Life Extension

The effective altruism movement aims to save lives in the most cost-effective ways. In the future, technology will allow radical life extension, and anyone who survives until that time will gain potentially indefinite life extension. Fighting aging now increases the number of people who will survive until radical life extension becomes possible. We suggest a simple model, where radical life extension is achieved in 2100, the human population is 10 billion, and life expectancy is increased by simple geroprotectors like metformin (...) or nicotinamide mononucleotide by three more years on average, so an additional 750 million people survive until “immortality”. The cost of clinical trials to prove that metformin is a real geroprotector is $65 million. In this simplified case, the price of a life saved is around eight cents, 10 000 times cheaper than saving a life from malaria by providing bed nets. However, fighting aging should not be done in place of fighting existential risks, as they are complementary causes. (shrink)

Abstract: The field of life extension is full of ideas but they are unstructured. Here we suggest a comprehensive strategy for reaching personal immortality based on the idea of multilevel defense, where the next life-preserving plan is implemented if the previous one fails, but all plans need to be prepared simultaneously in advance. The first plan, plan A, is the surviving until advanced AI creation via fighting aging and other causes of death and extending one’s life. Plan B is cryonics, (...) which starts if plan A fails, and assumes cryopreservation of the brain until technical capabilities to return it to life appear. Plan C is digital immortality in the sense of collecting data about the person now so future AI will be able to recreate a model of a person. Plan D is the hope based on some unlikely scenarios of infinite survival, like so-called “quantum immortality”. All these plans have personal and social perspective. The personal aspect means efforts of the increasing chances of personal survival via taking care about one’s own health, signing cryocontract or collecting digital immortality data. The social aspect means the participation in collective work towards creation and increase of the availability of life extension technologies, which includes funding scientific research, promotion of life extension value and direct performing of research and implementation, as well as preventing global catastrophic risk. All plans converge at the end, as their result is the indefinite survival as an uploaded mind inside an ecosystem, created by a superintelligent AI. (shrink)

Individuals suffering from anorexia-nervosa experience dysmorphic perceptions of their body and desire to act on these perceptions by refusing food. In some cases, anorexics want to refuse food to the point of death. In this paper, I answer this question: if an anorexic, A, wants to refuse food when the food would either be life-saving or prevent serious bodily harm, can A’s refusal be valid? I argue that there is compelling reason to think that anorexics can validly refuse food, even (...) in these extreme circumstances. (shrink)

Recent progress in geroscience holds the promise of significantly slowing down or even reversing ageing and age‐related diseases, and thus increasing our healthspans. In this paper, I offer a novel argument in favour of developing such technology and making it unconditionally available to everyone. In particular, I argue that justice requires that each person be provided with sufficient opportunities to have a ‘complete life’, that many people currently lack such opportunities, and that we would substantially improve the status quo by (...) giving them access to anti‐ageing technology. (shrink)

The biosphere represents the global sum of all ecosystems. According to a prominent view in environmental ethics, ecocentrism, these ecosystems matter for their own sake, and not only because they contribute to human ends. As such, some ecocentrists are critical of the modern industrial civilization, and a few even argue that an irreversible collapse of the modern industrial civilization would be a good thing. However, taking a longer view and considering the eventual destruction of the biosphere by astronomical processes, we (...) argue that humans, a species with considerable technological know-how and industrial capacity could intervene to extend the lifespan of Earth’s biosphere, perhaps by several billion years. We argue that human civilization, despite its flaws and harmful impacts on many ecosystems, is the biosphere’s best hope of avoiding premature destruction. We argue that proponents of ecocentrism, even those who wholly disregard anthropocentric values, have a strong moral reason preserve the modern industrial civilization, for as long as needed to ensure biosphere survival. (shrink)

Two recent collections of papers—Social Equality: On What It Means to Be Equals, edited by Carina Fourie, Fabian Schuppert, and Ivo Wallimann-Helmer and The Equal Society: Essays on Equality in Theory and Practice, edited by George Hull —demonstrate well the wide diversity of perspectives on egalitarianism within political theory today. But there are unifying themes amidst all this diversity. In particular, these collections make plain the extent to which contemporary egalitarianism in all forms is indebted to Rawls. This debt is (...) reflected, for example, in the luck egalitarianism/social egalitarian debate which plays a central role in both books. It is also reflected in the concern so many contemporary egalitarians have for respect and its social basis. But while egalitarianism today owes much to Rawls, this does not mean that Rawls has nothing left to contribute to the conversation. This essay will argue that a return to Rawls can help contemporary egalitarians avoid taking their debates in certain unproductive directions. (shrink)

In response to Bernard Williams’ suspicion that we would inevitably become bored with immortal life, John Martin Fischer has argued that we could continue to enjoy repeatable pleasures such as fine wine, beautiful music, and spiritual experiences. In more recent work on near-death experiences, Fischer has also explored the non-religious meaning of spiritual experiences in more depth. I join this deeper exploration of spiritual experience, and I also join Williams’ critics who question his view that character and desire are needed (...) to explain the desirability of life, while providing additional reason for concern that Williams’ way of valuing life may itself actually be a cause of boredom with life. With an eye to spiritual experience, I indicate how we can distance ourselves even further from Williams’ view, and I suggest how the attitude thatlife is good but death is not bademerges from spiritual experience, as expressed in numerous religious and secular spiritual traditions. This lends support to the conclusion that radically extended life is desirable even if not actively desired. (shrink)

Modern society makes extensive use of automated algorithmic decisions, fueled by advances in artificial intelligence. However, since these systems are not perfect, questions about fairness are increasingly investigated in the literature. In particular, many authors take a Rawlsian approach to algorithmic fairness. This article aims to identify some complications with this approach: Under which circumstances can Rawls’s original position reasonably be applied to algorithmic fairness decisions? First, it is argued that there are important differences between Rawls’s original position and a (...) parallel algorithmic fairness original position with respect to risk attitudes. Second, it is argued that the application of Rawls’s original position to algorithmic fairness faces a boundary problem in defining relevant stakeholders. Third, it is observed that the definition of the least advantaged, necessary for applying the difference principle, requires some attention in the context of algorithmic fairness. Finally, it is argued that appropriate deliberation in algorithmic fairness contexts often require more knowledge about probabilities than the Rawlsian original position allows. Provided that these complications are duly considered, the thought-experiment of the Rawlsian original position can be useful in algorithmic fairness decisions. (shrink)

Biomedical technologies capable of sharply reducing or ending human aging, “radical life extension”, call for a Christian response. The authors featured in this article offer some preliminary thoughts. Common themes include: What kind of life counts as a “good life;” the limits, if any, of human freedom; the consequences of extended life on the human species and on the Earth; the meaning and value of finite and vulnerable embodied life; the experience of time; anthropological self-understanding; and human dignity. Notably, all (...) four authors share serious concerns about RLE’s potential effects. (shrink)

This paper represents an attempt to correlate the concept of hope with the notion of human longevity and reflects the actual debates around the problem of life extension. Our analysis combines ideas from philosophy, sociology, bioethics, and religion to illustrate the problem of longevity in the context of biomedical and technological progress, and - at the same time - to show the (possible) consequences of prolonging life over the human body limits. Extending human life through emerging technologies is much closer (...) to us than we might think and is a particularly challenging topic. (shrink)

Famously, Bernard Williams has argued that although death is an evil if it occurs when we still have something to live for, we have no good reason to desire that our lives be radically extended because any such life would at some point reach a stage when we become indifferent to the world and ourselves. This is supposed to be so bad for us that it would be better if we died before that happens. Most critics have rejected Williams’ arguments (...) on the grounds that it is far from certain that we will run out of things to live for, and I don't contest these objections. Instead, I am trying to show that they do not affect the persuasiveness of Williams’ argument, which in my reading does not rely on the claim that we will inevitably run out of things to live for, but on the far less contentious claim that it is not unthinkable we will do so and the largely ignored claim that if that happens, we will have died too late. (shrink)

The debate between Jürgen Habermas and John Rawls concerns the question of how to do political philosophy under conditions of cultural pluralism, if the aim of political philosophy is to uncover the normative foundation of a modern liberal democracy. Rawls’s political liberalism tries to bypass the problem of pluralism, using the intellectual device of the veil of ignorance, and yet paradoxically at the same time it treats it as something given and as an arbiter of justification within the political conception (...) of justice. Habermas argues that Rawls not only incorrectly operationalizes the moral point of view from which we discern what is just but also fails to capture the specificity of democracy which is given by internal relations between politics and law. This deprives Rawls’s political philosophy of the conceptual tools needed to articulate the normative foundation of democracy. (shrink)

BackgroundThe Life Extension Medical Decision law enacted on February 4, 2018 in South Korea was the first to consider the suspension of futile life-sustaining treatment, and its enactment caused a big controversy in Korean society. However, no study has evaluated whether the actual implementation of life-sustaining treatment has decreased after the enforcement of this law. This study aimed to compare the provision of patient consent before and after the enforcement of this law among cancer patients who visited a tertiary university (...) hospital's emergency room to understand the effects of this law on the clinical care of cancer patients.MethodsThis retrospective single cohort study included advanced cancer patients aged over 19 years who visited the emergency room of a tertiary university hospital. The two study periods were as follows: from February 2017 to January 2018 and from May 2018 to April 2019. The primary outcome was the length of hospital stay. The consent rates to perform cardiopulmonary resuscitation, intubation, continuous renal replacement therapy, and intensive care unit admission were the secondary outcomes.ResultsThe length of hospital stay decreased after the law was enforced from 4 to 2 days. The rates of direct transfers to secondary hospitals and nursing hospitals increased from 8.2 to 21.2% and from 1.0 to 9.7%, respectively. The consent rate for admission to the ICU decreased from 6.7 to 2.3%. For CPR and CRRT, the consent rates decreased from 1.0 to 0.0% and from 13.9 to 8.8%, respectively, but the differences were not significant.ConclusionAfter the enforcement of the Life Extension Medical Decision law, the length of stay in the tertiary university hospital decreased in patients who established their life-sustaining treatment plans in the emergency room. Moreover, the rate of consent for ICU admission decreased. (shrink)

Wenn eine Person unter einer tödlichen Krankheit leidet und nicht über die Ressourcen für eine medizinische Behandlung verfügt, sind wir normalerweise dazu verpflichtet, ihr die notwendigen Ressourcen bereitzustellen. Wären wir aber in einem biotechnischen Zukunftsszenario, in dem die menschliche Lebensspanne durch Eingriffe in den Alterungsprozess erhöht werden kann, auch dazu verpflichtet, anderen Personen die notwendigen Ressourcen für solche Maßnahmen bereitzustellen? John Harris hat argumentiert, dass wir zu solch einer direkten biotechnischen Lebensverlängerung verpflichtet wären, da ein Leben zu verlängern das Gleiche (...) sei, wie ein Leben zu retten. Im vorliegenden Aufsatz wird gezeigt, dass Harris’ Argument nicht schlüssig ist, da entgegen seiner Prämisse ein begrifflicher Unterschied zwischen der Rettung und der Verlängerung eines Lebens besteht. Auf Grundlage von Harris’ zurückgewiesenem Argument werden dann aber zwei alternative Argumente für eine (prima facie) Pflicht zur direkten Lebensverlängerung konstruiert. Das erste Argument basiert auf der Überlegung, dass durch eine direkte biotechnische Lebensverlängerung trotz des begrifflichen Unterschieds mit einer substanziellen Wahrscheinlichkeit Leben gerettet werden würden. Das zweite Argument besagt, dass trotz deskriptiver Unterschiede eine moralische Äquivalenz zwischen der Rettung und der Verlängerung eines Lebens besteht, sofern durch die bloße Lebensverlängerung das Leben um die gleiche Dauer und Qualität verlängert wird wie durch die Lebensrettung. ---------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------- When a person suffers from a deadly disease and is lacking the resources for a medical treatment, we are normally obliged to provide the necessary resources. But would we also be morally obliged to provide the resources for an extension of someone’s lifespan through anti-aging treatments which might be developed due to biotechnological progress? John Harris has argued that there would be an obligation to such a direct biotechnical life extension because extending a life is the same as saving a life. In the present paper, it will be shown that Harris’ argument is not sound since, contrary to his premise, there is a conceptual difference between extending and saving a life. On the basis of Harris’ rejected argument, though, two alternative arguments for a (prima facie) obligation to direct biotechnical life extension will be developed. The first argument is based on the idea that, despite the conceptual difference, one saves someone’s life with a substantial probability when extending it by direct biotechnical means. In the second argument, it will be argued that there is a moral equivalence between extending and saving someone’s life despite the descriptive differences as far as the additional lifetime has the same duration and quality in both cases. (shrink)

The term “value of life” can refer to life’s intrinsic dignity: something nonincremental and time-unaffected in contrast to the fluctuating, incremental “value” of our lives, as they are longer or shorter and more or less flourishing. Human beings are equal in their basic moral importance: the moral indignities we condemn in the treatment of e.g. those with dementia reflect the ongoing human dignity that is being violated. Indignities licensed by the person in advance remain indignities, as when people might volunteer (...) their living, unconscious bodies for surrogacy or training in amputation techniques. Respect for someone’s dignity is significantly impacted by a failure to value that person’s very existence, whatever genuine respect and good will is shown by wanting the person’s life to go well. Valuing and respecting life is not, however, vitalism: there can be good and compelling reasons for eschewing some means of prolonging life. (shrink)

Worldwide populations are aging with economic development as a result of public health initiatives and advances in therapeutic discoveries. Since 1850, life expectancy has advanced by 1 year for every four. Accompanying this change is the rapid development of anti‐aging science. There are three schools of thought in the field of aging science. One perspective is the life course approach, which considers that aging is a good and natural process to be embraced as a necessary and positive aspect of life, (...) where the aim is to improve the quality of existing lifespan and “compress” morbidity. Another view is that aging is undesirable, and that rejuvenation and indeed immortality are possible since the biological basis of aging is understood, and therefore, strategies are possible for engineering negligible senescence. Finally, a hybrid approach is that life span can be extended by anti‐aging medicines but with uncertain effects on health. While these advances offer much promise, the ethical perspectives are seldom discussed in cross‐disciplinary settings. This article discusses some of the key ethical issues arising from recent advances in biogerontology. (shrink)

Is there a moral difference between euthanasia for terminally ill adults and euthanasia for terminally ill children? Luc Bovens considers five arguments to this effect, and argues that each is unsuccessful. In this paper, I argue that Bovens' dismissal of the sensitivity argument is unconvincing.

Various debates on the desirability and rationality of life-extending enhancements have been pursued under the presupposition that a generic psychological theory of personal identity is correct. I here discuss how the narrative approach to personal identity can contribute to these debates. In particular, I argue that two versions of the narrative approach offer good reasons to reject an argument against the rationality of life-extending enhancements.

Philosophy is not usually seen as a guidance for modern housing policy, but in this new book, Dr Helen Taylor argues that there is something innovative, unusual, and worth discussing about the application of philosophy to housing. The philosophical framework used within this book is John Rawls' conception of justice as fairness. The UK has gone through several shifts in housing policy over the past decade, most recently by introducing the controversial 'Bedroom Tax', in an effort to make more cuts (...) to benefits and social welfare. Social Justice in Contemporary Housing: Applying Rawls' Difference Principle suggests that by using ideas of agency we can understand the impact that social policy has on individuals and wider society. The work outlines the liberal principle of legitimacy and argues that Rawls' concept of reasonableness can, and should, be used to justify the intervention of policy in individuals' lives. This book will be of interest to undergraduate and postgraduate students of housing as well as philosophy and social policy, and also those working around the creation and implementation of social housing in the UK. (shrink)

A quiet revolution is occurring in the field of transplantation. Traditionally, transplants have involved solid organs such as the kidney, heart and liver which are transplanted to prevent recipients from dying. Now transplants are being done of the face, hand, uterus, penis and larynx that aim at improving a recipient's quality of life. The shift away from saving lives to seeking to make them better requires a shift in the ethical thinking that has long formed the foundation of organ transplantation. (...) The addition of new forms of transplants requires doctors, patients, regulators and the public to rethink the risk and benefit ratio represented by trade-offs between saving life, extending life and risking the loss of life to achieve improvements in the quality of life. (shrink)

The primary intention of Ren and Canavero's article (2017) is to respond to various criticisms raised by their proposal of the head anastomosis venture (HEAVEN) procedure. Before we launch a deeper analysis of Ren and Canavero's article, I would like to draw attention to a sentence, “Unfortunately, humility is not a part of medical lore,” where they refer to the arrogance and unsuccessfulness of medical science to recognize the importance and breakthrough of the HEAVEN procedure. Interestingly, with this repeated citation, (...) they acknowledge a familiar criticism of medical lore, so that we would expect that they provide a good example of the appreciation of humility in their present article. (shrink)

As things currently stand, our deaths are unavoidable and our lifespans short. It might be thought that these qualities leave room for improvement. According to a prominent line of argument in philosophy, however, this thought is mistaken. Against the idea that a longer life would be better, it is claimed that negative psychological states, such as boredom, would be unavoidable if our lives were significantly longer. Against the idea that a deathless life would be better, it is claimed that such (...) a life would be lacking in important sources of value, because death is a precondition for many of our valuing attitudes. I argue that these problems are avoided by very long lives that incorporate fading memory, limited ignorance of future events, and temporal scarcity. I conclude that very long lives are, in principle, desirable, and that death does not play an essential role in our valuing attitudes. (shrink)

This chapter discusses the moral framework for surrogate decision-making for incompetent medical patients. The chapter focuses on the question of how we can respect the autonomy of those who are no longer competent to make such decisions. The standard counterfactual account of how to respect the autonomy of the incompetent is evaluated, along with accounts that ground respect for autonomy on the patient’s most recent desires and values (regardless of whether the patient still possesses those desires and values) as well (...) as accounts according to which only the current desires and values of the patient matter. Other issues discussed include whether questions of personal identity should affect decision-making for incompetent patients, whether a patient’s former desires and values factor in to the patient’s current well-being, and whether an incompetent patient’s “investment interests” should guide decisions on the patient’s behalf. (shrink)

Impending environmental crises have led to general consensus within green political thought that liberal principles of justice and green concerns make for uneasy bedfellows. This book critiques the contextual framework within which Rawls's political liberalism is assessed as suitable or unsuitable for 'greening'. It provides a detailed and comprehensive overview of the research done on the subjects of Rawls and environmental concerns. It challenges an emerging consensus within the existing literature that Rawls's political philosophy can only incorporate minimal green concerns (...) by offering an alternative communitarian reading of Rawls's 'well-ordered society' that allows for the possibility of a 'darker' green, Rawlsian stewardship ethic. The book outlines the plurality of methodological and ethical approaches undertaken by green political theorists in analysing the contribution Rawls's theory makes to environmental concerns. The variety of approaches undertaken by theorists in this area highlight a certain arbitrariness of the 'tests' or 'standards' used to measure the green credentials of Rawls's political theory. Finally the book argues that attempts to rule out the green credentials of Rawls's theory form part of a wider disquiet, and even frustration, with the inability of liberal and procedurally-neutral polities to instil the requisite virtues and qualities of character to develop a new generation of environmental citizens able to address environmental crises. „Rawls and Environmental Stewardship" fills the gap for a much needed reassessment of 25 years of critiques of Rawls. This inspiring book is of great interest to researchers in contemporary political philosophy, environmental ethics, green political theory, stewardship theory and all those interested in renewing existing conceptions of deliberative democracy. (shrink)

Miracle Max, it seems, is the only remaining miracle worker in all of Florin. Among other things, this means that he (unlike anyone else) can resurrect the recently dead, at least in certain circumstances. Max’s peculiar talents come with significant perks (for example, he can basically set his own prices!), but they also raise a number of ethical dilemmas that range from the merely amusing to the truly perplexing: -/- How much about Max’s “methods” does he need to reveal to (...) his patients? Is it really OK for Max to lie about Valerie’s being a witch, even though she really isn’t? Just how much of the “truth” does Max have to tell his patients? -/- Let’s suppose that Humperdinck had offered Max his old job back. Would it have been OK for Max to accept this offer? What about if Humperdinck wanted him to do experiments at “the Zoo”? -/- Is Max obligated to offer his services to everyone who needs them, such as the (mostly) dead Westley and friends? Or is he free to pick and choose? -/- In this chapter, I’ll consider how these questions might be addressed using concepts of medical ethics. As it turns out, Max’s dilemmas are not too different from the sorts of dilemmas that many medical professionals encounter in their daily lives, and exploring how Max could (or should) respond to them can help us figure out what we can do here in the “real” world. (shrink)

Theaspirationforvolitionalevolution,orhumanevolutiondirectedbyhumansthemselves,has increased in philosophical, scientific, technical, and commercial literature. The prospect of shaping the very being who is the consumer of all other innovations offers great commercial potential, one to which all other innovations would in effect be subservient. Actually an amalgam of projected technical/commercial developments, this prospective innovation has practical and ethical ramifications. However, because it is often discussed in a scientific way (specifically that of evolutionary theory), it first calls for examination in terms of common scientific approaches to (...) evolution. Yet, as evolutionary-theory controversies point up, evolution may be considered as neither a directed nor a directable process – a problem for the ontology of volitional evolution. One challenge for theories and programs aiming to implement the proposed innovation is then whether it is theoretically coherent. While I offer responses to the challenge in the form of objections, these in turn remain problematic. Two central issues of responsible innovation arise: (1) If this prospect were feasible, would it be responsible to implement it, and (2) if it is not even theoretically coherent, is it responsible for innovators, even this early-on, to keep promoting it as if it were? (shrink)

In this book, Jeffrey Bercuson presents the immense, and yet for the most part unrecognized, influences of Jean-Jacques Rousseau and Georg Wilhelm Friedrich Hegel on John Rawls, the most important political philosopher of the 20th century. While the well-documented influence of Immanuel Kant on Rawls is deep and profound, Kantian features and interpretation of justice as fairness do not tell the whole story about that doctrine. Drawing on Rawls's Lectures on the History of Moral Philosophy and his Lectures on the (...) History of Political Philosophy, Bercuson presents the reader with a more nuanced, accurate account of the moral and political philosophy of Rawls in light of these under-appreciated influences. This new, richer image of Rawls's political philosophy shows that Rawls's notion of reasonableness – his notion of the kind and extent of our obligations to those fellows with whom we are engaged in social cooperation – is conspicuously more demanding, and therefore more attractive, than most interpreters and critics assume. Rawls turns to Rousseau and to Hegel, both of whom provide attractive images of engaged citizenship worthy of emulation. Written accessibly, and contributing to key contemporary debates of global justice, this book will be read by scholars within the fields of social and political theory, ethics, and philosophy. (shrink)

This dissertation discusses several ethical and moral issues which arise from the cryonics movement. Within each section, the question is posed: how does that problem impact on how we should think about cryonics? Is cryonics morally permissible and/or morally obligatory? Issues include a consideration of economic resource allocation, bodily ownership and identity.

Some bioethicists have questioned the desirability of a line of biomedical research aimed at extending the length of our lives over what some think to be its natural limit. In particular, Leon Kass has argued that living longer is not such a great advantage, and that mortality is not a burden after all. In this essay, I evaluate his arguments in favour of such a counterintuitive view by elaborating upon some critical remarks advanced by John Harris. Ultimately, I argue that (...) nothing substantial has been said by Kass to undermine the desirability of life-extending technologies. (shrink)

Since before we can remember, humanity aims to overcome its biological limitations; such a goal has certainly played a key role in the advent of technique. However, despite the benefits that technique may bring, the people who make use of it will inevitably be under risk of harm. Even though human technical wisdom consists in attaining the best result without compromising anybody’s safety, misuses are always a possibility in the horizon. Nowadays, technology can be used for more than just improving (...) human capacities, preserving and restoring health or promoting human well-being. It also enables us to overcome human limitations and reach way beyond our "natural design". That being said, what could possibly justify the fear for these new directions of biotechnology? Should medicine and health care change their traditional goals and begin searching for artificial improvements to wellness in human nature? In this paper, I will hereby present and briefly discuss the main topics of the contemporary issue of human enhancement: the therapy-enhancement distinction, the possibility of cognitive enhancements and better physical performances, the fight against senescence, the arguments for and against human eugenics, the search for perfection, the quest of moral enhancement, the problem of public priorities, and some questions on medical ethics. Then, finally, I will want to present some realist perspectives on the subject. (shrink)

The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means. A particular focus was on ontologies, as these are a key technology to systematically integrate heterogeneous information about the aging process. Related topics were databases and data integration. Other talks tackled modeling issues and applications, the latter including talks focussed on marker development and cellular stress as well as on diseases, in particular on diseases of kidney (...) and skin. (shrink)

This volume gathers together previously unpublished articles focusing on the relationship between preference adaptation and autonomy in connection with human enhancement and in the end-of-life context.

The American Journal of Bioethics, Volume 12, Issue 6, Page 48-49, June 2012.

Over a long period of time, particularly from the nineteenth century on, Francis Bacon's philosophy has been interpreted as centred on the Novum organum and focused on the role that a well-organized method may play in securing a reliable knowledge of nature. In fact, if we examine Bacon's oeuvre as a whole, including some recent manuscript findings, we can safely argue that the issues addressed in the Novum organum represent only a part of Bacon's agenda, and not even the most (...) important ones. By contrast, it is apparent that, from the very beginning of his investigations, he emphasized the central role of medicine, the need to establish new approaches in the study of the vital functions and the importance of promoting new discoveries in the medical field, not so much to find a cure for the many illnesses that plagued mankind as to prolong human life. In this sense, Historia vitae et mortis plays a central role in Bacon's programme to extend human knowledge and power, for, in his opinion, human beings could recover their lost ability to live a long and healthy life by embarking on careful investigations of nature. Far from being a purely descriptive or abstract exercise, Bacon's historia can therefore be seen as an operative tool to attain some of mankind's basic aims. (shrink)

Addressing the question in the form of Kant’s maxim, this paper moves on to a more controversial topic in biomedical ethics, physician-assisted suicide. However, my conclusion is tentative, and what is worse, negative: I partially approve suicide. It does not imply a moral hazard. The situation is opposite: in the present times, terminal patients seriously wish it. I, as an author, put an emphasis on this very respect. Now suicide is, for certain circles, nothing but justice. The arguments of thinkers (...) who approve suicide are also cited from this angle. (shrink)

November 2009’s announcement of the USPSTF’s recommendations for screening for breast cancer raised a firestorm of objections. Chief among them were that the panel had insufficiently valued patients’ lives or allowed cost considerations to influence recommendations. The publicity about the recommendations, however, often either simplified the actual content of the recommendations or bypassed significant methodological issues, which a philosophical examination of both the science behind screening recommendations and their import reveals. In this article, I discuss two of the leading ethical (...) considerations at issue in screening recommendations: respect for patient autonomy and beneficence and then turn to the most significant methodological issues raised by cancer screening: the potential biases that may infect a trial of screening effectiveness, the problem of base rates in communicating risk, and the trade-offs involved in a judgment of screening effectiveness. These issues reach more broadly, into the use of “evidence-based” medicine generally, and have important implications for informed consent. (shrink)

Contemporary philosophers and bioethicists argue that life extension is bad for the individual. According to the agency objection to life extension, being constrained as an agent adds to the meaningfulness of human life. Life extension removes constraints, and thus it deprives life of meaning. In the paper, I concede that constrained agency contributes to the meaningfulness of human life, but reject the agency objection to life extension in its current form. Even in an extended life, decision-making remains constrained, and many (...) obstacles to the fulfilment of an agent’s goals are preserved. Agents with longer lives are also presented with new challenges: for instance, it might be harder for them to avoid chronic boredom, and sustain their motivation to act in the pursuit of their goals. Although objections from agency and boredom are often used in combination to support the view that a much longer life is likely to bring misery or become meaningless, I argue that the acceptance of the boredom objection undermines the persuasiveness of the agency objection. (shrink)

Peter Singer has argued that we should not proceed with a hypothetical life-extension drug, based on a scenario in which developing the drug would fail to achieve the greatest sum of happiness over time. However, this is the wrong test. If we ask, more simply, which policy would be more benevolent, we reach a different conclusion from Singer’s: even given his scenario, development of the drug should go ahead. Singer’s rigorous utilitarian position pushes him in the direction of an implausible (...) “total view” utilitarianism when it encounters the problems presented by certain thought experiments. A more pluralistic account of the nature of morality promises to solve these problems, and in this case it reaches a benevolent recommendation on life-extension technology. (shrink)

Important scientific, ethical and sociological debates are emerging over the trans-humanist goal to achieve therapeutic treatments to ‘cure’ the debilitation of age-related illness and extend the healthy life span of individuals through interventive biogerontological research. The scientific and moral discourses surrounding this contentious scientific field are mapped out, followed by a normative argument favouring ‘strong’ deliberative democratic control of human life extension research. This proposal incorporates insights from constructive and participatory technology assessment, upstream public engagement and back-casting analysis; to outline (...) a programme of participatory approaches to encourage two-way dialogue between scientific and citizen perspectives, and foster the long-term deliberative democratic governance of this developing field. (shrink)

Cryonic suspension is a relatively new technology that offers those who can afford it the chance to be 'frozen' for future revival when they reach the ends of their lives. This paper will examine the ethical status of this technology and whether its use can be justified. Among the arguments against using this technology are: it is 'against nature', and would change the very concept of death; no friends or family of the 'freezee' will be left alive when he is (...) revived; the considerable expense involved for the freezee and the future society that will revive him; the environmental cost of maintaining suspension; those who wish to use cryonics might not live life to the full because they would economize in order to afford suspension; and cryonics could lead to premature euthanasia in order to maximize chances of success. Furthermore, science might not advance enough to ever permit revival, and reanimation might not take place due to socio-political or catastrophic reasons. Arguments advanced by proponents of cryonics include: the potential benefit to society; the ability to cheat death for at least a few more years; the prospect of immortality if revival is successful; and all the associated benefits that delaying or avoiding dying would bring. It emerges that it might be imprudent not to use the technology, given the relatively minor expense involved and the potential payoff. An adapted and more persuasive version of Pascal's Wager is presented and offered as a conclusive argument in favour of utilizing cryonic suspension. (shrink)

It seems to be a widespread opinion that increasing the length of existing happy lives is better than creating new happy lives although the total welfare is the same in both cases, and that it may be better even when the total welfare is lower in the outcome with extended lives. I shall discuss two interesting suggestion that seems to support this idea, or so it has been argued. Firstly, the idea there is a positive level of wellbeing above which (...) a life has to reach to have positive contributive value to a population, so-called Critical Level Utilitarianism. Secondly, the view that it makes an outcome worse if people are worse off than they otherwise could have been, a view I call Comparativism. I shall show that although these theories do capture some of our intuitions about the value of longevity, they have such counterintuitive implications in other cases that we ultimately have to reject them. (shrink)

Some of the objections to life-extension stem from a concern with overpopulation. I will show that whether or not the overpopulation threat is realistic, arguments from overpopulation cannot ethically demand halting the quest for, nor access to, life-extension. The reason for this is that we have a right to life, which entitles us not to have meaningful life denied to us against our will and which does not allow discrimination solely on the grounds of age. If the threat of overpopulation (...) creates a rights conflict between the right to come into existence, the right to reproduce, the right to more opportunities and space , and the right to life, the latter ought to be given precedence. (shrink)