About this topic
Summary

Developmental Biology is the study of organisms’ life cycles from single cell to complex reproducing and aging multi-cellular organisms. It endeavours to explain phenomena such as: cellular differentiation (e.g. neurons vs. liver cells) and cellular aging, the development of gross morphology and anatomical structures (e.g. body shape and organs -eyes and limbs-), and the development of an organism as an integrated part of an eco-system (e.g. phenotypic plasticity). The philosophically relevant points, in addition to broader philosophy of science inquiries (e.g. confirmation and explanation) are those that have to do with the ontological status of biological kinds and with inter-level relations, specifically the integration of developmental biology with evolutionary biology and to a lesser extent, with ecology. Keeping this is in mind the subcategories within Developmental Biology can be grouped into three main themes: Evolution, Ecology and Ontology.    

Evolution

(Evolutionary-Developmental Biology, Developmental Constraints and Process Structuralism)

Ecology 

(Ecological Developmental Biology, Epigenetic Inheritance, Nature vs. Nurture and Innateness) 

and 

Ontology 

(Developmental Modularity, Developmental System Theory and Process Structuralism).

Key works Key works will be arranged by sub-category and cited there.
Related categories

1565 found
Order:
1 — 50 / 1565
Material to categorize
  1. Darwinian and Autopoietic Views of the Organism.Walter Veit & Heather Browning - 2022 - Constructivist Foundations 18 (1):103–105.
    Our goal is to illustrate that Darwinian and autopoietic views of the organism are not as squarely opposed to each other as is often assumed. Indeed, we will argue that there is much common ground between them and that they can usefully supplement each other.
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  2. Darwinian and Autopoietic Views of the Organism.Walter Veit & Heather Browning - 2022 - Constructivist Foundations 18 (1):103–105.
  3. Developmental biology.Alan Love - 2020 - The Stanford Encyclopedia of Philosophy.
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark  
  4. Situating evolutionary developmental biology in evolutionary theory.Alan Love - 2020 - In S. M. Scheiner and D. P. Mindell (ed.), The Theory of Evolution: Principles, Concepts, and Assumptions. Chicago, IL, USA: pp. 144-169.
    Remove from this list  
     
    Export citation  
     
    Bookmark  
  5. John Tyler Bonner: Remembering a scientific pioneer.Ingo Brigandt, L. A. Katz, V. Nanjundiah, S. F. Gilbert, P. R. Grant, B. R. Grant, Alan Love, S. A. Newman & M. J. West-Eberhard - 2019 - Journal of Experimental Evolution (Mol Dev Evol) 332:365-370.
    Throughout his life, John Tyler Bonner contributed to major transformations in the fields of developmental and evolutionary biology. He pondered the evolution of complexity and the significance of randomness in evolution, and was instrumental in the formation of evolutionary developmental biology. His contributions were vast, ranging from highly technical scientific articles to numerous books written for a broad audience. This historical vignette gathers reflections by several prominent researchers on the greatness of John Bonner and the implications of his work.
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark  
  6. Evolutionizing human nature.John Klasios - 2016 - New Ideas in Psychology 40.
    Many have argued that the very notion of human nature is untenable given the facts of evolution and should accordingly be discarded. This paper, by contrast, argues that the notion can be retained in a coherent and modern way. The present account expounds on the view of human nature as a collection of species-typical psychological adaptations, and outlines how it can be understood in formally modeled computational terms. The view defended is also heavily developmental and connects directly with contemporary evolutionary (...)
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark  
  7. Transgenerational trauma and worlded brains: an interdisciplinary perspective on ‘post-traumatic slave syndrome’.Machiel Keestra - forthcoming - In Stephan Besser & Flora Lysen (eds.), Worlding the Brain. Interdisciplinary Explorations in Cognition and Neuroculture. Leiden, Nederland:
    Trauma and traumatization have arguably always been part of the human experience yet have in the last few decades come to occupy a prominent place in various popular and academic contexts. This chapter offers an interdisciplinary and comparative investigation of trauma and traumatization in different historical contexts. More specifically, my aim is to discuss whether the rich bodies of research in trauma and traumatization in Holocaust survivors and their descendants yield relevant insights for post-slavery contexts. It has been shown that (...)
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark  
  8. Michelini, F. y Köchy, K. (eds.). (2020). Jakob von Uexküll and Philosophy. Life, Environments, Anthropology. Routledge. 284 pp. [REVIEW]Maximiliano S. Beckel - 2021 - Tópicos: Revista de Filosofía 62:485–490.
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  9. The Reduction of Classical Experimental Embryology to Molecular Developmental Biology: A Tale of Three Sciences.Marcel Weber - forthcoming - In William Bausman, Janella Baxter & Oliver Lean (eds.), From Biological Practice to Scientific Metaphysics. Minnesota Studies in Philosophy of Science, Vol. 23. Minneapolis: University of Minnesota Press.
    I attempt to characterize the relationship of classical experimental embryology (CEE) and molecular developmental biology and compare it to the much-discussed case of classical genetics. These sciences are treated here as discovery practices rather than as definitive forms of knowledge. I first show that CEE had some causal knowledge and hence was able to answer specific why?-questions. A paradigm was provided by the case of eye induction, perhaps CEE’s greatest success. The case of the famous Spemann-Mangold organizer is more difficult. (...)
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark  
  10. Linking Mitochondria and Synaptic Transmission: The CB1 Receptor.Marie-Ange Djeungoue-Petga & Etienne Hebert-Chatelain - 2017 - Bioessays 39 (12):1700126.
    CB1 receptors are functionally present within brain mitochondria, although they are usually considered specifically targeted to plasma membrane. Acute activation of mtCB1 alters mitochondrial ATP generation, synaptic transmission, and memory performance. However, the detailed mechanism linking disrupted mitochondrial metabolism and synaptic transmission is still uncharacterized. CB1 receptors are among the most abundant G protein-coupled receptors in the brain and impact on several processes, including fear coping, anxiety, stress, learning, and memory. Mitochondria perform several key physiological processes for neuronal homeostasis, including (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  11. Physical Limits on the Precision of Mitotic Spindle Positioning by Microtubule Pushing forces.Jonathon Howard & Carlos Garzon-Coral - 2017 - Bioessays 39 (11):1700122.
    Tissues are shaped and patterned by mechanical and chemical processes. A key mechanical process is the positioning of the mitotic spindle, which determines the size and location of the daughter cells within the tissue. Recent force and position-fluctuation measurements indicate that pushing forces, mediated by the polymerization of astral microtubules against­ the cell cortex, maintain the mitotic spindle at the cell center in Caenorhabditis elegans embryos. The magnitude of the centering forces suggests that the physical limit on the accuracy and (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  12. Counting with Cilia: The Role of Morphological Computation in Basal Cognition Research.Wiktor Rorot - 2022 - Entropy 24 (11):1581.
    “Morphological computation” is an increasingly important concept in robotics, artificial intelligence, and philosophy of the mind. It is used to understand how the body contributes to cognition and control of behavior. Its understanding in terms of "offloading" computation from the brain to the body has been criticized as misleading, and it has been suggested that the use of the concept conflates three classes of distinct processes. In fact, these criticisms implicitly hang on accepting a semantic definition of what constitutes computation. (...)
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark  
  13. Mindsponge Theory.Quan-Hoang Vuong - 2023 - Warsaw, Poland: Walter de Gruyter GmbH.
    As humans, we use the power of thinking to make scientific discoveries, develop technologies, manage social interactions, and transmit knowledge to the next generations. With the ability to think, we can trace back and discover the origin of the universe, the natural world, and ourselves. The content of this book, Mindsponge Theory, is part of that discovery process. -/- Product Details -/- Publisher ‏ : ‎ Walter de Gruyter (December 6, 2022) Publication date ‏ : ‎ December 6, 2022 Language (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  14. Biological Information: New Perspectives.Bruce Gordon - 2013 - Singapore: World Scientific.
    Based on a conference on the nature and origin of biological information held at Cornell University in 2011, this edited volume presents new research by experts in information theory, computer science, numerical simulation, thermodynamics, evolutionary theory, whole organism biology, developmental biology, molecular biology, genetics, physics, biophysics, mathematics, and linguistics.
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark  
  15. Scientific Humility: Scientific Honesty – Hypothesis and Science.Bhakti Madhava Puri - 2009 - Darwin Under Siege.
    It is not that scientists make an hypothesis first, and then try to find the data to fit that hypothesis. Rather, the process is first observation, then an hypothes is made to describe the data, then conclude that the data has been described by the hypothesis. But this is not an explanation of the phenomenon. It is merely a description of the data in different terms, usually mathematics. It is essentially a tautology. Thus to observe various points and connect them (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  16. The Logic of Life.Bhakti Madhava Puri - 2008 - Science and Scientist.
    Modern science generally assumes that the same laws of logic apply to mechanical, chemical and biological entities alike because they are all ultimately material objects. This may seem to be so obvious that there would be no need to validate it -- experimentally or logically. In this article we would like to critically examine this assumption and show that from an experiential/observational level, as well as from a rational/logical level, it is not valid. This becomes apparent, for instance, when we (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  17. From Obesity to Energy Metabolism: Ontological Perspectives on the Metrics of Human Bodies.Davide Serpico & Andrea Borghini - 2020 - Topoi 40 (3):577-586.
    In this paper, we aim at rethinking the concept of obesity in a way that better captures the connection between underlying medical aspects, on the one hand, and an individual’s developmental history, on the other. Our proposal rests on the idea that obesity is not to be understood as a phenotypic trait or character; rather, obesity represents one of the many possible states of a more complex phenotypic trait that we call ‘energy metabolism.’ We argue that this apparently simple conceptual (...)
    Remove from this list   Direct download (3 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  18. La guerra de la Naturaleza, la carestía y la muerte como fuente del diseño de los seres vivos.Giorgio Airoldi & Cristian Saborido - 2020 - Endoxa 46:123.
    El proyecto del ‘Darwinismo Formal’ de Alan Grafen propone una formulación matemática de la teoría de Darwin que pretende demostrar que la selección natural moldea los rasgos fenotípicos a través de la maximización de la eficacia. El proyecto de Grafen reposa sobre tres premisas: la selección natural es la única fuerza que moldea los fenotipos; la eficacia es la única medida de le evolución; y el diseño biológico surge como resultado de un proceso de optimización selectiva. En este trabajo argumentamos (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  19. Het laatste woord is niet gezegd: de moderne synthese voorbij.Nathalie Gontier - 2005 - In I. Tallon (ed.), Evolutie vandaag: hoe de dingen ontstaan en waarom ze veranderen. pp. 57-84.
  20. Evolutionary epistemology and the origin and evolution of language: taking symbiogenesis seriously.Nathalie Gontier - 2006 - In Nathalie Gontier, Jean Paul Van Bendegem & Diederik Aerts (eds.), Evolutionary Epistemology, Language and Culture: A Non-Adaptationist Systems Theoretical Approach. pp. 195-226.
  21. Introduction to evolutionary epistemology, language and culture.Nathalie Gontier - 2006 - In Nathalie Gontier, Jean Paul Van Bendegem & Diederik Aerts (eds.), Evolutionary Epistemology, Language and Culture: A Non-Adaptationist Systems Theoretical Approach. pp. 1-29.
  22. Studying Language Evolution: From Ethology and Comparative Zoology to Social Primatology and Evolutionary Psychology.Nathalie Gontier & Marco Pina - 2014 - In Marco Pina & Nathalie Gontier (eds.), The Evolution of Social Communication in Primates: A Multidisciplinary Approach. pp. 1-30.
  23. Genes, Brains, and Language: Would Someone Please Pull the Brakes?Nathalie Gontier - 2008 - Review of General Psychology 2 (12):170-180.
  24. Michael Tomasello, Becoming human: a theory of ontogeny, Cambridge, MA: The Belknap Press of Harvard University Press, 2019, xi + 379 pp, $35.00/£28.95/€31.50. [REVIEW]Ivan Gonzalez-Cabrera - 2020 - History and Philosophy of the Life Sciences 42 (4):1-5.
    In this book, Michael Tomasello proposes an overarching theoretical framework that organizes the research that he and his colleagues at the Department of Developmental and Comparative Psychology of the Max Planck Institute in Leipzig have carried out for the past 20 years. The book is recommended for students and academics working on the evolution of human cognition, especially those interested in the intersection between evolutionary developmental biology and developmental psychology.
    Remove from this list   Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  25. Life, Local Constraints and Meaning Generation. An Evolutionary Approach to Cognition (2015).Christophe Menant - manuscript
    The relations between life and cogntion have been addressed through different perspectives [Stewart 1996, Boden 2001, Bourgine and Stewart 2004, van Duijn & all 2006, Di Paolo 2009]. We would like here to address that subject by relating life to cognition through a process of meaning generation. Life emerged on earth as a far from thermodynamic equilibrium performance that had to maintain herself. Life is charactertized by a ‘stay alive’ constraint that has to be satisfied (such constraint can be included (...)
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark   1 citation  
  26. Peer competition and cooperation.Ivan Gonzalez-Cabrera - 2018 - In T. K. Shackelford & V. A. Weekes-Shackelford (eds.), Encyclopedia of Evolutionary Psychological Science. Basel:
    Peer competition and peer cooperation can be intuitively seen as opposing phenomena. However, depending on multiple factors, they might be complementary. In a population divided into groups, for instance, members of each group may cooperate with their peers in order to compete with neighboring groups. Alternatively, they may compete with their peers as a means of choosing the best cooperative partners and demonstrate that they are reliable cooperative partners. For instance, if subjects can choose with whom they wish to interact, (...)
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark  
  27. Psychic Unity.Marta Facoetti & Nathalie Gontier - 2020 - Encyclopedia of Evolutionary Psychological Science.
    Synonyms Cognitive universals; Human nature; Human universals Definition The “psychic unity” idea denotes the existence of a set of psychological and cognitive capacities universally shared by human beings and grounded in biological equality.
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark  
  28. Beyond quantitative and qualitative traits: three telling cases in the life sciences.Davide Serpico - 2020 - Biology and Philosophy 35 (3):1-26.
    This paper challenges the common assumption that some phenotypic traits are quantitative while others are qualitative. The distinction between these two kinds of traits is widely influential in biological and biomedical research as well as in scientific education and communication. This is probably due to both historical and epistemological reasons. However, the quantitative/qualitative distinction involves a variety of simplifications on the genetic causes of phenotypic variability and on the development of complex traits. Here, I examine three cases from the life (...)
    Remove from this list   Direct download (3 more)  
     
    Export citation  
     
    Bookmark   6 citations  
  29. Developmental Biology as a Science of Dependent Co-origination.Scott Gilbert - manuscript
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark  
  30. Is the Neo-Aristotelian Concept of Organism Presupposed in Biology?Parisa Moosavi - 2020 - In Martin Hähnel (ed.), Aristotelian Naturalism: A Research Companion. Springer.
    According to neo-Aristotelian ethical naturalism, moral goodness is an instance of natural goodness, a kind of normativity supposedly already present in nature in the biological realm of non-human living things. Proponents of this view appeal to Michael Thompson’s conception of a life-form--the form of a living organism--to give an account of natural goodness. However, although neo-Aristotelians call themselves naturalists, they hardly ever consult the science of biology to defend their commitments regarding biological organisms. This has led many critics to argue (...)
    Remove from this list  
     
    Export citation  
     
    Bookmark   1 citation  
  31. Civilizational structure of regional integration organizations.Sergii Sardak & Y. Prysiazhniuk S. Sardak, S. Radziyevska - 2019 - Przegląd Strategiczny 12:59-79.
    The paper advances a new comprehensive complex approach to the investigation of the civilizational aspects in the development of regional associations of countries. The research starts with the overview of historical dimensions of the civilizational approach and the contribution of the founding scholars to its development. It continues with the analysis of the scientific and methodological input of the followers and the critics of this approach. The authors suggest their theoretical approach to the identification of the modern local civilizations according (...)
    Remove from this list   Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  32. Levels of Organization in the Biological Sciences.Daniel Stephen Brooks, James DiFrisco & William C. Wimsatt (eds.) - 2021 - Cambridge, Massachusetts: MIT Press.
    The subject of this edited volume is the idea of levels of organization: roughly, the idea that the natural world is segregated into part-whole relationships of increasing spatiotemporal scale and complexity. The book comprises a collection of essays that raise the idea of levels into its own topic of analysis. Owing to the wide prominence of the idea of levels, the scope of the volume is aimed at theoreticians, philosophers, and practicing researchers of all stripes in the life sciences. The (...)
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark   1 citation  
  33. The Machine Conception of the Organism in Development and Evolution: A Critical Analysis.Daniel J. Nicholson - 2014 - Studies in History and Philosophy of Biological and Biomedical Sciences 48:162-174.
    This article critically examines one of the most prevalent metaphors in modern biology, namely the machine conception of the organism (MCO). Although the fundamental differences between organisms and machines make the MCO an inadequate metaphor for conceptualizing living systems, many biologists and philosophers continue to draw upon the MCO or tacitly accept it as the standard model of the organism. This paper analyses the specific difficulties that arise when the MCO is invoked in the study of development and evolution. In (...)
    Remove from this list   Direct download (5 more)  
     
    Export citation  
     
    Bookmark   19 citations  
  34. Control by Viability in a Chemotherapy Cancer Model.M. Serhani, H. Essaadi, K. Kassara & A. Boutoulout - 2019 - Acta Biotheoretica 67 (3):177-200.
    The aim of this study is to provide a feedback control, called the Chemotherapy Protocol Law, with the purpose to keep the density of tumor cells that are treated by chemotherapy below a “tolerance level” L_c, while retaining the density of normal cells above a “healthy level” N_c. The mathematical model is a controlled dynamical system involving three nonlinear differential equations, based on a Gompertzian law of cell growth. By evoking viability and set-valued theories, we derive sufficient conditions for the (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  35. Beeing & Time: Kiss of Chemoreception & the Bug in Dasein's Mouth.Virgil W. Brower - 2014 - In Laurence Talairach-Vielmas & Marie Bouchet (eds.), Insects in Literature & the Arts. Brussels, Belgium: pp. 197-217.
    "Brower explores the way philosophers were inspired by entomological social systems and communication to reflect on human psyche, social behavior, community organization, communication, and inter-individual relationships. His essay rehearses the swarms of insects embedded in contemporary philosophy and literary theory, not only showing how many of the major concepts (or philosophemes) in continental philosophy – sexuality, politics, thinking, time, interdependence, and language – draw lessons from the world of insects, but also illustrating again how the insect world spurred human reflection.".
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  36. Developmental Roles and Evolutionary Significance of AMPA‐Type Glutamate Receptors.Shinobu Hirai, Kohji Hotta & Haruo Okado - 2018 - Bioessays 40 (9):1800028.
    Organogenesis and metamorphosis require the intricate orchestration of multiple types of cellular interactions and signaling pathways. Glutamate (Glu) is an excitatory extracellular signaling molecule in the nervous system, while Ca2+ is a major intracellular signaling molecule. The first Glu receptors to be cloned are Ca2+‐permeable receptors in mammalian brains. Although recent studies have focused on Glu signaling in synaptic mechanisms of the mammalian central nervous system, it is unclear how this signaling functions in development. Our recent article demonstrated that Ca2+‐permeable (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  37. The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity.Snehal N. Chaudhari & Edward T. Kipreos - 2018 - Bioessays 40 (8):1800005.
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  38. Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity.Simone Ecker, Vera Pancaldi, Alfonso Valencia, Stephan Beck & Dirk S. Paul - 2018 - Bioessays 40 (2):1700148.
    Epigenetic and transcriptional variability contribute to the vast diversity of cellular and organismal phenotypes and are key in human health and disease. In this review, we describe different types, sources, and determinants of epigenetic and transcriptional variability, enabling cells and organisms to adapt and evolve to a changing environment. We highlight the latest research and hypotheses on how chromatin structure and the epigenome influence gene expression variability. Further, we provide an overview of challenges in the analysis of biological variability. An (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark   4 citations  
  39. Multicellular Individuality: The Case of Bacteria.Rafael Ventura - 2019 - Biological Theory 14 (2):131-140.
    Recent attention to complex group-level behavior amongst bacteria has led some to conceive of multicellular clusters of bacteria as individuals. In this article, I assess these recent claims by first drawing a distinction between two concepts of individuality: physiological and evolutionary. I then survey cases that are representative of three different modes of growth: myxobacteria, Bacillus subtilis, and cyanobacteria. A closer look at these cases indicates that multicellular individuality among bacteria is remarkably complex. Physiologically, the three cases of multicellular clusters (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  40. Targeting the Spleen as an Alternative Site for Hematopoiesis.Christie Short, Hong K. Lim, Jonathan Tan & Helen C. O'Neill - 2019 - Bioessays 41 (5):1800234.
    Bone marrow is the main site for hematopoiesis in adults. It acts as a niche for hematopoietic stem cells (HSCs) and contains non‐hematopoietic cells that contribute to stem cell dormancy, quiescence, self‐renewal, and differentiation. HSC also exist in resting spleen of several species, although their contribution to hematopoiesis under steady‐state conditions is unknown. The spleen can however undergo extramedullary hematopoiesis (EMH) triggered by physiological stress or disease. With the loss of bone marrow niches in aging and disease, the spleen as (...)
    Remove from this list   Direct download  
     
    Export citation  
     
    Bookmark  
  41. How Does Inflammation‐Induced Hyperglycemia Cause Mitochondrial Dysfunction in Immune Cells?Gustav Niekerk, Tanja Davis, Hugh-George Patterton & Anna-Mart Engelbrecht - 2019 - Bioessays 41 (5):1800260.
    Inflammatory mediators have an established role in inducing insulin resistance and promoting hyperglycemia. In turn, hyperglycemia has been argued to drive immune cell dysfunction as a result of mitochondrial dysfunction. Here, the authors review the evidence challenging this view. First, it is pointed out that inflammatory mediators are known to induce altered mitochondrial function. In this regard, critical care patients suffer both an elevated inflammatory tone as well as hyperglycemia, rendering it difficult to distinguish between the effects of inflammation and (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  42. Why the Lipid Divide? Membrane Proteins as Drivers of the Split between the Lipids of the Three Domains of Life.Victor Sojo - 2019 - Bioessays 41 (5):1800251.
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  43. The Nature of Programmed Cell Death.Pierre M. Durand & Grant Ramsey - 2019 - Biological Theory 14 (1):30-41.
    In multicellular organisms, cells are frequently programmed to die. This makes good sense: cells that fail to, or are no longer playing important roles are eliminated. From the cell’s perspective, this also makes sense, since somatic cells in multicellular organisms require the cooperation of clonal relatives. In unicellular organisms, however, programmed cell death poses a difficult and unresolved evolutionary problem. The empirical evidence for PCD in diverse microbial taxa has spurred debates about what precisely PCD means in the case of (...)
    Remove from this list   Direct download (4 more)  
     
    Export citation  
     
    Bookmark   3 citations  
  44. Cell Fate and Developmental Regulation Dynamics by Polycomb Proteins and 3D Genome Architecture.Vincent Loubiere, Anne-Marie Martinez & Giacomo Cavalli - 2019 - Bioessays 41 (3):1800222.
    Targeted transitions in chromatin states at thousands of genes are essential drivers of eukaryotic development. Therefore, understanding the in vivo dynamics of epigenetic regulators is crucial for deciphering the mechanisms underpinning cell fate decisions. This review illustrates how, in addition to its cell memory function, the Polycomb group of transcriptional regulators orchestrates temporal, cell and tissue‐specific expression of master genes during development. These highly sophisticated developmental transitions are dependent on the context‐ and tissue‐specific assembly of the different types of Polycomb (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  45. Veins and Arteries Build Hierarchical Branching Patterns Differently: Bottom‐Up versus Top‐Down.Kristy Red-Horse & Arndt F. Siekmann - 2019 - Bioessays 41 (3):1800198.
    A tree‐like hierarchical branching structure is present in many biological systems, such as the kidney, lung, mammary gland, and blood vessels. Most of these organs form through branching morphogenesis, where outward growth results in smaller and smaller branches. However, the blood vasculature is unique in that it exists as two trees (arterial and venous) connected at their tips. Obtaining this organization might therefore require unique developmental mechanisms. As reviewed here, recent data indicate that arterial trees often form in reverse order. (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  46. Cell-Cycle-Dependent Regulation of Cell Adhesions: Adhering to the Schedule.Yitong Li & Keith Burridge - 2019 - Bioessays 41 (1):1800165.
    Focal adhesions disassemble during mitosis, but surprisingly little is known about how these structures respond to other phases of the cell cycle. Three recent papers reveal unexpected results as they examine adhesions through the cell cycle. A biphasic response is detected where focal adhesions grow during S phase before disassembly begins early in G2. In M phase, activated integrins at the tips of retraction fibers anchor mitotic cells, but these adhesions lack the defining components of focal adhesions, such as talin, (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  47. Reconsidering Morphology Through an Experimental Case Study.Alessandro Minelli, Rocco Micciolo, Mara Rosa, Paolo Chistè, Luisa Canal & Liliana Albertazzi - 2017 - Biological Theory 12 (3):131-141.
    This study analyzes shells of marine gastropods of a zoological museum and the Latin epithets expressing perceptual and connotative attributes that they have received in the standard, Linnaean nomenclature. Making use of the Osgood semantic differential, we presented the subjects with digital 3-D reproductions of the shell specimens to be subjectively evaluated according to 17 pairs of attributes. The results show that, overall, the subjective evaluations given by the subjects are consistent, which suggests that an intersubjective characterization of the shells (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  48. Discrete Mesh Approach in Morphogenesis Modelling: the Example of Gastrulation.E. Promayon, A. Lontos & J. Demongeot - 2016 - Acta Biotheoretica 64 (4):427-446.
    Morphogenesis is a general concept in biology including all the processes which generate tissue shapes and cellular organizations in a living organism. Many hybrid formalizations have been proposed for modelling morphogenesis in embryonic or adult animals, like gastrulation. We propose first to study the ventral furrow invagination as the initial step of gastrulation, early stage of embryogenesis. We focus on the study of the connection between the apical constriction of the ventral cells and the initiation of the invagination. For that, (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  49. Cancer Ecology: The Intracellular Interactome Makes Little Sense without the Intercellular One.Andrew Moore - 2018 - Bioessays 40 (11):1800202.
  50. TGF‐β Control of Adaptive Immune Tolerance: A Break From Treg Cells.Ming Liu & Shun Li - 2018 - Bioessays 40 (11):1800063.
    The vertebrate adaptive immune system has well defined functions in maintaining tolerance to self‐tissues. Suppression of autoreactive T cells is dependent on the regulatory cytokine transforming growth factor‐β (TGF‐β) and regulatory T (Treg) cells, a distinct T cell lineage specified by the transcription factor Foxp3. Although TGF‐β promotes thymic Treg (tTreg) cell development by repressing T cell clonal deletion and peripheral Treg cell differentiation by inducing Foxp3 expression, a recent study shows that TGF‐β suppresses autoreactive T cells independent of Foxp3+ (...)
    Remove from this list   Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
1 — 50 / 1565