This article reconstructs Henri Bergson’s argument at the beginning of the second chapter of his Essai sur les données immédiates de la conscience for his view that every idea of number involves sp...

The endoplasmic reticulum (ER) organelle is the key intracellular site of both protein and lipid biosynthesis. ER dysfunction, termed ER stress, can result in protein accretion within the ER and cell death; a pathophysiological process contributing to a range of metabolic diseases and cancers. ER stress leads to the activation of a protective signalling cascade termed the Unfolded Protein Response (UPR). However, chronic UPR activation can ultimately result in cellular apoptosis. Emerging evidence suggests that cells undergoing ER stress and UPR (...) activation can release extracellular signals that can propagate UPR activation to target tissues in a cell non‐autonomous signalling mechanism. Separately, studies have determined that the UPR plays a key regulatory role in the biosynthesis of bioactive signalling lipids including sphingolipids and ceramides. Here we weigh the evidence to combine these concepts and propose that during ER stress, UPR activation drives the biosynthesis of ceramide lipids, which are exported and function as cell non‐autonomous signals to propagate UPR activation in target cells and tissues. (shrink)

This article challenges three widespread assumptions about Kant’s argument for the antithesis of the Second Antinomy. The first assumption is that this argument consists of an argument for the claim that “[no] composite thing in the world consists of simple parts”, and a logically independent argument for the claim that “nothing simple exists anywhere in the world”. The second assumption is that when Kant argues that “[no] composite thing in the world consists of simple parts”, he is making a claim (...) about the mereological structure of spatially extended things in particular, as opposed to a claim about the mereological structure of things in general. And the third assumption is that Kant’s argument for this part of the antithesis is based on a claim about the relationship between the size of the extension of a composite thing and the sizes of the extensions of the things of which this composite thing consists. (shrink)

This paper draws out from Kierkegaard’s work a distinctive critical perspective on an influential contemporary approach in moral philosophy: namely, Christine Korsgaard’s transcendental argument for the value of humanity. From Kierkegaard’s perspective, we argue, Korsgaard argument goes too far, in attributing absolute value to humanity – but also that she is required to make this claim if her transcendental argument is to work. From a Kierkegaardian perspective, to place this sort of value in humanity is problematic since it threatens to (...) make the relation between individuals too claustrophobic. Finally, we explore the possibility of a rival approach, in which we should view others as ethically significant because they too are related to the kind of ‘third’ which Kierkegaard argues is needed to bring stability to the structure of the self. In this way, we claim, a different and more successful transcendental argument to the value of humanity can be found in the work of Kierkegaard. (shrink)

The subject of this article is a powerful objection to the non-conceptualist interpretation of Kant’s transcendental deduction of the categories. Part of the purpose of the deduction is to refute the sort of scepticism according to which there are no objects of empirical intuition that instantiate the categories. But if the non-conceptualist interpretation is correct, it does not follow from what Kant is arguing in the transcendental deduction that this sort of scepticism is false. This article explains and assesses a (...) number of possible responses to this objection. (shrink)

The Bibliotheca Britannica is one of the most remarkable examples of bibliographical scholarship in the English Language. This scarce work of reference continues to be an invaluable resource for scholars and librarians who wish to identify early printed materials covering a wide range of disciplines. Routledge is pleased to make this important source of information more widely available. Published in 1824, it is estimated to include more than 200,000 books, pamphlets and periodicals printed from 1450 to the early nineteenth century. (...) The Bibliotheca is divided into four large-format volumes which are presented as a boxed set. The first and second volumes contain an alphabetical listing of over 40,000 authors and their biographical details. Full length titles of works, date and place of publication, and information on translations and subsequent editions are provided for each author. The entries covering the earliest printed texts contain details of British and foreign printers. Volumes three and four provide an encyclopedic index to volumes one and two. The works are listed within 30,000 subject areas, in chronological order of publication. Subjects, authors and titles are fully cross-referenced using an ingenious indexing system. Robert Watt devoted 25 years of his life to the Bibliotheca's compilation. He was born in 1774 and studied classical languages and philosophy at Glasgow University. Later he became a student of anatomy and theology at Edinburgh, and practised as a doctor. His interest in the history of medicine led him to begin compiling the Bibliography, which he extended to include works on law, history, language, philosophy, science, technology, travel and geography, and classical literature. (shrink)

European Journal of Philosophy, Volume 29, Issue 4, Page 1010-1025, December 2021.

Many philosophers have been puzzled by Kant's decision to insert the Refutation of Idealism into the second edition of the first Critique at the end of his elucidation of the Second Postulate. This article proposes a solution to the puzzle. It defends an explanation for the location of Kant's Refutation of Idealism that is plausibly expressed by Kant's claim at the end of his elucidation of the Second Postulate that the Refutation of Idealism is ‘here in its right place’ because (...) ‘[a] powerful objection against these rules for proving existence indirectly is made by idealism’. According to this explanation, the Refutation of Idealism is Kant's response to the objection that the Second Postulate must be false since otherwise idealism is true. This article also considers and rejects a number of alternative explanations for the location of Kant's Refutation of Idealism. (shrink)

In standard times, approximately 20% of children and youth experience significant emotional, behavioral, or social challenges. During COVID-19, however, over half of parents have reported mental health symptoms in their children. Specifically, depressive symptoms, anxiety, contamination obsessions, family well-being challenges, and behavioral concerns have emerged globally for children during the pandemic. Without treatment or prevention, such concerns may hinder positive development, personal life trajectory, academic success, and inhibit children from meeting their potential. A school-based resiliency program for children for children (...) was developed, and the goal of this study was to collaborate with stakeholders to translate it into an online-live hybrid. Our team developed a methodology to do this based on Knowledge Translation-Integration, which incorporates stakeholder engagement throughout the entire research to action process. KTI aims to ensure that programs are acceptable, sustainable, feasible, and credible. Through collaboration with parents and school board members, qualitative themes of concerns, recommendations and validation were established, aiding in meaningful online-live translation. Even though the original program was developed for intellectually gifted children, who are at greater risk for mental health concerns, stakeholders suggested using the program for both gifted and non-gifted children, given the universal applicability of the tools, particularly during this pandemic time period when mental health promotion is most relevant. An online-live approach would allow students studying at home and those studying in the classroom to participate in the program. Broader implications of this study include critical recommendations for the development of both online-live school programs in general, as well as social-emotional literacy programs for children. (shrink)

This paper seeks to highlight the importance of spatial cognition in Bergson’s Données immédiates by engaging with Robert Watt’s reconstruction of Bergson’s argument that every idea of number involves the idea of space. We focus on the second stage of Watt’s reconstruction, where Bergson argues that only space can provide the distinction required for our counting of otherwise identical items. Watt bases his reconstruction on a premise regarding the possibility that identical objects, in the absence of (...) spatial distinction, might remain identical across different “temporal locations”. Our paper raises the prospect that Bergson is committed to a stronger thesis, namely one implying that identical objects would necessarily remain indistinguishable without the intervention of space. The paper thus concludes by emphasizing the indispensability of space for knowledge according to Bergson. (shrink)

This article examines the arguments used by Robert Watts, a contemporary of John Stuart Mill, in his criticism of Mill's Utilitarianism. The pamphlet in which Watts expresses his views is a scarce and neglected work. Pioneering studies by J.C. Rees and J.B. Schneewind emphasize the importance of Mill's early critics for historians of nineteenth-century ethics and politial thought. Rees, however, confines his study to the responses to Mill's On Liberty. Schneewind's work is more comprehensive and does mention Watts, but (...) without examining in detail the actual arguments that Watts uses. Further, while Watts criticizes Mill's ethical views from a theological standpoint the arguments he uses are philosophical in character. Watts should not be thought of as a major philosophical critic of Mill, but his relative neglect leaves a gap in the study of the reception of Mill's thought which this article is intended to fill. (shrink)

This a clear and concise introduction to Danish philosopher Soren Kierkegaard.ichael Watts uses Kierkegaard's own writings to introduce his theoriesbout living a truthfu; and spiritual life, while explaining the enormousnfluence of the philosopher's personal life on his work and beliefs. As theounder of 20th century existentialism, and the first philosopher to definehe idea of angst, Kierkegaard's profound influence on modern life is clearlyefined in accessible terms in this guide for students and general readers.

“Life exists only at this very moment, and in this moment it is infinite and eternal. For the present moment is infinitely small; before we can measure it, it has gone, and yet it exists forever…. You may believe yourself out of harmony with life and its eternal Now; but you cannot be, for you are life and exist Now.”–from Become What You Are In this collection of writings, including nine new chapters never before available in book form, Watts displays (...) the intelligence, playfulness of thought, and simplicity of language that has made him so perennially popular as an interpreter of Eastern thought for Westerners. He draws on a variety of religious traditions, and covers topics such as the challenge of seeing one’s life “just as it is,” the Taoist approach to harmonious living, the limits of language in the face of ineffable spiritual truth, and the psychological symbolism of Christian thought. (shrink)

In this new edition of his acclaimed autobiography — long out of print and rare until now — Alan Watts tracks his spiritual and philosophical evolution from a child of religious conservatives in rural England to a freewheeling spiritual teacher who challenged Westerners to defy convention and think for themselves. From early in this intellectual life, Watts shows himself to be a philosophical renegade and wide-ranging autodidact who came to Buddhism through the teachings of Christmas Humphreys and D. T. Suzuki. (...) Told in a nonlinear style, In My Own Way wonderfully combines Watts’ own brand of unconventional philosophy and often hilarious accounts of gurus, celebrities, psychedelic drug experiences, and wry observations of Western culture. A charming foreword written by Watts’ father sets the tone of this warm, funny, and beautifully written story of a compelling figure who encouraged readers to “follow your own weird” — something he always did himself, as his remarkable account of his life shows. (shrink)

Theories of discourse bring to realism new ideas about how knowledge develops and how representations of reality are influenced. We gain an understanding of the conceptual aspect of social life and the processes by which meaning is produced. This collection reflects the growing interest realist critics have shown towards forms of discourse theory and deconstruction. The diverse range of contributions address such issues as the work of Derrida and deconstruction, discourse theory, Eurocentrism and poststructuralism. What unites all of the contributions (...) is a sense that it is essential to provide a realist alternative to the hitherto dominance of social constructionism, hermeneutics and postmodernism, over many of the issues discussed. By developing a realist perspective the different authors attempt to embed discourse within the structured nature of the reality of the world. Realism can situate language, discourse and ideology within context specific, or 'causally efficacious' circumstances. Realism can help to uncover issues of power, representation, and subjectivity and how discursive and other social practices produce real effects. This can help us understand the manner in which social structures are reproduced through various forms of ideology and discourse. And by knowing this, we can start to address questions concerning human emancipation and how the world is to be transformed. (shrink)

In order to come to your senses, Alan Watts often said, you sometimes need to go out of your mind. Perhaps more than any other teacher in the West, this celebrated author, former Anglican priest, and self-described spiritual entertainer was responsible for igniting the passion of countless wisdom seekers to the spiritual and philosophical delights of India, China, and Japan. With Out of Your Mind, you are invited to immerse yourself in six of this legendary thinker's most engaging teachings on (...) how to break through the limits of the rational mind and expand your awareness and appreciation for the great game unfolding all around us. Distilled from Alan Watts’s pinnacle lectures, Out of Your Mind brings you an inspiring new resource that captures the true scope of this brilliant teacher in action. For those both new and familiar with Watts, this book invites us to delve into his favorite pathways out of the trap of conventional awareness, including: • The art of the “controlled accident”—what happens when you stop taking your life so seriously and start enjoying it with complete sincerity • How we come to believe “the myth of myself”—that we are skin-encapsulated egos separate from the world around us—and how to transcend that illusion • Why we must fully embrace chaos and the void to find our deepest purpose • Unconventional and refreshing insights into the deeper principles of Buddhism, Hinduism, Western philosophy, Christianity, and much more. (shrink)

What makes something an embryo—as opposed to what is actually, and not just in biotech parlance, a collection of cells? This question has come to the fore in recent years with proposals for producing embryonic stem cells for research. While some of those opposed to use of standard embryonic stem cells emphasise that adult cells have a clinical track record, others argue that there may be further benefits obtainable from cells very like those of embryos, provided such cells can be (...) derived in new ways. Rather than deriving them in ways that kill or otherwise endanger a living human embryo, they could be obtained from an entity that merely resembles a human embryo sufficiently closely for its cells to be of use. Such an entity might be created after introducing genetic changes to an ovum before it is activated by, for example, a cloning-type procedure, such that a gene essential to embryogenesis will be either absent, blocked in its expression, or overexpressed.1,2 The claim is that the ovum could be made to give rise to embryonic stem cells—mere living parts—without ever giving rise to a whole embryo, who is killed to obtain them. Whereas cloning “proper” winds back the specialisation of the cell nucleus to a point where a whole embryo is formed who has not yet specialised its cells, oocyte-assisted reprogramming , it is claimed, would wind back the specialisation merely to an intermediate point at which no embryo is created. Other methods proposed for deriving pseudoembryonic cells include parthenogenesis, in which an ovum is activated without a sperm, or even the insertion of an adult cell nucleus.1MORAL STATUS OF THE EMBRYOIn this paper, I assume that a genuine …. (shrink)

In Logic, Watts address proper thinking under the four basic functions of the human mind: perception, judgment, reasoning, and disposition. In part one, Watts addresses human perception, the cultivation of ideas, and how we associate them with words. In part two, Watts treats human judgment and its ability to construct various kinds of propositions, while giving guidance for avoiding the formation of bad judgments. Part three covers our ability to reason, giving instruction on the use of syllogisms for constructing a (...) good argument. Part four discusses the mind's disposition as a method of arranging our thoughts for better understanding and memory. (shrink)

This is a paradigmatic work of contemporary philosophy.

Robert Stern investigates how scepticism can be countered by using transcendental arguments concerning the necessary conditions for the possibility of experience, language, or thought. He shows that the most damaging sceptical questions concern neither the certainty of our beliefs nor the reliability of our belief-forming methods, but rather how we can justify our beliefs.

Robert Hanna presents a fresh view of the Kantian and analytic traditions that have dominated continental European and Anglo-American philosophy over the last two centuries, and of the connections between them. But this is not just a study in the history of philosophy, for out of this emerges Hanna's original approach to two much-contested theories that remain at the heart of contemporary philosophy. Hanna puts forward a new 'cognitive-semantic' interpretation of transcendental idealism, and a vigorous defense of Kant's theory (...) of analytic and synthetic necessary truth, making this compelling reading for all who are interested in these fundamental philosophical issues. (shrink)

One of our great behavioral scientists, the bestselling author of Behave, plumbs the depths of the science and philosophy of decision-making to mount a devastating case against free will, an argument with profound consequences Robert Sapolsky's Behave, his now classic account of why humans do good and why they do bad, pointed toward an unsettling conclusion: We may not grasp the precise marriage of nature and nurture that creates the physics and chemistry at the base of human behavior, but (...) that doesn't mean it doesn't exist. Now, in Determined, Sapolsky takes his argument all the way, mounting a brilliant (and in his inimitable way, delightful) full-frontal assault on the pleasant fantasy that there is some separate self telling our biology what to do. Determined offers a marvelous synthesis of what we know about how consciousness works-the tight weave between reason and emotion and between stimulus and response in the moment and over a life. One by one, Sapolsky tackles all the major arguments for free will and takes them out, cutting a path through the thickets of chaos and complexity science and quantum physics, as well as touching ground on some of the wilder shores of philosophy. He shows us that the history of medicine is in no small part the history of learning that fewer and fewer things are somebody's "fault"; for example, for centuries we thought seizures were a sign of demonic possession. Yet, as he acknowledges, it's very hard, and at times impossible, to uncouple from our zeal to judge others and to judge ourselves. Sapolsky applies the new understanding of life beyond free will to some of our most essential questions around punishment, morality, and living well together. By the end, Sapolsky argues that while living our daily lives recognizing that we have no free will is going to be monumentally difficult, doing so is not going to result in anarchy, pointlessness, and existential malaise. Instead, it will make for a much more humane world. (shrink)

Classical American pragmatism: the pragmatist -- Enlightenment-and its problematic semantics -- Analyzing pragmatism: pragmatics and pragmatisms -- A Kantian rationalist pragmatism: pragmatism -- Inferentialism, and modality in Sellars's arguments against -- Empiricism -- Linguistic pragmatism and pragmatism about norms: an arc of -- Thought from Rorty's eliminative materialism to his pragmatism -- Vocabularies of pragmatism: synthesizing naturalism and -- Historicism -- Towards an analytic pragmatism: meaning-use analysis -- Pragmatism, expressivism, and anti-representationalism: -- Local and global possibilities.

Fetuses and their mothers (and other adults) share many objective interests. These include interests in disjunctive ways of achieving human well-being, including the formation and success of good projects such as particular friendships. Pursuing such good projects is in the individual’s interests and is what growing up is all about. Some interests are time-sensitive, and determining which interests apply at what stages in life requires asking which benefits are in some sense appropriate to the individual and still in his/her actual (...) or possible or even hypothetical future. Human individuals not only have interests in unconditional benefits to them, including the welfare of existing family members, but in conditional benefits to them, including the welfare of possible future family members. Even if not all interests apply to the individual at every stage, if an adult-type benefit is still in the (long-term) future, the young individual including the fetus has a stake in that benefit, conditional as the benefit may sometimes be. Fulfilment is enhanced by pursuit and conscious enjoyment of ‘human goods’, but as with adults, the stake in these remains strong even if psychological links with the long-term future in which this happens are tenuous or non-existent. (shrink)