Recent research shows that a faulty or sub‐optimally operating metabolic network can often be rescued by the targeted removal of enzyme‐coding genes – the exact opposite of what traditional gene therapy would suggest. Predictions go as far as to assert that certain gene knockouts can restore the growth of otherwise nonviable gene‐deficient cells. Many questions follow from this discovery: What are the underlying mechanisms? How generalizable is this effect? What are the potential applications? Here, I approach these questions from the (...) perspective of compensatory perturbations on networks. Relations are drawn between such synthetic rescues and naturally occurring cascades of reaction inactivation, as well as their analogs in physical and other biological networks. I specially discuss how rescue interactions can lead to the rational design of antagonistic drug combinations that select against resistance and how they can illuminate medical research on cancer, antibiotics, and metabolic diseases. Editor's suggested further reading in BioEssaysThe evolutionary context of robust and redundant cell biological mechanisms AbstractReprogramming cell fates: reconciling rarity with robustness Abstract. (shrink)

"Method: The Nature of Nature" is the first of several volumes exposing Edgar Morin's general systems view on life and society. The present volume maintains that the organization of all life and society necessitates the simultaneous interplay of order and disorder. All systems, physical, biological, social, political and informational, incessantly reshape part and whole through feedback, thereby generating increasingly complex systems. For continued evolution, these simultaneously complementary, concurrent, and antagonistic systems require a priority of love over truth, (...) of subject over object, of Sy-bernetics over cybernetics. (shrink)

The aim of the article is to show that the contradiction between dialogue and antagonism can be overcome with the help of the idea of dialogue as developed by the Russian thinker Mikhail Bakhtin. The lack of such theory led to the rejection of liberalism or to the introduction of dialogical principle into the body of liberal politics. It was Jürgen Habermas who first understood the necessity of dialogical consensus as the basis of liberal democracy. On the other hand, Ernesto (...) Laclau and Chantal Mouffe developed the concept of agonistic democracy, claiming that conflict is inevitable in liberal democracy because consensual relations cannot harmonize contradictory political identities. The second part of the article is the elaboration of Bakhtin’s theory of dialogue and its relevance for political theory. The main point is that dialogue leads to better understanding but not necessarily to consensus. If this is so, then both conceptions of the political are moments in never-ending dialogical relations. The significance of Bakhtin’s idea of dialogue for political theory consists thus in the recognition of the inevitable dialogical nature of society. However, this dialogical concept also has a normative character. Society has to find a balance between two extremes: excessive dialogue, which leads to anarchy, and the lack of dialogue, which leads to totalitarianism. (shrink)

A persistent sociological thesis posits that the spread of formal education causes an inevitable decline in religion as a social institution and diminishes adherence to religious beliefs in postindustrial society. Now that worldwide advanced education is a central agent in developing and disseminating Western rationality emphasizing science as the ultimate truth claim about a humanly constructed society and the natural world this seems an ever more relevant thesis. Yet in the face of a robust “education revolution,” religion and spirituality endure, (...) and in certain respects thrive, thus creating a sociological paradox: How can both expanding education and mass religion coexist? The solution proposed here is that instead of educational development setting the conditions for the decline and eventual death of religion, the two institutions have been, and continue to be, more compatible and even surprisingly symbiotic than is often assumed. This contributes to a culture of mass education and mass religion that is unique in the history of human society, exemplified by the heavily educated and churched United States. After a brief review of the empirical trends behind the paradox, a new confluence of streams of research on compatible worldviews, overlapping ideologies, and their enactments in educational and religious social movements illustrates the plausibility of an affinity argument and its impact on theory about post-secular society. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Human Nature in Nineteenth-Century British Novels:Doing the MathJoseph Carroll, Jonathan Gottschall, John A. Johnson, and Daniel J. KrugerIThree broad ambitions animate this study. Building on research in evolutionary social science, we aimed (1) to construct a model of human nature—of motives, emotions, features of personality, and preferences in marital partners; (2) use that model to analyze some specific body of literary texts and the responses of readers (...) to those texts, and (3) produce data—information that could be quantified and could serve to test specific hypotheses about those texts.Evolutionary social science is still in the process of constructing a full and adequate model of human nature. Evolutionary social scientists know much already about how human reproductive behavior and human sociality fit into the larger pattern of human evolution. They still have much to learn, though, about the ways literature and the other arts enter into human nature. Our model of human nature draws on our knowledge of imaginative culture, integrates that knowledge with evolutionary theories of culture, and produces data that enable us to draw conclusions on an issue of broad significance for both literary study and evolutionary social science: the adaptive function of literature and the other arts.1In order to make advances in knowledge, it is necessary to choose some particular subject. Genetics is a basic science that applies to all organisms, but geneticists first got an empirical fix on their subject by focusing minutely, with Mendel, on peas, and, with Morgan, on fruit flies. In place of peas and flies, we have taken as our subject British novels of [End Page 50] the longer nineteenth century (Austen to Forster). As a literary topic, the subject is fairly broad, but our theoretical and methodological aims ultimately extend well beyond the specialist fields of British novels, the nineteenth century, British literature, narrative fiction, or even literary scholarship generally. This study is designed to engage the attention of literary scholars in all fields and also to engage the attention of social scientists. If it achieves its aims, this study would help persuade literary scholars that empirical methods offer rich opportunities for the advancement of knowledge about literature, and it would help persuade social scientists that the quantitative study of literature can shed important light on fundamental questions of human psychology and human social interaction. Our own research team combines these two prospective audiences. Two of us (Carroll and Gottschall) have been trained primarily as literary scholars, and two of us (Johnson and Kruger) primarily as social scientists.The focal point for this study is "agonistic" structure: the organization of characters into protagonists, antagonists, and minor characters. The central question in the study is this: does agonistic structure reflect evolved dispositions for forming cooperative social groups? Suppressing or muting competition within a social group enhances group solidarity and organizes the group psychologically for cooperative endeavor. Our chief hypothesis was that protagonists and good minor characters would form communities of cooperative endeavor and that antagonists would exemplify dominance behavior. If this hypothesis proved correct, the ethos reflected in the agonistic structure of the novels would replicate the egalitarian ethos of hunter-gatherers, who stigmatize and suppress status-seeking in potentially dominant individuals. If suppressing dominance in hunter-gatherers fulfills an adaptive social function, and if agonistic structure in the novels engages the same social dispositions that animate hunter-gatherers, our study would lend support to the hypothesis that literature fulfills an adaptive social function.2One of our chief working hypotheses is that when readers respond to characters in novels, they respond in much the same way, emotionally, as they respond to people in everyday life. They like or dislike them, admire them or despise them, fear them, feel sorry for them, or are amused by them. In writing fabricated accounts of human behavior, novelists select and organize their material for the purpose of generating such responses, and readers willingly cooperate with this purpose. They participate vicariously in the experiences depicted and form personal opinions about the qualities of the characters. Authors and readers [End Page 51] thus collaborate in producing a simulated experience of emotionally responsive evaluative judgment. If agonistic structure is a... (shrink)

A key issue of contention between political philosophers has been the quest to resolve the tension between self-determination and the recognition of the intersubjective nature of self-development. This paper will argue that although the early work of Jean-Paul Sartre was characterised by the attempt to avoid defining self-determination as un-situated, in trying to situate self-determination Sartre paradoxically endorsed a radical notion of separation. This paradox manifested itself most clearly in his profoundly problematic account of intersubjectivity. Rather than denying the (...) importance of intersubjectivity as is often supposed, Sartre in fact showed a deep awareness of its centrality even though his account of intersubjectivity was premised upon the inevitability of eternal antagonism. The paper will conclude by arguing that the problems in Sartre's arguments may lead to a more secure definition of autonomy and thereby, point toward more hopeful attempts to resolve the tension between autonomy and intersubjectivity. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Nature and Nurture in French Ethnography and Anthropology, 1859-1914Martin StaumThe adaptability of non-European peoples to "civilization" was a critical issue deriving from the perennial nature-nurture question that haunted debates in the human sciences in late nineteenth-century France.1 The emerging scholarly disciplines of anthropology and ethnography helped provide a scientific veneer that bolstered existing cultural prejudices concerning the innate limitations or retarded development of non-Europeans. Certainly there were (...) many other pragmatic reasons for imperial expansion, and racists did not automatically become imperialists. But if, as Edward Said contended, imperialism "depends upon the idea of having an empire," there is no doubt that many ethnographers and anthropologists helped legitimate the idea.2 Their debates retain a resonance in our twenty-first century postcolonial world struggling with questions of identity, integration, and cultural diversity.Relying on reports from travelers, missionaries, or colonial officials, human scientists from across the political and religious spectrum justified European superiority. Although a few journalists and philosophers outside the scholarly societies represented a minority anti-imperialist counter-current, the remarkable pervasiveness of hierarchical thinking affected both socially radical anthropologists and more conservative ethnographers.3 While ethnographers proclaimed universal fraternity, they conceded that physical differences affected [End Page 475] intellect and character. The later attack on hereditarianism by Durkheimian sociologists and isolated anthropologists with the catalyst of the Dreyfus Affair is all the more striking.4 As George Stocking has argued concerning a British Victorian thinker, the cultural differences between Europeans and non-Europeans became so entangled with biological issues that there was "difficulty conceptualizing them except in terms of 'race.' "5The two most notable anthropological scholarly societies of the late nineteenth century, both founded in 1859, were the Société d'ethnographie orientale et américaine and the Société d'anthropologie de Paris. Historians have justifiably noted their mutual aversion and have contrasted their differences over scientific method, politics, and religion.6 The ethnographers, inspired by a student of Japanese language and Asian religion, Léon de Rosny (1837-1914), were largely linguists and specialists in Asian texts and pre-Columbian codices that represented partly civilized peoples. Rosny invented the term "ambiantisme" for a philosophy that ostensibly privileged the cultural milieu rather than inborn human nature.7 The society membership varied between 115 in 1864 and 470 in 1878, though it declined to 165 by 1903.8 As a group, compared to the anthropologists, they were more politically conservative, more socially elite, and more inclined toward conventional religion, with its belief in the unity of the species. Their "science of destiny" stressed human freedom and unalterably opposed philosophical materialism.9 [End Page 476]The anthropologists, headed by physician and anatomist Paul Broca (1824-80) consisted of a hard core of like-minded medically trained colleagues. The anthropologists' membership peaked around 500 both in 1885 and 1905, though, they, too declined to 165 by 1914.10 Historians have analyzed the nature-nurture issue more subtly for the anthropologists.11 While the Society almost always expressed interest in both physical and cultural spheres, they privileged the study of crania as an index to the intellectual and moral characteristics of "races." The more extreme hereditarians thought that the nature of allegedly inferior "races" precluded perfectibility. Armand de Quatrefages (1810-92), professor of anthropology at the Muséum national d'histoire naturelle and pioneer of the so-called Muséum school, in his later years cast doubt on whether physical indicators actually demonstrated human superiority. However, the Muséum school did not generally renounce racial hierarchy, though they believed that environmental influences formed and continued to shape human varieties.12 In addition, philosophical materialists, militant atheists, and politically radical thinkers dominated the society in the generation after Broca's death. Almost all were neo-Lamarckians who leavened the idea of a fixed human nature with the possibility of adaptation to a milieu and transmissible acquired characteristics.13 The medical physiologist Charles Richet reported that "heredity and milieu are not antagonistic, but synergistic."14 However, many accounts underplay the differential application of neo-Lamarckianism. In this "racial evolutionist paradigm" already noticed by Laurent Mucchielli, even the Muséum school found only civilized people adaptable... (shrink)

Throughout Chinese history, the Legalists and the Confucians have always been antagonistic schools of thought. The idea that the Legalists have their origins in the Confucians, that they are the successors of the Confucians, is nonsense. Explaining the problem and clarifying the class nature of the Confucian-Legalist struggle has important and real significance for deepening the Campaign to Criticize Lin Piao and Confucius, for criticizing the reactionary thought of honoring Confucius and opposing Legalism, and for grasping class struggle (...) in the realm of ideology. (shrink)

Ernst Bloch, one of the most original and influential of contemporary European thinkers and a founder of the Frankfurt School, has left his mark on a range of fields from philosophy and social theory to aesthetics and theology. Natural Law and Human Dignity, the first of his major works to appear in English is unique in its attempt to get beyond the usual oppositions between the natural law and social utopian traditions, providing basic insights on the question of human rights (...) in a socialist society. Natural Law and Human Dignity is a sweeping yet synthetic work that critically reviews the great legal philosophies, from Plato to the present, in order to uncover and clarify the normative features of true socialism. Along the way it offers thoughtful reflections on topics as diverse as the abolition of poverty and degradation, the nature of the state, and the installation of freedom and dignity.Taking the idea of natural law as his guiding thread, Bloch argues that revolution and right, rather than being antagonistic, are fundamentally interconnected. With their emphasis on human dignity, the traditions of natural law have an irreplaceable contribution to make to the socialist vision of a more humane society. In his effort to wed the demands of law and right to the agenda of social revolution, Bloch offers a radical restructuring of our understanding of the social world. This rethinking of the fundamental principles of political philosophy is the product of a long personal and philosophical odyssey. Bloch lived as a writer in Munich, Bern, and Berlin until he was forced to emigrate to Czechoslovakia and then to the United States during World War 11. After the war he returned to East Germany, where he held a chair in philosophy at the University of Leipzig. He emigrated to the west as the Berlin Wall was being built, and he taught at the University of Tübingen until his death. Natural Law and Human Dignity is included in the series Studies in Contemporary German Social Thought, edited by Thomas McCarthy. (shrink)

To answer the question in the title, we take as an example the model for the regulation of agonistic antagonistic couples (MRAAC). It is a model that associates 4 non-linear differential equations and allows to simulate balance, imbalance between two state variables, and control, if necessary, by two control variables of the same nature as the state variables: this control is defined as a bilateral strategy (bipolar therapy in the medical field). The super model for the regulation of (...) agonism antagonistic couples (SMRAAC), that may be also considered as an agonistic antagonistic network (AAN), associates several elementary MRAAC's, but the interconnection structure falls equally under the category of the agonistic antagonism (AA). First we indicate what may be the results of the interconnection, favourable or not. In the last case, a control can be performed, by acting upon a sole couple of the SMRAAC, even if other couples were imbalanced (with two AA control variables only). Simulation examples are given. We bring also a new result with the SMRAAC, i.e. the appearance of strange auractors with this model. The general models belonging to the AA phylum should put on a growing importance in the future, because they could be the sole models enable to control some complex systems by avoiding the perverse effects of the unilateral strategies. (shrink)

_ Source: _Page Count 25 I explore the role of practical necessity in Kant’s essay _Idea for a Universal History with a Cosmopolitan Aim_. This form of necessity arises on the basis of social and interstate antagonism and Kant appeals to it with the aim of avoiding the introduction of a standpoint that is external to the agents whose attitudes and actions are being described. In connection with the role that Kant accords to practical necessity in the establishment of the (...) legal and political conditions required to fulfil the ‘plan of nature’ in the course of history, I argue that in this essay he fails to identify a mechanism that would explain a fundamental moral change in that which motivates human beings once these conditions have been established. This in turn invites questions concerning the kind of universal history that Kant proposes. In particular, I argue that the choice of historical material that it demands could, in certain circumstances, be regarded as counterpurposive in relation to the aim of nature of which Kant speaks in the same essay. (shrink)

Against the growing trend in philosophy toward naturalistic analysis, Kant’s Critique of the Power of Judgment has gained significant attention. Some scholars suggest that Kant’s insights bear on our aesthetic appreciation of nature, others on our account of the life sciences. In this paper I draw these lines of inquiry together to identify two overlooked dimensions of Kant’s project: the role of moral hope in problematizing the limits of natural science and the role of culture in providing a solution. (...) Kant argues that we cannot think consistently unless we are able to conceive of nature as a domain that is hospitable to human freedom. His response is to identify the productive capacity of the imagination to transform the material of nature into something more. While the prevailing conception of nature today is at best indifferent and at worst antagonistic to human habitation, this dimension of Kant’s work has much to bear on contemporary thought. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Human Nature in Nineteenth-Century British Novels:Doing the MathJoseph Carroll, Jonathan Gottschall, John A. Johnson, and Daniel J. KrugerIThree broad ambitions animate this study. Building on research in evolutionary social science, we aimed (1) to construct a model of human nature—of motives, emotions, features of personality, and preferences in marital partners; (2) use that model to analyze some specific body of literary texts and the responses of readers (...) to those texts, and (3) produce data—information that could be quantified and could serve to test specific hypotheses about those texts.Evolutionary social science is still in the process of constructing a full and adequate model of human nature. Evolutionary social scientists know much already about how human reproductive behavior and human sociality fit into the larger pattern of human evolution. They still have much to learn, though, about the ways literature and the other arts enter into human nature. Our model of human nature draws on our knowledge of imaginative culture, integrates that knowledge with evolutionary theories of culture, and produces data that enable us to draw conclusions on an issue of broad significance for both literary study and evolutionary social science: the adaptive function of literature and the other arts.1In order to make advances in knowledge, it is necessary to choose some particular subject. Genetics is a basic science that applies to all organisms, but geneticists first got an empirical fix on their subject by focusing minutely, with Mendel, on peas, and, with Morgan, on fruit flies. In place of peas and flies, we have taken as our subject British novels of [End Page 50] the longer nineteenth century (Austen to Forster). As a literary topic, the subject is fairly broad, but our theoretical and methodological aims ultimately extend well beyond the specialist fields of British novels, the nineteenth century, British literature, narrative fiction, or even literary scholarship generally. This study is designed to engage the attention of literary scholars in all fields and also to engage the attention of social scientists. If it achieves its aims, this study would help persuade literary scholars that empirical methods offer rich opportunities for the advancement of knowledge about literature, and it would help persuade social scientists that the quantitative study of literature can shed important light on fundamental questions of human psychology and human social interaction. Our own research team combines these two prospective audiences. Two of us (Carroll and Gottschall) have been trained primarily as literary scholars, and two of us (Johnson and Kruger) primarily as social scientists.The focal point for this study is "agonistic" structure: the organization of characters into protagonists, antagonists, and minor characters. The central question in the study is this: does agonistic structure reflect evolved dispositions for forming cooperative social groups? Suppressing or muting competition within a social group enhances group solidarity and organizes the group psychologically for cooperative endeavor. Our chief hypothesis was that protagonists and good minor characters would form communities of cooperative endeavor and that antagonists would exemplify dominance behavior. If this hypothesis proved correct, the ethos reflected in the agonistic structure of the novels would replicate the egalitarian ethos of hunter-gatherers, who stigmatize and suppress status-seeking in potentially dominant individuals. If suppressing dominance in hunter-gatherers fulfills an adaptive social function, and if agonistic structure in the novels engages the same social dispositions that animate hunter-gatherers, our study would lend support to the hypothesis that literature fulfills an adaptive social function.2One of our chief working hypotheses is that when readers respond to characters in novels, they respond in much the same way, emotionally, as they respond to people in everyday life. They like or dislike them, admire them or despise them, fear them, feel sorry for them, or are amused by them. In writing fabricated accounts of human behavior, novelists select and organize their material for the purpose of generating such responses, and readers willingly cooperate with this purpose. They participate vicariously in the experiences depicted and form personal opinions about the qualities of the characters. Authors and readers [End Page 51] thus collaborate in producing a simulated experience of emotionally responsive evaluative judgment. If agonistic structure is a... (shrink)

Recently some philosophers have emphasized a potentially irreconcilable conceptual antagonism between the statistical characterization of natural selection and the standard scientific discussion of natural selection in terms of forces and causes. Other philosophers have developed an account of the causal character of selectionist statements represented in terms of counterfactuals. I examine the compatibility between such statisticalism and counterfactually based causal accounts of natural selection by distinguishing two distinct statisticalist claims: firstly the suggested impossibility for natural selection to be a cause (...) acting upon populations and secondly the conceptualization that all evolutionary causes occur at the level of interactions between individual organisms. I argue that deriving the latter from the former involves supplementary assumptions concerning precisely what causation is. I critically examine two of these assumptions purportedly preventing natural selection being regarded as a cause: the locality claim and the modularity claim. I conclude that justifying the strongest version of statisticalism—i.e. evolutionary causation only occurs at the level of individual interactions between organisms—would require further metaphysical arguments that are likely to be deemed highly problematic. Additionally, I argue that such a metaphysical position would be considered incongruous with both our scientific and ordinary use of the concepts of causality and explanation as employed within our everyday epistemological framework. (shrink)

As science developed many of the established facts tended to appear in a new light and were seen from an aspect that had earlier been ignored and as a rule new scientific theory originated from the clash of old theories and new facts. Not only that, science has reached at the highest peak of its development. Nevertheless, in this era of science and technology, it has not been fully harnessed to the welfare of humanity. The world today is in a (...) serious crisis and humanity is being constantly threatened or misuse of science. Science ‘therefore’ is not only a blessing but also presents an unprecedented threat to the very existence of the human race. This unhappy consequence is not because of science itself but because of the antagonistic nature of social relationships. It is very clear that, social reality is distinct from biological relating or individual cognitive reality representing as it does a phenomenological level created through social interaction and transcending thereby individual motives and actions. We cannot hope to understand the role of a social scientist properly unless we have some idea of the reality with which he is supposed to be involved either passionately or dispassionately. Philosophy and Progress, Vol#71-72; No#1-2; Jan-Dec 2022 P 29-43. (shrink)

In this chapter, I put Hobbes’s natural philosophy into its larger European context. First, I relate Hobbes’s project in natural philosophy to those of two other illustrious contemporaries, Galileo and Descartes. Hobbes was a great admirer of Galileo and an antagonist of Descartes. Yet, I argue, there are ways in which Hobbes’s project was much closer to that of Descartes than to that of Galileo. I then turn briefly to some aspects of the legacy of Hobbes’s project. First, I argue (...) that Spinoza’s conception of natural philosophy is fundamentally Hobbesian in its inspiration. I then end with a brief discussion of the young Leibniz’s early Hobbesian physics, a project that, ironically enough, succeeded in the Royal Society much better than Hobbes’s own did there. (shrink)

For Friedrich Hölderlin, the mediatory role of aesthetics was central to overcoming the challenges of modern life, in particular human beings’ antagonistic relationship to nature. This article claims that Hölderlin preserves and improves what is true in Kant’s conception of the beautiful: that the experience of beauty concerns recognizing our dependence on nature, and that this recognition resonates in the works of artistic geniality as well. The article furthermore argues that the twentieth-century philosopher Theodor W. Adorno’s interpretation (...) of Hölderlin sheds light on how Hölderlin’s late poetry constitutes a remembrance of nature that avoids fetishizing nature as an origin to which we should return, while still allowing for an acknowledgment of its priority. Hölderlin’s poetry, as a work of spirit or mind, is exemplary in its commemoration of the precondition for spirit’s achievements: finite, empirical life. In this way, the self-reflectivity of Hölderlin’s poems also constitute a corrective to subjectivist tendencies that still reverberate in post-Kantian idealism. (shrink)

Yang Hsien-chen and other comrades' theory of "combining two into one" consciously uses the bourgeois world view to oppose the proletarian world outlook. It is basically opposed to the philosophy of Marxism. "Marxist philosophy holds that the law of the unity of opposites is the fundamental law of the universe. This law is universally existent in the natural world, human society, and people's thinking." However, the theory of "two into one" declares that "there is nothing in the phenomena of the (...) natural world, or in human society, thought, etc. which is not a case of ‘two combining into one.’" The law of the unity of opposites holds that all things in the world are always dividing into two opposite sides which struggle with each other in a unity. The unity of opposites is conditional and relative, but the struggle of opposites is unconditional and absolute. The theory of "two into one" asserts that "anything is a combination of two into one." "The unity of contradiction only means that the two sides of the contradiction are inseparably connected." However, the law of the unity of opposites holds that "the result of the struggle between the two opposite sides of the contradiction is that there is nothing which cannot be transformed into its opposite under definite conditions" , and "in human society and the natural world, unities are always splitting into different parts." The theory of "two into one" simply regroups the contradictory relationships of things into "two opposite sides indivisibly linked together" , that is, things possess a so-called "inseparability." Since the theory of "two into one" in this way obliterates antagonistic contradictions and the absoluteness of antagonism, it also denies that the antagonism of contradiction must, under certain conditions, lead to the splitting of a unity and the transformation of opposites. (shrink)

The war between natural law philosophy and legal positivism is an ancient one. For a time the stunning victories of Bentham and Austin virtually drove the forces of natural law from the battlefield. However, upon the collapse of Germany and Japan at the end of the Second World War, natural law became a useful tool in attempting to resolve the practical difficulties of trying war criminals. This fact and the rise of two able antagonistic generals, H. L. A. Hart (...) and Lon Fuller, have sparked a new series of battles. (shrink)

The war between natural law philosophy and legal positivism is an ancient one. For a time the stunning victories of Bentham and Austin virtually drove the forces of natural law from the battlefield. However, upon the collapse of Germany and Japan at the end of the Second World War, natural law became a useful tool in attempting to resolve the practical difficulties of trying war criminals. This fact and the rise of two able antagonistic generals, H. L. A. Hart (...) and Lon Fuller, have sparked a new series of battles. (shrink)

Forster explains how Santayana squares his commitment to naturalism with his reliance on methods of transcendental criticism. Rather than view naturalism and transcendental criticism as antagonistic, Santayana reconciles them in an account of human knowledge that he considers more comprehensive than either is alone.

What was science for the Orthodox Greek theologian of the nineteenth century? How did it feature in his (theologians were all men at the time) own work? This article is an attempt to describe the science and religion interactions by placing Greek Orthodox theologians of the nineteenth century in the center of the historical narrative, rather than treat them as occasional deuteragonists in the scientists’ historiography. The picture that emerges is far more complicated than one of antagonism, indifference, conflict, or (...) coexistence. Greek theologians saw themselves as scientists and treated theology as a positive, rational science. They developed strategies to delineate their disciplinary borders and safeguard their identity as expert scholars by harnessing their university and academic credentials. For that reason, they had to invoke famous German and other Western theologians, while ensuring that they were seen as true defenders of Orthodox Christianity. The idea of science was an integral part of this achievement. (shrink)

Mencius, a prominent Confucian philosopher in the Warring States period of ancient China, is well-known for his argumentative skills, including his refutational skills used to maintain his own standpoints. This paper attempts to reveal how Mencius refuted his opponents argumentatively and strategically on the issue of human nature. To this end, the pragma-dialectical approach to argumentation is adopted to first reconstruct Mencius’s argumentative discourse on human nature according to the four stages in critical discussion—the confrontation, opening, argumentation and (...) concluding stages. Under the ancient Chinese historical and cultural context, Mencius’s argumentative discourse about human nature was developed in three critical discussions, between Mencius the protagonist, and his explicit interlocutors and implicit adversaries who held different views on human nature—the antagonists. The discussions were undertaken around three single mixed differences of opinion concerning three propositions, with resolution of the first difference of opinion serving as a starting point of the second, and the resolution of the second as a starting point of the third. Then based on the reconstruction, the paper elaborates the refutational strategies that Mencius employed in various stages, such as dissociation, reductio ad absurdum based on refutational analogy, and conciliation. It further points out that the employment of these strategies is strategic maneuvering undertaken by Mencius in an attempt to realize both dialectical and rhetorical aims. (shrink)

The paper delves into manuscript sources connected with various disputations held at Prague University from around 1390 to 1420 and singles out a set of hitherto unknown quaestiones dealing with the nature of the human intellect and its relation to the body. Prague disputations from around 1400 arguably offer a unique vantage point on late medieval anthropological issues, since they encompass an entanglement of numerous doctrinal influences from Buridanian De anima commentaries to John Wyclif’s theories. The paper delineates several (...) conceptual tensions regarding the nature of the intellect, e.g., between materialism (entailed by the emphasis on the intellect’s inherence in the body) and personal immortality. It presents several strategies Prague masters employed to overcome these tensions. For example, an anonymous participant of the 1409 quodlibet develops the Buridanian distinction between the rationally demonstrable materialist tendency and the indemonstrable “catholic truth” about the intellect both inhering in and separable from the body. On the other hand, Wyclif’s adherents (Jacob of Mies and another anonymous master) postulate an immortal spirit hypostatically united to each human being beside the human soul educed from the potency of the matter. Yet, the boundaries between the doctrinal standpoints in question seem permeable, whereby a rigid definition of antagonistic groups in late medieval Prague intellectual milieu (e.g., Buridanians vs Wycliffites) is rendered ineffective. (shrink)

Since the dawn of molecular biology, cancer therapy has focused on druggable targets. Despite some remarkable successes, cell‐level evolution remains a potent antagonist to this approach. We suggest that a deeper understanding of the breakdown of cooperation can synergize the evolutionary and druggable‐targets approaches. Complexity requires cooperation, whether between cells of different species (symbiosis) or between cells of the same organism (multicellularity). Both forms of cooperation may be associated with nutrient scarcity, which in turn may be associated with a chemiosmotic (...) metabolism. A variety of examples from modern organisms supports these generalities. Indeed, mammalian cancers—unicellular, glycolytic, and fast‐replicating—parallel these examples. Nutrient scarcity, chemiosmosis, and associated signaling may favor cooperation, while under conditions of nutrient abundance a fermentative metabolism may signal the breakdown of cooperation. Manipulating this metabolic milieu may potentiate the effects of targeted therapeutics. Specific opportunities are discussed in this regard, including avicins, a novel plant product. (shrink)

Will the ecological crises of our time be resolved using the same form of thought that has brought them about? Are technological prowess and political power the proper tools to address them? Is there not a deeper connection between our ecological crises and our human, social, political, economic, and ethical crises? This book argues that the popular approaches to ecological, bioethical, and other human crises are not working because they fail to examine the problem in its full depth. This depth (...) escapes us because we have abandoned true metaphysical reflection on the whole and substituted it unknowingly for a series of inadequate alternatives. Both the technocratic paradigm that views all of nature mechanistically and its antagonists--the eco-philosophies that argue for the realities of intrinsic value, relationality, and beauty--carry partial truths but are insufficient. This book presents a more radical alternative, rooted in the classical tradition yet fresh and vibrant. The metaphysics of gift, based in the giftedness of existence shared by all, offers a deeper and more satisfying vision of all things that can transform our relationship with nature and touches every aspect of human life: social, political, economic, technical, and ethical"-- Back cover. (shrink)

While there is a growing literature on “dark traits” (i.e., socially aversive traits), there has been a lack of integration with the burgeoning research literature on positive traits and fulfilling and growth-oriented outcomes in life. To help move the field toward greater integration, we contrasted the nomological network of the Dark Triad (a well-studied cluster of socially aversive traits) with the nomological network of the Light Triad, measured by the 12-item Light Triad Scale (LTS). The LTS is a first draft (...) measure of a loving and beneficent orientation toward others (“everyday saints”) that consists of three facets: Kantianism (treating people as ends unto themselves), Humanism (valuing the dignity and worth of each individual), and Faith in Humanity (believing in the fundamental goodness of humans). Across four demographically diverse samples (N = 1,518), the LTS demonstrated excellent reliability and validity, predicting life satisfaction and a wide range of growth-oriented and self-transcendent outcomes above and beyond existing measures of personality. In contrast, the Dark Triad was negatively associated with life satisfaction and growth-oriented outcomes, and showed stronger linkages to selfish, exploitative, aggressive, and socially aversive outcomes. This exploratory study of the contrasting nomological networks of the Light vs. Dark Triad provides several ways forward for more principled and data driven approaches to explore both the malevolent and benefice... (shrink)

Since the early decades of the sixteenth century, Pomponazzi has been a name to conjure with: to some, the first of the modern atheists; to others, a hero of the new philosophy. But how much direct influence did his work have? This question is explored in terms of the way in which oracular divination is treated. In the sixteenth century, the range of conceptual categories available to explain such phenomena was threefold: natural, supernatural or simply unreal. In some cases, such (...) as those of demonic possession, the person was able to be examined directly. But the same conceptual triad was also applied to another kind of case, one whose subject could not be examined, since she had long been consigned to history ? the Pythia or priestess of the ancient Delphic oracle, who had famously foamed and babbled during her prophetic frenzy. For some writers on divination, this subject was of particular interest, since it had been explicitly discussed by ancient sources: whether the Pythia's ravings were real or invented, natural or supernatural, could be analysed with categories borrowed from Cicero, Plutarch and, above all, Aristotle. Within the sixteenth?century territory disputes over Aristotle's corpus, the pagan oracles, represented above all by the Pythia, offered a test case for the broader problem of the place of divination within the natural world. The central antagonist in this tussle was Pietro Pomponazzi, whose treatment of the ancient oracles, although brief, played an important part in his radical interpretation of Aristotle. For many of his contemporary readers, it was this subject, with its specific historical dimension, that highlighted the faults in his positions on nature and divination. (shrink)

The paper deals with the issue of the common nature (extramental universal) and universal unity (logical universal) in the theories of two of the foremostScotists in the Baroque Era, the Italian Conventual Bartholomew Mastrius and the Irish Observant John Punch. They are in the scholarly community well-known for their antagonistic interpretations of the teaching of Duns Scotus. On the basis of the exposition of two representative places from Scotus’s Ordinatio and Questions on Aristotle’s Metaphysics, I claim that it (...) is Mastrius’s theory, which follows Scotus’s model more tightly. Punch’s theories are doctrines which are syncretically inspired by un-Scotist’s sources (above all “Suarezian,” “Thomistic,” and “Ockhamistic”). The hermeneutical advantage of Punch’s theory is that it remarkably mirrors the “Zeitgeist” of early modern academic philosophy, substantially determined by the Jesuit’s exposition of Aquinas. (shrink)

The paper deals with the issue of the common nature (extramental universal) and universal unity (logical universal) in the theories of two of the foremostScotists in the Baroque Era, the Italian Conventual Bartholomew Mastrius and the Irish Observant John Punch. They are in the scholarly community well-known for their antagonistic interpretations of the teaching of Duns Scotus. On the basis of the exposition of two representative places from Scotus’s Ordinatio and Questions on Aristotle’s Metaphysics, I claim that it (...) is Mastrius’s theory, which follows Scotus’s model more tightly. Punch’s theories are doctrines which are syncretically inspired by un-Scotist’s sources (above all “Suarezian,” “Thomistic,” and “Ockhamistic”). The hermeneutical advantage of Punch’s theory is that it remarkably mirrors the “Zeitgeist” of early modern academic philosophy, substantially determined by the Jesuit’s exposition of Aquinas. (shrink)

Fyodor Dostoevsky understood this practical dimension well, and it is embodied in his literary treatment of the problem of evil in his masterpiece, The Brothers' Karamazov.1 In what follows, I will interpret the powerful existential repudiation of Christianity based on the facts of human suffering voiced by the antagonist, Ivan. After noting some similarities of Ivan’s case to that given by the French existentialist philosopher Albert Camus in his novel, The Plague, I then turn to Dostoevsky’s response, expressed through the (...) final discourse of the Elder Zossima. My goal here is solely to interpret and to set in a clearer focus the way Dostoevsky approaches the problem of evil. At the end, I briefly note some outstanding issues facing his strategy for resolving it. (shrink)

William Bateson has long occupied a controversial role in the history of biology at the turn of the twentieth century. For the most part, Bateson has been situated as the British translator of Mendel or as the outspoken antagonist of W. F. R. Weldon and Karl Pearson's biometrics program. Less has been made of Bateson's transition from embryologist to advocate for discontinuous variation, and the precise role of British and American influences in that transition, in the years leading up to (...) the publication of his massive Materials for the Study of Variation. In this paper, I first attempt to trace Bateson's development in his early career before turning to search for the development of the moniker "anti-Darwinist" that has been attached to Bateson in well-known histories of the neo-Darwinian Synthesis. (shrink)

It is argued that, of the three distinct approaches usually adhered to in discussions of this controversy, none will produce an adequate reconstruction of the episode. The philosophical-methodological type of approach leads to a glossing over of the intricacies of deductive and inductive procedures inhering in the writings of both antagonists (§ 1). The metaphysical approach leads to oversimplification as to the thinking of either scientist on the problem of the continuous or discontinuous character of Nature(§ 2). The epistemological (...) (theory of knowledge) type of approach, finally, leads authors to posit a Linnaean realism vs. a Buffonian nominalism, whereas the true position was much more complex than what transpires(§ 3). The paper proceeds, therefore, to provide a novel reconstruction of this wellknown controversy (§ 4-5), concentrating on the differing choices made by the two naturalists in their work of botanical or zoological classification : thus seeking to show that the clash came about because Buffon rejected the rigid principle of character subordination put forward by Linnaeus, and, on a more general level, because the two protagonists were proceeding from deeply diverging views of what natural history, and what the naturalist's function, should be. (shrink)

William Bateson (1861-1926) has long occupied a controversial role in the history of biology at the turn of the twentieth century. For the most part, Bateson has been situated as the British translator of Mendel or as the outspoken antagonist of W. F. R. Weldon and Karl Pearson's biometrics program. Less has been made of Bateson's transition from embryologist to advocate for discontinuous variation, and the precise role of British and American influences in that transition, in the years leading up (...) to the publication of his massive Materials for the Study of Variation (1894). In this paper, I first attempt to trace Bateson's development in his early career before turning to search for the development of the moniker "anti-Darwinist" that has been attached to Bateson in well-known histories of the neo-Darwinian Synthesis. (shrink)

This study of the antagonists of Cartesian thought in the Netherlands during Descartes' lifetime focuses principally on the reactions and criticisms of the Dutch Calvinist theologian, Gisbertu Voetius. It not only offers insights into cultural and intellectual aspects of seventeenth-century university life in the Low Countries, but also a detailed analysis of Calvinist theologians' utilization of Scholastic sources in order to confront the implications of Descartes' doctrines.

In this paper I focus on the Hungarian intellectual and politician Paul Szende’s sociologically oriented epistemology. I trace the influences of physiology, psychology, economy, evolutionary theory of his day on his sociological theory of abstractive knowledge, and discuss the close connection between physiological, social, and economic aspects in the early sociology of knowledge. My discussion continues with an examination of Szende’s differentiation between two economic effects within social epistemology: on the one hand the ‘economy of thought’ in the tradition of (...) Ernst Mach, with its physiological, organic, and integrative functioning of knowledge; on the other hand, the socio-economic effects of social selection, exclusion, and societal antagonism. Besides the Marxist and more specifically the Austro-Marxist environment of Szende’s writings, I trace the influence of the economic theory of Italian economist Achille Loria on Szende’s understanding of the antagonistic nature of the transformation of knowledge. The paper is set at the intersection of philosophy of science and history of science. It relates epistemological issues to historical, social, and scientific developments in Szende’s day and thus combines a philosophical analysis of Szende’s sociological theory of knowledge with historical research into the natural, social, and economic sciences of his time. (shrink)

Adorno's saying that ‘art is the promise of happiness’ radiates into every corner of his work from his aesthetic theory to his critical theory of society. However, it is much misunderstood. This can be seen from the standard answer to the question: in virtue of what formal features do art works, according to Adorno, promise happiness? The standard answer to this question suggests that the aesthetic harmony occasioned by the organic wholeness of the form realized in the artwork contrasts with (...) and throws into relief the antagonistic nature of society. The trouble is that this answer is flatly incompatible with Adorno's historicism and central components of his aesthetic modernism, including his critique of classicism, and his negativism. I propose a re-interpretation of Adorno's thesis that art is the promise of happiness that overcomes these difficulties. (shrink)

In today's conditions of Ukraine's development, strengthening its legal foundation and establishing a democratic civil society is an urgent problem of the person's ability to exercise the rights and freedoms guaranteed by the constitution and other legislative acts. Recently, in the world, cases of human rights violations in connection with religious, racial, linguistic and other differences have become more frequent and more frequent in the world. The ambiguity, the antagonistic nature of the definitions and the relation between the (...) concepts of various social groups, such as the national, religious minority, etc., often leads to speculation and aggravation of the ethnopolitical situation. This explains the relevance of this study. (shrink)

Electoral debates are a win-lose game in which the stakes for the political contenders are extremely high. The antagonistic nature of these encounters very frequently results in impoliteness or face aggravating moves with which the debaters aim to hurt the opponent’s positive or negative face.The aim of this research is to investigate the impoliteness strategies employed by politicians during electoral debates. Garcia-Pastor’s (2008) positive-face and negative-face impoliteness strategies are taken as a starting point in the analysis at hand. (...) The final electoral debate of the 2019 presidential elections in the Republic of North Macedonia is used as a data source for this research, which is based on several different hypotheses and is both qualitatively and quantitative oriented. The findings of the research are in line with the insights gained from previous studies, which, more or less, suggests that Macedonian politicians follow the mainstream “rules” when it comes to using impoliteness in political debates. (shrink)

This article offers a new scheme of the relation between positive and negative freedom that is based on a retrieval of T. H. Green's theory of freedom and on further reconstructions of his theory. Some of the distinctions in the literature have proven difficult to sustain, and this has resulted in a weakening of the dichotomy in principle, and of the concepts of positive and negative freedom independently of each other. The main distinction between negative and positive freedom offered here (...) is based on the relation of freedom to the will. We have two kinds of freedom, in both our private and social spheres, because there are two types of goods that we, as human beings, pursue: ordinary and moral. This distinction proves to be sustainable, manages to explain the antagonistic nature of the two concepts, and provides grounds for the support of the two kinds of freedom in their own right. (shrink)

This article offers a new scheme of the relation between positive and negative freedom that is based on a retrieval of T. H. Green's theory of freedom and on further reconstructions of his theory. Some of the distinctions in the literature have proven difficult to sustain, and this has resulted in a weakening of the dichotomy in principle, and of the concepts of positive and negative freedom independently of each other. The main distinction between negative and positive freedom offered here (...) is based on the relation of freedom to the will. We have two kinds of freedom, in both our private and social spheres, because there are two types of goods that we, as human beings, pursue: ordinary and moral. This distinction proves to be sustainable, manages to explain the antagonistic nature of the two concepts, and provides grounds for the support of the two kinds of freedom in their own right. (shrink)

Is it possible to explicate tolerant principles in the philosophy-political discourse of Kant? It seems the answer to this question is positive. And it is the philosophical project of Kant “Perpetual Peace”, which is the most representative in this respect, for it is based on the principles of tolerance. This project is included in ethic-legal (liberal) system and is connected with such notions as civil society, legal state, duty, moral law. Tolerance exists, on the one hand, as a result of (...) moral effort and choice, and on the other, as legal obligation. In Kantian conception tolerance appears as a multi-aspect phenomenon: firstly, as a natural deposit of the human race, developing as a result of the influence of antagonistic nature of the human society; secondly, as a demand of the moral law; thirdly, as a means of peace attaining; fourthly, as a principle of peaceful state, a universal civic alliance and eternal peace. The dynamic development of the world society, the acceleration of processes of globalization and intercultural communication dictate new strategies of the world development, make the problem of political responsibility the topic of today. According to Kant’s logic, it is necessary to be tolerant in the modern world. (shrink)

This dissertation develops a conception of reasonableness that can adequately respond to agonistic critiques of this concept. As an aspect of practical reason, reasonableness refers to the moral capacity of citizens to cooperate politically, especially in pluralistic societies. More specifically, the principles or rules of political association governing society ought to be acceptable to all reasonable members of that society. This relates, furthermore, to the idea of justification: the acceptability of fundamental political principles refers to their justifiability. Justification, in turn, (...) requires ideas of public reason and political deliberation: political deliberation, for example, facilitates the ability of citizens to determine what political principles are justifiable. The explication of justifiability in terms of universal acceptability (acceptable to all reasonable persons, for example) is indicative of a central concern of proponents of reasonableness (and public reason), namely, that politics at least at a fundamental level ought to be governed by consensus. However, this conception of reasonableness has been the target of critique by agonistic theories of democracy. These theorists deny that politics ought to be governed by such a consensus. Most importantly, this orientation toward consensus ignores, or at least underestimates, the antagonistic and hegemonic nature of the political. That is, the consensus orientation of proponents of reasonableness and public reason suggests that society can be given a non-hegemonic and rational foundation. This goal, in turn, leads to the suppression or exclusion of dissensus. Nonetheless, this dissertation affirms the importance of reasonableness to democratic theory and identifies an implicit commitment to reasonableness within agonistic democratic theory. This commitment is evident, for example, in the claim that that political participants must adhere to the basic principles and institutions of liberal democracy. Given this implicit commitment, this dissertation will formulate a middle ground between prominent proponents of reasonableness and their agonistic critics. The primary goal will be to construct an agonistic conception of reasonableness, or reasonable agonism, in light of agonistic critiques of this concept. The agonistic conception of reasonableness developed in this dissertation is understood primarily in terms of the deliberative relationships citizens form and maintain. This opposes accounts of reasonableness and justification that privilege the universal acceptability of political principles and related idealizations of practical reason (understood in terms of its capacity for determining universally acceptable reasons). The defining feature of an agonistic conception of reasonableness is not the universal acceptability of political principles or of the reasons offered in political deliberation, but rather the maintenance of adversarial deliberative relationships. This approach to reasonableness does not require a consensus orientation and it is more sensitive to the antagonistic nature of the political. That is, political participants are able to adhere (at one level) to a particular, partisan conception of justice, as long as (at another level) they remain committed to maintaining deliberative relationships with their political rivals. In this way, an agonistic conception of reasonableness combines the best features of reasonableness and agonism, while addressing the shortcomings involved in theories of both concepts. Additionally, this account of reasonableness has a related critical function, namely, the contestation of prevailing normative orders that can be viewed as illegitimate or unjustifiable by those excluded from such orders. (shrink)

In the past few years, social and cultural theorists have pointed to the dynamic and performative character of forms of disparagement such as public shaming, humiliation, invective or hate speech. In this paper, I endorse a different route and focus on the distinctive affective and dialectical nature of what might be called the ‘politics of disparagement’. I will do so by elaborating on the affective intentionality of hatred, which can be seen as an affective attitude that paradigmatically encapsulates the (...) dialectical antagonism at play in the politics of disparagement. I argue that the affective intentionality of hatred is distinctive in three interrelated ways: First, it has an overgeneralising, indeterminate affective focus, which typically leads to a certain collectivisation of its target. Secondly, short of a determinate affective focus, haters derive the indeed extreme affective powers of the attitude not in reaction to any specific features or actions of the targets or from some phenomenological properties of the attitude but, rather, from the sheer commitment to the attitude itself. Finally, in sharing this commitment to hate with others, hatred involves a certain negative dialectics and becomes entrenched as a shared habitus. Ultimately, I suggest that we can only counteract the politics of disparagement if we understand how a shared commitment to disparagement and hatred establishes its own normative logic, which not only concerns their victims but also, dialectically, sanctions their enactors. (shrink)

This paper reconstructs the natural philosophical method of Geminiano Montanari, one of the most prominent Italian natural philosophers of the late seventeenth century. Montanari’s views are used as a case study to assess recent claims concerning early modern experimental philosophy. Having presented the distinctive tenets of seventeenth-century experimental philosophers, I argue that Montanari adheres to them explicitly, thoroughly, and consistently. The study of Montanari’s views supports three claims. First, experimental philosophy was not an exclusively British phenomenon. Second, in spite of (...) some portrayals of experimental philosophy as an ‘atheoretical’ or ‘purely descriptive’ enterprise, experimental philosophers could consistently endorse a variety of natural philosophical explanations and postulate theoretical entities. Third, experimental philosophy and mechanical philosophy were not, as such, antagonistic. They could be consistently combined in a single philosophical enterprise. (shrink)

Philosophical antagonism and dispute — by no means confined to the early modern period — nonetheless enjoyed a moment of particular ferment as new methods and orientations on questions of epistemology and ethics developed in the seventeenth and eighteenth centuries. John Locke played a key part in them with controversies initiated by the Essay concerning Human Understanding. This essay develops a wider typology of modes of philosophical quarrelling by focusing on a key debate — the issue of whether human (...) class='Hi'>nature came pre-endowed with innate ideas and principles, resulting in a moral consensus across mankind, or remained, on the contrary, dependent on reason to achieve moral insight, and, in practice, divided by diverse and irreconcilable cultural practices as a result of the force of custom and the limited purchase of reason. The essay ultimately concludes on the idea that we should not only attend to the genealogy of disputes but also to the morphology of disputation as a practice. (shrink)

Contemporary philosophy is often divided into two approaches or orientations: analytic philosophy and continental philosophy. The relation between these two philosophical approaches is often presented as oppositional and exclusionary. This chapter illuminates the distinction between analytic and continental philosophy and to clarify the position of hermeneutics within the field of philosophy. It argues that rather than being philosophical or empirical in nature, the analytic–continental distinction operates rhetorically and serves regulative functions. The origin of the division between analytic and continental (...) philosophy is usually traced back to the difference between the new philosophies that Husserl and Frege developed in parallel at the turn of the twentieth century. In the phenomenological‐hermeneutical tradition, we can find some dismissive comments about logical positivism and logical empiricism. This chapter indicates that the roots of the opposition between analytic philosophy and continental philosophy are in the cultural‐political antagonism of postwar Europe. (shrink)

The general attributes of ecosystems are examined and a naturally occurring reference ecosystem is established, comparable with the isolated system of classical thermodynamics. Such an autonomous system with a stable, periodic input of energy is shown to assume certain structural characteristics that have an identifiable thermodynamic basis. Individual species tend to assume a state of least dissipation; this is most clearly evident in the dominant species (the species with the best integration of energy acquisition and conservation). It is concluded that (...) ecosystem structure results from the antagonistic interaction of two nearly equal forces. These forces have their origin in the Principle of Most Action (least dissipation or least entropy production) and the universal Principle of Least Action. Most action is contingent on the equipartitioning of the energy available, through uniform interaction of similar individuals. The trend to Least action is contingent on increased dissipation attained through increasing diversity and increasing complexity. These principles exhibit a basic asymmetry. Given the operation of these opposing principles over evolutionary time, it is argued that ecosystems originated in the vicinity of thermodynamic equilibrium through the resonant amplification of reversible fluctuations. On account of the basic asymmetry the system was able to evolve away from thermodynamic equilibrium provided that it remained within the vicinity of ergodynamic equilibrium (equilibrium maintained by internal work, where the opposing forces are equal and opposite).At the highest level of generalization there appear to be three principles operating: i) maximum association of free-energy and materials; ii) energy conservation (deceleration of the energy flow) through symmetric interaction and increased homogeneity; and iii) the principle of least action which induces acceleration of the energy flow through asymmetrical interaction. The opposition and asymmetry of the two forces give rise to natural selection and evolution. (shrink)