (e.g. sleep or feeding) may be engaged to maintain energy homeostasis. (shrink)

ABSTRACT:A wide range of research uses patterns of genetic variation to infer genetic similarity between individuals, typically referred to as genetic ancestry. This research includes inference of human demographic history, understanding the genetic architecture of traits, and predicting disease risk. Researchers are not just structuring an intellectual inquiry when using genetic ancestry, they are also creating analytical frameworks with broader societal ramifications. This essay presents an ethics framework in the spirit of virtue ethics for these researchers: rather than focus on (...) rule following, the framework is designed to build researchers’ capacities to react to the ethical dimensions of their work. The authors identify one overarching principle of intellectual freedom and responsibility, noting that freedom in all its guises comes with responsibility, and they identify and define four principles that collectively uphold researchers’ intellectual responsibility: truthfulness, justice and fairness, anti-racism, and public beneficence. Researchers should bring their practices into alignment with these principles, and to aid this, the authors name three common ways research practices infringe these principles, suggest a step-by-step process for aligning research choices with the principles, provide rules of thumb for achieving alignment, and give a worked case. The essay concludes by identifying support needed by researchers to act in accord with the proposed framework. (shrink)

In three respects, ethics can be marked by the category of the ‘priceless’. Its key reference point, ‘human dignity’, was described by Kant as the exact opposite to what can be priced in equivalents. As an enterprise, ethics is ‘priceless’ as a commitment of the human spirit which goes beyond and against the attitude of success calculation. Yet, an understanding of ethics as unconditional recognition and the anticipatory, asymmetric, innovative praxis (Helmut Peukert) that expresses it have a cost. Where does (...) the motivation to forego, for example, ethically problematic therapies, originate? How can respect for what is priceless be sustained in the face of the relentless spread of market categories diagnosed, among others, by Jürgen Habermas and Paul Ricoeur, against which religions may raise a delaying veto? Only a Christology that can adequately conceptualise the experience of the graciousness and superabundance of God’s gift is able to support the increasingly counter-cultural conviction of something beyond our disposition. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

The aim of this review is to show the fruitfulness of using images of facial expressions as experimental stimuli in order to study how neural systems support biologically relevant learning as it relates to social interactions. Here we consider facial expressions as naturally conditioned stimuli which, when presented in experimental paradigms, evoke activation in amygdala–prefrontal neural circuits that serve to decipher the predictive meaning of the expressions. Facial expressions offer a relatively innocuous strategy with which to investigate these normal variations (...) in affective information processing, as well as the promise of elucidating what role the aberrance of such processing might play in emotional disorders. (shrink)

In Religion and the Obligations of Citizenship Paul J. Weithman asks whether citizens in a liberal democracy may base their votes and their public political arguments on their religious beliefs. Drawing on empirical studies of how religion actually functions in politics, he challenges the standard view that citizens who rely on religious reasons must be prepared to make good their arguments by appealing to reasons that are 'accessible' to others. He contends that churches contribute to democracy by enriching political (...) debate and by facilitating political participation, especially among the poor and minorities, and as a consequence, citizens acquire religiously based political views and diverse views of their own citizenship. He concludes that the philosophical view which most defensibly accommodates this diversity is one that allows ordinary citizens to draw on the views their churches have formed when voting and offering public arguments for their political positions. (shrink)

The editors of this unique volume have brought together 24 leading emotion theorists with a wide variety of perspectives to address 12 fundamental questions about the subject.

For over twenty years, Paul Weithman has explored the thought of John Rawls to ask how liberalism can secure the principled allegiance of those people whom Rawls called 'citizens of faith'. This volume brings together ten of his major essays, which reflect on the task and political character of political philosophy, the ways in which liberalism does and does not privatize religion, the role of liberal legitimacy in Rawls's theory, and the requirements of public reason. The essays reveal Rawls (...) as a thinker deeply engaged with political and existential questions that trouble citizens of faith, and explore how - in firm opposition to political realism - he tries to show that the possibility of liberal democracy and the natural goodness of humanity are objects of reasonable faith. The volume will be of interest to political philosophers, political theorists, moral theologians, and religious ethicists. (shrink)

Like nature itself, modern economic life is driven by relentless competition and unbridled selfishness. Or is it? Drawing on converging evidence from neuroscience, social science, biology, law, and philosophy, Moral Markets makes the case that modern market exchange works only because most people, most of the time, act virtuously. Competition and greed are certainly part of economics, but Moral Markets shows how the rules of market exchange have evolved to promote moral behavior and how exchange itself may make us more (...) virtuous. Examining the biological basis of economic morality, tracing the connections between morality and markets, and exploring the profound implications of both, Moral Markets provides a surprising and fundamentally new view of economics--one that also reconnects the field to Adam Smith's position that morality has a biological basis. Moral Markets, the result of an extensive collaboration between leading social and natural scientists, includes contributions by neuroeconomist Paul Zak; economists Robert H. Frank, Herbert Gintis, Vernon Smith, and Bart Wilson; law professors Oliver Goodenough, Erin O'Hara, and Lynn Stout; philosophers William Casebeer and Robert Solomon; primatologists Sarah Brosnan and Frans de Waal; biologists Carl Bergstrom, Ben Kerr, and Peter Richerson; anthropologists Robert Boyd and Michael Lachmann; political scientists Elinor Ostrom and David Schwab; management professor Rakesh Khurana; computational science and informatics doctoral candidate Erik Kimbrough; and business writer Charles Handy. (shrink)

Because Paul has proven difficult to understand, the interpreter must pay careful attention to the language, the rhetorical structure, and the context if unnecessary difficulties are to be avoided.

This collection of papers makes a step towards increased dialogue among philosophical liberals and their theological, sociological and legal critics. The text should be significant for those concerned with the place of religion within a liberal society.

_Exploring Religious Diversity_ analyzes the philosophical questions raised by the fact that many religions in the world often appear to contradict each other in doctrine and practice. Analyzes the philosophical questions raised by the fact that many religions in the world often appear to contradict each other in doctrine and practice. Evaluates the fundamental philosophical underpinnings of the debates between religious and non-religious approaches to religious diversity. Contains a glossary that defines the book's key technical terms and how they are (...) related to one another. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:THOMISTIC PRIDE AND LIBERAL VICE 1 PAUL J. WEITHMAN University of Notre Dame Notre Dame, Indiana L IBERALISM IS often portrayed, and sometimes portrays itself, as a moral and political view that rejects the claims of tradition. Thus liberals characteristically claim that the traditional standing of a social arrangement contributes little or nothing to its political legitimacy. Whether an arrangement is legitimate depends upon whether or not those (...) who currently live under it can understand and accept its rationale. Members of each generation must be able to examine arrangements as if they themselves were signatories of the social contract; the justification of regimes must, as it were, be susceptible of renewal in every age and to every citizen. Jefferson gave this view its most extreme expression when he claimed that each generation has the right to begin its nation's political life anew, and that national constitutions should be rewritten every two decades.2 Liberals often seem no kinder to intellectual than to political traditions. As they think political life can periodically begin anew, so they sometimes seem to think that political and moral philosophy can begin anew. Hobbes famously castigated the obscurities of scholasticism and argued that political philosophy could achieve firm footing only if the rubble of the past were swept away.3 Liberal contract theorists have followed Hobbes's lead, developing political theories that rely not at all upon classi1 Thanks to Alasdair Macintyre, David O'Connor, Michael Pakaluk, David Solomon, Eleonore Stump, and Allen Wood for helpful comments on earlier drafts. This paper is dedicated to the memory of my teacher and friend, Prof. Judith Shklar. 2 See Jefferson's famous letter to Madison of September 6, 1789 (The Portable Jefferson, ed. Merrill D. Peterson [New York: Viking, 1977], 444ff.), as well as his lesser known missive to Samuel Kercheval of July 12, 1816 (ibid., SS2ff.). 3 See Thomas Hobbes, Leviathan, ed. C. B. MacPherson (New York: Penguin Books, 1985), 727, for an especially pungent expression of a view that runs throughout the Leviathan. 241 242 PAUL J. WEITHMAN cal and medieval moral philosophy. To take but one example of this neglect of the past, the ethical writings of scholasticism are dominated by richly detailed analyses of the virtues and vices, yet liberal writers roundly ignore these discussions. Liberals have been quick to defend their suspicions of the thought and politics of the past, but critics of liberalism have been equally quick to seize upon them. Champions of virtue ethics have been among the most vocal critics of liberalism in recent years, arguing that liberals court philosophical peril by neglecting the insights of earlier moral theories. Edmund Burke, the eighteenth-century opponent of liberalism, had an additional complaint. Burke discerned an arrogance in the liberal rejection of intellectual and political tradition. It was mere pride, Burke thought, to suppose that politics and political theory could be made transparent to the reason of every individual in the way that liberals sometimes claim.4 Burke's allegation that the liberal rejection of tradition reflects pride is ironic, for pride is a central element of one of the traditions of moral thought that liberals seem determined to reject. During a lengthy period of philosophy's history, pride was thought to be a motive of all wrong action. The biblical book of Sirach says that pride is the beginning of all evil5 and a long line of medieval moralists labored to explain how this might be so. Yet the tradition of moral thought that accorded pride so central a role now suffers from neglect at the hands of many philosophers. And pride itself is a vice that many philosophers now consider unworthy of attention. Most fail to consider it seriously as a motive for any wrong action at all. I have three aims in this paper. One is to examine pride's neglect more closely. I shall argue that pride suffers this neglect because of its centrality to a religiously based tradition of moral thought that many philosophers no longer accept. The alleged connection between pride and religion is, I shall argue, suggestive. It suggests what an account of pride would have to include 4 See Edmund Burke, Reflections on... (shrink)

There is a growing crisis in scientific research characterized by failures to reproduce experimental results, fraud, lack of innovation, and burn-out. In Science and Christian Ethics, Paul Scherz traces these problems to the drive by governments and business to make scientists into competitive entrepreneurs who use their research results to stimulate economic growth. The result is a competitive environment aimed at commodifying the world. In order to confront this problem of character, Scherz examines the alternative Aristotelian and Stoic models (...) of reforming character, found in the works of Alasdair MacIntyre and Michel Foucault. Against many prominent virtue ethicists, he argues that what individual scientists need is a regime of spiritual exercises, such as those found in Stoicism as it was adopted by Christianity, in order to refocus on the good of truth in the face of institutional pressure. His book illuminates pressing issues in research ethics, moral education, and anthropology. (shrink)

ABSTRACTHélène Landemore's Democratic Reason offers a new justification for democracy and for broad-based citizen participation, appealing to the “emergent” intelligence of large, diverse groups. She argues that ordinary citizens should rule as directly as possible because they will make better informed, more intelligent decisions than, for example, appointed officials, councils of experts, or even elected representatives. The foundation of this conclusion is the premise that “diversity trumps ability” in a wide range of contexts. But the main support for that claim (...) is merely a series of computer experiments that are strongly biased toward that result and tell us essentially nothing about decision making in real-world political settings. Moreover, Landemore's analyses of alternative forms of rule deal only in abstract comparisons between sharply distinguished ideal types. Among other difficulties, they entirely overlook the central consideration in such comparisons: the relative ability of any decision-making process to go beyond stereotyped, intrinsic strategies and integrate multiple sources and varieties of information. In the end, Landemore's claims for the superior intelligence of broadly participatory forms are thus not supported by credible evidence. (shrink)

Since the last century, vaccination has been one of the most important tools we possess for the prevention and elimination of disease. Yet the tremendous gains from vaccination are now threatened by a growing hesitance to vaccinate based on a variety of concerns or objections. Geographic clustering of some families who choose not to vaccinate has led to a number of well-publicized outbreaks of vaccine-preventable diseases. Of note is that some of these outbreaks are centered within some Christian religious groups (...) that increasingly avoid vaccination due to moral concerns, fears about safety, or doubts about the necessity of vaccines. We argue from the perspective of Catholic social teaching on why there is a moral duty to vaccinate. (shrink)

Trust is a temporary attachment between humans that pervades our daily lives. Recent research has shown that the affiliative hormone oxytocin rises with a social signal of interpersonal trust and is associated with trustworthy behavior (the reciprocation of trust). This commentary reports these results and relates them to the target article's findings for variations in affiliative-related behaviors.

In his essay "Natural Law, Property, and Justice," B. Andrew Lustig argues for what he calls "significant correspondences" between John Locke's theory of property and scholastic theories of property on the one hand, and between Locke's theory and contemporary Catholic social teaching on the other. These correspondences, Lustig claims, establish an intellectual "tradition of property in common." I argue that linking Aquinas--even via Locke--to the redistributivism of contemporary Catholic social teaching requires distorting his political theory. This distortion, I argue, obscures (...) the possibility of using Aquinas's political theory as a basis for radical social criticism. (shrink)

Liberal political theorists are often accused of "privatizing" religion; the work of philosopher John Rawls has been especially subject to this criticism. I begin by examining what is meant by "privatization." I then consider the criticisms of Rawls advanced by Timothy Jackson, David Hollenbach, and John Langan. I argue (1) that Rawls does not privatize religion to the extent that his critics believe and (2) that criticisms of what privatization of religion Rawls does defend cannot be sustained.

_Exploring Religious Diversity_ analyzes the philosophical questions raised by the fact that many religions in the world often appear to contradict each other in doctrine and practice. Analyzes the philosophical questions raised by the fact that many religions in the world often appear to contradict each other in doctrine and practice. Evaluates the fundamental philosophical underpinnings of the debates between religious and non-religious approaches to religious diversity. Contains a glossary that defines the book's key technical terms and how they are (...) related to one another. (shrink)

Western Buddhology, the responsible scholarly study of Buddhist languages, history and ideas, is now more than a century and a half old. For most of that time scholars working in this field have been primarily concerned to understand and expound their sources, not to criticize or assess the views found therein, much less to make any attempt at deciding whether the central views of Buddhist philosophers are likely to be true statements of the way things are. There are good reasons (...) for this restriction; before a given set of philosophical views can be assessed it must be understood, and in the case of Buddhism the gaining of such understanding has involved the collective philological labours of several generations of scholars and is still in many respects in its infancy. What is the case for the scholarly community as a whole is magnified for the individual working in this field; the effort involved in becoming competent in several Buddhist canonical languages and in becoming familiar with a range of philosophical ideas and preconceptions which are in many respects alien to one's own culture tends to mean that the Buddhologist's apprenticeship is long, his publications so clogged with jargon as to be inaccessible to any non-specialist, and his appetite for truth stifled by Sanskrit syntax and Tibetan declensions. There is the added problem that the Western intellectual who makes the study of Buddhism his avocation is likely to be, in some more or less well defined sense, a Buddhist; and the dangers of making religious commitment the major motivation for scholarly study have been so amply illustrated by Christian history that they scarcely need rehearsing here. (shrink)

In his justly celebrated Expert Political Judgment, Philip E. Tetlock evaluates the judgment of economic and political experts by rigorously testing their ability to make accurate predictions. He finds that ability profoundly limited, implying that expert judgment is virtually useless, if not worse. He concludes by proposing a project that would seek to improve experts' performance by holding them publicly accountable for their claims. But Tetlock's methods severely underestimate the value of expert opinion. Despite their notorious disagreements, experts have highly (...) pertinent information and advice in many areas of public policy. The main problem with experts is that political actors seize on their most extreme views in one direction or the other, and overlook their areas of general agreement and the core of relatively reliable information that they provide. (shrink)

In their analysis Childress et al. (2023) suggest that withdrawal of extracorporeal membrane oxygenation (ECMO) over a patient’s dissent is not justified by existing ethical arguments. The alternat...

Complex clinical ethics cases require a blend of compassion, sensitivity, and tenacity in order to navigate the hard work required of stakeholders. Each person comes to the table with rich historie...

This essay argues that, for Aquinas, grace both intends and makes possible the theological life of charity and that charity reveals the path to beatitude. But it also emphasizes that charity is not a private or purely spiritual relationship with God, but is rather a way of life that continually draws one out of the self in love and service to others. This is most clearly seen in Aquinas’s treatise on love of enemy and the different effects of charity. The (...) essay begins by exploring how Aquinas’s theology of the Trinity informs his account of grace and charity. It then investigates his understanding of the nature and necessity of grace and the form of life that grace makes possible. This is followed by an analysis of Aquinas’s account of charity as friendship with God and its implications for the life of grace. The essay concludes by considering some of the effects of charity and why they make a life of friendship with God a genuinely ecstatic existence. (shrink)