A growing body of literature has argued that environmental discourses in general, and climate change in particular, have a tendency to become depoliticized. In this article, I discuss how the mechanisms of depoliticization can be traced back to the commonly deployed nature–society dualism. By analysing ecomodernism, one of the most prominent articulations of politics in the Anthropocene, I assess the recent suggestion that the ‘end of nature’-thesis could provide a way out of this dualism and the related problem of depoliticization. (...) I argue that while early ecomodernism showed great prospect in overcoming the depoliticization of environmental discourses by effectively challenging the externalization of nature from society, and critically questioning technocratic solutions, later ecomodernism displays a more depoliticized vision of environmental politics, one which once again separates nature from society, and places it in the realm of necessity, rather than contingency. (shrink)

In the absence of shared beliefs and even common interests, it should not be surprising that so much of the well-intentioned art acquired for public spaces has failed—failed as art and as art for a civic site. The conventional wisdom of simply choosing “the best artist” and then turning him or her loose to create a work within time and budget guidelines lost much credibility with the drama of Richard Serra’s Tilted Arc commission: the process of selection, erection, litigation, rejection, (...) and removal of the sculpture from the Federal Building plaza in New York City. The new conventional wisdom? The jury, not the artist, was ultimately responsible. For Serra did precisely the kind of work for which he is respected worldwide but in a context and for a specific public whose requirements, in their view, were not met but even abrogated by what Serra had done so well: made a Serra.The issues raised by this particular controversy as well as by the very different response now accorded the once-controversial Vietnam Veterans Memorial by Maya Lin, together with firsthand frustration with the selection process for public commissions, were some of the specific reasons for organizing the day-long symposium held 16 September 1989 in First Chicago Center under the auspices of Sculpture Chicago, a biennial exhibition and educational series. John Hallmark Neff, director of the First National Bank of Chicago’s art program, is a former director of the Museum of Contemporary Art, Chicago. He is the author of Anselm Kiefer: Brüch und Einung , and he is currently working on a book on Max Neuhaus and a catalogue essay for the forthcoming Agnes Denes retrospective exhibition. (shrink)

Most early studies of consciousness have focused on human subjects. This is understandable, given that humans are capable of reporting accurately the events they experience through language or by way of other kinds of voluntary response. As researchers turn their attention to other animals, “accurate report” methodologies become increasingly difficult to apply. Alternative strategies for amassing evidence for consciousness in non-human species include searching for evolutionary homologies in anatomical substrates and measurement of physiological correlates of conscious states. In addition, creative (...) means must be developed for eliciting behaviors consistent with consciousness. In this paper, we explore whether necessary conditions for consciousness can be established for species as disparate as birds and cephalopods. We conclude that a strong case can be made for avian species and that the case for cephalopods remains open. Nonetheless, a consistent effort should yield new means for interpreting animal behavior. (shrink)

This chapter discusses a pair of interrelated theses that are hallmarks of Objectivism: the benevolent universe premise and the heroic view of man. These theses are dramatic consequences of the defining essentials of the philosophy, and they are central to the sense of life conveyed by Ayn Rand's novels. The benevolent universe premise permeates all her novels, and much of her non‐fiction, but it seems that she first conceptualized this view under this name sometime in the 1940s. The benevolent (...) universe premise is what Rand calls a metaphysical value‐judgment. It is metaphysical in that it answers a question about the nature of the universe. The chapter briefly describes the heroic view of man, looking not at the content of Rand's view of heroism, but at how this view of heroism colored her view of humanity and of specific human beings. (shrink)

This provocative, interdisciplinary, and transnational collection delves deeply into the educational and public intellectual hallmarks of Stuart M. Hall, a core figure in the development of the post-War British New Left, of Cultural Studies at the Centre for Contemporary Cultural Studies and later, of the Open University. It opens new vistas on both critical educational studies and cultural studies through interviews with, and essays by, leading writers, shedding light on the under-appreciated public pedagogical and cultural politics of the New (...) Left, of Thatcherism, and of Rightist, neo-colonial, diasporic, and neo-liberal formations in Jamaica, the UK, Australia, North America, and Brazil. Intimate and moving, the contributors describe Hall’s diasporic formation as a courageous ‘artist’ and educator of cultural politics and social movements, showing both the reach and the relevance of his public pedagogies in the construction of alternatives to essentialist racial politics and the despairing cynicism of neo-liberalism. With contributors and interviewees including Leslie G. Roman, Michael W. Apple, Avtar Brah, John Clarke, Annette Henry, Lawrence Grossberg, Luis Gandin, and Fazal Rizvi, _Hallmarks: The Cultural Politics and Public Pedagogies of Stuart Hall_ reveals that neither cultural politics nor public pedagogies are stable or self-evident constructs. Each legitimates and requires the other as part of a longer radical democratic project for social justice. This book was originally published as a special issue of _Discourse: Studies in the Cultural Politics of Education. _. (shrink)

During tumor evolution, cancer cells use the tumor‐stroma crosstalk to reorganize the microenvironment for maximum robustness of the tumor. The success of immune checkpoint therapy foretells a new cancer therapy paradigm: an effective cancer treatment should not aim to influence the individual components of super complex intracellular interactomes (molecular targeting), but try to disrupt the intercellular interactions between cancer and stromal cells, thus breaking the tumor as a whole. Arguments are provided in favor of a hypothesis that such interactions include (...) formation of synapse‐like structures (interfaces) where the interacting cells are located at a distance of ∼10–15 nm. Within these interfaces, molecules initiating and strengthening the interaction are organized, and allow optimum cross‐signaling; a very confined intercellular space facilitates the concentration of secreted cytokines, enhancing the paracrine cross‐communication. These features of tumors form a druggable cancer hallmark the tumor‐stroma symbiotic crosstalk—which represents a new target for efficient cancer drug discovery. (shrink)

This chapter contains sections titled: Childhood and Christmas Heaven is at Stake Moving around the Spiral Hecate at the Crossroads It's Not about Me? It's Not Me or You: It's Hallmark Spiraling Around the Christmas Tree.

The reprogramming of metabolism has been identified as one of the hallmarks of cancer. It is becoming more and more frequent to connect other diseases with metabolic reprogramming. This article aims to argue that metabolic reprogramming is not driven by disease but instead is the main hallmark of metabolism, based on its dynamic behavior that allows it to continuously adapt to changes in the internal and external conditions.

High‐precision tumor targeting with conventional therapeutics is based on the concept of the ideal drug as a “magic bullet”; this became possible after techniques were developed for production of monoclonal antibodies (mAbs). Innovative DNA technologies have revolutionized this area and enhanced clinical efficiency of mAbs. The experience of applying small‐size recombinant antibodies (monovalent binding fragments and their derivatives) to cancer targeting showed that even high‐affinity monovalent interactions provide fast blood clearance but only modest retention time on the target antigen. Conversion (...) of recombinant antibodies into multivalent format increases their functional affinity, decreases dissociation rates for cell‐surface and optimizes biodistribution. In addition, it allows the creation of bispecific antibody molecules that can target two different antigens simultaneously and do not exist in nature. Different multimerization strategies used now in antibody engineering make it possible to optimize biodistribution and tumor targeting of recombinant antibody constructs for cancer diagnostics and therapy. BioEssays 30:904–918, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Classically, the question of recognizing another subject is posed unilaterally, in terms of the observed behaviour of the other entity. Here, we propose an alternative, based on the emergent patterns of activity resulting from the interaction of both partners. We employ a minimalist device which forces the subjects to externalize their perceptual activity as trajectories which can be observed and recorded; the results show that subjects do identify the situation of perceptual crossing with their partner. The interpretation of the results (...) is guided by comparable evolutionary robotics simulations. There are two components to subjects’ recognition capacities: distinguishing mobile and fixed entities; and behaving so as to interact with their partner rather than with a mobile lure. The “Other” is characterized by the feature that there is sufficient regularity in the interactions to encourage the formation of anticipations; but sufficient indetermination that the actual behaviour is consistently surprising. Keywords: Recognition of other; perceptual crossing; evolutionary robotics. (shrink)

Classically, the question of recognizing another subject is posed unilaterally, in terms of the observed behaviour of the other entity. Here, we propose an alternative, based on the emergent patterns of activity resulting from the interaction of both partners. We employ a minimalist device which forces the subjects to externalize their perceptual activity as trajectories which can be observed and recorded; the results show that subjects do identify the situation of perceptual crossing with their partner. The interpretation of the results (...) is guided by comparable evolutionary robotics simulations. There are two components to subjects’ recognition capacities: distinguishing mobile and fixed entities; and behaving so as to interact with their partner rather than with a mobile lure. The “Other” is characterized by the feature that there is sufficient regularity in the interactions to encourage the formation of anticipations; but sufficient indetermination that the actual behaviour is consistently surprising. Keywords: Recognition of other; perceptual crossing; evolutionary robotics. (shrink)

Stuart M. Shieber’s name is well known to computational linguists for his research and to computer scientists more generally for his debate on the Loebner Turing Test competition, which appeared a decade earlier in Communications of the ACM. 1 With this collection, I expect it to become equally well known to philosophers.

Some people live to work, others work to live, while still others prefer to live lives of leisure. Since the Puritans, American culture and literature have been dominated by individuals who have valued hard work. However, shortly after its founding, America managed to produce the leisurely Rip Van Winkle, who, over time, has been followed by kindred spirits such as, for instance, Walt Whitman, Henry David Thoreau, Twain’s Huck Finn, Melville’s Bartleby, Jack Kerouac, Diane di Prima, the Hippies, and Christopher (...) McCandless. With the rise of the Indie Film movement of the 1990s, so came the rise of the slacker film. Films such as Slacker, Singles, Wayne’s World, Reality Bites, Clerks, Kicking and Screaming, Mallrats, Chasing Amy, The Big Lebowski, and Office Space filled theatres over the decade with characters who take an unorthodox view of work and stress the importance of leisure in life. This essay discusses two slacker films, Richard Linklater’s Slacker and Kevin Smith’s Clerks, which defined the slacker phenomenon in the 1990s and constituted two important landmarks in American independent film. While many of us may find the slacker pathetic and annoying, this essay argues that there is much value to be found in this healthy counterculture. By offering their perspectives on issues such as the Puritan work ethic, work-incited self-importance, leisure versus idleness and human relationships, Linklater and Smith join the preceding generations of slackers, providing a much needed balance to the American obsession with work and success. (shrink)

Transitive inference (TI) plays a part in many aspects of reasoning, and is usually assessed using variants on a particular task dubbed the “IP-paradigm”. Advocates of this paradigm assume it ensures that subjects must use deduction to solve the inferential questions. The present task with 63 adults strengthened this claim by removing all possible perceptual cues and limiting as far as possible all cues from the training procedure itself. Response speed and accuracy were measured as premises were learned. Findings show (...) that when over-training and non-logical cues are avoided, adults nevertheless reach high levels of overall performance. However, key indexes of Lexical Marking, Relative-End-Anchoring, and Symbolic Distance are largely absent or in the opposite direction to the generally accepted view at the start of training, and are present only for response time (RT) at the end of training. The widely accepted strategy of retrieval from an integrated mental representation does emerge; but only after an initial associative process and a deductive process. Regarding three comparisons critical for demonstrating deductive TI, the inference was more demanding than its antecedents both in terms of accuracy and RT, and both after initial and final training. Existing theories of TI account for some of these findings, but what is required is a theory accommodating them all. (shrink)

Stuart M. Shieber’s name is well known to computational linguists for his research and to computer scientists more generally for his debate on the Loebner Turing Test competition, which appeared a decade earlier in Communications of the ACM. 1 With this collection, I expect it to become equally well known to philosophers.

A hallmark of recent critical social science has been the commitment to methodological and theoretical pluralism. Habermas and others have argued that diverse theoretical and empirical approaches are needed to support informed social criticism. However, an unresolved tension remains in the epistemology of critical social science: the tension between the epistemic advantages of a single comprehensive theoretical framework and those of methodological and theoretical pluralism. By shifting the grounds of the debate in a way suggested by Dewey's pragmatism, the author (...) argues that a thoroughgoing pluralism strengthens, rather than weakens, both the social scientific and political aims of critical social science. Not only does pragmatism offer a plausible interpretation of the epistemic pluralism of the social sciences, but it also provides a way of thinking about their fundamentally practical and political character. With a better normative vocabulary with which to discuss the epistemological issues of such a pluralistic mode of inquiry, the democratic role of critical inquiry and its specifically practical form of verification can be clarified. (shrink)

A hallmark of Confucian morality is its emphasis on duties to family and kin as weighty features of moral life. The virtue of ‘filiality’ or ‘filial piety’ (xiao 孝), for example, is one of the most important in the Confucian canon. This aspect of Confucianism has been of renewed interest recently. On the one hand, some have claimed that, precisely because it acknowledges the importance of kin duties, Confucianism should be seen as an ethics rooted in human nature that remains (...) a viable system of morality today. On the other hand, some have argued that the extreme emphasis on filial duties is precisely the aspect of Confucian moral philosophy that ought to be jettisoned in favor of greater impartialism; without mitigating its emphasis on filial piety, Confucianism risks irrelevance to modern concerns. In this paper, I will outline the nature of filial morality in the Confucian tradition and discuss these recent contributions to the literature. (shrink)

The hallmark of the deductive systems known as ‘conceptivist’ or ‘containment’ logics is that for all theorems of the form , all atomic formulae appearing in also appear in . Significantly, as a consequence, the principle of Addition fails. While often billed as a formalisation of Kantian analytic judgements, once semantics were discovered for these systems, the approach was largely discounted as merely the imposition of a syntactic filter on unrelated systems. In this paper, we examine a number of prima (...) facie unrelated deductive contexts in which Addition fails and attempt to harmonise them by developing a computational interpretation of conceptivist logics. (shrink)

The hallmark of modern liberalism is its embrace of the Millian harm principle and its antipathy to legal moralism. In this article I consider whether aesthetic regulations can be justified under the harm principle as that principle has been elaborated by Joel Feinberg. I conclude that aesthetic and other regulations that most liberals regard as unproblematic are actually instances of legal moralism.

A hallmark of skilled motor performance is behavioral flexibility – i.e., experts can not only produce a movement pattern to reliably achieve a given task goal, but also possess the ability to change that movement pattern to fit a new context. In this perspective article, we briefly highlight the factors that are critical to understanding behavioral flexibility, and its connection to movement variability, stability, and learning. We then address how practice strategies should be developed from a motor learning standpoint to (...) enhance behavioral flexibility. Finally, we highlight some important future avenues of work that are needed to advance our understanding of behavioral flexibility. We use examples from sport as a context to highlight these issues, especially in regard to elite performance and development. (shrink)

A hallmark of ecological research is dealing with complexity in the systems under investigation. One strategy is to diminish this complexity by constructing models and theories that are general. Alternatively, ecologists can constrain the scope of their generalizations to particular phenomena or types of systems. However, research employing the second strategy is often met with scathing criticism. I offer a theoretical argument in support of moderate generalizations in ecological research, based on the notions of interdependence and causal heterogeneity and their (...) effect on the trade-off between generality and realism. (shrink)

A hallmark of the war on terror is the use of unmanned aerial vehicles, commonly known as drones, to kill terrorists abroad. I argue that the justification for targeted killing is based on the same logic as the justification for killing the Naked Soldier in traditional wars. Since many drone strikes are personal strikes—the targeted killing of known individuals—this seems like a more justifiable attack than one against anonymous soldiers. Yet, I propose there are three problems to this analogy that (...) makes killing the Naked Terrorist—one unaware of the danger he is in—worse than killing the Naked Soldier: First, there is the epistemological problem regarding knowing with some certainty that the targets are indeed terrorists. Second, terrorists do not seem to pose a great enough danger for the necessity claim. Lastly, drones may not be as precise as the US claims they are. (shrink)

A hallmark of Christian mysticism is negative theology, which refers to the school of thought that gives prominence to negation in reference to God. By denying the possibility to name God, negative theology cuts at the very root of our cognitive makeup--the human impulse to name and put things into categories--and thereby situates us "halfway between a 'no longer' and a 'not yet'" , a temporality in which "the past is negated, but...the present is not yet formulated" . The affective (...) corollary of this "no longer" and "not yet" state is the "dark night of the soul" that mystics are known to have bouts of. One particular variant of the "dark night of the soul" is awe, which will be the focus of this paper. My investigation starts with an introduction to the two primary themes of negative theology--negativity and self-reflexivity, followed by a critique of D. Keltner and J. Haidt's model of awe, which is compared with R. Otto's phenomenology of mysticism in general and religious awe in particular. In the concluding section, I examine the relevance of religious awe to contemporary life on the one hand, and to emotion research on the other. 2012 APA, all rights reserved). (shrink)

A hallmark of correspondence theories of truth is the principle that sentences are made true by some truth-makers. A well-known objection to treating Tarski’s definition of truth as a correspondence theory has been put forward by Donald Davidson. He argued that Tarski’s approach does not relate sentences to any entities (like facts) to which true sentences might correspond. From the historical viewpoint, it is interesting to observe that Tarski’s philosophical teacher Tadeusz Kotarbinski advocated an ontological doctrine of reism which accepted (...) only concrete individuals and rejected all such abstract entities as facts, states of affairs, properties, and sets. Kotarbinski’s physicalism influenced Tarski who also avoided concepts like “fact” and “property” in his theory of truth, but—unlike Kotarbinski—he used freely set-theoretical terminology. In his mature work in model theory in the 1950s, Tarski used systematically the notion of a relational system (i.e., a domain of objects with designated elements, subsets, and relations). Wilfrid Hodges has argued that the notions of “structure” and “truth in a structure” appeared in Tarski’s work only in 1950. In my view, one can find the main ingredients of the model-theoretic account of truth already in the 1930s. These considerations suggest, against Davidson, that Tarski’s definition presupposes that material truth is always related to some kind of truth-maker. Further, facts as truth-makers can be reconstructed by employing the resources of model theory. (shrink)

The hallmark of implicit learning is that complex knowledge can be acquired unconsciously. The second order conditionals of Reed and Johnson were developed to be complex, and they are popular materials for implicit learning research. Recently, it was demonstrated that in a sequence made noisy , shared features of the SOCs may be learned explicitly . What are these shared features? We hypothesized that low reversal frequency may play a significant role. We have varied reversal frequency, and discovered that reversal (...) frequency affected response times, inclusion exclusion behavior, and recognition ratings. Not only does it appear to be important to distinguish implicit and explicit knowledge, but also to distinguish what the knowledge is of. (shrink)

It is a hallmark of a good model to make accurate a priori predictions to new conditions (Busemeyer & Wang, 2000). This study compared 8 decision learning models with respect to their generalizability. Participants performed 2 tasks (the Iowa Gambling Task and the Soochow Gambling Task), and each model made a priori predictions by estimating the parameters for each participant from 1 task and using those same parameters to predict on the other task. Three methods were used to evaluate the (...) models at the individual level of analysis. The first method used a post hoc fit criterion, the second method used a generalization criterion for short‐term predictions, and the third method again used a generalization criterion for long‐term predictions. The results suggest that the models with the prospect utility function can make generalizable predictions to new conditions, and different learning models are needed for making short‐versus long‐term predictions on simple gambling tasks. (shrink)

A hallmark of Western culture is a massive moral confusion, rendering the very idea of virtue "exotic and incomprehensible." McInerny here drags the conversation back to the beginning, establishing the terms and the tools of what it means to think and to do what is moral. As he asserts, the virtuous life and the moral life are one and the same. To be moral is to be good, and the goodness of one's acts reflects the fundamentals of thought placed in (...) the service of a pursuit of a virtuous life. Why is the concept of a virtuous life so foreign to many? We do not know the basics of a moral life. As McInerny states, "To be good we have to know what that means." The two biggest judgments one will make during life pertain to knowing what is good, what is bad, and the difference between the two. This bleeds into a study of morality and ethics when it pertains to concrete acts, but in reality all aspects of our lives bear on these judgments. "Being ethical is not simply a state of mind, it is a state of being, a way of living one's life that reflects the fundamental principles of ethics [...] [it is one] who lives in a certain way." Nevertheless, the subject of this book focuses on ethics--namely, the goodness or badness of human acts. McInerny's great reason for writing this work is to teach the reader that he or she cannot properly tackle ethical questions (even if they are not identified as such) if one is not himself or herself actually ethical (living virtuously). Writing very much as a teacher of teachers, McInerny relies on the foundations of Aristotle and Thomas Aquinas, as well as his late brother, Ralph McInerny, to reiterate the principles of ethics that inform both thought and act. To speak of ethics, then, is to admit a commitment to virtue and how the theoretical distinction of good and bad is necessarily practical. Acting well will lead to thinking better, but McInerny notes that culture has lost sight of the former and thereby the coherency to address ethical questions. Being Ethical aims to correct this disconnect in forty-eight cogent lessons. Being Ethical is fundamentally intended to serve as a sequel to D. Q. McInerny's Being Logical (Random House, 2004), which has remained in print and has been translated into six languages. Its style lends itself to being used as a textbook in liberal studies. More generally, it is a refreshing presentation of this topic and timely and timeless exhortation to readers of the necessity of a love of virtue for ethical thought. For friends and students of Aristotle, Thomas Aquinas and Ralph McInerny, this book bears a style and manner that is both familiar and much loved. (shrink)

: A hallmark of Dogen's legacy is his introduction of Chinese Ch'an koan literature to Japan in the first half of the thirteenth century and his unique and innovative style of interpreting dozens of koan cases, many of which are relatively obscure or otherwise untreated in the annals. What constitutes the distinctiveness of Dogen's approach? According to Hee-Jin Kim's seminal study, Dogen shifts from an instrumental to a realizational model of koan interpretation. While this essay agrees with some features of (...) Kim's approach, especially his emphasis on the importance of language, it is argued that Kim overlooks the diversity of aims and intentions in Dogen's use of rhetorical and narrative strategies to highlight diverse doctrinal and ritual themes. There is no single underlying view of koans for Dogen, who continually modifies his interpretive approach to particular cases in order to articulate specific themes. (shrink)

A hallmark of positive‐sense RNA viruses is the formation of membranous shelters for safe replication in the cytoplasm. Once considered invisible to the immune system, these viral shelters are now found to be antagonized through the cooperation of autophagy proteins and anti‐microbial GTPases. This coordinated effort of autophagy proteins guiding GTPases functions against not only the shelters of viruses but also cytoplasmic vacuoles containing bacteria or protozoa, suggesting a broad immune‐defense mechanism against disparate vacuolar pathogens. Fundamental questions regarding this process (...) remain: how the host recognizes these membranous structures as a target, how the autophagy proteins bring the GTPases to the shelters, and how the recruited GTPases disrupt these shelters. In this review, these questions are discussed, the answers to which will significantly advance our understanding of the response to vacuole‐like structures of pathogens, thereby paving the way for the development of broadly effective anti‐microbial strategies for public health. (shrink)

A hallmark of intelligent behavior is rationality – the disposition and ability to think analytically to make decisions that maximize expected utility or follow the laws of probability. However, the question remains as to whether rationality and intelligence are empirically distinct, as does the question of what cognitive mechanisms underlie individual differences in rationality. In a sample of 331 participants, we assessed the relationship between rationality and intelligence. There was a common ability underpinning performance on some, but not all, rationality (...) tests. Latent factors representing rationality and general intelligence were strongly correlated (r =.54), but their correlation fell well short of unity. Rationality correlated significantly with fluid intelligence (r =.56), working memory capacity (r =.44), and attention control (r =.49). Attention control fully accounted for the relationship between working memory capacity and rationality, and partially accounted for the relationship between fluid intelligence and rationality. We conclude by speculating about factors rationality tests may tap that other cognitive ability tests miss, and outline directions for further research. (shrink)

One of the hallmarks of virtue is reliably acting well. Such reliable success presupposes that an agent is able to recognize the morally salient features of a situation, and the appropriate response to those features and is motivated to act on this knowledge without internal conflict. Furthermore, it is often claimed that the virtuous person can do this in a spontaneous or intuitive manner. While these claims represent an ideal of what it is to have a virtue, it is (...) less clear how to make good on them. That is, how is it actually possible to spontaneously and reliably act well? In this paper, we will lay out a framework for understanding how it is that one could reliably act well in an intuitive manner. We will do this by developing the concept of an action schema, which draws on the philosophical and psychological literature on skill acquisition and self-regulation. In short, we will give an account of how self-regulation, grounded in skillful structures, can allow for the accurate intuitions and flexible expertise required for virtue. While our primary goal in this paper is to provide a positive theory of how virtuous intuitions might be accounted for, we also take ourselves to be raising the bar for what counts as an explanation of reliable and intuitive action in general. (shrink)

It is a hallmark of the Frankfurt School tradition of critical theory that it has consistently made philosophical reflection a central component of its overall project. Indeed, the core identity that this tradition has been able to maintain arguably stems from the fact that a number of key philosophical assumptions have been shared by the generations of thinkers involved in it. These assumptions form a basic ‘philosophical matrix’, whose main aim is to allow for a ‘critique of reason’, the heart (...) of the critique of modern society, which emphasises the collective, historically situated and naturalistically grounded nature of rationality. In this matrix, Feuerbach's place has been only a minor one. This paper aims to show that there is more to be retrieved from Feuerbach for critical theory than at first meets the eye. The first section identifies key conceptual features that are shared by the central authors of the Frankfurt School. They signal a collectivist and materialist shift from Kant to Marx via Hege.. (shrink)

One of the hallmark themes of Karl Popper’s approach to the social sciences was the insistence that when social scientists are members of the society they study, then they are liable to affect that society. In particular, they are liable to affect it in such a way that the claims they make lose their validity. “The interaction between the scientist’s pronouncements and social life almost invariably creates situations in which we have not only to consider the truth of such pronouncements, (...) but also their actual influence on future developments. The social scientist may be striving to find the truth; but, at the same time, he must always be exerting a definite influence upon society. The very fact that his pronouncements do exert an influence destroys their objectivity.” (Popper 1963. (shrink)

Ethical conduct is the hallmark of excellence in engineering and scientific research, design, and practice. While undergraduate and graduate programs in these areas routinely emphasize ethical conduct, few receive formal ethics training as part of their curricula. The first purpose of this research study was to assess the relative effectiveness of ethics education in enhancing individuals’ general knowledge of the responsible conduct of research practices and their level of moral reasoning. Secondly, we examined the effects of ethics education on the (...) positive psychological outcomes of perspective-taking, moral efficacy, moral courage, and moral meaningfulness. To examine our research hypotheses, we utilized a pretest–posttest quasi-experimental design consisting of three ethics education groups (control, embedded modules, and stand-alone courses). Findings revealed that both embedded and stand alone courses were effective in enhancing participants’ perspective-taking, moral efficacy, and moral courage. Moral meaningfulness was marginally enhanced for the embedded module condition. Moral judgment and knowledge of responsible conduct of research practices were not influenced by either ethics education condition. Contrary to expectations, stand alone courses were not superior to embedded modules in influencing the positive psychological outcomes investigated. Implications of these findings for future research and practice are discussed. (shrink)

A hallmark of good antenatal care is to respect prospective parent’s choices and provide information in a way that encourages their autonomy and informed decision making. In this paper, we analyse the meaning of autonomous and informed decision making from the theoretical perspective and attempt to show how those concepts are described among prospective parents in early pregnancy and in the public media in a society where NT screening is almost a norm. We use interviews with Icelandic prospective parents in (...) early pregnancy (N = 40) and material covering the discourse around prenatal screening in the media over 5 years period. Our analysis indicates that both prospective parents and the public media include ethical terms in their rhetoric around prenatal screening although those concepts differ in their expression. We conclude that the context in which these decisions are taken does not encourage moral reflection. Prospective parents describe that there is a lack of dialogue with professionals when decisions are made about screening. With routine offer of screening the conceptualization of bioethical concepts finds its own way through a mainstream discourse which has limited connections to the theoretical notions. This has been neglected in the implementation of screening, as limited effort has been subject to audit with reference to explore how the offer of screening and informed choice is experienced among prospective parents. (shrink)

Self-reflection, as the hallmark of the modern age, originates more profoundly with Dante than with Descartes. This book rewrites modern intellectual history, taking Dante’s lyrical language in Paradiso as enacting a Trinitarian self-reflexivity that gives a theological spin to the birth of the modern subject already with the Troubadours. Dante’s thought and work indicate an alternative modernity along the path not taken. This alternative shows up in Nicholas of Cusa’s conjectural science and in Giambattista Vico’s new science of imagination as (...) alternatives to positive empirical science. (shrink)

Productivity—the hallmark of linguistic competence—is typically attributed to algebraic rules that support broad generalizations. Past research on spoken language has documented such generalizations in both adults and infants. But whether algebraic rules form part of the linguistic competence of signers remains unknown. To address this question, here we gauge the generalization afforded by American Sign Language (ASL). As a case study, we examine reduplication (X→XX)—a rule that, inter alia, generates ASL nouns from verbs. If signers encode this rule, then they (...) should freely extend it to novel syllables, including ones with features that are unattested in ASL. And since reduplicated disyllables are preferred in ASL, such rule should favor novel reduplicated signs. Novel reduplicated signs should thus be preferred to nonreduplicative controls (in rating), and consequently, such stimuli should also be harder to classify as nonsigns (in the lexical decision task). The results of four experiments support this prediction. These findings suggest that the phonological knowledge of signers includes powerful algebraic rules. The convergence between these conclusions and previous evidence for phonological rules in spoken language suggests that the architecture of the phonological mind is partly amodal. (shrink)

Inequity has been a hallmark of the COVID-19 pandemic in the United States, especially in the sharply disproportionate impacts among people of color. Recent studies have confirmed that t...

What is the hallmark of success in human–agent interaction? In animation and robotics, many have concentrated on the looks of the agent — whether the appearance is realistic or lifelike. We present an alternative benchmark that lies in the dyad and not the agent alone: Does the agent’s behavior evoke intersubjectivity from the user? That is, in both conscious and unconscious communication, do users react to behaviorally realistic agents in the same way they react to other humans? Do users appear (...) to attribute similar thoughts and actions? We discuss why we distinguish between appearance and behavior, why we use the benchmark of intersubjectivity, our methodology for applying this benchmark to embodied conversational agents, and why we believe this benchmark should be applied to human–robot interaction. (shrink)

Failure of substitutivity of coreferential terms, one of the hallmarks of referential opacity, is standardly explained in terms of the presence of an expression (such as a verb of propositional attitude, a modal adverb or quotation marks) with opacity-inducing properties. It is thus assumed that any term in a complex expression for which substitutivity fails will be within the scope of an expression of one of these types, and that where there is an expression of one of these types (...) there will be failure of substitutivity for terms within its scope. I shall discuss a series of examples that have been thought to challenge this explanation by exhibiting failure of substitutivity of coreferential terms for positions not within the scope of any of the standard opacity-inducing expressions. If these examples are genuine, then the usual explanations of opacity are either incomplete – because there are sources of opacity other than those standardly identified, or completely mistaken – because the standardly identified expressions are not causes of opacity. I will argue, however, that the examples only exhibit failure of substitutivity of non-coreferential terms, and, hence, do not present a challenge to standard explanations of opacity. (shrink)

One of the hallmarks of Descartes' philosophy is the doctrine that the human mind has a faculty of pure intellect. This doctrine is so central to Descartes' teaching that it is difficult to believe that any of his disciplines would abandon it. Yet this is what happened in the case of Malebranche. This paper argues that in his later philosophy Malebranche adopted a theory of divine illumination which leaves no room for a Cartesian doctrine of pure intellect. It is (...) further argued that Malebranche's abandonment of the Cartesian doctrine left a void in his philosophy which he filled with the theory of efficacious ideas. (shrink)

Major hallmarks of Alzheimer's disease include brain deposition of the amyloid-beta peptide , which is proteolytically cleaved from a large Abeta precursor protein by beta and gamma- secretases. A transmembrane aspartyl protease, beta-APP cleaving enzyme , has been recognized as the beta-secretase. We review the structure and function of the BACE1 protein, and of 4129 bp of the 5'-flanking region sequence of the BACE1 gene and its interaction with various transcription factors involved in cell signaling. The promoter region and (...) 5'-untranslated region contain multiple transcription factor binding sites, such as AP-1, CREB and MEF2. A 91 bp fragment is the shortest region with significant reporter gene activity and constitutes the minimal promoter element for BACE1. The BACE1 promoter contains six unique functional domains and three structural domains of increasing sequence complexity as the "ATG" start codon is approached. Notably, the BACE1 gene promoter contains basal regulatory elements, inducible features and sites for regulation by various important transcription factors. Herein, we also discuss and speculate how the interaction of these transcription factors with the BACE1 promoter can modulate synaptic plasticity, neuronal apoptosis and oxidative stress, which are pertinent to the pathogenesis and progression of AD. (shrink)

Anti-representationalism is the hallmark of Richard Rorty's critique of the epistemological tradition. According to it, knowledge does not "mirror" reality and the human mind is not a representational device. Anti-representationalism is a family of philosophical theses, respectively dealing with the notion of "representation" in different ways. Though prima facie one may feel entitled to think about anti-representationalism as a kind of uniform philosophical movement, things stand quite differently. In fact, among many anti-representationalist options, we can identify two main versions: a (...) global anti-representationalism that entirely rejects the philosophical uses of the notion of "representation", and a local version that just removes the notion of "representation" from the explanatory toolbox. In this chapter I try to compare Rorty's global anti-representationalism and Robert Brandom's local version, exploiting a recent discussion by Brandom and a famous exchange between Rorty and Bjørn Ramberg about Donald Davidson's take on the special role of the intentional vocabulary. (shrink)

For most of the history of prejudice research, negativity has been treated as its emotional and cognitive signature, a conception that continues to dominate work on the topic. By this definition, prejudice occurs when we dislike or derogate members of other groups. Recent research, however, has highlighted the need for a more nuanced and “inclusive” (Eagly 2004) perspective on the role of intergroup emotions and beliefs in sustaining discrimination. On the one hand, several independent lines of research have shown that (...) unequal intergroup relations are often marked by attitudinal complexity, with positive responses such as affection and admiration mingling with negative responses such as contempt and resentment. Simple antipathy is the exception rather than the rule. On the other hand, there is mounting evidence that nurturing bonds of affection between the advantaged and the disadvantaged sometimes entrenches rather than disrupts wider patterns of discrimination. Notably, prejudice reduction interventions may have ironic effects on the political attitudes of the historically disadvantaged, decreasing their perceptions of injustice and willingness to engage in collective action to transform social inequalities.These developments raise a number of important questions. Has the time come to challenge the assumption that negative evaluations are inevitably the cognitive and affective hallmarks of discrimination? Is the orthodox concept of prejudice in danger of side-tracking, if not obstructing, progress towards social justice in a fuller sense? What are the prospects for reconciling a prejudice reduction model of change, designed to get people to like one another more, with a collective action model of change, designed to ignite struggles to achieve intergroup equality? (shrink)