Abstract:Should we use modern bioengineering techniques to design species? An instrumentalist account of species’ value offers permissive guidance. But what if species exemplify final value? Is it always very good to create new species? Is it always very wrong to blend or modify existing species? In this paper, I argue that both extremes are implausible. However, final value theories struggle to deliver a flexible, moderate treatment of these issues, and so the ethics of designing species presents a challenge for final (...) value theorists. Fortunately, a design-based account of the value of species has the resources to offer plausible, nuanced, context-sensitive guidance on the ethics of designing species. It holds that designing species is sometimes very bad, sometimes quite good, and sometimes neither very good nor very bad. The plausibility of these results lends credibility to the design-based framework, and gives final value theorists reason to prefer the design-based approach. (shrink)

Internalists and externalists disagree over how intimately normative judgment and motivation are linked. Proponents on both sides typically try to settle the issue by descriptively interpreting our concept of a normative judgment. Unfortunately, this approach has resulted in deep and apparently intractable disagreement. It is time to consider alternative strategies. In this paper, I argue that the internalist/externalist debate is particularly ripe for revisionary arguments that evaluate conceptions of normative judgment in light of the costs and benefits of their adoption. (...) I then develop a revisionary case for externalism by identifying three practical hazards that come with internalist conceptions of normative judgment. Along the way, I show how these internalist hazards are mirrored by externalist benefits. I also argue that two potential benefits of internalism are not very beneficial. Together, these considerations give us strong practical reasons to adopt externalist conceptions of normative judgment, regardless of which account is descriptively accurate. (shrink)

David Enoch has recently proposed that the deliberative indispensability of irreducibly normative facts suffices to support their inclusion in our ontology, even if they are not necessary for the explanation of any observable phenomena. He challenges dissenters to point to a relevant asymmetry between explanation and deliberation that shows why explanatory indispensability, but not deliberative indispensability, is a legitimate guide to ontology. In this paper, I aim to do just that. Given that an entity figures in the actual explanation of (...) some phenomenon, it is not an open question whether that entity exists. Thus, if you can manage to find actual explanations, you can find answers to ontological questions. In contrast, even if some entity is indispensable to deliberation, it still might not exist. For example, even if some form of libertarian free will is deliberatively indispensable, we still might not have libertarian free will. So even if you manage to discover the indispensable commitments of deliberation, there is still more work to do to get to the bottom of things. That additional work is explanatory work, and so deliberative indispensability is not an independent guide to what there is. (shrink)

Evolutionary debunking arguments purport to undercut the justification of our moral judgments by showing why a tendency to make moral judgments would evolve regardless of the truth of those judgments. Machery and Mallon (2010. Evolution of morality. In J.M. Doris and The Moral Psychology Research Group (Eds.), The Moral Psychology Handbook (pp. 3-46). Oxford: Oxford University Press) have recently tried to disarm these arguments by showing that moral cognition – in the sense that is relevant to debunking – is not (...) the product of natural selection. Specifically, they present a barrage of increasingly influential challenges against reciprocity-based approaches to moral nativism. In the present paper I defend the nativist account of moral cognition against these criticisms, thereby bolstering the skeptical conclusions of evolutionary debunking arguments. However, Machery and Mallon's critique does successfully highlight several vulnerabilities in Richard Joyce's approach to debunking, suggesting several ways in which it can be revised toward generating a more robust version of the argument. (shrink)

The protection of species ranks highly among environmentalist priorities, and many environmentalists expect the public to respect and support efforts to protect and rehabilitate endangered species. There are a range of instrumental and anthropocentric justifications for these attitudes, yet some environmentalists want more. It is unclear that more is to be had. In particular, it is challenging to justify some environmentalist attitudes without appealing to some version of the claim that species are intrinsically valuable. However, this has been a notoriously (...) difficult thesis to defend, and it is clearly not available to those who doubt the existence of species. In this paper, I show how a number of environmentalist commitments that appear to be about the value of species can be interpreted and defended in a way that is compatible with antirealism about species. According to my proposal, the proper target of environmentalists’ evaluative concern is the irreplaceable design that is embodied by the individuals that make up a (putative) species. This approach can capture and justify many environmentalist attitudes about the value of biological variety without attributing intrinsic value to species, or even requiring a place for species in our ontology. This enables environmentalists to effectively sidestep a number of puzzling issues surrounding the nature and value of species. (shrink)

While Richard Joyce’s moral skepticism might seem to be an extreme metaethical view, it is actually far more moderate than it might first appear. By articulating four challenges facing his approach to moral skepticism, I argue that Joyce’s moderation is, in fact, a theoretical liability. First, the fact that Joyce is not skeptical about normativity in general makes it possible to develop close approximations to morality, lending support to moderate moral revisionism over moral error theory. Second, Joyce relies on strong, (...) contentious conceptual and empirical claims in support of his views. Third, Joyce’s evolutionary debunking argument threatens to backfire, generalizing to all normative judgments. Finally, Joyce fails to offer an adequate account of the normativity of desire. Each of these four challenges can be either sidestepped or embraced by radicalizing and defending a global form of normative skepticism. There are thus several ways in which global normative skepticism appears to be in a more robust dialectical position than Joyce’s moral skepticism. Furthermore, I argue, Joyce’s arguments against global normative skepticism are unconvincing. While this discussion is framed in terms of Joyce’s work, its arguments will apply to other moral skeptics who are not also global normative skeptics. The result is an invitation for Joyce and other moral skeptics to leave these problems behind and join the radical camp. (shrink)

Cornell realists maintain that irreducible moral properties have earned a place in our ontology in virtue of the indispensable role they play in a variety of explanations. These explanations can be divided into two groups: those that employ thin ethical concepts and those that employ thick ethical concepts. Recent work on thick concepts suggests that they are not inherently evaluative in their meaning. If correct, this creates problems for the moral explanations of Cornell realists, since the most persuasive moral explanations (...) are those that employ thick concepts. If thick concepts are not inherently evaluative, then the most plausible explanations on offer cannot support Cornell realism. Moral explanations employing thin concepts, however, are too flimsy to support the view. Unless proponents can develop a compelling story about thick concepts or thin explanations, Cornell realism is in trouble. (shrink)

In The Moral Problem, Michael Smith argues that only motivational internalists can offer an adequate explanation of why changes in moral judgment tend to be accompanied by changes in motivation in morally virtuous people. Smith argues that the failure of motivational externalism to account for this phenomenon amounts to a reductio of the view. In this paper, I draw on dual-process models of moral judgment to develop an externalist response to Smith’s argument. The key to my proposal is that motivationally (...) efficacious states are often the source of our moral judgments, and changes in judgment are typically the result of changes in these states. However, moral judgments can also be formed via an alternative pathway that does not necessarily affect motivation, and so motivation and judgment can come apart. This response not only defuses Smith’s objections to externalism, but challenges Smith to square his internalist proposal with the empirical details of moral judgment. (shrink)

A central source of support for expressivist accounts of normative discourse is the intimate relationship between normative judgment and motivation. Expressivists argue that normative judgments must be noncognitive, desire-like states in order to be so tightly linked with motivation. Normative statements are then construed as expressions of these noncognitive states. In this paper, I draw on dual-process models in cognitive psychology to respond to this argument. According to my proposal, normative judgments are ordinary beliefs that are typically produced by two (...) kinds of process: intuitive-affective processes and domain-general reasoning. When produced by the first kind of process, motivation and judgment tend to align. When produced by the second kind, motivation and judgment might not align. Since the first kind of process is the most common pathway of normative belief formation, normative judgments are typically accompanied by aligning motivation. This proposal enables cognitivists to explain the intimate link between normative judgment and motivation, thereby removing the major obstacle to interpreting normative statements truth-conditionally. (shrink)

Many environmentalists hold that the loss of a species is intrinsically bad, and many also think that we have moral obligations to species as such. In an attempt to capture these thoughts, some philosophers have suggested that species are bearers of intrinsic value. This approach works well in paradigmatic cases. However, it begins to break down in more difficult scenarios, such as when species boundaries are unclear or when resources are scarce. The case study of the Galápagos giant tortoises in (...) this essay illustrates the limitations of traditional accounts of the non-instrumental value of species. Careful attention to this case indicates how species-centric accounts diverge from the evaluative attitudes of environmentalists, and suggests new directions for theoretical replacements. (shrink)

There has lately been substantial interest in scrutinizing our evaluative attitudes in light of our evolutionary history. However, these discussions have been hampered by an insufficiently expansive vantage. Our history did not begin ex nihilo a few million years ago with the appearance of hominins, or apes, or primates—those are very recent chapters of a much larger story that spans billions of years. This paper situates the mechanisms underlying normative thought within this broader context. I argue that this historical perspective (...) creates difficulties for metaethical nonnaturalists. The expanded scope enables the story to be anchored in negative claims about value, making room for novel epistemological and metaphysical challenges that are more threatening than extant evolutionary debunking arguments. (shrink)

Deferred internalists accept that sometimes, agents can form genuine normative judgments without any accompanying motivation. However, they propose that these judgments can only exist when they are embedded within psychologies or communities in which judgment and motivation typically align. In this paper, I sketch a version of externalism that challenges the interpretation of key evidence claimed by deferred internalists. According to this account, there is a robust but contingent connection between judgment and motivation that is explained by the structure of (...) the neurocognitive apparatus we happen to employ in evaluative thought. This proposal allows that all of our judgments lacking accompanying motivation are contingently parasitic on judgments that are accompanied by motivation. It also suggests that it is not possible to create communities of _beings like us_ whose judgments and motivation radically come apart. These results undermine current strategies for supporting deferred internalism. Proponents will need to find support elsewhere. (shrink)

Recent work in moral philosophy has emphasized the foundational role played by interpersonal accountability in the analysis of moral concepts such as moral right and wrong, moral obligation and duty, blameworthiness, and moral responsibility (Darwall 2006; 2013a; 2013b). Extending this framework to the field of moral psychology, we hypothesize that our moral attitudes, emotions, and motives are also best understood as based in accountability. Drawing on a large body of empirical evidence, we argue that the implicit aim of the central (...) moral motives and emotions is to hold people - whether oneself or others - accountable for compliance with the demands of morality. Moral condemnation is based in a motive to get perpetrators to hold themselves accountable for their wrongdoing, not, as is commonly supposed, a mere retributive motive to make perpetrators suffer (�2). And moral conscience is based in a genuine motive to hold oneself accountable for behaving in accordance with moral demands, not, as is commonly supposed, a mere egoistic motive to appear moral to others (�3). The accountability-based theory of the moral motives and emotions we offer provides better explanations of the extant empirical data than any of the major alternative theories of moral motivation. Moreover, conceiving of moral psychology in this way gives us a new and illuminating perspective on what makes morality distinctive: its essential connection to our practice of holding one another accountable (�4). (shrink)

One way to challenge the substantiveness of a particular philosophical issue is to argue that those who debate the issue are engaged in a merely verbal dispute. For example, it has been maintained that the apparent disagreement over the mind/brain identity thesis is a merely verbal dispute, and thus that there is no substantive question of whether or not mental properties are identical to neurological properties. The goal of this paper is to help clarify the relationship between mere verbalness and (...) substantiveness. I first argue that we should see mere verbalness as a certain kind of discourse defect that arises when the parties differ as to what each takes to be the immediate question under discussion. I then argue that mere verbalness, so understood, does not imply that the question either party is attempting to address is a non-substantive one. Even if it turns out that the parties to the mind/brain dispute are addressing subtly different questions, these might both be substantive questions to which their respective metaphysical views provide substantive answers. One reason it is tempting to reach deflationary conclusions from the charge of mere verbalness is that we fail to distinguish it from the claim that a sentence under dispute is, in a certain sense, indisputable. Another reason is that we fail to distinguish mere verbalness from a certain sort of indeterminacy. While indisputability and indeterminacy plausibly capture forms of nonsubstantiveness, I argue that mere verbalness is insufficient to establish either indisputability or indeterminacy. (shrink)

According to current hierarchies of evidence for EBM, evidence of correlation is always more important than evidence of mechanisms when evaluating and establishing causal claims. We argue that evidence of mechanisms needs to be treated alongside evidence of correlation. This is for three reasons. First, correlation is always a fallible indicator of causation, subject in particular to the problem of confounding; evidence of mechanisms can in some cases be more important than evidence of correlation when assessing a causal claim. Second, (...) evidence of mechanisms is often required in order to obtain evidence of correlation. Third, evidence of mechanisms is often required in order to generalise and apply causal claims. While the EBM movement has been enormously successful in making explicit and critically examining one aspect of our evidential practice, i.e., evidence of correlation, we wish to extend this line of work to make explicit and critically examine a second aspect of our evidential practices: evidence of mechanisms. (shrink)

In this thesis, I give a metascientific account of causality in medicine. I begin with two historical cases of causal discovery. These are the discovery of the causation of Burkitt’s lymphoma by the Epstein-Barr virus, and of the various viral causes suggested for cervical cancer. These historical cases then support a philosophical discussion of causality in medicine. This begins with an introduction to the Russo- Williamson thesis (RWT), and discussion of a range of counter-arguments against it. Despite these, I argue (...) that the RWT is historically workable, given a small number of modifications. I then expand Russo and Williamson’s account. I first develop their suggestion that causal relationships in medicine require some kind of evidence of mechanism. I begin with a number of accounts of mechanisms and produce a range of consensus features of them. I then develop this consensus position by reference to the two historical case studies with an eye to their operational competence. In particular, I suggest that it is mechanistic models and their representations which we are concerned with in medicine, rather than the mechanism as it exists in the world. -/- I then employ these mechanistic models to give an account of the sorts of evidence used in formulating and evaluating causal claims. Again, I use the two human viral oncogenesis cases to give this account. I characterise and distinguish evidence of mechanism from evidence of difference-making, and relate this to mechanistic models. I then suggest the relationship between types of evidence presents us with a means of tackling the reference-class problem. This sets the scene for the final chapter. Here, I suggest the manner in which these two different classes of evidence become integrated is also reflected in the way that developing research programmes change as their associated causal claims develop. (shrink)

Evolutionary fitness threats and rewards are associated with subjectively unpleasant and pleasant sensations, respectively. Initially, these correlations appear explainable via adaptation by natural selection. But here I analyse the major metaphysical perspectives on consciousness – physicalism, dualism, and panpsychism – and conclude that none help to understand the adaptive-seeming correlations via adaptation. I also argue that a recently proposed explanation, the phenomenal powers view, has major problems that mean it cannot explain the adaptive-seeming correlations via adaptation either. So the mystery (...) – call it the evolutionary paradox of consciousness – remains. Some have used this mystery to argue for non-naturalistic (e.g. theistic) explanations. But I propose a naturalistic, non-adaptive explanation of the adaptive-seeming correlations: namely, ‘sensational associative learning’ during development. In this perspective, pairing of particular sensations with unconditioned stimuli – fitness rewards or threats – cause the sensations themselves to come to be interpreted as good or bad, respectively. Sensations, like colours, that are not reliably paired with either fitness rewards or threats remain largely unvalenced. Sensational associative learning also provides explanations for adaptive-seeming structural aspects of sensations, such as the observation that sounds of different pitch are experienced as ordinal in correspondence to their wavelengths while the same is not true of colours of different hue. The sensational associative learning perspective appears compatible with physicalism, panpsychism, and dualism (though not epiphenomenalism). (shrink)

Several times, when faced with a difficult passage of scripture in Sermones ad populum, Augustine implores his audience, “knock and it shall be opened” (Matt. 7:7c; par. Luke 11:9c). Augustine uses this phrase to stress humility and the human need for God’s activity when interpreting scripture. Studying the archeological record of domestic architecture of locked doors in Roman North Africa elucidates Augustine’s message. Knowledge of the material culture shows that Augustine calls upon Christians to “knock” upon scripture as if it (...) were a door, locked and barred in such a way that it could only be opened from inside. Thus, a reader of scripture is like a petitioner calling from outside a locked door, needing God to open its meaning. Augustine’s use of “knocking” contrasts with the metaphor of “keys” to scripture, which was favored by Tyconius and other early Christian writers. In De doctrina Christiana, Augustine expresses concern that “keys” could lead a person into overconfidence, expecting to unlock obscure passages of the Bible by his or her own power. Augustine’s frequent use of Matt. 7:7c is a call for exegetes to approach scripture with humility. All members of the totus Christus, great and small, must humbly knock. The image of “knocking” provides a versatile theological message: human effort is important, but the meaning of the Bible is ultimately unlocked by God’s activity. (shrink)

This paper argues that promises are proposals in joint practical deliberation, the activity of deciding together what to do. More precisely: to promise to ϕ is to propose (in a particular way) to decide together with your addressee(s) that you will ϕ. I defend this deliberative theory by showing that the activity of joint practical deliberation naturally gives rise to a speech act with exactly the same properties as promises. A certain kind of proposal to make a joint decision regarding (...) one's own actions turns out to have the very same normative effects, under the very same conditions, as a promise. I submit that this cannot be a coincidence: we should conclude that promises and the relevant kind of proposals in joint practical deliberation are one and the same. (shrink)

Burt's argument relies on a motte-and-bailey fallacy. Burt aims to argue against the value of genetics for social science; instead she argues against certain interpretations of a specific kind of genetics tool, polygenic scores (PGSs). The limitations, previously identified by behavioural geneticists including ourselves, do not negate the value of PGSs, let alone genetics in general, for social science.

Erin M. Cline expresses skepticism of several dimensions of Chun Hin Tsoi’s attempt to establish a classical Confucian view of distributive justice. She admonishes us to distinguish the constructive derivation or development of such a concept from Confucian views from descriptive attribution of those views to the early thinkers themselves. Cline also dissuades us from constructivism that draws indiscriminately across a diversity of texts, since the Analects, Mencius, and Xunzi each offer their own distinct views on matters of (...) justice, which may variously align or conflict. She then further defends her particular interpretations of Analects passages. These rebuttals conclude by pointing to a shared sensitivity to moral luck in early Confucianism and contemporary liberalism that again draws together the sense of justice in Rawls and Confucius. In closing, Cline reminds us that the dimensions of justice she and Tsoi discuss are deeply interwoven into the rich fabric of values and concerns presented in the Analects, and encourages that we take account of the more robust content and context of these records of Confucius’ teachings. (shrink)

Political conspiracy theories—e.g., unsupported beliefs about the nefarious machinations of one’s cunning, powerful, and evil opponents—are adopted enthusiastically by a great many people of widely varying political orientations. In many cases, these theories posit that there exists a small group of individuals who have intentionally but secretly acted to cause economic problems, political strife, and even natural disasters. This group is often held to exist “in the shadows,” either because its membership is unknown, or because “the real nature” of its (...) members’ allegiances, motives, and methods has been concealed from the public at large. Paradigmatic examples of these political conspiracy theories include anti-Semitic beliefs of the sort associated with The Protocols of the Elder of Zion, the “Red Scare” of the 1950s, claims about the “New World Order,” and many others. -/- Why do these theories attract so many adherents? In this essay, I’ll attempt to spread some light on this issue by applying Kahneman and Tversky’s highly influential work on reasoning under uncertainty. I’ll proceed by first providing a brief introduction to Kahneman and Tversky’s work on reasoning under uncertainty, and the way in which this relates to standard economic and philosophic accounts of rational behavior, as well as philosophical ideas about the role of intuition. Next, I’ll move onto some specific interconnected aspects of this work that are relevant to understanding conspiracy theories, including errors involving probabilistic reasoning (“Prospect Theory”), those involving the inappropriate use of heuristics, and those related to the “framing” of certain outcomes as losses from a baseline. This essay will conclude by making two related points. First, some of the most important reasoning errors committed by adherents of conspiracy theories are errors that many of us regularly commit. Given that self-awareness of these errors provides only minimal protection from committing them, this suggests that many of use may be more vulnerable to conspiratorial reasoning than we may like to believe. Second, in the light of this danger, I will outline a few steps that might be taken to help inoculate ourselves against the appeal of these theories, and to help respond to the conspiratorial arguments of others. (shrink)

"A Little More Logical" is the perfect guide for anyone looking to improve their critical thinking and logical reasoning skills. With chapters on everything from logic basics to fallacies of weak induction to moral reasoning, this book covers all the essential concepts you need to become a more logical thinker. You'll learn about influential figures in the field of logic, such as Rudolph Carnap, Betrrand Russell, and Ada Lovelace, and how to apply your newfound knowledge to real-world situations. Whether you're (...) looking to engage in debates with others, make better decisions in your personal and professional life, or simply want to improve your overall critical thinking skills, "A Little More Logical" has you covered. So why wait? Start learning and become a little more logical today! -/- "A Little More Logical" differs from typical logical textbooks in a number of ways. One key difference is its emphasis on engaging and relatable examples and case studies. Rather than simply presenting dry definitions and concepts, the book uses fables, stories, and real-world situations to illustrate key ideas and make them more relatable for readers. -/- Another unique aspect of "A Little More Logical" is its inclusion of "Minds that Mattered" sections, which highlight the contributions and insights of influential figures in the field of logic and critical thinking. These sections provide readers with a deeper understanding of the history and development of logical principles and offer valuable context for the concepts being discussed. -/- Additionally, "A Little More Logical" covers a wide range of topics beyond the basics of logic and argument evaluation. Chapters on moral reasoning, probability and inductive logic, scientific reasoning, conspiracy theories, statistical reasoning, and the history of formal logic offer a more comprehensive and well-rounded understanding of logic and critical thinking. -/- Overall, "A Little More Logical" stands out as a dynamic and engaging resource for anyone looking to improve their logical reasoning abilities. Its relatable examples, historical context, and broad coverage make it a valuable resource for anyone interested in mastering the principles of logic. -/- This is a free, Creative-Commons-licensed book. (shrink)

This is the text of a paper (along with appendixes) delivered at the 2019 annual meeting of the Minnesota Philosophical Society on Oct 26 in Cambridge, MN. -/- Beauchamp and Childress’s “Four Principles” (or “Principlism”) approach to bioethics has become something of a standard not only in bioethics classrooms and journals, but also within medicine itself. In this teaching-focused workshop, I’ll be doing the following: (1) Introducing the basics of the “Four Principles” approach, with a special focus on its relation (...) to the common morality and the importance to weighing and balancing of competing norms. (2) Comparing and contrasting this to other potential approaches, such as those provided by virtue ethics, act utilitarianism, casuistry, and competing versions of principles-based ethics. (3) Considering the ways in which the principles-based approach can best be implemented for lower-level, introductory bioethics classes, where the average student may have little background knowledge in either philosophy or medicine. I’ll be presenting sample activities, case studies, and lesson plans. There will be considerable time reserved for discussion at the end, so that participants can exchange ideas relating to the teaching of both bioethics and other varieties of applied ethics. (shrink)

Over the course of its six seasons, the Netflix show the House of Cards (HOC) details the rise to power of Claire and Frank Underwood in a fictional United States. They achieve power not by winning free and fair elections, but by exploiting various weaknesses of the U.S. political system. Could such a thing happen to our own democracies? This chapter argues that it is a threat that should be taken seriously, as the structure of HOC’s democratic institutions closely mirrors (...) our own, and the flaws that the Underwoods exploit are precisely those that have allowed autocrats to capture democracies “from the inside.” Of even greater concern, these flaws may flow from the nature of democracy itself. This possibility is explored by considering the events of the HOC in the light of the anti-democratic arguments of Plato and Hobbes. The chapter concludes by briefly considering responses to these arguments. (shrink)

Evidence-based medicine (EBM) makes use of explicit procedures for grading evidence for causal claims. Normally, these procedures categorise evidence of correlation produced by statistical trials as better evidence for a causal claim than evidence of mechanisms produced by other methods. We argue, in contrast, that evidence of mechanisms needs to be viewed as complementary to, rather than inferior to, evidence of correlation. In this paper we first set out the case for treating evidence of mechanisms alongside evidence of correlation in (...) explicit protocols for evaluating evidence. Next we provide case studies which exemplify the ways in which evidence of mechanisms complements evidence of correlation in practice. Finally, we put forward some general considerations as to how the two sorts of evidence can be more closely integrated by EBM. (shrink)

Over the course of its six seasons, the Netflix show House of Cards (HOC) details the rise to power of Claire and Frank Underwood in a fictional United States. They achieve power not by winning free and fair elections, but by exploiting various weaknesses of the US political system. Could such a thing happen to our own democracies? This chapter argues that it is a threat that should be taken seriously, as the structure of HOC’s democratic institutions closely mirrors our (...) own, and the flaws that the Underwoods exploit are precisely those that have allowed autocrats to capture democracies “from the inside.” Of even greater concern, these flaws may flow from the nature of democracy itself. This possibility is explored by considering the events of HOC in light of the antidemocratic arguments of Plato and Hobbes. The chapter concludes by briefly considering responses to these arguments. (shrink)

In this paper, I offer one example of conceptual change. Specifically, I contend that the discovery that viruses could cause cancer represents an excellent example of branch jumping, one of Thagard’s nine forms of conceptual change. Prior to about 1960, cancer was generally regarded as a degenerative, chronic, non-infectious disease. Cancer causation was therefore usually held to be a gradual process of accumulating cellular damage, caused by relatively non-specific component causes, acting over long periods of time. Viral infections, on the (...) other hand, were generally understood to be acute processes, whereby single, specific and necessary causal agents acted alone to produce disease. However, during the 1960s and 1970s, a number of cancers were discovered to have an infectious aetiology. Of particular note were two—Burkitt’s lymphoma and cervical cancer—which I will discuss in detail later in this piece. Together, these discoveries led, in the short term, to a tentative aetiological reclassification of some types of cancer as infectious diseases and, in the longer term, to a full-blown reclassification of cancer as an aetiological disease branch in its own right. This process of reclassification forms the empirical basis for my concluding remarks on the influence of classification upon causation in medicine. Through this, I aim to demonstrate that conceptual change, far from being a purely abstract concern of the philosopher of science, is of substantial import to scientific practitioners. (shrink)

In the context of transgender health, most people are not comfortable with allowing a twelve‐year‐old child with gender dysphoria to elect to undergo gender reassignment surgery. The likelihood is too high that the child would be unable to fully comprehend the scope of a decision that carries significant, permanent consequences, particularly because the decision to surgically change gender is based upon a conception of gender that can fluctuate during adolescent years. Conversely, however, most people would not contend that this fluidity (...) is reason to wholly deny certain medical care such as hormonal treatments to transgender youth, a demographic with extremely high rates of violent behavior, self‐harm, and suicide. This paper will explore ethical considerations to this emerging debate of what therapeutic options should be offered to transgender children and adolescents.Pediatric endocrinologists have been treating gender dysphoric adolescents with puberty‐suppressing drugs and, to a lesser extent, with cross‐sex hormone therapies for more than twenty years. Clinicians and thought leaders have mentioned ethical components of this emerging practice in the few cohort studies and clinical review articles about the subject. However, ethics have generally been a secondary consideration in the medical academic literature. In this paper, I will provide a brief overview of the practice, summarize the current research on hormone treatment for transgender minors, and provide an ethical analysis of the practice. (shrink)

Over 115 000 people are waiting for life-saving organ transplants, of whom a small fraction will receive transplants and many others will die while waiting. Existing efforts to expand the number of available organs, including increasing the number of registered donors and procuring organs in uncontrolled environments, are crucial but unlikely to address the shortage in the near future and will not improve donor/recipient compatibility or organ quality. If successful, organ bioengineering can solve the shortage and improve functional outcomes. Studying (...) manufactured organs in animal models has produced valuable data, but is not sufficient to understand viability in humans. Before risking manufactured organ experimentation in living humans, study of bioengineered organs in recently deceased humans would facilitate evaluation of the function of engineered tissues and the complex interactions between the host and the transplanted tissue. Although such studies do not pose risk to human subjects, they pose unique ethical challenges concerning the previous wishes of the deceased, rights of surviving family members, effective operation and fair distribution of medical services, and public transparency. This article investigates the ethical, legal and social considerations in performing engineered organ research on the recently deceased. (shrink)

The early modern period (roughly, 1600–1800 ce) in Europe brought tremendous changes in intellectual, political, and cultural life. It was a period in which philosophical debates were inevitably bound up with questions about the nature and sources of religious truth. A chronological examination of some of the period’s major thinkers highlights two issues that were central to the development of philosophy of religion in the period. The first concerns the relations between God, the soul, and the body; the other concerns (...) the relationship between human reason and divine revelation. (shrink)

What accounts for the capacity of ordinary speakers to comprehend utterances of their language? The phenomenology of hearing speech in one’s own language makes it tempting to many epistemologists to look to perception for an answer to this question. That is, just as a visual experience as of a red square is often taken to give the perceiver immediate justification for believing that there is a red square in front of her, perhaps an auditory experience as of the speaker asserting (...) that p gives the competent hearer immediate justification for believing that the speaker has asserted that p. My aim here is to offer reasons for resisting this temptation. I argue that the perceptual model cannot adequately account for the hearer’s justification in many cases. The arguments here also allow us to draw certain further morals about the role of phenomenology in the epistemology of perception. (shrink)

This paper attempts to nudge the reader in the direction of an enlightened account of democratic choice, a sense of reflective choice which undermines our present support of discriminatory sectarian doctrine. I use Gutmann’s and Altman’s views as prologues to my own, though they might well reject my conclusions about discriminatory religion. I contrast my view with Macedo’s, Gray’s, Larmore’s, Rosenblum’s, and Galston’s.My argument utilizes common sense and relatively uncontroversial metaphysical principles to make it more difficult to dismiss as being (...) on an ontic par with the discriminatory doctrines which it challenges. I argue that discriminatory religion might be allowed to continue to be practiced and expressed by those who would pay their own way, much as with hate groups generally, but I view our continued public subsidization of it as a failure to recognize it for what it is. (shrink)

The product of a Kickstarter fundraising campaign, "Clear and Present Thinking" is a college-level textbook in logic and critical thinking. Chapters: 1. Questions, Problems, and World Views 2. Good and Bad Thinking Habits 3. Basics of Argumentation 4. Fallacies 5. Reasonable Doubt 6. Moral Reasoning In an effort to reduce the cost of education for students, this textbook was funded by over 700 people through the Kickstarter online crowd-funding platform.

This paper makes the case for an environmental justice approach to the practice and study of participation and effectiveness in agrobiodiversity governance. It is argued that, in order to understand the conditions under which participation leads to improved outcomes, the concept has to be rethought, both from a political and a methodological perspective. This can be done by applying an ex-ante environmental justice approach to participation, including notions of distribution, recognition and representation. By exploring the approach through empirical examples of (...) participation in biodiversity and environmental governance, a research framework is outlined, attempting to bridge normative and practical approaches to environmental justice, and tested on two cases of agrobiodiversity governance in Western Europe. (shrink)

Miracle Max, it seems, is the only remaining miracle worker in all of Florin. Among other things, this means that he (unlike anyone else) can resurrect the recently dead, at least in certain circumstances. Max’s peculiar talents come with significant perks (for example, he can basically set his own prices!), but they also raise a number of ethical dilemmas that range from the merely amusing to the truly perplexing: -/- How much about Max’s “methods” does he need to reveal to (...) his patients? Is it really OK for Max to lie about Valerie’s being a witch, even though she really isn’t? Just how much of the “truth” does Max have to tell his patients? -/- Let’s suppose that Humperdinck had offered Max his old job back. Would it have been OK for Max to accept this offer? What about if Humperdinck wanted him to do experiments at “the Zoo”? -/- Is Max obligated to offer his services to everyone who needs them, such as the (mostly) dead Westley and friends? Or is he free to pick and choose? -/- In this chapter, I’ll consider how these questions might be addressed using concepts of medical ethics. As it turns out, Max’s dilemmas are not too different from the sorts of dilemmas that many medical professionals encounter in their daily lives, and exploring how Max could (or should) respond to them can help us figure out what we can do here in the “real” world. (shrink)

In “Does Controlled Donation after Circulatory Death Violate the Dead Donor Rule?” the authors maintain that compliance with the dead donor rule (DDR) does not require a valid determination of deat...

Mechanistic philosophy of science views a large part of scientific activity as engaged in modelling mechanisms. While science textbooks tend to offer qualitative models of mechanisms, there is increasing demand for models from which one can draw quantitative predictions and explanations. Casini et al. (Theoria 26(1):5–33, 2011) put forward the Recursive Bayesian Networks (RBN) formalism as well suited to this end. The RBN formalism is an extension of the standard Bayesian net formalism, an extension that allows for modelling the hierarchical (...) nature of mechanisms. Like the standard Bayesian net formalism, it models causal relationships using directed acyclic graphs. Given this appeal to acyclicity, causal cycles pose a prima facie problem for the RBN approach. This paper argues that the problem is a significant one given the ubiquity of causal cycles in mechanisms, but that the problem can be solved by combining two sorts of solution strategy in a judicious way. (shrink)

The control of floral organ identity has received much attention since the first homeotic genes were isolated five years ago. The homeotic factors may be subject to a bewildering variety of control mechanisms including spatial and temporal transcriptional regulation, autoregulation, mutual protein stabilization, specific heterodimerization, post‐transcriptional modification and interaction with accessory factors. Now another level of complexity has been added by the recent discovery that the ‘B function factors’ depend on each other for nuclear localization(1) and can act non‐cell‐autonomously in (...) a polar fashion(2). (shrink)

When in the sixth century Dionysius the Areopagite declared beauty to be a name for God, he gave birth to something that had long been gestating in the womb of philosophical and theological thought. In doing so, Dionysius makes one of his most pivotal contributions to Christian theological discourse. It is a contribution that is enthusiastically received by the schoolmen of the Middle Ages, and it comes to permeate the thought of scholasticism in a multitude of ways. But perhaps nowhere (...) is the Dionysian influence more pronounced than in the thought of Thomas Aquinas. This book examines both the historical development of beauty's appropriation as a name for God in Dionysius and Thomas, and the various contours of what it means. The argument that emerges from this study is that given the impact that the divine name theological tradition has within the development of Christian theological discourse, beauty as a divine name indicates the way in which beauty is most fundamentally conceived in the Christian theological tradition as a theological theme. As a phenomenon of inquiry, beauty proves itself to be enigmatic and elusive to even the sharpest intellects in the Greek philosophical tradition. When it is absorbed within the Christian theological synthesis, however, its enigmatic content proves to be a powerful resource for theological reasoning. (shrink)