Although the principle of fair subject selection is a widely recognized requirement of ethical clinical research, it often yields conflicting imperatives, thus raising major ethical dilemmas regarding participant selection. In this paper, we diagnose the source of this problem, arguing that the principle of fair subject selection is best understood as a bundle of four distinct sub-principles, each with normative force and each yielding distinct imperatives: (1) fair inclusion; (2) fair burden sharing; (3) fair opportunity; and (4) fair distribution of (...) third-party risks. We first map out these distinct sub-principles, and then identify the ways in which they yield conflicting imperatives for the design of inclusion and exclusion criteria, and the recruitment of participants. We then offer guidance for how decision makers should navigate these conflicting imperatives to ensure that participants are selected fairly. (shrink)

I give an overview of the trust literature and then of six central issues concerning epistemic trust. The survey of trust zeroes in on the kinds of expectations that trust involves, trust’s characteristic psychology, and what makes trust rational. The discussion of epistemic trust focuses on its role in testimony, the epistemic goods that we trust for, the significance of epistemic trust in contrast to reliance, what makes epistemic trust rational, and epistemic self-trust.

Appeals to intersectionality serve to remind us that social categories like race and gender cannot be adequately understood independently from each other. But what, exactly, is the intersectional thesis a thesis about? Answers to this question are remarkably diverse. Intersectionality is variously understood as a claim about the nature of social kinds, oppression, or experience ; about the limits of antidiscrimination law or identity politics ; or about the importance of fuzzy sets, multifactor analysis, or causal modeling in social science.

Scientific researchers welcome disagreement as a way of furthering epistemic aims. Religious communities, by contrast, tend to regard it as a potential threat to their beliefs. But I argue that religious disagreement can help achieve religious epistemic aims. I do not argue this by comparing science and religion, however. For scientific hypotheses are ideally held with a scholarly neutrality, and my aim is to persuade those who arecommittedto religious beliefs that religious disagreement can be epistemically beneficial for them too.

Resolving religious disagreements is difficult, for beliefs about religion tend to come with strong biases against other views and the people who hold them. Evidence can help, but there is no agreed-upon policy for weighting it, and moreover bias affects the content of our evidence itself. Another complicating factor is that some biases are reliable and others unreliable. What we need is an evidence-weighting policy geared toward negotiating the effects of bias. I consider three evidence-weighting policies in the philosophy of (...) religion and advocate one of them as the best for promoting the resolution of religious disagreements. (shrink)

Identity politics has been critiqued in various ways. One central problem—the Reinforcement Problem—claims that identity politics reinforces groups rooted in oppression thereby undermining its own liberatory aims. Here I consider two versions of the problem—one psychological and one metaphysical. I defang the first by drawing on work in social psychology. I then argue that careful consideration of the metaphysics of social groups and of the practice of identity politics provides resources to dissolve the second version. Identity politics involves the creation (...) or transformation of groups in ways that do not succumb to the metaphysical Reinforcement Problem. (shrink)

Cooperation has been analyzed primarily in the context of theories of collective intentionality. These discussions have primarily focused on interactions between pairs or small groups of agents who know one another personally. Cooperative game theory has also been used to argue for a form of cooperation in large unorganized groups. Here I consider a form of minimal cooperation that can arise among members of potentially large organized groups (e.g., corporate teams, committees, governmental bodies). I argue that members of organized groups (...) can be minimally cooperative in virtue of playing roles in an organizational structure and having a common goal. The minimal form of cooperation I argue for is not grounded in collective intentions involving symmetric mental states, special collective intentional modes, or joint commitments. More generally, I show how considering minimal cooperation in the context of organized groups provides an opportunity to reevaluate the extent to which the social world and social phenomena depend on internalist mental factors (e.g., intentions, beliefs) and externalist non-mental factors (e.g., documents, laws, job descriptions). The view of minimal cooperation among members of organized groups I offer provides support for an externalist rather than internalist theory of at least one social phenomenon. (shrink)

This paper argues that in Christian Wolff’s theory of knowledge, logical regimentation does not take the place of experiential justification, but serves to facilitate the application of empirical information and clearly exhibit its warrant. My argument targets rationalistic interpretations such as R. Lanier Anderson’s. It is common ground in this dispute that making concepts “distinct” issues in the premises on which all deductive justification rests. Against the view that concepts are made distinct only by analysis, which is carried out by (...) the understanding independently of experience, I contend that for Wolff some distinct concepts are arrived at through experience. I emphasize that Wolff countenances empirical methods of obtaining distinct concepts even in mathematics. This striking feature of his view indicates how its empiricist elements can be reconciled with his injunction to follow “mathematical” method. (shrink)

Findings from the cognitive sciences suggest that the cognitive mechanisms responsible for some memory errors are adaptive, bringing benefits to the organism. In this paper we argue that the same cognitive mechanisms also bring a suite of significant epistemic benefits, increasing the chance of an agent obtaining epistemic goods like true belief and knowledge. This result provides a significant challenge to the folk conception of memory beliefs that are false, according to which they are a sign of cognitive frailty, indicating (...) that a person is less reliable than others or their former self. Evidence of memory errors can undermine a person’s view of themselves as a competent epistemic agent, but we show that false memory beliefs can be the result of the ordinary operation of cognitive mechanisms found across the species, which bring substantial epistemic benefits. This challenge to the folk conception is not adequately captured by existing epistemological theories. However, it can be captured by the notion of epistemic innocence, which has previously been deployed to highlight how beliefs which have epistemic costs can also bring significant epistemic benefits. We therefore argue that the notion of epistemic innocence should be expanded so that it applies not just to beliefs but also to cognitive mechanisms. (shrink)

Religious communities often discourage disagreement with religious authorities, on the grounds that allowing it would be epistemically detrimental. I argue that this attitude is mistaken, because any social position in a community—including religious authority—comes with epistemic advantages as well as epistemic limitations. I argue that religious communities stand to benefit epistemically by engaging in disagreement with people occupying other social positions. I focus on those at the community’s margins and argue that religious marginalization is apt to yield religiously important insights; (...) so their disagreement with religious authorities should be encouraged. (shrink)

People are described as suffering from impostor syndrome when they feel that their external markers of success are unwarranted, and fear being revealed as a fraud. Impostor syndrome is commonly framed as a troubling individual pathology, to be overcome through self-help strategies or therapy. But in many situations an individual’s impostor attitudes can be epistemically justified, even if they are factually mistaken: hostile social environments can create epistemic obstacles to self-knowledge. The concept of impostor syndrome prevalent in popular culture needs (...) greater critical scrutiny, as does its source, the concept of impostor phenomenon which features in psychological research. (shrink)

Faith is often regarded as having a fraught relationship with evidence. Lara Buchak even argues that it entails foregoing evidence, at least when this evidence would influence your decision to act on the proposition in which you have faith. I present a counterexample inspired by the book of Job, in which seeking evidence for the sake of deciding whether to worship God is not only compatible with faith, but is in fact an expression of great faith. One might still think (...) that foregoing evidence may make faith more praiseworthy than otherwise. But I argue against this claim too, once more drawing on Job. A faith that expresses itself by a search for evidence can be more praiseworthy than a faith that sits passively in the face of epistemic adversity. (shrink)

The ethics of autonomous vehicles has received a great amount of attention in recent years, specifically in regard to their decisional policies in accident situations in which human harm is a likely consequence. Starting from the assumption that human harm is unavoidable, many authors have developed differing accounts of what morality requires in these situations. In this article, a strategy for AV decision-making is proposed, the Ethical Valence Theory, which paints AV decision-making as a type of claim mitigation: different road (...) users hold different moral claims on the vehicle’s behavior, and the vehicle must mitigate these claims as it makes decisions about its environment. Using the context of autonomous vehicles, the harm produced by an action and the uncertainties connected to it are quantified and accounted for through deliberation, resulting in an ethical implementation coherent with reality. The goal of this approach is not to define how moral theory requires vehicles to behave, but rather to provide a computational approach that is flexible enough to accommodate a number of ‘moral positions’ concerning what morality demands and what road users may expect, offering an evaluation tool for the social acceptability of an autonomous vehicle’s ethical decision making. (shrink)

In a fallen world fraught with evidence against religious beliefs, it is tempting to think that, on the assumption that those beliefs are true, the best way to protect them is to hold them dogmatically. Dogmatic belief, which is highly confident and resistant to counterevidence, may fail to exhibit epistemic virtues such as humility and may instead manifest epistemic vices such as arrogance or servility, but if this is the price of secure belief in religious truths, so be it. I (...) argue, however, that even in a world full of misleading evidence against true religious beliefs, cultivating epistemic humility is the better way to achieve believers’ epistemic aims. The reason is that dogmatic belief courts certain epistemic dangers, including to the true religious beliefs themselves, whereas epistemic humility empowers believers to counter them. (shrink)

If we are sympathetic to the project of naturalising metaphysics, how should we approach the metaphysics of the social world? What role can the social sciences play in metaphysical investigation? In the light of these questions, this paper examines three possible approaches to social metaphysics: inference to the best explanation from current social science, conceptual analysis, and Haslanger-inspired ameliorative projects.

Trust is fundamental to epistemology. It features as theoretical bedrock in a broad cross-section of areas including social epistemology, the epistemology of self-trust, feminist epistemology, and the philosophy of science. Yet epistemology has seen little systematic conversation with the rich literature on trust itself. This volume aims to promote and shape this conversation. It encourages epistemologists of all stripes to dig deeper into the fundamental epistemic roles played by trust, and it encourages philosophers of trust to explore the epistemological upshots (...) and applications of their theories. The contributors explore such issues as the risks and necessity of trusting others for information, the value of doing so as opposed to relying on oneself, the mechanisms underlying trust’s strange ability to deliver knowledge, whether depending on others for information is compatible with epistemic responsibility, whether self-trust is an intellectual virtue, and the intimate relationship between epistemic trust and social power. (shrink)

Some religious communities argue that public policy is best decided by their own members, on the grounds that collaborating with those reasoning from secular or “worldly” perspectives will only foment error about how society should be run. But I argue that epistemology instead recommends fostering disagreement among a plurality of religious and secular worldviews. Inter-worldview disagreement over public policy can challenge our unquestioned assumptions, deliver evidence we would likely have missed, and expose us to new epistemic alternatives; when done respectfully, (...) it can also combat epistemically problematic biases and groupthink. I address two objections that members of a politically active religious community might raise: one that inter-worldview disagreement about public policy is not needed because one’s own beliefs are already true, and another that it is not needed because one’s own beliefforming processes are divinely guided. (shrink)

Many philosophers have attempted to provide a solution to the paradox of fiction, a triad of sentences that lead to the conclusion that genuine emotional responses to fiction are irrational. We suggest that disagreement over the best response to this paradox stems directly from the formulation of the paradox itself. Our main goal is to show that there is an ambiguity regarding the word ‘exist’ throughout the premises of the paradox. To reveal this ambiguity, we display the diverse existential commitments (...) of several leading theories of emotion, and argue that none of the theories we consider are committed to notions of ‘exist’ employed by the paradox. We conclude that it is unclear whether or not there remains a paradox of fiction to be solved—rather than to be argued for—once this ambiguity is addressed. (shrink)

Volume 20, Issue 3, March 2020, Page 27-29.

This paper proposes and defends the multifactorial view of stereotyping. According to this view, multiple factors determine whether or not any act of stereotyping increases the chance of an accurate judgment being made about an individual to whom the stereotype is applied. To support this conclusion, various features of acts of stereotyping that can determine the accuracy of stereotyping judgments are identified. The argument challenges two existing views that suggest that it is relatively easy for an act of stereotyping to (...) increase the chance of an accurate judgment being made. In the process, it shows why stereotyping that associates black people more strongly than white people with criminality in the United States cannot be defended, and actions to reduce the stereotyping criticized, on the basis that engaging in this form of stereotyping increases the chance of accurate judgments. As each of these important conclusions is supported by results from empirical psychology, the discussion exemplifies and vindicates the naturalistic approach to epistemology, according to which psychological findings provide an important contribution to understanding the epistemic standing of beliefs. (shrink)

In this paper, I utilise the tools of analytic philosophy to amalgamate mono-causal and multi-causal theories of disease. My aim is to better integrate viral and socio-economic explanations of AIDS in particular, and to consider how the perceived divide between mono-causal and multi-causal theories played a role in the tragedy of AIDS denialism in South Africa in the early 2000s. Currently, there is conceptual ambiguity surrounding the relationship between mono-causal and multi-causal theories in biomedicine and epidemiology. Mono-causal theories focus on (...) single, typically microbial, sources of illness and are most concerned with infectious diseases. By contrast, multi-causal theories allow for multiple factors to underpin a disease’s aetiology, including socio-economic and behavioural factors, and they usually focus on chronic non-communicable diseases. However, if these theories are taken to be strictly distinct, this prevents the inclusion of both microbial and socio-economic factors in a single explanation of any particular disease. This strict distinction became a problem when trying to explain the disproportionate prevalence of AIDS in southern Africa and ultimately contributed to the tragedy of AIDS denialism in South Africa. In tandem with viewing how the perceived divide between multi-causal and mono-causal theories underpinned AIDS denialism, I examine Thabo Mbeki’s specific role, while acknowledging that AIDS is being deprioritised on a broader international level. Overall, I will demonstrate that any long-term plan to eliminate AIDS will require viral and socio-economic factors to be considered simultaneously and that such a theoretical approach requires a clearer understanding of the underlying concepts of disease aetiology. (shrink)

Herein developmental psychological research complementary to Hutto's narrative practices hypothesis is considered. Specifically, I discuss experiential development from the perspective of first, second and third person in the acquisition of knowledge and the con-struction and comprehension of narratives, with relevance for theo-ries of 'theory of mind' and in particular tests of the child's understanding of false belief. I propose that the development of distinct third person belief states requires significant developmental work, which is advanced through social sharing of memory and (...) knowledge, by means of linguistic representations especially through narrative practices of different kinds, personal narratives and story telling. The final sections summarize the view that these developments are part of a broader expansion of consciousness that is evident in many aspects of cognitive change during the later preschool years. (shrink)

Perceptual grouping has traditionally been thought to be governed by innate, universal principles. However, recent work has found differences in Japanese and English speakers' non-linguistic perceptual grouping, implicating language in non-linguistic perceptual processes (Iversen, Patel, & Ohgushi, 2008). Two experiments test Japanese- and English-learning infants of 5-6 and 7-8 months of age to explore the development of grouping preferences. At 5-6 months, neither the Japanese nor the English infants revealed any systematic perceptual biases. However, by 7-8 months, the same age (...) as when linguistic phrasal grouping develops, infants developed non-linguistic grouping preferences consistent with their language's structure (and the grouping biases found in adulthood). These results reveal an early difference in non-linguistic perception between infants growing up in different language environments. The possibility that infants' linguistic phrasal grouping is bootstrapped by abstract perceptual principles is discussed. (shrink)

Robust technology infrastructure is needed to enable learning health care systems to improve quality, access, and cost. Such infrastructure relies on the trust and confidence of individuals to share their health data for healthcare and research. Few studies have addressed consumers’ views on electronic data sharing and fewer still have explored the dual purposes of healthcare and research together. The objective of the study is to explore factors that affect consumers’ willingness to share electronic health information for healthcare and research. (...) This study involved a random-digit dial telephone survey of 800 adult Californians conducted in English and Spanish. Logistic regression was performed using backward selection to test for significant associations of each explanatory variable with the outcome variable. The odds of consent for electronic data sharing for healthcare decreased as Likert scale ratings for EHR impact on privacy worsened, odds ratio = 0.74, 95% CI [0.60, 0.90]; security, OR = 0.80, 95% CI [0.66, 0.98]; and quality, OR = 0.59, 95% CI [0.46–0.75]. The odds of consent for sharing for research was greater for those who think EHR will improve research quality, OR = 11.26, 95% CI [4.13, 30.73]; those who value research benefit over privacy OR = 2.72, 95% CI [1.55, 4.78]; and those who value control over research benefit OR = 0.49, 95% CI [0.26, 0.94]. Consumers’ choices about electronically sharing health information are affected by their attitudes toward EHRs as well as beliefs about research benefit and individual control. Design of person-centered interventions utilizing electronically collected health information, and policies regarding data sharing should address these values of importance to people. Understanding of these perspectives is critical for leveraging health data to support learning health care systems. (shrink)

This paper reimagines the traditional problem of other minds. On a Cartesian view, the problem involves humans’ inability to perceive other persons’ minds. Similarly, Gilbert Ryle claims that we cannot directly access another’s mind. The paper’s rethinking of the problem of other minds moves beyond these questions of perceptibility and accessibility. It asks whether there are certain groups of people whose minds are systematically misinterpreted, or even denied mentality. It argues that there are. This claim builds off recent work in (...) philosophy and social psychology on epistemic injustice and the role of social categories in mental state attribution. The paper proposes the Problem of the Other’s Mind: the phenomenon of a (relatively) socially privileged person’s inability or lack of desire to understand the mind of a (relatively) socially underprivileged person. (shrink)

Personal narratives can let us in on aspects of reality which we have not experienced for ourselves, and are thus important sources for philosophical reflection. Yet a venerable tradition in mainstream philosophy has little room for arguments which rely on personal narrative, on the grounds that narratives are particular and testimonial, whereas philosophical arguments should be systematic and transparent. I argue that narrative arguments are an important form of philosophical argument. Their testimonial aspects witness to novel facets of reality, but (...) their argumentative aspects help us to understand those facets for ourselves. My argument takes the form of a case study of the exemplary narrative argument penned by Rachel Moran, a former prostitute who uses her experiences to argue that prostitution amounts to sexual abuse. We’ll see that narrative arguments can enjoy expository Advantages over analytic ones. (shrink)

Should religious believers proportion their religious beliefs to their evidence? They should: Religious faith is better, ceteris paribus, when the beliefs accompanying it are evidence-proportioned. I offer two philosophical arguments and a biblical argument. The philosophical arguments conclude that love and trust, two attitudes belonging to faith, are better, ceteris paribus, when accompanied by evidence-proportioned belief, and that so too is the faith in question. The biblical argument concludes that beliefs associated with faith, portrayed in the Hebrew Bible and the (...) New Testament, are typically, and normatively, exhorted on the basis of evidence. I hope to convince religious believers and nonbelievers alike that religious beliefs should be evidence-proportioned. (shrink)

Purpose Cybercrime is a prevalent and serious threat to publicly traded companies. Defending company information systems from cybercrime is one of the most important aspects of technology management. Cybercrime often not only results in stolen assets and lost business but also damages a company’s reputation, which in turn may affect the company’s stock market value. This is a serious concern to company managers, financial analysts, investors and creditors. This paper aims to examine the impact of cybercrime on stock prices of (...) a sample of publicly traded companies. Design/methodology/approach Financial data were gathered on companies that were reported in news stories as victims of cybercrime. The market price of the company’s stock was recorded for several days before the news report and several days after. The percentage change in the stock price was compared to the change in the Dow Jones Industrial average to determine whether the stock price increased or decreased along with the rest of the market. Findings Stock prices were negatively affected in all time periods examined, significantly so in one period. Practical implications This paper describes cases concerning cybercrime, thereby bringing attention to the value of cybersecurity in protecting computers, identity and transactions. Cyber security is necessary to avoid becoming a victim of cybercrime. Specific security improvements and preventive measures are provided within the paper. Preventive measures are generally less costly than repairs after a cybercrime. Originality/value This is an original manuscript that adds to the literature regarding cybercrime and preventive measures. (shrink)

Wir leben in einem Zeitalter der religiösen Vielfalt. Es gibt viele unterschiedliche und scheinbar inkompatible religiöse und säkulare Glaubensformen, die einander mit einer erstaunlichen Intensität und Geschwindigkeit dank Globalisierung und sozialen Medien begegnen. Damit wächst die Einsicht, dass das eigene Überzeugungssystem nicht mehr einfach als gegeben und plausibel anzunehmen ist. Aufgrund dieser neuen Entwicklungen haben sich in den letzten Jahren intensive philosophische Diskussionen ergeben.

In the 1920s and 30s, Heidegger developed three explicit readings of Plato’s Phaedrus. These readings emphasize different dimensions of Plato’s dialogue and, at times, seem even to contradict one another. Though Heidegger pursues quite different interpretations of the dialogue, he remains steadfast in praising this Platonic dialogue above all others. I argue that these explicit readings provide fertile ground for reconsidering Heidegger’s engagement with Plato and not just with Platonism. I further develop an argument that a fourth, implicit reading of (...) Phaedrus can be found in Heidegger’s own dialogical text from the late 1940s, “das abendländische Gespräch”. I suggest that it is in this conversational text, where Plato’s name is never once mentioned, that Heidegger manages his most authentic engagement with the Platonic dialogue and with Plato himself. (shrink)

Digital technology is rapidly transforming human life. But our cognition is honed for an analog world. I call this the problem of digital whiplash: that the digital transformation of society, like a vehicle whose sudden acceleration injures its occupants, is too fast to be safe. I focus on the unprecedented phenomenon of digital surveillance, which I argue poses a long-term threat to human autonomy that our cognition is ill-suited to recognize or respond to. Human cognition is embodied and context-sensitive, and (...) thus faces four problems of digital whiplash vis-à-vis digital surveillance. First is the problem of signal sparsity, that there are few if any perceptible indications of digital surveillance. Second is the problem of signal elusiveness, that the few indications there are prohibitively difficult to discover. Third is the distraction problem, that using digital technologies corrodes the cognitive abilities we need to recognize and respond to digital surveillance. Fourth is the hooking problem, that digital technologies are engineered to cultivate dependency. I address, among other objections, the idea that we choose to exchange our privacy for the use of digital technologies, so their use is in fact an expression of autonomy. The response to digital whiplash, I argue, is not to slow down the digitalization of society in its current form so that we can adapt our cognitive capacities. It is to allow ourselves the time to reflect on and debate whether digitalization, in its current form, is delivering a socially and ethically desirable future. (shrink)

Spelling is a fundamental literacy skill facilitating word recognition and thus higher-level reading abilities via its support for efficient text processing (Adams, 1990; Joshi et al., 2008; Perfetti and Stafura, 2014). However, relatively little work examines second language (L2) spelling in adults, and even less work examines learners from different first language (L1) writing systems. This is despite the fact that the influence of L1 writing system on L2 literacy skills is well documented (Hudson, 2007; Koda and Zehler, 2008; Grabe, (...) 2009). To address this shortcoming, this study collected data on real word spelling, pseudoword spelling, and phonological awareness (elision) abilities from 70 participants (23 native speakers; 47 ELLs with alphabetic, abjad, and morphosyllabic L1s). Analyses compared performance on real word and pseudoword spelling between L1 English speakers and ELLs, and additionally among the non-native-speaker L1 groups (categorized into alphabet, abjad, and morphosyllabary groups). Similar comparisons were made across groups for performance on phonological awareness. Further, correlations were calculated between phonological awareness and real word spelling and between phonological awareness and pseudoword spelling, separately for L1 English speakers and the various ESL groups. Spelling accuracy on real words and pseudowords as well as phonological awareness skill differed between native speakers and ESL speakers, and also varied by the ESL speakers’ L1 writing system. Theoretically interesting patterns emerged in the spelling data. For example, the morphosyllabic L1 speakers had strong real word spelling (better than the other ESL groups) but greatly decreased pseudoword accuracy (a drop of 59% in accuracy). Although alphabetic L1 speakers had low spelling accuracy in terms of strict scoring, they had lower rates of errors per item, highlighting the importance of scoring approach for shaping the conclusions that are drawn. Error rates also revealed vowels to be more problematic than consonants, particularly in abjad L1 speakers. The results demonstrate that L2 spelling abilities, phonological awareness, and the relationships among them vary by L1 writing system, and that differing approaches to scoring and analysis may lead to varying conclusions. (shrink)

This essay contextualises Wittgenstein’s remarks on aspect-seeing in connection with his reading of Wolfgang Köhler, and thereby within a wider discussion of seeing. Most commentators devote little attention to the use of ‘see’ with which aspect-seeing is contrasted. It tends to be interpreted in the literature in two contrasting ways which, the author suggests, could be lined up with Köhler’s distinction between ‘analytic’ and ‘normal’ modes of perception, corresponding to a distinction between ‘seeing shapes and colours’ and ‘seeing things’. It (...) is argued that Wittgenstein’s ‘aspect-seeing’ use of ‘see’ contrasts differently with each of these. Moreover, it is argued that these three uses of ‘see’ work differently in the context of looking at pictures and looking at the world. Finally, it is suggested that understanding Wittgenstein’s claim that seeing an aspect is ‘seeing a meaning’ is an invitation to contemplate what would be missing from the life of the aspect-blind; and it is suggested that seeing a thingis likewise ‘seeing a meaning’. (shrink)

This article draws from Hannah Arendt's theory of “inter-est” to formulate a model of coalition discourse that can coarticulate difference and commonality and approach them as mutually nourishing conditions rather than as polarities. By disrupting the normative fantasies of unified, a priori subjectivity and universal truth, interest-based discourse facilitates political interactions that neither rely on sameness nor reify difference to the exclusion of connection.

Dependency relationships within the cell cycle allow cells to arrest the cycle reversibly in response to agents or conditions that interfere with specific aspects of its normal progression. In addition, overlapping pathways exist which also arrest the cell cycle in response to DNA damage. Collectively, these control mechanisms have become known as checkpoints. Analysis of checkpoints is facilitated by the fact that dependency relationships within the cell cycle, such as the dependency of mitosis on the completion of DNA synthesis, and (...) the DNA damage checkpoint can be separated genetically. In fission yeast, Schizosaccharomyces pombe, the dependency of mitosis on prior completion of DNA synthesis is mediated through tyrosine‐15 phosphorylation of the ubiquitous mitotic regulator p34cdc2. In contrast, the arrest of mitosis caused by DNA damage acts through a separate mechanism that appears to be independent of tyrosine‐15 phosphorylation. Despite these distinct interactions with the mitotic machinery, the majority of fission yeast mutants that are deficient in mitotic arrest after DNA damage are also unable to respond to inhibition of DNA synthesis. In this essay we survey the current knowledge concerning feedback controls and checkpoints within fission yeast and relate this to information derived from other systems. (shrink)

We agree that conceptualisation is key in understanding the brain basis of emotion. We argue that by conflating facial emotion recognition with subjective emotion experience, Lindquist et al. understate the importance of biological predisposition in emotion. We use examples from the anxiety disorders to illustrate the distinction between these two phenomena, emphasising the importance of both emotional hardware and contextual learning.

Throughout history, one focus of society has been expanding and educating its less fortunate or less advanced. This has not change in the twenty-first century. It seems to be a topic in every political election: what are you going to do to help the poor? What are you going to do to help the poor in other countries? The mistreatment of others is all over the media. It fills the home and the head. The squalor of poorer countries is featured (...) on the nightly news. People typically say, send food. Send medicine. One man had a different idea. Send education in the form of inexpensive laptops. (shrink)