Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

As Christians, we affirm that Scripture is our supreme guide to truth and righteousness. Some wish to go further and assert that it is our only guide. But how then can we account for the remarkable insight and moral integrity that many unbelievers seem to display? Indeed, how to account for the myriad ways in which believers themselves navigate the world based on knowledge and intuition not always derived from Scripture? Enter the doctrine of natural law. Frequently misrepresented as an (...) assertion of the autonomous power of human reason or as a uniquely Roman Catholic doctrine, natural law has actually been an integral part of orthodox Christian theology since the beginning, and is even clearly asserted in Scripture itself. In this brief guide, David Haines and Andrew Fulford explain the philosophical foundations of natural law, clear up common misunderstandings about the term, and demonstrate the robust biblical basis for natural law reasoning. (shrink)

Christians affirm that Scripture alone reveals truths about God which cannot be known by mere reason, such as the Trinity or the Gospel itself. But how do we account for Scripture’s apparent talk of a knowledge of God possible solely from creation? Or for our own sense of the divine in nature? Or for the startling insights of ancient philosophers about the nature of God? The answer: natural theology. Often misrepresented as a fruitless human attempt to comprehend God, natural theology (...) has in fact been a significant part of Christian theology throughout history. It has shaped the Christian doctrine of God and provided a starting point for evangelizing non-Christians. In an age when theologians and missionaries alike are in need of stronger doctrinal foundations, it is a doctrine as vital as ever. In this guide, David Haines first outlines the biblical basis for natural theology, suggesting that, if Scripture is correct, certain truths about God should be well attested by non-Christians. A thorough historical survey demonstrates that this is indeed the case, and that the Church has long made use of that which is revealed to reason in order to serve Christ, who is revealed to faith. (shrink)

W. David Solomon sits at the very center of the revival of virtue ethics. Solomon's work extended what began with the publication of G. E. M. Anscombe's "Modern Moral Philosophy" (1958) by solidifying virtue ethics as a viable approach within contemporary moral philosophy. Beyond the Self: Virtue Ethics and the Problem of Culture comprises twelve chapters: eleven that employ Solomon's work and legacy, followed by a twelfth concluding chapter by Solomon himself. Each chapter deepens and develops virtue ethics as (...) a rich intellectual tradition rooted in Aristotle and Thomas Aquinas. Editor Raymond Hain divides the volume into three sections. The first addresses the historical contexts of happiness, justice, and mercy in the tradition of Aristotle and Thomas Aquinas. The second turns to recent themes in normative ethics, focusing on topics such as morality, virtue, and egoism. The third discusses broader ethical issues with significant cultural implications, such as human dignity, physician-assisted suicide, and secularization. Beyond the Self uncovers the shortcomings of contemporary moral philosophy and the depth and capacity of the Aristotelian and Thomistic traditions, reminding the reader that classical virtue ethics remains the most promising framework for understanding the moral life. Contributors include: Michael Beaty, Kevin L. Flannery, Raymond Hain, John Haldane, Thomas Hibbs, Irfan Khawaja, Alasdair MacIntyre, John O'Callaghan, Bryan C. Pilkington, W. David Solomon, Christopher Toner, and Candace Vogler. (shrink)

The public often believes that parents have a right to make medical decisions about their child. The idea that, in respect of children, doctors should do what parents tell them to do is problematic on the face of it. The effect of such a claim would be that a doctor who acted deliberately to harm a child would be making a morally correct decision, providing only that it is what the child’s parents said they wanted. That is so obviously nonsense (...) that it cannot be what people who claim it actually mean. In this paper, I suggest that the claim actually represents either or both of two misunderstandings. It can be a result of wrongly appealing to the principle of respect for autonomy, or a belief that doctors are not committed to acting in the interests of the child. In this paper, I show that, while neither belief is entirely justified, there are elements of truth in both. I argue that if ethically correct decisions are those that are directed to improving the quality of a child’s existence, then neither parents nor doctors are in a position to make ethically correct decisions about a child except in discussion with one another. Where such discussion is not possible, I suggest there should be a national Children’s Interests Panel to agree on the child’s interests. The panel should include, but not be limited to, paediatricians and lawyers and its decisions should be legally binding on all parties. (shrink)

The twentieth century was unkind to classical Reformed theology. While theological conservatives often blame liberals for undermining traditional Protestant doctrines, the staunchest conservatives and neo-Orthodox also revised several key doctrines. Although Cornelius Van Til developed presuppositional apologetics as an attempt to remain faithful to timeless Christian truth as the Reformed tradition expresses it, he sacrificed the catholic and Reformed understanding of the use of natural revelation in theology and apologetics in the process. -/- "The invisible things of him from the (...) creation of the world are clearly seen, being understood by the things that are made...so that they are without excuse," writes the Apostle Paul. Without Excuse seeks to grapple with this indictment and show how Van Til's presuppositionalism fails as an account of natural revelation in light of Scripture, philosophy, and historical theology. It argues that these three sources speak with one voice: creation reveals itself and its God to the believer and unbeliever alike. (shrink)

Drawing on the author’s experience carrying out qualitative research in the field of occupational therapy with people with intellectual disabilities, this article explores ethical issues inherent in ethnographic and case study research, where study designs can evolve over time. Such qualitative methodologies can enable deep understanding of research topics, but detailed description of methods and of the range of potential experiences participants may have is necessary to ensure that they are fully informed and ethics committees satisfied. Thorough consideration is required (...) of ethical issues related to topic relevance and design, recruitment, collection of data and portrayal of participants in the eventual case report. The article illustrates a way in which research of this type can be explained and justified, including how recruitment can be achieved of participants likely to lack capacity to consent to participation themselves. (shrink)

“Assessment of learning” is a key phrase well known to all quality business schools. This paper presents a detailed description of the processes undertaken by one university’s school of business to assess its ethics education learning environment with respect to internal values and goals, AACSB standards and expectations, and best practices established by external entities. This paper shows that generous resources are not the sine qua non of quality ethics instruction. There are many steps that cost virtually nothing, beyond focused (...) effort, that a school can take to improve the quality of ethics instruction. This paper provides guidance and lessons learned for those who may be undertaking an extended review of ethics instruction. Many elements of this framework also may be adapted to a similar analysis in other competency areas. (shrink)

“Assessment of learning” is a key phrase well known to all quality business schools. This paper presents a detailed description of the processes undertaken by one university’s school of business to assess its ethics education learning environment with respect to internal values and goals, AACSB standards and expectations, and best practices established by external entities. This paper shows that generous resources are not the sine qua non of quality ethics instruction. There are many steps that cost virtually nothing, beyond focused (...) effort, that a school can take to improve the quality of ethics instruction. This paper provides guidance and lessons learned for those who may be undertaking an extended review of ethics instruction. Many elements of this framework also may be adapted to a similar analysis in other competency areas. (shrink)

SummaryAn account is given of one of the most heated controversies in nineteenth-century British geology—the battle between Archibald Geikie and John Judd concerning the interpretation of the Palaeogene igneous rocks of the Inner Hebrides, particularly those of the Cuillins and the Red Hills of Skye. The controversy erupted in the first instance over the question of the respective ‘territories’ of the two geologists, then developed into disagreement as to the origin of the plateau lavas of Skye: were they formed from (...) fissure eruptions (Geikie's view) or from the outpourings of great volcanoes (Judd's view)? Debate then focused on the question of the relative age of the gabbro of the Cuillins and the granite (granophyre) of the Red Hills. A certain locality at Druim Hain (Druim an Eihdne) at the junction between the two rock-types became crucial for the dispute. Following earlier observers, Judd held that the granite was older and had been intruded by the gabbro. Geikie took the opposite view. Geikie's work relied particularly on field observations, for which he was assisted by several other geologists. Judd, who worked by himself, rested his argument more on the evidence furnished by petrology, using thin sections. Both geologists were influenced by Ferdinand von Richthofen. Geikie's work appeared to be vindicated in his own lifetime by the map work of Alfred Harker, which effectively closed the controversy. But later commentators such as Walker hold that in a sense both were correct. There were indeed great volcanoes active in the Inner Hebrides in the Palaeogene, as well as fissure eruptions. Moreover, recent mapping does not support all the observations of Geikie and Harker. The controversy illustrates different styles in nineteenth-century geology, with petrological arguments, based on the examination of thin sections, pitted against field observations. It may also be seen as being linked with the ongoing rivalry in the nineteenth century between the members of the Geological Survey (particularly the Directors General) and the ‘amateur’ university geologists. Geikie prevailed in the debate in part because he was able to draw on more resources for its prosecution, being helped by various friends and members of the Geological Survey. The study draws on the newly discovered Geikie archive at Haslemere, which contains his complete outgoing official correspondence, and 27 of his field notebooks, previously missing. With the help of this material, it is possible to gain a clearer insight into the methods deployed by Geikie in his fieldwork, and his ways of working and thinking. (shrink)

This book is a series of essays by distinguished scholars concerned with the improvement of primary, secondary, and tertiary studies, most especially in arts but also in mathematics and science. It is concerned with past ideas about education in Australia, most particularly with the traditions that have yielded an education that has proven most beneficial to Australia in terms of comparison with other countries; and it advocates and emphasises how this tradition can be maintained and improved in specific ways. Essays (...) focus on primary and secondary education in music, and art, mathematics, history and the classics, on the improvement of memory and vocabulary, but more particularly on university education, discussing the purpose of education, learning in general, the use of the seminar, the necessity of freedom of debate, the inadequacies and contradictions of French and Anglo-post modernism, the teaching of history, of philosophy, and its branch aesthetics, mathematics, equality in education, teaching at university and funding of the whole enterprise. The authors are all well known in their disciplines and some are experts, internationally recognised in their fields. This book features essays by: David Daintree, Karl Schmude, Simon Haines, Kevin Donnelly, Matthew Lesh, Chris Berg & Bella d'Abrera, David Furse-Roberts, Greg Melleuish, Steven Schwartz, Blaise Joseph, James Franklin, Christopher Allen, Richard Gill, Jeremy Bell, Barry Spurr, David Brooks, Natalie Kennedy, Sarah Williams, Sarah Lawrence, Ivan Francis Head. (shrink)

In this book, which thoroughly revises and greatly expands his classic work Sameness and Substance, David Wiggins retrieves and refurbishes in the light of twentieth-century logic and logical theory certain conceptions of identity, of substance and of persistence through change that philosophy inherits from its past. In this new version, he vindicates the absoluteness, necessity, determinateness and all or nothing character of identity against rival conceptions. He defends a form of essentialism that he calls individuative essentialism, and then a (...) form of realism that he calls conceptualist realism. In a final chapter he advocates a human being-based conception of the identity and individuation of persons, arguing that any satisfactory account of personal memory must make reference to the life of the rememberer himself. This important book will appeal to a wide range of readers in metaphysics, philosophical logic, and analytic philosophy. (shrink)

Lipsey and Lancaster's "general theory of second best" is widely thought to have significant implications for applied theorizing about the institutions and policies that most effectively implement abstract normative principles. It is also widely thought to have little significance for theorizing about which abstract normative principles we ought to implement. Contrary to this conventional wisdom, I show how the second-best theorem can be extended to myriad domains beyond applied normative theorizing, and in particular to more abstract theorizing about the normative (...) principles we should aim to implement. I start by separating the mathematical model used to prove the second-best theorem from its familiar economic interpretation. I then develop an alternative normative-theoretic interpretation of the model, which yields a novel second best theorem for idealistic normative theory. My method for developing this interpretation provides a template for developing additional interpretations that can extend the reach of the second-best theorem beyond normative theoretical domains. I also show how, within any domain, the implications of the second-best theorem are more specific than is typically thought. I conclude with some brief remarks on the value of mathematical models for conceptual exploration. (shrink)

Why study notations, diagrams, or more broadly the variety of nonverbal “representations” or “signs” that are used in mathematical practice? This chapter maps out recent work on the topic by distinguishing three main philosophical motivations for doing so. First, some work (like that on diagrammatic reasoning) studies signs to recover norms of informal or historical mathematical practices that would get lost if the particular signs that these practices rely on were translated away; work in this vein has the potential to (...) broaden our view of the specific normativity of mathematics beyond logical proof. Second, some work focuses on signs to highlight the open-ended and “nonrigorous” aspects of mathematical practice, and the role of these aspects in the historical development of mathematics. The third motivation is based on the following observation: the reason differences in signs matter in mathematics is that humans are finite agents, with cognitive and computational limitations. Accordingly, studying signs can be a way to study how human computational constraints shape the mathematics that we do, and to tackle the topic of mathematical understanding. (shrink)

Artificial intelligence has historically been conceptualized in anthropomorphic terms. Some algorithms deploy biomimetic designs in a deliberate attempt to effect a sort of digital isomorphism of the human brain. Others leverage more general learning strategies that happen to coincide with popular theories of cognitive science and social epistemology. In this paper, I challenge the anthropomorphic credentials of the neural network algorithm, whose similarities to human cognition I argue are vastly overstated and narrowly construed. I submit that three alternative supervised learning (...) methods—namely lasso penalties, bagging, and boosting—offer subtler, more interesting analogies to human reasoning as both an individual and a social phenomenon. Despite the temptation to fall back on anthropomorphic tropes when discussing AI, however, I conclude that such rhetoric is at best misleading and at worst downright dangerous. The impulse to humanize algorithms is an obstacle to properly conceptualizing the ethical challenges posed by emerging technologies. (shrink)

A collection of 14 essays honoring the life and work of Oxford philosopher Wiggins touching on topics from ancient philosophy to ethics, metaphysics and the theory of meaning. The contributing scholars debate many of the seminal issues of Wiggins' work, including the determinancy of distinctness, relative identity, naturalism in ethics, logic and truth in moral judgments, and the practical wisdom of Aristotle. The collection uniquely features replies by Wiggins to each of the papers. Annotation copyright by Book News, Inc., Portland, (...) OR. (shrink)

According to dispositionalism about modality, a proposition <p> is possible just in case something has, or some things have, a power or disposition for its truth; and <p> is necessary just in case nothing has a power for its falsity. But are there enough powers to go around? In Yates (2015) I argued that in the case of mathematical truths such as <2+2=4>, nothing has the power to bring about their falsity or their truth, which means they come out both (...) necessary and not possible. Combining this with axiom (T), it is easy to derive a contradiction. I suggested that dispositionalists ought to retreat a little and say that <p> is possible just in case either p, or there is a power to bring it about that p, grounding the possibility of mathematical propositions in their truth rather than in powers. Vetter’s (2015) has the resources to provide a response to my argument, and in her (2018) she explicitly addresses it by arguing for a plenitude of powers, based on the idea that dispositions come in degrees, with necessary properties a limiting case of dispositionality. On this view there is a power for <2+2=4>, without there being a power to bring about its truth. In this paper I argue that Vetter’s case for plenitude does not work. However, I suggest, if we are prepared to accept metaphysical causation, a case can be made that there is indeed a power for <2+2=4>. (shrink)

We propose a formal framework for interpretable machine learning. Combining elements from statistical learning, causal interventionism, and decision theory, we design an idealised explanation game in which players collaborate to find the best explanation for a given algorithmic prediction. Through an iterative procedure of questions and answers, the players establish a three-dimensional Pareto frontier that describes the optimal trade-offs between explanatory accuracy, simplicity, and relevance. Multiple rounds are played at different levels of abstraction, allowing the players to explore overlapping causal (...) patterns of variable granularity and scope. We characterise the conditions under which such a game is almost surely guaranteed to converge on a optimal explanation surface in polynomial time, and highlight obstacles that will tend to prevent the players from advancing beyond certain explanatory thresholds. The game serves a descriptive and a normative function, establishing a conceptual space in which to analyse and compare existing proposals, as well as design new and improved solutions. (shrink)

Extant theoretical work on the political resource curse implies that dependence on resource revenues should decrease autocracies’ likelihood of democratizing but not necessarily affect democracies’ chances of survival. Yet most previous empirical studies estimate models that are ill-suited to address this claim. We improve upon earlier studies, estimating a dynamic logit model that interacts a continuous measure of resource dependence with an indicator of regime type using data from 166 countries, covering the period from 1816-2006. We find that an increase (...) in resource dependence at time t - 1 increases the likelihood of autocratic persistence at t, but has no appreciable effect on democratic survival. We go beyond existing empirical studies to show that increases in resource dependence have persistent and substantial cumulative effects on autocracies' likelihood of becoming democratic over the long-term, showing that the total effect of resource dependence on regime type is much larger than the short-term (one period) effect indicates. (shrink)

Japan and the Enemies of Open Political Science argues that Eurocentric blindness is a scientific failing, not a moral one. In a way true of no other political system, Japan's greatness has the potential to enliven and reform almost all the main branches of Western Political Science. David Williams criticizes Western social science, Anglo-American Philosophy and French Theory and explains why mainstream economists, historians of political thought and postculturalists have ignored Japan's modern achievements. Williams demonstrates why the renewal of (...) social science and the nurturing of a "a philosophy of the Pacific Century" requires a sustained act of intellectual demolition. (shrink)

This is an in-depth study of J.G. Fichte’s philosophy of mathematics and theory of geometry. It investigates both the external formal and internal cognitive parallels between the axioms, intuitions and constructions of geometry and the scientific methodology of the Fichtean system of philosophy. In contrast to “ordinary” Euclidean geometry, in his Erlanger Logik of 1805 Fichte posits a model of an “ursprüngliche” or original geometry – that is to say, a synthetic and constructivistic conception grounded in ideal archetypal elements that (...) are grasped through geometrical or intelligible intuition. -/- Accordingly, this study classifies Fichte’s philosophy of mathematics as a whole as a species of mathematical Platonism or neo-Platonism, and concludes that the Wissenschaftslehre itself may be read as an attempt at a new philosophical mathesis, or “mathesis of the mind.” -/- “This work testifies to the author's exact and extensive knowledge of the Fichtean texts, as well as of the philosophical, scientific and historical contexts. Wood has opened up completely new paths for Fichte research, and examines with clarity and precision a domain that up to now has hardly been researched.” Professor Dr. Marco Ivaldo -/- “This study, written in a language distinguished by its limpidity and precision, and constantly supported by a close reading of the Fichtean texts and secondary literature, furnishes highly detailed and convincing demonstrations. In directly confronting the difficult historical relationship between the Wissenschaftslehre and mathematics, the author has broken new ground that is at once stimulating, decidedly innovative, and elegantly audacious.” Professor Dr. Emmanuel Cattin. (shrink)

In 1962, the philosopher Richard Taylor used six commonly accepted presuppositions to imply that human beings have no control over the future. David Foster Wallace not only took issue with Taylor's method, which, according to him, scrambled the relations of logic, language, and the physical world, but also noted a semantic trick at the heart of Taylor's argument. _Fate, Time, and Language_ presents Wallace's brilliant critique of Taylor's work. Written long before the publication of his fiction and essays, Wallace's (...) thesis reveals his great skepticism of abstract thinking made to function as a negation of something more genuine and real. He was especially suspicious of certain paradigms of thought-the cerebral aestheticism of modernism, the clever gimmickry of postmodernism-that abandoned "the very old traditional human verities that have to do with spirituality and emotion and community." As Wallace rises to meet the challenge to free will presented by Taylor, we witness the developing perspective of this major novelist, along with his struggle to establish solid logical ground for his convictions. This volume, edited by Steven M. Cahn and Maureen Eckert, reproduces Taylor's original article and other works on fatalism cited by Wallace. James Ryerson's introduction connects Wallace's early philosophical work to the themes and explorations of his later fiction, and Jay Garfield supplies a critical biographical epilogue. (shrink)

The author of this book has traced the major lines of argument over those years in a most engaging style with clear descriptions of the concepts and ideas.

Interpretation -- Introduction -- Interpreting Plato -- The political culture of Plato's early dialogues -- Dialogue -- Character and history -- The mouthpiece principle -- Forms of evidence -- Desire -- Socrates and eros -- The subjectivist conception of desire -- Instrumental and terminal desire -- Rational and irrational desires -- Desire in the critique of Akrasia -- Interpreting Lysis -- The deficiency conception of desire -- Inauthentic friendship -- Platonic desire -- Antiphilosophical desires -- Knowledge -- Excellence as wisdom (...) -- The epistemic unity of excellence -- Dunamis and technê -- Goodness and form -- The epistemological priority of definitional knowledge -- Ordinary ethical knowledge -- Method -- The Socratic fallacy -- Socrates' pursuit of definitions -- Hupothesis -- Two postulates -- The geometrical illustration -- Geometrical analysis -- The method of reasoning from a postulate -- Elenchus and hupothesis -- Knowledge and aitia -- F-conditions -- Cognitive security -- Aporia -- Forms of aporia -- Dramatic aporia -- The example of Charmides -- Charmides as autobiography -- The politics of Sôphrosunê -- Critias' Philotimia -- Self-knowledge and the knowledge of knowledge -- Knowledge of knowledge and knowledge of the good -- Philosophy and the polis. (shrink)

David Williams explores the complex links between Condorcet as visionary ideologist and pragmatic legislator, and between his concept of modernity and the management of change. The Marquis de Condorcet was one of the few Enlightenment thinkers to witness and participate in the French Revolution. Based on an extensive array of printed and original manuscript sources, Williams' analysis of Condorcet's politics will be a major contribution to Enlightenment studies.

The Discovery of Evolution explains what the theory of evolution is all about by providing a historical narrative of discovery. Some of the major puzzles that confront anyone studying living things are discussed and it details how these were solved from an evolutionary perspective. Beginning with the emergence of the early naturalists in the seventeenth century, the scientific discoveries that led up to and then flowed from Darwin and Wallace's theory of evolution by natural selection are then discussed, and finally (...) the modern evolutionary studies at the close of the twentieth century are detailed. This new edition of The Discovery of Evolution is fully updated and contains a new chapter on the evolutionary studies of the twentieth century. By approaching the topic of evolution in this way, it is made accessible to the non-specialist and no previous study of biology is required in order to read and understand this book. (shrink)

This essay is the first general study of the work of You Ruo or Youzi. It also defends his views and argues that he was an important independent figure in the origins of Confucianism. Youzi is thought to have been a disciple of Confucius, and his work is studied mainly for its insight into Confucius. Hence, his work is seriously misunderstood. In fact Youzi's main views were not shared by Confucius, and the evidence suggests that Youzi did not study with (...) Confucius. Youzi's surviving writings form a tightly coherent whole in style and substance. Together they sketch a powerful general vision of the psychology of the virtues and use it to generate parallel solutions to four basic moral dilemmas. Youzi's thought is highly plausible and directly relevant to current issues in moral theory and practice. (shrink)

Just before the second world war, in a paper read to the British Association, Morris Ginsberg talked about the failure of social philosophy and the social sciences to work together in the universities ‘toward the rational ordering of society’. Some time after the war Alexander Macbeath complained to British sociologists of his own vain search for a social philosopher who could teach in a course on public administration. Then a few years later A. E. Teale told an inter-professional conference at (...) Keele that people who teach and train teachers, those who train social workers of all kinds, were disappointed when philosophers professed themselves unable to help those who had to ‘equip students with the skill to change prevailing moral attitudes and standards’. (shrink)

His “practical purpose” was first to express the popular notion of responsibility and then to relate it to the philosophical theories of “freewill and necessity.” For he could not approve the suggestion that to understand popular comments on morality was a worthless occupation; indeed, while he respected the Westminster Reviewers for the blunt declaration that vulgar responsibility was a “horrid figment of the imagination,” he plainly considered it his business as a philosopher to examine ordinary morality and to reconcile it, (...) if possible, with philosophical theory. (shrink)