While acknowledging the potential benefits of pharmacogenomics as a methodology, a number of comprehensive reports in the past several years examine a multitude of ethical, legal, and social factors that may limit the extent to which these benefits are realized — and realized in ethically acceptable ways. This article aims to identify and explore the most basic ethical and regulatory issues that are likely to arise if pharmacogenomics becomes widely enough used to have a significant impact on research and clinical (...) practice. First, however, it addresses the question of whether pharmacogenomic tests are unique when compared to other genetic tests and thus deserving of more or less stringent ethical and regulatory requirements. (shrink)

It has become increasingly difficult for individuals to exercise meaningful control over the personal data they disclose to companies or to understand and track the ways in which that data is exchanged and used. These developments have led to an emerging consensus that existing privacy and data protection laws offer individuals insufficient protections against harms stemming from current data practices. However, an effective and ethically justified way forward remains elusive. To inform policy in this area, we propose the Ethical Data (...) Practices framework. The framework outlines six principles relevant to the collection and use of personal data—minimizing harm, fairly distributing benefits and burdens, respecting autonomy, transparency, accountability, and inclusion—and translates these principles into action-guiding practical imperatives for companies that process personal data. In addition to informing policy, the practical imperatives can be voluntarily adopted by companies to promote ethical data practices. (shrink)

Smart Thinking: Skills for Critical Understanding and Writing 2E is a practical step-by-step guide to improving skills in analysis, critical thinking, and the effective communication of arguments and explanations. The book combines an accessible and straightforward style, with a strong foundation of knowledge. The text treats reasoning as an aspect of communication, not an abstract exercise in logic. The book not only provides detailed advice on how to practise analytical skills, but also demonstrates how these skills can be used in (...) research and writing. In particular, it emphasises how to develop arguments that are coherent and that take account of their audience and context. (shrink)

There are several reasons for the current prominence of global health issues. Among the most important is the growing awareness that some risks to health are global in scope and can only be countered by global cooperation. In addition, human rights discourse and, more generally, the articulation of a coherent cosmopolitan ethical perspective that acknowledges the importance of all persons, regardless of where they live, provide a normative basis for taking global health seriously as a moral issue. In this paper (...) we begin the task of translating the vague commitment to doing something to improve global health into a coherent set of more determinate obligations. One chief conclusion of our inquiry is that the responsibilities of states regarding global health are both more determinate and more extensive than is usually assumed. We also argue, however, that institutional innovation will be needed to achieve a more comprehensive, fair distribution of concrete responsibilities regarding global health and to provide effective mechanisms for holding various state and nonstate actors accountable for fulfilling them. (shrink)

Ranging from miniaturized biological robots to organoids, multi-cellular engineered living systems (M-CELS) pose complex ethical and societal challenges. Some of these challenges, such as how to best distribute risks and benefits, are likely to arise in the development of any new technology. Other challenges arise specifically because of the particular characteristics of M-CELS. For example, as an engineered living system becomes increasingly complex, it may provoke societal debate about its moral considerability, perhaps necessitating protection from harm or recognition of positive (...) moral and legal rights, particularly if derived from cells of human origin. The use of emergence-based principles in M-CELS development may also create unique challenges, making the technology difficult to fully control or predict in the laboratory as well as in applied medical or environmental settings. In response to these challenges, we argue that the M-CELS community has an obligation to systematically address the ethical and societal aspects of research and to seek input from and accountability to a broad range of stakeholders and publics. As a newly developing field, M-CELS has a significant opportunity to integrate ethically responsible norms and standards into its research and development practices from the start. With the aim of seizing this opportunity, we identify two general kinds of salient ethical issues arising from M-CELS research, and then present a set of commitments to and strategies for addressing these issues. If adopted, these commitments and strategies would help define M-CELS as not only an innovative field, but also as a model for responsible research and engineering. (shrink)

Sometimes in the course of image-making, images are asked to represent unusual things. Around 1960, scientists and engineers working on the Computer-Aided Design Project at MIT began imagining that computers could be “active partners” to human designers. They began talking about a future of “human-computer symbiosis.” And they created a new type of image—the screenshot—that represented this new possibility. This paper describes early CAD research as a site for the emergence of the ideal of the interactive computer and how this (...) ideal was described and distributed through screenshots.Though we now routinely associate computers with interactivity, interactivity was beyond the average user’s experience in 1960.... (shrink)

Thanks to Michel Foucault, Jeremy Bentham's panopticon has become the iconic modern prison. But Foucault and most of his readers neglect the fact that a significant proportion of Bentham's panoptical writings were concerned with critically contrasting his ideal prison with the reality of penal transportation to New South Wales. Among his many criticisms, Bentham focussed particular attention on the problem of convict reform, arguing that surveillance was necessary to ensure genuine reformation, and that such surveillance was impossible in the open (...) prison of New South Wales. This connection between reformation and surveillance was a pervasive feature of Bentham's thought, reflected in his ideas for a centralised information state as well as his wider corpus on criminal justice. In this paper, I historicise Bentham's theory of reformative surveillance, and argue that Bentham, writing from London, misunderstood the importance of surveillance to the penal colony. At least in theory, convicts in New South Wales were subject to extensive systems of surveillance, and the failure of these systems in practice point to the limitations of Bentham's own, largely hypothetical, plans. (shrink)

All parties involved in researching, developing, manufacturing, and distributing COVID-19 vaccines need guidance on their ethical obligations. We focus on pharmaceutical companies' obligations because their capacities to research, develop, manufacture, and distribute vaccines make them uniquely placed for stemming the pandemic. We argue that an ethical approach to COVID-19 vaccine production and distribution should satisfy four uncontroversial principles: optimising vaccine production, including development, testing, and manufacturing; fair distribution; sustainability; and accountability. All parties' obligations should be coordinated and mutually consistent. For (...) instance, companies should not be obligated to provide host countries with additional booster shots at the expense of fulfilling bilateral contracts with countries in which there are surges. Finally, any satisfactory approach should include mechanisms for assurance that all parties are honouring their obligations. This assurance enables countries, pharmaceutical companies, global organisations, and others to verify compliance with the chosen approach and protect ethically compliant stakeholders from being unfairly exploited by unethical behaviour of others. (shrink)

COVID-19 vaccines are likely to be scarce for years to come. Many countries, from India to the U.K., have demonstrated vaccine nationalism. What are the ethical limits to this vaccine nationalism? Neither extreme nationalism nor extreme cosmopolitanism is ethically justifiable. Instead, we propose the fair priority for residents framework, in which governments can retain COVID-19 vaccine doses for their residents only to the extent that they are needed to maintain a noncrisis level of mortality while they are implementing reasonable public (...) health interventions. Practically, a noncrisis level of mortality is that experienced during a bad influenza season, which society considers an acceptable background risk. Governments take action to limit mortality from influenza, but there is no emergency that includes severe lockdowns. This “flu-risk standard” is a nonarbitrary and generally accepted heuristic. Mortality above the flu-risk standard justifies greater governmental interventions, including retaining vaccines for a country's own citizens over global need. The precise level of vaccination needed to meet the flu-risk standard will depend upon empirical factors related to the pandemic. This links the ethical principles to the scientific data emerging from the emergency. Thus, the FPR framework recognizes that governments should prioritize procuring vaccines for their country when doing so is necessary to reduce mortality to noncrisis flu-like levels. But after that, a government is obligated to do its part to share vaccines to reduce risks of mortality for people in other countries. We consider and reject objections to the FPR framework based on a country: having developed a vaccine, raising taxes to pay for vaccine research and purchase, wanting to eliminate economic and social burdens, and being ineffective in combating COVID-19 through public health interventions. (shrink)

ABSTRACT:The relationship between equality and equity has been theorized and described in many ways. Recently, this relationship has been popularly illustrated via a meme depicting three people watching a baseball game while standing on boxes. The meme's analogy, that achieving health equity is the ability to view a spectator sport, is a neoliberal account of health. The analogy defines equality at the expense of equity, characterizes health as individualistic, describes health equity as a static outcome, and implies that the bioethical (...) questions for achieving health equity are about the distribution and redistribution of resources. As the SARS CoV-2 pandemic vividly reminded us, health equity is no spectator sport. Health equity is the intentional removal of obstacles to health and the enabling of human flourishing to assure that everyone has fair and just opportunities for health. That relational and radical account of health equity requires different analogies. This article reimagines and re-illustrates the relationship between equality and equity using an organic analogy of three plants. The analogy calls for bioethics to nurture communal relationships and engage community leaders in pursuit of communal flourishing. (shrink)

Political theory is a field that finds nourishment in others. From economics, history, sociology, psychology, and political science, theorists have drawn a rich repertoire of schemas to parse the social world and make sense of it. With each of these encounters, new subjects are brought into focus as others recede into the background, ushering a change not only in how questions are tackled but also in what questions are thought worth asking.

In this article, we propose the Fair Priority Model for COVID-19 vaccine distribution, and emphasize three fundamental values we believe should be considered when distributing a COVID-19 vaccine among countries: Benefiting people and limiting harm, prioritizing the disadvantaged, and equal moral concern for all individuals. The Priority Model addresses these values by focusing on mitigating three types of harms caused by COVID-19: death and permanent organ damage, indirect health consequences, such as health care system strain and stress, as well as (...) economic destruction. It proposes proceeding in three phases: the first addresses premature death, the second long-term health issues and economic harms, and the third aims to contain viral transmission fully and restore pre-pandemic activity. -/- To those who may deem an ethical framework irrelevant because of the belief that many countries will pursue "vaccine nationalism," we argue such a framework still has broad relevance. Reasonable national partiality would permit countries to focus on vaccine distribution within their borders up until the rate of transmission is below 1, at which point there would not be sufficient vaccine-preventable harm to justify retaining a vaccine. When a government reaches the limit of national partiality, it should release vaccines for other countries. -/- We also argue against two other recent proposals. Distributing a vaccine proportional to a country's population mistakenly assumes that equality requires treating differently situated countries identically. Prioritizing countries according to the number of front-line health care workers, the proportion of the population over 65, and the number of people with comorbidities within each country may exacerbate disadvantage and end up giving the vaccine in large part to wealthy nations. (shrink)

Designer Biology: The Ethics of Intensively Engineering Biological and Ecological Systems consists of thirteen chapters that address the ethical issues raised by technological intervention and design across a broad range of biological and ecological systems. Among the technologies addressed are geoengineering, human enhancement, sex selection, genetic modification, and synthetic biology.

_Kant and Applied Ethics_ makes an important contribution to Kant scholarship, illuminating the vital moral parameters of key ethical debates. Offers a critical analysis of Kant’s ethics, interrogating the theoretical bases of his theory and evaluating their strengths and weaknesses Examines the controversies surrounding the most important ethical discussions taking place today, including abortion, the death penalty, and same-sex marriage Joins innovative thinkers in contemporary Kantian scholarship, including Christine Korsgaard, Allen Wood, and Barbara Herman, in taking Kant’s philosophy in (...) new and interesting directions Clarifies Kant’s legacy for applied ethics, helping us to understand how these debates have been structured historically and providing us with the philosophical tools to address them. (shrink)

ABSTRACTThis paper is a critical response to Amy Allen’s The End of Progress: Decolonising the Normative Foundations of Critical Theory. We take up her book’s call for a “problematizing” history which challenges “taken-for-granted” preconceptions in order to contest Allen’s own representation of the thought of the enlightenment. Allen accepts that all the enlighteners agreed upon a stadial, progressive account of history, which she critiques epistemically and normatively. But we show in Part 2, drawing on the work of (...) Henri Vyverberg and other historians of eighteenth century ideas, that a cyclical, rise and fall account of historical succession was more prominent than the progressive narrative in leading enlighteners such as Montesquieu, Voltaire, Diderot, D’Alembert, Condillac, Jancourt, Grimm, and Raynal, all of whom Allen does not mention. In Part 3, we show that not all thinkers of the enlightenment were pro-colonial or pro-imperialist, as Allen also presupposes in The End of Progress. By examining Abbé Raynal’s History of The Two Indies in Part 3, and notably its Diderotian interpolations, we show that many enlighteners propounded fierce criticisms of European colonialism and the slave trade, even calling directly for armed resistance against European infractions. In critical theorists’ search for chastened normative foundations, our concluding remarks contend, there is a need to develop more accurate, balanced, post-postmodern reckonings of the enlightenment. (shrink)

This paper is a critical response to Amy Allen’s The End of Progress: Decolonising the Normative Foundations of Critical Theory. We take up her book’s call for a “problematizing” history which challenges “taken-for-granted” preconceptions in order to contest Allen’s own representation of the thought of the enlightenment. Allen accepts that all the enlighteners agreed upon a stadial, progressive account of history, which she critiques epistemically and normatively (Part 1). But we show in Part 2, drawing on the (...) work of Henri Vyverberg and other historians of eighteenth century ideas, that a cyclical, rise and fall account of historical succession was more prominent than the progressive narrative in leading enlighteners such as Montesquieu, Voltaire, Diderot, D’Alembert, Condillac, Jancourt, Grimm, and Raynal, all of whom Allen does not mention. In Part 3, we show that not all thinkers of the enlightenment were pro-colonial or pro-imperialist, as Allen also presupposes in The End of Progress. By examining Abbé Raynal’s History of The Two Indies in Part 3, and notably its Diderotian interpolations, we show that many enlighteners propounded fierce criticisms of European colonialism and the slave trade, even calling directly for armed resistance against European infractions. In critical theorists’ search for chastened normative foundations, our concluding remarks contend, there is a need to develop more accurate, balanced, post-postmodern reckonings of the enlightenment. (shrink)

This essay builds on recent work by Susan Haack to suggest that Oliver Wendell Holmes Jr.’s conception of the common law was influenced by Darwinian evolution and classical pragmatism. This is no small claim: perceptions of what the common law is and does within the constitutional framework of the United States continue to be heavily debated. Holmes’s paradigm for the common law both revised and extended the models set forth by Sir Edward Coke, Thomas Hobbes, Sir Matthew Hale, and (...) Sir William Blackstone. Adding additional substance to Haack’s argument by pointing out passages in Holmes’s opinions and in his only book, The Common Law, that corroborate her claims about the particular features of Holmes’s pragmatism, this essay concludes by suggesting that, because of his connections with the classical pragmatists and his reverence for Emerson, Holmes is the best place to begin answering the famous question formulated by Stanley Cavell: “What’s the Use in Calling Emerson a Pragmatist?”. (shrink)

This review essay evaluates The Dialectics of Liberty, a recent collection, edited by Roger E. Bissell, Chris Matthew Sciabarra, and Edward W. Younkins. It describes the dialectical turn in libertarian political and economic theory and analyzes the diverse contributions to dialectics by the various authors in this volume.

Kevin J. Hayes is a writer of high regard, having published many books over his distinguished career, including biographical studies such as Herman Melville, Mark Twain, George Washington: A Life in Books, and several on Edgar Allen Poe. Works like the 2020 monograph Shakespeare and the Making of America showcase his intersecting interests in biography, literature, and American political history. It is these interests that are very much on display in his 2022 monograph The Future of the Book: Images (...) of Reading in the American Utopian Novel, and we should be thankful that Hayes has turned his attention to the subject of utopian fiction as he certainly has much to add to the discussion. The book is clearly a labor of... Read More. (shrink)

Yates has recently argued that modal dispositionalism invalidates the axiom. Both Yates and Allen have advanced responses to the objection: Yates’s response proposes installing truth into the possibility biconditional, and Allen’s response requires that all properties be construed as being essentially dispositional. I argue that supporters of Borghini and Williams’s modal dispositionalist theory cannot accept these responses, given critical tenets of their theory. But, since these responses to the objection are the most plausible in the literature, I conclude (...) that the threat that Borghini and Williams’s modal dispositionalist theory invalidates the axiom still looms large. (shrink)

Allen Buchanan’s ‘The Heart of Human Rights’ addresses the moral justification of the international legal human rights system. Buchanan identifies two functions of the ILHRS: a well-being function and a status egalitarian function. Because Buchanan assumes that the well-being function is sufficientarian, he augments it with a status egalitarian function. However, if the well-being function is utilitarian or prioritarian, there is no need for a separate status egalitarian function, because the status egalitarian function can be subsumed by the utilitarian (...) or prioritarian well-being function. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Directions in Contemporary German AestheticsMatthew PritchardÄsthetisches Denken, 6th ed., by Wolfgang Welsch. Stuttgart: Reclam, 1990 (2003), 223 pp.Aisthetik: Vorlesungen Über Ästhetik Als Allgemeine Wahrnehmungslehre, by Gernot Böhme. Munich: Wilhelm Fink, 2001, 199 pp.Ästhetische Korrespondenzen: Denken Im Technischen Raum, by Reinhard Knodt. Stuttgart: Reclam, 1994, 166 pp.The relationship between the Anglo-American and German aesthetic traditions is a paradoxical one. On the one hand, acquaintance with one or more figures from (...) the “great tradition” in German aesthetic thought over the last 250 years is a given for most philosophically oriented writers on aesthetics in Britain and America. Thinkers such as Kant or Adorno form a real and abiding part of our background. In some cases the connection with German intellectual lineages goes a good deal further. As an extreme case, take Terry Eagleton’s The Ideology of the Aesthetic,1 whose engagement with German thought is so deep that I have come across it as a set text for aesthetics courses in German universities (despite the fact that none of the dozen authors Eagleton analyzes are cited in their original language). On the other hand, interest in contemporary German aesthetics in English and American circles appears to be relatively slight. One would have little idea, from reading any of the philosophical journals in English, of just how much activity there is in this area, only a small proportion of which has been translated, cited, or reviewed. And yet the past two decades have seen the publication of dozens of relevant books by German authors, many proposing independent theoretical approaches. Among these—aside from the books reviewed here—are the substantial work done on performance and performativity by Erika Fischer-Lichte (Ästhetik des Performativen, 2004) and Dieter Mersch (Ereignis und Aura, 2002); the theoretical oeuvre of the prize-winning literary critic Karl Heinz Bohrer, of which Suddenness: On the Moment of Aesthetic Appearance, originally published in 1981, has made it into English; Ruth Sonderegger’s Romantic-leaning plea Für eine Ästhetik des Spiels (2000); Dieter Heinrich’s work on the philosophy of art and subjectivity, Fixpunkte: Aufsätze [End Page 117] und Essays zur Theorie der Kunst (2003); Martin Seel’s Aesthetics of Appearing (2004); the traditional neo-Kantian perspective of the late Rüdiger Bubner as set out in his Ästhetische Erfahrung (1989); Gábor Paál’s Was ist schön?—Ästhetik und Erkenntnis (2003); Konrad Paul Liessmann’s Reiz und Rührung: Über ästhetische Empfindungen (2003)... the list could be continued. And this is not to mention empirical-psychological approaches, works on the history of aesthetics, the reception accorded to analytical aesthetics and American philosophers such as Goodman and Danto, or the continuation of European poststructuralist and Frankfurt School traditions (for example, in the work of Albrecht Wellmer and Christoph Menke).Given this large “backlog” of writing not yet assimilated into Anglo-American discussion, it makes sense to be selective and range a little further than the most recently published texts. Owing to sheer diversity, I cannot honestly claim that the three books I am going to discuss here are “representative” of the interests driving contemporary German aesthetics. But I have chosen them for certain common traits, traditions, and emphases that seem to me to present a stimulating contrast with the approach of Anglo-American philosophical aesthetics, while retaining many points of contact with non-German thought. That the contrast does not come down to the crass standoff of “analytical” vs. “Continental,” and all the clichés about academic style that go with it, should become obvious. It is more interesting than that, and although I want to leave the details to the discussion of the three books, I can mention at the outset a few aspects I regard as important. One is that none of these authors addresses themselves exclusively to either the philosophy of art or to the aesthetics of nature and the environment. Instead they tend to make points relating to both, or to regard both as aspects of a single situation. “Environmental aesthetics” in Anglo-American philosophy—for instance, the work of Allen Carlson—is not only of recent date but is still a subdiscipline separated from aesthetics... (shrink)

According to many traditional accounts, one important difference between international and domestic law is that international law depends on the consent of the relevant parties (states) in a way that domestic law does not. In recent years this traditional account has been attacked both by philosophers such as Allen Buchanan and by lawyers and legal scholars working on international law. It is now safe to say that the view that consent plays an important foundational role in international law is (...) a contested one, perhaps even a minority position, among lawyers and philosophers. In this paper I defend a limited but important role for actual consent in legitimating international law. While actual consent is not necessary for justifying the enforcement of jus cogens norms, at least when they are narrowly understood, this leaves much of international law unaccounted for. By drawing on a Lockean social contract account, I show how, given the ways that international cooperation is different from cooperation in the domestic sphere, actual consent is both a possible and an appropriate legitimating device for much of international law. (shrink)

Employers seeking to control employee behavior outside of working hours is nothing new. However, recent developments have extended efforts to control employee behavior into new areas, with new significance. Employers seek to control legal behavior by employees outside of working hours, to have significant influence over employee’s health-related behavior, and to monitor and control employee’s social media, even when this behavior has nothing to do with the workplace. In this article, I draw on the work of political theorists Jon Elster, (...) Gerald Gaus and Michael Walzer, and privacy scholars Daniel Solove and Anita Allen, to show what is wrong with this extension of employer control of employee’s outside of work behavior. I argue that there are ethical limits on the controls that employers may put on their employees’ out of work behavior, and that many of these limits should be enshrined into legal protections which would prevent employers from conditioning employment on the regulations criticized. -/- (Please note that the version of this paper on SSRN is a pre-publication version. Please cite and refer to the published version when possible.). (shrink)

The Heart of Human Rights develops an account of human rights as legal entities that serve important moral purposes in a legitimate international human rights practice. This paper examines Allen Buchanan’s general concept of institutional legitimacy and aims to expand that concept by emphasizing its connection with several ideas developed in the book about the nature and function of a system of international human rights. When it incorporates those ideas, Buchanan’s ‘Metacoordination View’ can be seen to set a standard (...) of legitimacy not only for assessments of an international scheme of human rights institutions, but also for the basic institutional structures of domestic states. Furthermore, we can see how the nature and function of human rights in the international practice of human rights bears on legitimacy assessments of particular domestic institutions. (shrink)

For many years now Allen Buchanan has been one of the most important theorists working on the philosophy of human rights, producing a large number of papers and two books significantly devoted to the topic. In the work under consideration in this symposium, Buchanan breaks new ground by examining what he claims to be the “heart” of international human rights practice – the international legal human rights (“ILHR”) system, subjecting it to moral and philosophical analysis and criticism. Buchanan's book (...) was the subject of an author meets critics session sponsored by the APA Committee on Law and Philosophy at the 2015 Pacific APA Meeting. The following paper introduces the resulting special issue of the journal, _Law and Philosophy_, summarizing Buchanan's important contribution and criticisms by William Talbot, Brooke Ackerley, Erin Kelly, and Mathias Risse, as well as Buchanan's replies. (shrink)

The Heythrop Journal, Volume 63, Issue 2, Page 322-323, March 2022.

Forty years ago, Vaughn Ball demonstrated that the then received notion of conditional relevance served no useful purpose, as it would only come into effect if the probability of an element were 0.0. But, if the probability of an element were 0.0, a directed verdict would be in order and so once again conditional relevancy was doing no work. I extended that analysis to include the relationship between proffers of evidence and facts of consequence to demonstrate that the work that (...) conditional relevancy was supposedly doing was isomorphic to that done by relevancy in all significant ways, and yet the Federal Rules of Evidence provide different standards for the two situations to determine admissibility. I thus proposed an amendment to FRE 104(b) to provide for the same standard to be applied to ‘relevancy’ and ‘conditional relevancy’. In a recent article, Matthew Kotzen appears to subject this work to intense scrutiny and criticism, yet at the same time reaches, so far as I can tell, identical conclusions. This raises the question, which I examine, whether this is an example of cross-disciplinary difficulties in communication. (shrink)

Evolutionary gradualism, the randomness of mutations, and the hypothesis that natural selection exerts a pervasive and substantial influence on evolutionary outcomes are pair-wise logically independent. Can the claims about selection and mutation be used to formulate an argument for gradualism? In his Genetical Theory of Natural Selection, R.A. Fisher made an important start at this project in his famous “geometric argument” by showing that a random mutation that has a smaller effect on two or more phenotypes will have a higher (...) average fitness than a random mutation that has a larger phenotypic effect. Motoo Kimura’s demonstration that a gene’s probability of fixation depends on both the selection coefficient and the effective population size shows that Fisher’s argument for gradualism was mistaken. Here we analyze Fisher’s argument and explain how Kimura’s theory leads to a conclusion that Fisher did not anticipate. We identify a fallacy that reasoning about fitness differences and their evolutionary consequences should avoid. We then distinguish forward-directed from backward-directed versions of gradualism. The backward-directed thesis about a single mutation may be correct, but the forward-directed thesis is not. After that we consider a sequence of random mutations that all affect the same cluster of phenotypes and Allen Orr’s idea that there is an optimal sequence of mutation sizes, moving from larger to smaller as the population approaches a fixed optimum. This provides a likelihood justification for a forward-directed version of gradualism when there is a fixed optimum, but it also provides an argument against forward-directed gradualism if the optimum shifts substantially as the population evolves. Finally, we consider whether genome-wide association studies (GWASs) can furnish empirical evidence that bears on the truth of gradualism. The version of gradualism that GWASs directly bear on concerns the phenotypic effect size of a gene after it arises by mutation and has reached an appreciable frequency, not the phenotypic size of the mutation event itself. (shrink)

Legal philosophers have given relatively little attention to international law in comparison to other topics, and philosophers working on international or global justice have not taken international law as a primary focus, either. Allen Buchanan's recent work is arguably the most important exception to these trends. For over a decade he has devoted significant time and philosophical skill to questions central to international law, and has tied these concerns to related issues of global justice more generally. In what follows (...) I review Buchanan's new collection of essays, Human Rights, Legitimacy, and the Use of Force, paying special attention to Buchanan's argument that the philosophy of international law must be more empirically informed than it has been so far, and also to his claim that greater emphasis must be placed on the role of institutions. While these are important claims, I show that Buchanan often does not take the first far enough, and that appealing to institutions cannot do as much as Buchanan hopes or needs if his substantive conclusions are to be correct. (shrink)

The book collects seventeen new research papers on themes in Indian philosophy, contributed by contemporary scholars from around the world. The principal themes are knowledge and logic, consciousness, existence, and the self. The editor explains that the studies discuss Indian sources in their own context, rather than trying to be comparative or make connections to other traditions. This unfortunate directive is fortunately ignored by the strongest papers. Claus Oetke shows that despite their investigations of inference and syntax, Indian analysts had (...) little interest in formal structure per se. They investigated ways to exploit the formal structure in ordinary cases for the establishment of metaphysical tenets. Metaphysical aspirations rather than sheer formal analysis were the overriding concern. Another contributor describes Indian thought as “relentlessly empiricist in orientation.” Scripture is acknowledged for transcendent things like Dharma and Brahman, “but it is the senses that hold sway over the natural world.” Logic is not enough for inference, which must be grounded in perception. The fourth-century Buddhist Vasubandhu defines inference in terms of perception. The basis of inference is the observation of an object not occurring without the inferred object for one who knows the connection. Eli Franco explains how skepticism invaded Indian thought with the Madhyamaka movement in latter Buddhism, beginning with the great founder Nagarjuna. He denies any means to knowledge, using arguments that often resemble those of Western skepticism. Skepticism about means to knowledge became associated with the later materialist Lokayata school, from ninth century. Indian materialism is an anomaly somewhat like the Chinese rationalism of the Mohists. Pradeep Gokhale provides an overview of the school, which he describes as “a rationalist philosophical movement which attempted to solve individual and social issues merely on empirical, rational, and practical grounds without taking recourse to religion.” Like Epicurus, this materialism is a physical theory demystifying traditional morality and religion, which are replaced by hedonism. Consciousness originates in body and does not exist independent of matter. It is not originally in the elements but arises from them, as intoxication, not originally in molasses, arises by fermentation. Religion is a human creation. Other worlds do not exist. Nothing that we do makes a difference to future lives, which do not exist. Fallacious ideas like life after death vitiate sacrifice and morality. The path to liberation is to follow natural pleasure. Joel Feldman discusses the Buddhist doctrine of momentariness. Things do not endure. The experience of enduring things is a delusive result of imagining things to have a universal character when actually they are merely grouped together according to our desires by means of their exclusion from things that do not fulfill our purposes. We impose this vast delusion on what are in truth momentary self-characterized particulars, each with its own self-nature, producing an effect and then annihilating in a moment by that very self-nature. Destruction is never the work of an external cause. If a thing can self-destruct, then it must be destroyed immediately by its own self-nature as soon as it begins to exist. Papers by Alex Watson and Roy Tzohar survey the spectrum of Indian views on the self. Consciousness as light is an ancient image in Indian thought described in a contribution by Matthew MacKenzie. Isabelle Ratié explains the metaphor of the mirror in Indian thought about consciousness. For Brahminical tradition mirror images are sheer illusion. For the later Buddhists the perceived universe is comparable to an optical refection. The characteristic of reflecting entities like a mirror is the capacity to manifest themselves as something else while remaining what they are, and this is exactly like consciousness, which manifests itself in all the images of phenomenal nature. In all of these papers Indian ideas are repeatedly compared with ideas in Sartre, McGinn, Dretske, Searle, Husserl, Merleau-Ponty, Heidegger, Wittgenstein, and Sellars. (shrink)

Climate and evolution represents an important contribution to evolutionary biogeography, that influenced several authors, notably Karl P. Schmidt, George S. Myers, George G. Simpson, Philip J. Darlington, Ernst Mayr, Thomas Barbour, John C. Poynton, Allen Keast, Léon Croizat, Robin Craw, Michael Heads, and Osvaldo A. Reig. Authors belonging to the “New York School of Zoogeography” –a research community including Matthew, Schmidt, Myers and Simpson– accepted Matthew’s “Holarcticism” and the permanence of ocean basins and continents, whereas others, especially (...) panbiogeographers and cladistic biogeographers, were extremely critical and reacted against these ideas. “Holarcticism” has been falsified and rejected by dispersalists and the “New York School of Zoogeography” disappeared in the 1970s. Matthew, however, continues being identified by panbiogeographers and cladistic biogeographers as a key representative of classic dispersalism, helping provide some cohesion to their research communities. (shrink)

An important theme in recent experimental philosophy is that certain judgements (e.g. our judgements involving intentional action and causation) exhibit a kind of normative penetration whereby, in spite of a not-obviously-normative subject matter, they turn out to be sensitive to, and co-vary with, our normative attitudes in interesting and surprising ways. We present the results of several new experimental studies that suggest that our judgements about feasibility also appear to exhibit this kind of normative penetration in at least some cases; (...) that the best explanation of it involves attributing to subjects a certain kind of extensional error that results from conflating the question at hand with another question that is more salient given their normative attitudes; and that these conclusions have significant, though not straightforward, implications for our understanding of both normative penetration and feasibility, respectively. (shrink)