Three areas of rights violation for women and young girls across the globe are examined with an eye toward the specificity of the violation, and possible areas of help. The work of internationalists such as Bales and Sagade is adduced, and other thinkers such as Dorkenoo are cited. It is concluded that much work needs to be done in this area and that more overtly feminist theological views, in any of the major religions, would help.

The budget battles have hit the Indian Health Service hard: sequestration forced a 5 percent reduction in funds, followed by an additional 0.2 percent rescission in the recently passed Consolidated and Further Continuing Appropriations Act. Exempted from sequestration (and rightly so) were other very important health care programs such as the Veterans Administration Health Programs, the State Children's Health Insurance Programs, and Medicaid. Medicare has been reduced by only 2 percent, with that cut targeted to provider reimbursement so (...) as to avoid a reduction in service to beneficiaries. In March 2013, Representatives Betty McCollum, Tom Cole, and Michelle Lujan Grisham introduced a bill to reduce the impact of sequestration on the IHS to 2 percent (H.R. 1371). This bill was referred to the Committee on the Budget, but to date, there has been no movement on it.Why was the IHS susceptible to sequestration? Why is it considered a “discretionary” line item in the federal budget? Why is there not parity for Indians, whose health status remains far below that of mainstream America? As a matter of legal requirement, social contract, and moral obligation, the United States should fundamentally change how Indian Health is funded. (shrink)

Ocean biology helps regulate global climate by fixing atmospheric CO2 and exporting it to deep waters as sinking detrital particles. New observations demonstrate that particle fragmentation is the principal factor controlling the depth to which these particles penetrate the ocean's interior, and hence how long the constituent carbon is sequestered from the atmosphere. The underlying cause is, however, poorly understood. We speculate that small, particle‐associated copepods, which intercept and inadvertently break up sinking particles as they search for attached protistan prey, (...) are the principle agents of fragmentation in the ocean. We explore this idea using a new marine ecosystem model. Results indicate that explicitly representing particle fragmentation by copepods in biogeochemical models offers a step change in our ability to understand the future evolution of biologically‐mediated ocean carbon storage. Our findings highlight the need for improved understanding of the distribution, abundance, ecology and physiology of particle‐associated copepods. (shrink)

No discussion of academic freedom, research integrity, and patient safety could begin with a more disquieting pair of case studies than those of Nancy Olivieri and David Healy. The cumulative impact of the Olivieri and Healy affairs has caused serious self examination within the biomedical research community. The first part of the essay analyses these recent academic scandals. The two case studies are then placed in their historical context—that context being the transformation of the norms of science through increasingly close (...) ties between research universities and the corporate world. After a literature survey of the ways in which corporate sponsorship has biased the results of clinical drug trials, two different strategies to mitigate this problem are identified and assessed: a regulatory approach, which focuses on managing risks associated with industry funding of university research, and a more radical approach, the sequestration thesis, which counsels the outright elimination of corporate sponsorship. The reformist approach is criticised and the radical approach defended. (shrink)

This paper reports on a particular aspect of a larger ethnographic study of nursing culture in an intensive therapy unit (ITU), accomplished through participant observation over a 12‐month period, followed by interviews with 15 nurses. The paper suggests that the ITU environment is perceived as ‘dangerous’, its dangerousness stemming from the ambiguity of its patients’ conditions. Drawing on anthropological concepts of liminality, pollution, anomaly and breaching of boundaries, the paper identifies various ambiguities inherent in ITU patients’ conditions. It then explores (...) the ways in which these anomalies are managed through sequestration and other ritual and symbolic practices. Notwithstanding the undoubted scientific reasons for particular nursing practices, the paper argues that there are also ritual and symbolic elements serving other more complex purposes, both protecting patients and staff and symbolising the highly valued phenomenon of keeping patients safe. The paper identifies a contradiction inherent in nursing work in this locale inasmuch as rituals and symbolism coexist with technical and research‐based elements of nursing care. (shrink)

Land-based climate mitigation schemes such as REDD+ imply the creation of ‘rights to carbon’ for actions that enhance carbon sinks. In many cases, the legal and normative foundations of such rights are unclear. This article focuses on special rights on the basis of improvement. Considering improvement in relation to carbon sinks requires asking what it means to ‘improve’ an environmental resource. Our answer departs in two significant respects from the standard conception of improvement, namely by reconceiving action in relation to (...) ecosystem services, and accordingly, making the case for a counterfactual baseline to be used to compare an improved and unimproved state. Our modifications potentially allow for a variety of agents to claim special carbon rights on the basis of beneficial interactions with land-based carbon sinks. We give three archetypical examples of agents who may claim pro tanto special rights to carbon based on their interaction with carbon sinks. (shrink)

Forest tenure reforms are occurring in many developing countries around the world. These reforms typically include devolution of forest lands to local people and communities, which has attracted a great deal of attention and interest. While the nature and level of devolution vary by country, all have potentially important implications for resource allocation, local ecosystem services, livelihoods and climate change. This book helps students, researchers and professionals to understand the importance and implications of these reforms for local environmental quality, climate (...) change, and the livelihoods of villagers, who are often poor. It is shown that local forest management can often be more successful than top-down management of common pool forest resources. The relationship of local forest tenure reform to the important climate change initiative REDD+ is also considered. The work includes a number of generic chapters and also detailed case studies from China, Ethiopia, Kenya, Nepal, Tanzania and Uganda. Using specific examples and a wide variety of disciplinary perspectives, including quantitative and qualitative analytical methods, the book provides an authoritative and critical picture of local forest reforms in light of the key challenges humanity faces today. (shrink)

Many viruses evolved mechanisms for capping the 5′‐ends of their plus‐strand RNAs as a means of hijacking the eukaryotic messenger RNA (mRNA) splicing/translation machinery. Although capping is critical for replication, the RNAs of these viruses have other essential functions including their requirement to be packaged as either genomes or pre‐genomes into progeny viruses. Recent studies indicate that human immunodeficiency virus type‐1 (HIV‐1) RNAs are segregated between splicing/translation and packaging functions by a mechanism that involves structural sequestration of the 5′‐cap. (...) Here, we examined studies reported for other viruses and retrotransposons that require both selective packaging of their RNAs and 5′‐RNA capping for host‐mediated translation. Our findings suggest that viruses and retrotransposons have evolved multiple mechanisms to control 5′‐cap accessibility, consistent with the hypothesis that removal or sequestration of the 5′ cap enables packageable RNAs to avoid capture by the cellular RNA processing and translation machinery. (shrink)

Abstract This article explores interview data from a study of 50 Norwegian generalist nurses' focus group accounts of caring for dying patients in the hospital and care home. An eclectic discourse analytic approach was applied to nurses' accounts of the patient and three discursive contexts of reference to the patient were identified: the 'taken as read' patient, the patient paired with particular characteristics and the patient as psychologically present. Talk about the patient falls mainly into the first two contexts, which (...) position the patient in relation to three closely related discursive processes: individualization, anonymization and objectification. The third context presents the patient as a person with a particular identity. The analysis is discussed in a broader philosophical and sociological context in which we return to some of the theoretical work on death and dying of the 1990s and the topic of sequestration. We suggest that nurses' talk about the patient can be heard to participate in a continuing sequestration of the dying patient in healthcare institutions focused on 'result-oriented' care. (shrink)

[Opinion] This aims to begin deliberation about investing in negative emissions technologies (NETs) by suggesting that the investment could be responsive to two particular values: need and efficiency—and that these values point us towards taking different actions. For negative emissions technologies, I suggest, we face a Need-Efficiency Tradeoff, i.e. a “NET effect”. This tradeoff also highlights several contrasts: responding to need focuses on regional and short-term moral considerations; responding to efficiency focuses on global and long-term moral considerations. [Open access].

August Weismann is famous for having argued against the inheritance of acquired characters. However, an analysis of his work indicates that Weismann always held that changes in external conditions, acting during development, were the necessary causes of variation in the hereditary material. For much of his career he held that acquired germ-plasm variation was inherited. An irony, which is in tension with much of the standard twentieth-century history of biology, thus exists – Weismann was not a Weismannian. I distinguish three (...) claims regarding the germ-plasm: (1) its continuity, (2) its morphological sequestration, and (3) its variational sequestration. With respect to changes in Weismann’s views on the cause of variation, I divide his career into four stages. For each stage I analyze his beliefs on the relative importance of changes in external conditions and sexual reproduction as causes of variation in the hereditary material. Weismann believed, and Weismannism denies, that variation, heredity, and development were deeply intertwined processes. This article is part of a larger project comparing commitments regarding variation during the latter half of the nineteenth century. (shrink)

The pharmaceutical industry, in its marketing efforts, often turns to “key opinion leaders” or “KOLs” to disseminate scientific information. Drawing on the author's fieldwork, this article documents and examines the use of KOLs in pharmaceutical companies’ marketing efforts. Partly due to the use of KOLs, a small number of companies with well-defined and narrow interests have inordinate influence over how medical knowledge is produced, circulated, and consumed. The issue here, as in many other cases of institutional corruption, is that a (...) few actors have accumulated the power to shape the information on which many others base their decisions. Efforts to address this corruption should focus on correcting large imbalances in the current political economy of medical knowledge. A sequestration of pharmaceutical research and development on one hand from pharmaceutical marketing on the other, though difficult to achieve, would address this and many other problems. (shrink)

Forests play fundamental roles in the Earth’s ecosystems. With the great capability of carbon sequestration, tropical forests are expected to contribute substantially to reducing the CO2 in Earth’s atmosphere. However, global tropical forest areas have declined drastically over the last few decades due to pressures from socio-economic development pursuit. The current essay aims to demonstrate the ongoing global deforestation crisis and its underlying drivers and discuss the vital roles of tropical forests in the socio-economic development in the face of (...) climate change when developed countries start to tighten the carbon emission control regulations (e.g., European Union’s Carbon Border Adjustment Mechanism). It suggests why developing countries in tropical regions, particularly Vietnam, should not sacrifice forests for short- and medium-term socio-economic goals but capitalize on them to leverage long-term development. Moreover, evidence of Vietnamese political leaders’ commitment to forest protection and sustainable development is also provided. (shrink)

Decaying wood, while an abundant and stable resource, presents considerable nutritional challenges due to its structural rigidity, chemical recalcitrance, and low nitrogen content. Despite these challenges, certain insect lineages have successfully evolved saproxylophagy (consuming and deriving sustenance from decaying wood), impacting nutrient recycling in ecosystems and carbon sequestration dynamics. This study explores the uneven phylogenetic distribution of saproxylophagy across insects and delves into the evolutionary origins of this trait in disparate insect orders. Employing a comprehensive analysis of gut microbiome (...) data, from both saproxylophagous insects and their non‐saproxylophagous relatives, including new data from unexplored wood‐feeding insects, this Hypothesis paper discusses the broader phylogenetic context and potential adaptations necessary for this dietary specialization. The study proposes the “Detritivore‐First Hypothesis,” suggesting an evolutionary pathway to saproxylophagy through detritivory, and highlights the critical role of symbiotic gut microbiomes in the digestion of decaying wood. (shrink)

The shift to longitudinal, comprehensive electronic health records means that any health care provider or third-party user of the EHR will be able to access much health information of questionable clinical utility and possibly of great sensitivity. Genetic test results, reproductive health, mental health, substance abuse, and domestic violence are examples of sensitive information that many patients would not want routinely available. The likely policy response is to give patients the ability to segment information in their EHRs and to sequester (...) certain types of sensitive information, thereby limiting routine access to the totality of a patient's health record. This article explores the likely effect on the physician-patient relationship of patient-directed sequestration of sensitive health information, including the ethical and legal consequences. (shrink)

Fertilization triggers cytoplasmic movements in the frog egg that lead in mysterious ways to the stabilization of β‐catenin on the dorsal side of the embryo. The novel Huluwa (Hwa) transmembrane protein, identified in China, is translated specifically in the dorsal side, acting as an egg cytoplasmic determinant essential for β‐catenin stabilization. The Wnt signaling pathway requires macropinocytosis and the sequestration inside multivesicular bodies (MVBs, the precursors of endolysosomes) of Axin1 and Glycogen Synthase Kinase 3 (GSK3) that normally destroy β‐catenin. (...) In Xenopus, the Wnt‐like activity of GSK3 inhibitors and of Hwa mRNA can be blocked by brief treatment with inhibitors of membrane trafficking or lysosomes at the 32‐cell stage. In dorsal blastomeres, lysosomal cathepsin is activated and intriguing MVBs surrounded by electron dense vesicles are formed at the 64‐cell stage. We conclude that membrane trafficking and lysosomal activity are critically important for the earliest asymmetries in vertebrate embryonic development. (shrink)

SummaryMis‐regulation (e.g. overproduction) of the human Ndc80/Hec1 outer kinetochore protein has been associated with aneuploidy and tumourigenesis, but the genetic basis and underlying mechanisms of this phenomenon remain poorly understood. Recent studies have identified the ubiquitous Ndc80 internal loop as a protein‐protein interaction platform. Binding partners include the Ska complex, the replication licensing factor Cdt1, the Dam1 complex, TACC‐TOG microtubule‐associated proteins (MAPs) and kinesin motors. We review the field and propose that the overproduction of Ndc80 may unfavourably absorb these interactors (...) through the internal loop domain and lead to a change in the equilibrium of MAPs and motors in the cells. This sequestration will disrupt microtubule dynamics and the proper segregation of chromosomes in mitosis, leading to aneuploid formation. Further investigation of Ndc80 internal loop‐MAPs interactions will bring new insights into their roles in kinetochore‐microtubule attachment and tumourigenesis. (shrink)

This paper reviews current initiatives to establish carbon offset forests in suburban and peri-urban environments. While moments of density occur within urban territories the general spatial condition is one of fragmented and patchy networks made up of a heterogeneous mix of residential enclaves, industrial parks, waste sites, infrastructure easements interspersed with forests, agriculture, leftover voids and overlooked open space. These overlooked open spaces have the potential to form a new green urban structure of carbon offset forests as cities respond to (...) the carbon economy. Furthermore such urban spaces are not likely to diminish over time as cities are not only growing larger but are becoming more dispersed according to recent World Bank reports. This strong trend is not limited to developed or developing cities but is a worldwide phenomenon. In the future, policy incentives for carbon sequestration will drive land use change in rural and urban areas alike. The paper documents projects in Blacktown City Council in Western Sydney. (shrink)

Polyphosphate (polyP) is a ubiquitous biomolecule thought to be present in all cells on Earth. PolyP is deceivingly simple, consisting of repeated units of inorganic phosphates polymerized in long energy‐rich chains. PolyP is involved in diverse functions in mammalian systems—from cell signaling to blood clotting. One exciting avenue of research is a new nonenzymatic post‐translational modification, termed lysine polyphosphorylation, wherein polyP chains are covalently attached to lysine residues of target proteins. While the modification was first characterized in budding yeast, recent (...) work has now identified the first human targets. There is significant promise in this area of biomedical research, but a number of technical issues and knowledge gaps present challenges to rapid progress. In this review, the current state of the field is summarized and existing roadblocks related to the study of lysine polyphosphorylation in higher eukaryotes are introduced. It is discussed how limited methods to identify targets of polyphosphorylation are further impacted by low concentration, unknown regulatory enzymes, and sequestration of polyP into compartments in mammalian systems. Furthermore, suggestions on how these obstacles could be addressed or what their physiological relevance may be within mammalian cells are presented. (shrink)

Inspired by three monographs of Gladys Swain and Marcel Gauchet, my presentation traces the rise of the new science of psychiatry in Revolutionary France, with Philippe Pinel and his student J.-E. Esquirol. As the directors of the division of the aliénés in the Hôpital Bicêtre (Paris), Pinel and Esquirol pioneered a therapeutic programme that spread out between their “traitement moral” (reasoning with the passions) and an “energetic repression,” wherever necessary. The discipline they created sought to gain autonomy from medicine treating (...) diseases of the body, much as pathology would do in regard to physiology, some fifty years later. Using Canguilhem, Foucault’s teacher and significant influence, I show how the unfolding of a science of disorders (for Canguilhem, this was pathology) poses questions of taxonomy and runs the inevitable ‘risk’ of extensive fragmentation. This is what happens in France after Pinel. However, Pinel, above all, will have made one contribution that—by Swain and Gauchet’s argument—stands in stark contrast to the theses of the young Foucault. Rather than sequestering and excluding the fou by forcing him or her into exaggerated, discursive revelations or silence, Pinel and Esquirol “discover” the sense, or sens , at the heart of madness, notably in what Pinel called “manie intermittente.” Esquirol takes this discovery one step further, to discern in various attacks, a certain rationality. This rather modern conception of madness exerts a considerable influence on literature, criticism, philosophy, and medicine in their time. Hegel’s understanding of madness will come directly from Pinel, and it will see in folie the internal division of subjective Reason. From this characterization comes a therapeutics based on the conviction that one could often reintegrate the mad into society, and avoid prolonged sequestration and exclusion. Thus the presentation focuses on Swain and Gauchet’s question to Foucault ( Histoire de la folie à l’âge classique , notably), using the work of Pinel and Hegel to illustrate their claim. (shrink)

In , Sartre elevates the premature death of his father to the rank of a providential event which, by depriving him of a Super-Ego and relieving him of any legacy, consigned him to contingency and condemned him to be free. In this way, Sartre derives his uniqueness from this happy lack, this salutary void, i.e. a negated father, and casts himself in the role of an Aeneas liberated from the weight of his Anchises. Fatherless son, Sartre was nonetheless condemned to (...) return incessantly to a father who was destined to remain imaginary. The omnipresence of paternal figures in his oeuvre, from “Childhood of a Leader” to by way of and , is the expression of a double project, as systematic as it is paradoxical: to incarnate the Father, interrogate him and place him centre-stage—as he does with Flaubert's father—in order to eliminate all the better, through an unrelenting prosecution, that of which the Father is, in Sartre's view, the crystallization: the past, inheritance, the temptation of inauthenticity, the alienation of freedom by a foreign power. The Sartrean Father reveals in a privileged way the heart-rending paradoxes of freedom. French Dans Les Mots , J.-P. Sartre hisse la mort précoce de son père à la hauteur d'un événement providentiel qui, le privant de Surmoi et le délestant de tout héritage, le livra à la contingence et le condamna à être libre. Ainsi Sartre tire sa singularité de ce manque heureux, de ce vide salutaire, un père nié, et se dépeint en Enée libéré du poids de son Anchise. Fils sans père, Sartre n'en fut pas moins condamné à revenir sans fin à ce père voué à demeurer imaginaire : l'omniprésence des figures paternelles dans son œuvre, de L'Enfance d'un chef à L'Idiot de la famille , en passant par Le Scénario Freud et Les Séquestrés d'Altona , est l'expression d'un double projet, aussi systématique que paradoxal : incarner le Père, l'interroger et le mettre en scène - ainsi du père de Flaubert -, pour mieux liquider, par une mise en procès permanente, ce dont la figure du Père est, à ses yeux, la cristallisation : le passé, l'héritage, la tentation de l'inauthenticité, l'aliénation de la liberté par une puissance étrangère. Le Père sartrien se révèle dès lors comme le révélateur privilégié des paradoxes déchirants de la liberté. (shrink)

This article shows that Sartre's theatrical works offer a reflection on morality, in particular The Flies , The Devil and the Good Lord , and The Sequestered of Altona . The ethical reflections that we find in his plays fill a philosophical gap left after Being and Nothingness . The plays offer an exploration of freedom's rootedness in situation which complements the more theoretical notes of the posthumously published Notebooks for an Ethics . Additionally, I link Sartre's ethics and Nietzsche's (...) ethics showing that both thinkers rest their philosophies on a strict atheism. Further, their elaborations on morality follow a similar path by emphasizing individual freedom and thus subsequently the responsibility of the individual as the creator of values. French Cet article fait la démonstration que les œuvres théâtrales de Sartre, plus particulièrement Les Mouches , Le Diable et le bon dieu et Les Séquestrés d'Altona , tiennent lieu de réflexion morale chez Sartre. La réflexion éthique qu'on y retrouve comble un manque laissé par les écrits philosophiques suivant L'Être et le néant . Les pièces et leur exploration de l'ancrage de la liberté dans la situation offrent un complément aux notes plus théoriques des Cahiers pour une morale, publiés à titre posthume. En plus de faire cette démonstration, cet article explore les liens entre la morale des pièces sartriennes et la morale nietzschéenne. Il ressort de cet examen que ces deux morales s'appuient sur un athéisme pur et dur et s'élaborent de même façon en mettant l'emphase sur la liberté de l'individu et son rôle en tant que créateur de valeurs. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Spinoza's Religion: A New Reading of the Ethics by Claire CarlisleSanja SärmanCARLISLE, Claire. Spinoza's Religion: A New Reading of the Ethics. Princeton, N.J.: Princeton University Press, 2021. 288 pp. Cloth, $29.95; paper, $22.95Spinoza has variously been read as presenting a fully naturalized theology (Steven Nadler), as a secretive Marrano philosopher of immanence cleverly hiding his true allegiances in plain sight (Yirmiyahu Yovel, see also Leo Strauss) and as (...) a God-intoxicated man (Novalis). Rarely have the assessments of a man's religion been so varied and conflicted. In an exemplarily searching spirit, Claire Carlisle explores the issue while keeping the question of what religion is an open one. The book comprises nine chapters—essayistic in form but scholarly in content—devoted to examining the issue from different angles.The leitmotif of Spinoza's religiosity is, for Carlisle, being-in-God, a term of art that denotes at once a metaphysical reality and a spiritual project. We are inevitably in God: This is an ontological as well as a conceptual dependence-relation. Being-in-God is participatory dependence on God's own being. In illuminating the relation between God and non-God, Carlisle draws on the rich Catholic tradition. For example, being in-God means being in another (God) without ever being the other of God, to whom all being belongs. This asymmetrical take on the otherness-relation clearly echoes Nicholaus of Cusa's thoughts about God as non-aliud, and Carlisle cites him, not as an ancestor of Spinozism but as a cotraveler along a certain pathway for understanding God.Although being-in-God is an indisputable reality, it is also a spiritual challenge. Since we are by necessity in-God, the spiritual task will paradoxically consist in becoming what we already are, and thereby gaining freedom-in-necessity.In my view, Carlisle's reading reaps rich fruit from its assumption that ontology and normativity are not, indeed cannot be, sequestrated within Spinoza's thought. Moreover, its study of the affectivity—the qualia, even—of being-in-God presents us with a welcome counterweight to descriptions of Spinoza's system from without. Differently put, for Carlisle, the question "What is it like?" can sensibly be asked about being-in-God. Inspired by Spinoza's earliest work, Carlisle sketches a philosophical diagnosis of the devout person who is compelled ("necessitated") by the work she has to do and therefore enjoys an enviable singularity of purpose: Following Latour and Foucault, Carlisle sees a distinctively spiritual quality in certain modes of attention. Attending to oneself and others as they are in-God instills calm; in other words, on Carlisle's reading, the affective aspect of being-in-God is characterized by being at rest with oneself and others (quies is Latin for "rest"). Her careful reading of the Latin text exposes a network of acquiescentia (and cognate terms) in Spinoza's work, somewhat obfuscated through Curley's English translation, which variously renders the word as "esteem" and "satisfaction": What the text gains in stylistic points, it may lose in spiritual significance. In the Ethics, acquiescentia in se ipso is a kind of self-esteem or self-confidence that becomes religiously poignant when mediated through the insight that one is in God: [End Page 347] Through the realization of being in-God, one's calm yet affective appreciation of oneself becomes indistinguishable both from one's love of God and from God's love of oneself. This is an interesting phenomenal perspective on Spinoza's doctrine of the third kind of knowledge.At times, one could perhaps wish for a more systematic discussion of core concepts, such as that of infinity. For example, Carlisle cites Spinoza's idea that we cannot bridge the infinite distance which separates us from God but does not explicitly discuss how this infinite distance is to be reconciled with ontological intimacy; while we sense the proper response, it is not demonstrated.In the end, Carlisle's work successfully shows that we cannot understand Spinoza's religiosity if we model it after our late-modern concept of religion—a construct that, as the historian Peter Harrison has argued, was... (shrink)

“Offsetting” habitat destruction has widespread appeal as an instrument for balancing economic growth with biodiversity conservation. Requiring proponents to pay the nontrivial costs of habitat loss encourages sensitive planning approaches. Offsetting, biobanking, and biodiverse carbon sequestration schemes will play an important role in conserving biodiversity under increasing human pressures. However, untenable assumptions in existing schemes are undermining their benefits. Policies that allow habitat destruction to be offset by the protection of existing habitat are guaranteed to result in further loss (...) of biodiversity. Similarly, schemes that allow trading the immediate loss of existing habitat for restoration projects that promise future habitat will, at best, result in time lags in the availability of habitat that increases extinction risks, or at worst, fail to achieve the offset at all. We detail concerns about existing approaches and describe how offsetting and trading policies can be improved to provide genuine benefits for biodiversity. Due to uncertainties about the way in which restored vegetation matures, we propose that the biodiversity bank should be a savings bank. Accrued biodiversity values should be demonstrated before they can be used to offset biodiversity losses. We provide recommendations about how this could be achieved in practice. (shrink)

The landscape of the Sundarbans today is a product of two countervailing forces: conversion of wetland forests to cropland vs. sequestration of the forests in reserves to be managed for long-term sustained yield of wood products. For two centures, land-hungry peasants strove to transform the native tidal forest vegetation into an agroecosystem dominated by paddy rice and fish culture. During the colonial period, their reclamation efforts were encouraged by landlords and speculators, who were themselves encouraged by increasingly favorable state (...) policies (land grants, tax incentives, cadastral surveys, and eventually colonization projects and subsidized irrigation) designed by revenue officials to maximize the rate of transformation of wetland forest to taxable agricultural land.In the late nineteenth century, as the rate of agricultural conversion increased, the colonial Forest Department succcessfully sought to preserve large areas of the remaining Sundarbans tidal forest by giving them legal status as Reserved or Protected Forests. These forests were intensively managed to provide a sustainable supply of timber and firewood for the increasing population of southern Bengal. Institutionalization of conflicting policies by the Revenue and Forest Departments reflected the escalating needs for both food and forest products as the colony grew. Today, supplies of some economically valuable trees have been depleted, and some mammals are locally extinct (although the Bengal tiger remains), but government policy in both Bangladesh and India now favors use of the Sundarbans as forest rather than its transformation to agricultural land. Further expansion of cropland to meet the grain demands of the burgeoning Bengali population in both nations has largely taken place outside the boundaries of the Sundarbans. Overexploitation of these forests for wood products remains a possibility, but large-scale clearing for rice paddies is unlikely under present policies. (shrink)

Este trabajo surge a partir de la investigación general de las técnicas hidropónicas teniendo en cuenta sus ventajas y desventajas para de esta forma poder encontrar aquel factor determinante a través de una comparación de técnicas hidropónicas que permitan clasificarlas y escoger la mejor opción que genere menos impacto ambiental negativo y demuestre ser más productivo en los entornos urbanos. Adicionalmente, un factor determinante en las ciudades es su espacio limitado por lo que la mejor opción también deberá incluir un (...) óptimo manejo del espacio que permita a casi cualquier individuo poder aplicarlos desde su entorno sin recurrir a excesivas modificaciones. Como principal resultado se escogió a la Hidroponía recirculante como método predominante por los excelentes resultados que se obtienen con relación a los demás, adicionalmente, este puede ser fácilmente aplicado en los ambientes urbanos por su versatilidad y buen manejo de recursos. Palabras Clave: Hidroponia, ambiente, urbano, comparativa, técnicas, cultivo. Referencias [1]J. López, «La producción hidropónica de cultivos,» IDESIA, vol. 36, nº 2, pp. 139-141, 2018. [2]J. Lee, A. Rahman, J. Behrens, C. Brennan, B. Ham, H. Seok Kim, C. Won, S. Yun, H. Azam y M. Kwon, «Nutrient removal from hydroponic wastewater by a microbial consortium,» New Biotechnology, vol. 41, pp. 15-24, 2018. [3]H. Ku, C. Tiong, A. Suresh y B. Ong, «“Active” hydroponic greenhouse system to kick-start and augment reforestation program through carbon sequestration e an experimental and theoretical feasibility study,» Journal of Cleaner Production, vol. 129, pp. 637-646, 2016. [4]J. Beltrano y D. Gimenez, Cultivo en hidroponía, Buenos Aires: Universidad de la Plata, 2015. [5]L. Ramírez, M. Pérez, P. Jiménez, H. Giraldo y E. Gómez, «Evaluación preliminar de sistemas acuapónicos e hidropónicos en cama flotante para el cultivo de orégano,» Revista Facultad de Ciencias Básicas, vol. 7, nº 2, pp. 242-259, 2011. [6]S. Hosseinzadeh, D. Testai, M. BKheet y J. De Graeve, «Degradation of root exudates in closed hydroponic systems using UV/H2O2: Kinetic investigation, reaction pathways and cost analysis,» Science of the Total Environment, vol. 1, pp. 1-9, 2019. [7]N. Camarena, A. Rojas y M. Santos, «Fluoride bioaccumulation by hydroponic cultures of camellia,» Chemosphere, vol. 136, pp. 56-62, 2015. [8]W. Wang, Y. Ma, L. Fu, Y. Cui y M. Yaqoob, «Physical an mechanical properties of hydroponic lettuce for automatic harvesting,» Informatión processing in agriculture, vol. 1, pp. 2214-3173, 2020. [9]M. Zárate, Manual de Hidroponia, Coyoacán: Universidad Autónoma de Mexico, 2014. [10]S. Magwaza, L. Magwaza, A. Odindo y C. Buckley, «Partially treated domestic wastewater as a nutrient source for tomatoes grown in a hydroponic system: effect on nutrientabsorption and yield,» Heliyon, vol. 6, nº 12, pp. 2405-8440, 2020. [11]C. ARANO, «Hidroponía: Algunas paginas de historia,» Tecnología de Producción, nº 58, pp. 24-32, 2007. [12]G. Guzmán, Hidroponia en Casa: Una actividad familiar, Costa Rica: Ministerio de Agricultura y ganaderia, 2004. [13]J. Gilsanz, HIDROPONIA, Montevideo : Unidad de Comunicación y Transferencia de Tecnología, 2007. [14]C. Miller, «El debate de hidroponia orgánica: Perspectivas norteamericanas sobre si la producción hidropónica merece ser certificada como orgánica.,» Productores de Hortalizas, nº 6, pp. 36-38, 2017. [15]A. Herrera, «Manejo de la solución nutritiva en la producción de tomate en hidroponía,» Terra Latinoamericana, vol. 17, nº 3, pp. 221-229, 1999. [16]C. Espinal y D. Matulić, «Recirculating Aquaculture Technologies,» Biomedical and Life Sciences, pp. 35-76, 2020. [17]H. 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New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell (...) division and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

Fatty acids (FAs) are well known to serve as substrates for reactions that provide cells with membranes and energy. In contrast to these metabolic reactions, the physiological importance of FAs themselves known as free FAs (FFAs) in cells remains obscure. Since accumulation of FFAs in cells is toxic, cells must develop mechanisms to detoxify FFAs. One such mechanism is to sequester free polyunsaturated FAs (PUFAs) into a droplet‐like structure assembled by Fas‐Associated Factor 1 (FAF1), a cytosolic protein. This sequestration (...) limits access of PUFAs to Fe2+, thereby preventing Fe2+‐catalyzed PUFA peroxidation. Consequently, assembly of the FAF1‐FFA complex is critical to protect cells from ferroptosis, a cell death pathway triggered by PUFA peroxidation. The observations that free PUFAs in cytosol are not randomly diffused but rather sequestered into a membraneless complex should open new directions to explore signaling pathways by which FFAs regulate cellular physiology. (shrink)

A 450-ppm equivalent CO2 target by 2050 is an often-proposed goal under a future global emissions agreement, but there is considerable high side risk in global-warming models due to cloud formation, feedbacks in dissolved organic carbon from peat bogs in polar regions, and unaccounted solar dimming by particulates. The 450-ppm figure is predicated on absorption of some CO2 by oceans, but increasing acidification may dictate that CO2 produced during the next 50 years may have to be reduced further to preserve (...) species diversity in the oceans. By consideration of industry capability, a 400-ppm target is shown to be affordable and achievable by renewables using 2/3 direct solar electricity by 2050 with technology currently being proven, together with aggressive energy efficiency. Sequestration of liquid CO2 under pressure in enormous continually excavated caverns at 2-km depth is technically much less certain and later in development. (shrink)

Communities, policy actors and conservationists benefit from understanding what institutions and land management regimes promote ecosystem services like carbon sequestration and biodiversity conservation. However, the definition of success depends on local conditions. Forests’ potential carbon stock, biodiversity, and rate of recovery following disturbance are known to vary with a broad suite of factors including temperature, precipitation, seasonality, species’ traits and land use history. Methods like forest changes over time , and comparison with 'pristine' reference forests have been proposed to (...) compare the structure and biodiversity of forests in the face of underlying differences. However, data from previous visits or reference forests may be unavailable or costly to obtain. Here, we introduce a new metric of locally weighted forest inter-comparison to mitigate the above shortcomings. This method is applied to an international database of nearly 300 community forests, and compared with previously published techniques. It is particularly suited to large databases where forests may be compared among one another. Further, it avoids problematic comparisons with old-growth forests which may not resemble the goal of forest management. In most cases, the different methods produce broadly congruent results, suggesting that researchers have the flexibility to compare forest conditions using whatever type of data is available. Forest structure and biodiversity are shown to be independently measurable axes of forest condition, although users’ and foresters’ estimations of seemingly unrelated attributes are highly correlated, perhaps reflecting an underlying sentiment about forest condition. These findings contribute new tools for large-scale analysis of ecosystem condition and natural resource policy assessment. Although applied here to forestry, these techniques have broader applications to classification and evaluation problems using crowdsourced or repurposed data for which baselines or external validations are not available. (shrink)

This article argues that positioning disclosure as a primary remedy in addressing the ethical problems posed by conflicts of interest in medicine and health is an error. Instead, bioethical resources should be devoted to the problems associated with sequestration, defined as the elimination of relationships between commercial industries and health professionals in all cases where it is remotely feasible. The argument begins by arguing that adopting Andrew Stark’s conceptual framework for COIs leads to advantages in understanding COIs and in (...) ordering priorities for intervention. The article then draws on prior work establishing that COIs are, under ordinary epidemiologic standards, properly regarded as population health hazards. This justifies attention to possible remedies, of which disclosure generates by far the most analysis. Such primacy is unwarranted given the extensive evidence suggesting that disclosure as a remedy for COIs is at best ineffective. ‘At best’ is justified because the evidence also shows that disclosure may have a perverse effect, intensifying biased behaviors. Expending significant attention on an ineffective or even deleterious intervention is unjustified and also crowds out devotion of resources to the real problems that attend sequestration. Therefore, disclosure ought to be regarded as a lower priority among possible COI interventions. (shrink)

Lors d’une grève dans la bonneterie troyenne en 1921, un incident s’est produit dont les archives ne gardent quasiment pas de trace, mais qui est resté dans la mémoire populaire. Un patron d’usine est séquestré par une foule en colère : on parle même de le faire pendre. L’intervention, paraît-il, d’une femme, syndicaliste, lui sauve la vie : elle propose qu’on l’humilie plutôt,en l’envoyant éplucher des pommes de terre. On se calme, et le patron est conduit aux autorités municipales. Pour...

The twentieth century saw the emergence of a new episteme of death that fundamentally revolutionized values relating to mortality and life. Previously this revolution has been seen primarily in terms of the sequestration and denial of death, but it is necessary to go farther and recognize that these are really just an aspect of the industrialization ‐the Fordism ‐ of death. This takes two major institutional forms: the militarization, and the medicalization of death. Both ensure that death is administered (...) on an industrial scale and in accord with institutional and bureaucratic imperatives and values. The total mobilization of the Great War was the prototype that revealed the potential of this approach. With the subsequent medical revolution of the middle decades of the century the approach was quickly rationalized and refined into a new episteme of administered death, with ‘administer’ being understood in its twin senses of ‘to manage’ and ‘to dispense’ — the two characteristic orientations to death in contemporary society. This new episteme quickly displaced traditional values derived predominantly from religious, philosophical, mythological and traditional sources and has advanced far beyond their responsive capacity, as the many interminable debates around issues of bioethics reveal. While this new episteme might enhance the human condition, it also has great potential for the impoverishment of the human spirit, and for the further reduction of human beings to the status of mere components and functions to be administered within medico‐technological systems that are themselves parts of an increasingly globalized economic system. (shrink)

The noncoding RNA 7SK is a critical regulator of transcription by adjusting the activity of the kinase complex P‐TEFb. Release of P‐TEFb from 7SK stimulates transcription at many genes by promoting productive elongation. Conversely, P‐TEFb sequestration by 7SK inhibits transcription. Recent studies have shown that 7SK functions are particularly important for neuron development and maintenance and it can thus be hypothesized that 7SK is at the center of many signaling pathways contributing to neuron function. 7SK activates neuronal gene expression (...) programs that are key for terminal differentiation of neurons. Proteomics studies revealed a complex protein interactome of 7SK that includes several RNA‐binding proteins. Some of these novel 7SK subcomplexes exert non‐canonical cytosolic functions in neurons by regulating axonal mRNA transport and fine‐tuning spliceosome production in response to transcription alterations. Thus, a picture emerges according to which 7SK acts as a multi‐functional RNA scaffold that is integral for neuron homeostasis. (shrink)

In this essay, I explore non-human multispecies interactions in soils polluted by electronic waste and subsequently bioremediated by plants and microbes. I argue that regenerative transformation in polluted soil environments is principally through microbial degradation, a significant process for survival amidst disaster. In doing so, I combine two separate research areas – the materiality of electronic waste and of soils – thus contributing to theorization on the persistent problem of anthropogenically polluted soils. I do so by examining the process of (...) bioremediation, which ties anthropogenic pollution with underground soil processes, notably those that occur at the soil interface surrounding plant roots, the rhizosphere. Using empirical examples from scientific literature on the bioremediation of electronic waste-contaminated soils in China, I demonstrate that degradation, symbiosis, and sequestration are instrumental processes in polluted soils. The micro-scaled perspective of these relational processes and their toxic alterlives contributes to materialist, chemosocial understandings of toxic and polluted environments. (shrink)

An investigative reporter documents the destructive impact of the environmental movement in North America and beyond. When journalist Elizabeth Nickson sought to subdivide her twenty-eight acres on Salt Spring Island in the Pacific Northwest, she was confronted by the full force and power of the radical conservationists who had taken over the local zoning council. She soon discovered that she was not free to do what she wanted with her land, and that in the view of these arrogant stewards it (...) wasn’t really hers at all. Nickson’s long, frustrating, and eyeopening encounter with these zealots started her on a journey to investigate and expose the hugely destructive impact of the environmental movement on ordinary people and communities across North America—and the world. What she discovered is shocking. Forty million Americans have been driven from their land, and rural culture is being systematically crushed, even as wildlife, forests, and rangelands are dying. In Eco-Fascists, Nickson explores how environmental radicals have taken over government agencies at the local, state, and federal levels. The result? A wholesale sequestration of forest, range, and water—more than 40 percent of North America—impoverishing us all, especially the most vulnerable. This confiscation of America’s natural heritage is a major factor contributing to our current economic decline; until it is acknowledged and addressed, our economy will not recover. Nickson traces the tens of billions of dollars environmental nonprofits marshal every year to promote the notion that our essential natural systems are collapsing, and finds, in a brutal example of self-fulfilling prophesy, that their corrupted science is desertifying the heartland. She visits once-thriving communities that are turning to ghost towns because environmental legislation has forced mines, ranches, and mills to close and has forbidden critical forest, range, park, and wilderness maintenance. Eco-Fascists exposes the major fallacies of the environmental movement—from wildlife protection to zoning to forest-fire management—and introduces us to the individuals who are fighting back. Fast-paced, highly accessible, and sure to be controversial, this is a work that will change the national conversation about environmental protection and its impact. (shrink)

Climate change presents a fundamental challenge to the current global energy regime. Under the Framework Convention on Climate Change, the international community is developing the architecture of a policy response. Three serious flaws are examined: (a) the potential sacrifice of small island states, (b) the use of market-based policy measures to commodify the atmospheric commons, and (c) the substitution of carbon sequestration for meaningful reductions in energy use. The authors’ analysis of the politics of climate change, based on these (...) issues, suggests a new understanding of ecology is emerging—what they term postmodern ecology—in which a global environmental crisis is risked to secure the future of the world energy regime. An alternative, based on principles of sustainability and equity, is proposed that would require abandoning the global energy status quo. (shrink)

This paper examines the emergence and trajectory of a vernacular femicide memorial tree at Mount Gravatt (Meanjin/Brisbane) which is juxtaposed with established and regulated official commemorative placemaking practices in this social geography. The paper explores the implicit rules about marking gender in official publics of commemoration, arguing that they perform or conversely risk a doubling of women’s invisibility through assimilation into symbols and aesthetic conventions of seemingly settled history and settled subjects. They can become barely noticeable for the kinds of (...) messages they may seek to publicly speak and breakthrough in encounter. Conventional commemoration of violence against women also risks positioning women as ‘victims’ by not unsettling that position through passive, familiar and assimilationist design forms and narrative tropes. Importantly, memorials that address violence against women and intimate femicide should contest ‘active forgetting’ by insisting that this is a public facing, collective issue of responsibility against resistant effacements, disavowal, and sequestration into the private sphere and personal life. (shrink)

The role of intuition in scientific endeavor is examined through the lens of three philosophers/historians of science—Karl Popper, Thomas Kuhn, and Gerald Holton. All three attribute an important role to imagination/intuition in scientific endeavor. As a case study, the article examines the controversy between the generally accepted Vesicular Sequestration/Exocytosis Model of pancreatic digestive enzyme secretion and an alternative view called the Equilibrium Model. It highlights the intertwining of intuition and reason in the genesis of the Equilibrium Model developed in (...) response to findings that could not readily be explained by the consensus view. It suggests that tacit knowledge/understanding works in conjunction with philosophical and aesthetic presuppositions that function to a greater or lesser extent below awareness. Together they guide judgments about whether falsification has occurred and help frame alternative theories. (shrink)

The segregation of damaged components at cell division determines the survival and aging of cells. In cells that divide asymmetrically, such as Saccharomyces cerevisiae, aggregated proteins are retained by the mother cell. Yet, where and how aggregation occurs is not known. Recent work by Zhou and collaborators shows that the birth of protein aggregates, under specific stress conditions, requires active translation, and occurs mainly at the endoplasmic reticulum. Later, aggregates move to the mitochondrial surface through fis1‐dependent association. During replicative aging, (...) aggregate association with the mother‐cell mitochondria contributes to the asymmetric segregation of aggregates, because mitochondria in the daughter cell do not carry aggregates. With increasing age of mother cells, aggregates lose their connection to the mitochondria, and segregation is less asymmetric. Relating these findings to other mechanisms of aggregate segregation in different organisms, we postulate that fusion between aggregates and their tethering to organelles such as the vacuole, nucleus, ER, or mitochondria are common principles that establish asymmetric segregation during stress resistance and aging. (shrink)

Reorganization of cell organelle‐deprived host red blood cells by the apicomplexan malaria parasite Plasmodium falciparum enables their cytoadherence to endothelial cells that line the microvasculature. This increases the time red blood cells infected with mature developmental stages remain within selected organs such as the brain to avoid the spleen passage, which can lead to severe complications and cumulate in patient death. The Maurer's clefts are a novel secretory organelle of parasite origin established by the parasite in the cytoplasm of the (...) host red blood cell in order to facilitate the establishment of cytoadherence by conducting the trafficking of immunovariant adhesins to the host cell surface. Another important function of the organelle is the sorting of other proteins the parasite traffics into its host cell. Although the organelle is of high importance for the pathology of malaria, additional putative functions, structure, and genesis remain shrouded in mystery more than a century after its discovery. In this review, we highlight our current knowledge about the Maurer's clefts and other novel secretory organelles established within the host cell cytoplasm by human‐pathogenic malaria parasites and other parasites that reside within human red blood cells. (shrink)

What is factical life, and what sort of philosophical approach is needed to grasp it? Life is for Heidegger a basic phenomenon. Because factical life is immensely rich, evasive, manifold, fluid, and dynamic, one cannot hope to grasp it in static definitions which aim to exhaust its object, to take it as an immediate given. The importance of tailoring one’s mode of access to the subject matter is certainly an Aristotlelian insight, but Heidegger conceives it as a question of phenomenological (...) authenticity. Perhaps the most important contribution is the treatment of the formal indication, which appears often in Heidegger’s early writings, but is given a significant clarification here. Heidegger devises the notion of a formal indication as an alternative to traditional philosophical definition, the latter of which also arises from tendencies of life to grasp reality in static presence. Formal indication remains empty as to its content, but draws out a formal structure through which the categorical movements of life become visible from a certain preserved distance. Despite their formal qualification, it is clear that Heidegger’s interpretation of these movements is existentially oriented, their currents tending toward lostness from which life must be turned around. As in Being and Time, care is identified as life’s relational sense, which manifests four categorical directions: inclination, a pull toward something ; distance, or rather, the tendency to abolish the distance between itself and the things which stand before it; sequestration, wherein life avoids itself, looking away from itself, attempting to escape its worriedness about itself; and the “easy,” where life seeks to lose itself in mundane difficulties and/or carefreeness. Readers of Being and Time will notice characteristics of fallenness, Dasein’s inauthentic self-forgetfulness due to insatiable absorption in the world. (shrink)