BackgroundPreprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to published articles. An objective dimension of quality that is readily measurable is completeness of reporting, as transparency can improve the reader’s ability to independently interpret data and reproduce findings.MethodsIn this observational study, we initially compared independent samples of articles published in bioRxiv and in PubMed-indexed journals in 2016 using a quality of reporting questionnaire. After that, we performed paired comparisons (...) between preprints from bioRxiv to their own peer-reviewed versions in journals.ResultsPeer-reviewed articles had, on average, higher quality of reporting than preprints, although the difference was small, with absolute differences of 5.0% [95% CI 1.4, 8.6] and 4.7% [95% CI 2.4, 7.0] of reported items in the independent samples and paired sample comparison, respectively. There were larger differences favoring peer-reviewed articles in subjective ratings of how clearly titles and abstracts presented the main findings and how easy it was to locate relevant reporting information. Changes in reporting from preprints to peer-reviewed versions did not correlate with the impact factor of the publication venue or with the time lag from bioRxiv to journal publication.ConclusionsOur results suggest that, on average, publication in a peer-reviewed journal is associated with improvement in quality of reporting. They also show that quality of reporting in preprints in the life sciences is within a similar range as that of peer-reviewed articles, albeit slightly lower on average, supporting the idea that preprints should be considered valid scientific contributions. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

By a result of L.D. Beklemishev, the hierarchy of nested applications of the $$\Sigma _1$$ -collection rule over any $$\Pi _2$$ -axiomatizable base theory extending Elementary Arithmetic collapses to its first level. We prove that this result cannot in general be extended to base theories of arbitrary quantifier complexity. In fact, given any recursively enumerable set of true $$\Pi _2$$ -sentences, S, we construct a sound $$(\Sigma _2 \! \vee \! \Pi _2)$$ -axiomatized theory T extending S such that the (...) hierarchy of nested applications of the $$\Sigma _1$$ -collection rule over T is proper. Our construction uses some results on subrecursive degree theory obtained by L. Kristiansen. (shrink)

In this paper we continue the study of the theories IΔ n+1 (T), initiated in [7]. We focus on the quantifier complexity of these fragments and theirs (non)finite axiomatization. A characterization is obtained for the class of theories such that IΔ n+1 (T) is Π n+2 –axiomatizable. In particular, IΔ n+1 (IΔ n+1 ) gives an axiomatization of Th Π n+2 (IΔ n+1 ) and is not finitely axiomatizable. This fact relates the fragment IΔ n+1 (IΔ n+1 ) to induction (...) rule for Δ n+1 –formulas. Our arguments, involving a construction due to R. Kaye (see [9]), provide proofs of Parsons’ conservativeness theorem (see [16]) and (a weak version) of a result of L.D. Beklemishev on unnested applications of induction rules for Π n+2 and Δ n+1 formulas (see [2]). (shrink)

Current UK legislation is impacting upon the feasibility and cost-effectiveness of medical record-based research aimed at benefiting the NHS and the public heath. Whereas previous commentators have focused on the Data Protection Act 1998, the Health and Social Care Act 2001 is the key legislation for public health researchers wishing to access medical records without written consent. The Act requires researchers to apply to the Patient Information Advisory Group for permission to access medical records without written permission. We present a (...) case study of the work required to obtain the necessary permissions from PIAG in order to conduct a large scale public health research project. In our experience it took eight months to receive permission to access basic identifying information on individuals registered at general practices, and a decision on whether we could access clinical information in medical records without consent took 18 months. Such delays pose near insurmountable difficulties to grant funded research, and in our case £560 000 of public and charitable money was spent on research staff while a large part of their work was prohibited until the third year of a three year grant. We conclude by arguing that many of the current problems could be avoided by returning PIAG’s responsibilities to research ethics committees, and by allowing “opt-out” consent for many public health research projects. (shrink)

Quarterly publication discussing various topics in environmental ethics, including features, discussion papers, book reviews, editorial commentaries, and other text related to environmental philosophies. Some issues also include announcements and other news related to the environmental studies community.

Quarterly publication discussing various topics in environmental ethics, including features, discussion papers, book reviews, editorial commentaries, and other text related to environmental philosophies. Some issues also include announcements and other news related to the environmental studies community.

Moses Mendelssohn was the leading Jewish thinker of the German Enlightenment and the founder of modern Jewish philosophy. His writings, especially his attempt during the Pantheism Controversy to defend the philosophical legacies of Spinoza and Leibniz against F. H. Jacobi’s philosophy of faith, captured the attention of a young Leo Strauss and played a critical role in the development of his thought on one of the fundamental themes of his life’s work: the conflicting demands of reason and revelation. _ Leo (...) Strauss on Moses Mendelssohn_ is a superbly annotated translation of ten introductions written by Strauss to a multi-volume critical edition of Mendelssohn’s work. Commissioned in Weimar Germany in the 1920s, the project was suppressed and nearly destroyed during Nazi rule and was not revived until the 1960s. In addition to Strauss’s introductions, Martin D. Yaffe has translated Strauss’s editorial remarks on each of the passages he annotates in Mendelssohn’s texts and brings those together with the introductions themselves. Yaffe has also contributed an extensive interpretive essay that both analyzes the introductions on their own terms and discusses what Strauss writes elsewhere about the broader themes broached in his Mendelssohn studies. Strauss’s critique of Mendelssohn represents one of the largest bodies of work by the young Strauss on a single thinker to be made available in English. It illuminates not only a formerly obscure phase in the emergence of his thought but also a critical moment in the history of the German Enlightenment. (shrink)

Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products, implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. (...) Nanotherapeutics andin vivonanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents. (shrink)

The U.S. Food and Drug Administration's rationale for supporting the development and approval of BiDil for heart failure specifically in black patients was based on under-powered, post hoc subgroup analyses of two relatively old trials , which were further complicated by substantial covariate imbalances between racial groups. Indeed, the only statistically significant difference observed between black and white patients was found without any adjustment for potential confounders in samples that were unlikely to have been adequately randomized. Meanwhile, because the accepted (...) baseline therapy for heart failure has substantially improved since these trials took place, their results cannot be combined with data from the more recent trial amongst black patients alone. There is therefore little scientific evidence to support the approval of BiDil only for use in black patients, and the FDA's rationale fails to consider the ethical consequences of recognizing racial categories as valid markers of innate biological difference, and permitting the development of group-specific therapies that are subject to commercial incentives rather than scientific evidence or therapeutic imperatives. This paper reviews the limitations in the scientific evidence used to support the approval of BiDil only for use in black patients; calls for further analysis of the V-HeFT I and II data which might clarify whether responses to H-I vary by race; and evaluates the consequences of commercial incentives to develop racialized medicines. We recommend that the FDA revise the procedures they use to examine applications for race-based therapies to ensure that these are based on robust scientific claims and do not undermine the aims of the 1992 Revitalization Act. (shrink)

This project examined the ethical issues faced by academics and professionals in the Humanities. We conducted focus groups to gather information about the ethical concerns in these fields and used the qualitative data arising from the discussions to create a taxonomy that represents the structure of ethical issues in the Humanities. A key implication of our findings is that while the focus of ethics research and interventions has been primarily on the sciences and engineering, academics and professionals in other fields (...) also encounter some unique critical ethical dilemmas that require further research and methods of intervention. (shrink)

Martin Heidegger is, perhaps, the most controversial philosopher of the twentieth-century. Little has been written on him or about his work and its significance for educational thought. This unique collection by a group of international scholars reexamines Heidegger's work and its legacy for educational thought.

Il faut savoir gré à l’éditeur Gérard Monfort de poursuivre sa politique de traduction d’ouvrages étrangers d’histoire de l’art en publiant le livre de J.F. Hamburger, paru en 1997 aux Presses de l’Université de Californie, sous le titre Nuns as Artits. The Visual Culture of a Medieval Convent. L’objet de ce livre passionnant et novateur, dont il faut souligner également la qualité de la traduction, est un ensemble rare, découvert fortuitement par l’auteur, de dessins coloriés, sur feuilles v...

In lieu of an abstract, here is a brief excerpt of the content:Martin Warner PHILOSOPHICAL POETRY: THE CASE OF FOUR QUARTETS I FOR plato the quarrel between philosophy and poetry was already an ancient one. Since his day strenuous efforts have been made to eliminate it by circumscribing each widiin carefully specified boundaries, on die principle that strong fences make good neighbors, and allowing die one to venture onto the territory of the other only as licensed. Thus until recently assessments (...) of the literary quality of a philosopher's writing have commonly been treated as extraneous to its value as philosophy, and philosophical probing of die thought of a poem as irrelevant to a literary critic's final assessment ofit. For some works, however, such compromises seem forced; Four Quartets is a case in point. Here we have a sustained effort to explore issues of a philosophical and theological nature in poetic terms — in a manner that challenges our understanding and lays claim to our assent. The poetry does not merely encapsulate a theoretical position, but enacts a process ofthought perceived as bearing on diese topics at least as significandy as do those processes commonly termed "philosophical," and diereby raises by implication more general issues concerning die status of those "philosophical" modes themselves. F. R. Leavis is well known both for his engagement with the poetry of T. S. Eliot, and for his insistence on a clear separation between literary criticism and philosophy; dius his raising of philosophical questions as an integral and decisive element in his final and most extensive analysis ofthe Quartets is particularly striking: That Four Quartets offers us thought, searching, basic and rigorous, we have our assurance in the first ten lines of"Burnt Norton".... As thought, it aspires to a general validity.... 222 Martin Warner223 The questions, how must reality be conceived, and what is the nature of the human situation, have been raised in a way diat compels one to determine and verify one's own ultimate beliefs.1 Of course, Leavis is clear that the manner in which die poem raises these questions is not that traditionally associated with philosophy: "The 'music' of Four Quartets challenges a criterion that is not logic, but something equivalent in the field of total meaning. We can only tell what it is by intelligent self-exposure to the poetry" (p. 159). Similarly his mode of"determining " and "verifying" his own beliefs in response is that proper to literary criticism. But the questions are plainly philosophical ones, and one does not need the authority of Leavis to see that the poem raises them. From a philosophical point ofview, the interesting questions are the status of the manner in which it does so and the nature of the "criterion that is not logic" which is said to have an internal relation to that "intelligent selfexposure to the poetry" which Leavis in his critical practice seeks to exemplify. Unfortunately, this late commentary on Eliot's poetry is among the weakest in the Leavis corpus, precisely lacking "intelligent self-exposure to the poetry";2 but this should not lead us to dismiss its more general claims. In earlier and far stronger criticism Leavis had already argued that "Burnt Norton" does "by strictly poetical means the business ofan epistemological and metaphysical inquiry" ("Eliot's Later Poetry," p. 65). Further, die most distinguished recent criticism of Eliot's poetry is probably that of A. D. Moody,3 and he too finds himself driven to place his own "ultimate beliefs" in relation to it. On the one hand, "There is likely to be at least some degree of essential conformity between the way we live now and die way in which the poem would order life; and to that extent the poem can be said to express, and to give a form to, the sensibUity ofits age" (p. 264). But on the other, "It is a neurotic vision, one arising from some disorder or disease of the personality — or of his culture.... It is not easy to attain a detached view of die neurosis which is like a dominant gene in our culture. It is a matter... of the alienation ofman from mat to which he properly, of his nature, belongs — his being cut off from... (shrink)

Mr. F. is a fifty‐year‐old father of two school‐aged daughters. Six years ago, he received a double lung transplant because he was suffering from interstitial lung disease, a fatal illness that causes suffocation by progressive scarring of the lungs. He is now experiencing chronic rejection of the transplant and is being considered to receive another. Without it, he is expected to survive only a year and a half. With it, his prognosis will improve, but the numbers are still not good. (...) Three years after his lung transplant, Mr. F. stopped attending his office visits. For a period of sixteen months he went without the studies and attention essential to posttransplant care. He stopped performing the required daily self‐monitoring of his lung function about eight months after his transplant, but he has maintained a regular exercise regimen. While lost to follow‐up, he continued to take his immunosuppressant medications, but he stopped taking medicine to control his high blood pressure because of its expense. (shrink)

A is for Alice and astronomers arguing about acceleration -- B is for Bernard's body-exchange machine -- C is for the Catholic cannibal -- D is for Maxwell's demon -- E is for evolution (and an embarrassing problem with it) -- F is for the forms lost forever to the prisoners of the cave -- G is for Galileo's gravitational balls -- H is for Hume's shades -- I is for the identity of indiscernibles -- J is for Henri Poincaré (...) and alternative geometries -- K is for the Kritik and Kant's kind of thought experiments -- L is for Lucretius' spear -- M is for Mach's motionless chain -- N is for Newton's bucket -- O is for Olbers' paradox -- P is for Parfit's person -- Q is for the questions raised by thought experiments quotidiennes -- R is for the rule-ruled room -- S is for Salvatius' ship, sailing along its own space-time line -- T is for the time-travelling twins -- U is for the universe, and Einstein's attempts to understand it -- V is for the vexed case of the violinist -- W is for Wittgenstein's beetle -- X is for xenophanes and thinking by examples -- Y is for counterfactuals and a backwards approach to history -- Z is for Zeno and the mysteries of infinity. (shrink)

In Questioning Martin Heidegger, Martin Heidegger’s “Overcoming Metaphysics” provides the jumping-off point for a wide-ranging critique and deconstruction of Western philosophy. This book also addresses Martin Heidegger’s controversial relationship with German National Socialism and the Holocaust, as well as with contemporary philosophers like J. F. Lyotard and Jacques Derrida.

The extant marketing literature provides little guidance for theory development or practice with regard to questions of ethical conformity and the resulting market response. To begin to bridge this research gap, we advance a theoretical framework of ethical conformity in marketing, appealing to marketing ethics, management strategy, and sociological foundations. We set the stage for our theoretical arguments by considering the role of normative expectations related to marketing practices and behaviors held by societal constituents. Against this backdrop, we propose drivers (...) of conformity in marketing, including practices consistent with both overconformity and underconformity. The framework allows us to advance testable research propositions by which questions of ethical conformity may be explored. We conclude by suggesting additional future research needed to develop the domain, specifically in the form of empirical inquiries uncovering firm strategic decisions with ethical implications. (shrink)

In this paper, the authors respond to a recent critique of their Journal of Business Ethics article, which provided a meta- analytic review of ethical climate theory research. They review basic principles of meta- analytic research and discuss the methodological context of their work, which was not discussed in the recent reply article. Additional methodological and practical evidence is presented in support of Martin and Cullen, including a discussion of the paper’s findings and its contribution to ethical climate theory and (...) research. (shrink)

We prove that a form of the $Erd\H{o}s$ property (consistent with $V = L\lbrack H_{\omega_2}\rbrack$ and strictly weaker than the Weak Chang's Conjecture at ω1), together with Bounded Martin's Maximum implies that Woodin's principle $\psi_{AC}$ holds, and therefore 2ℵ0 = ℵ2. We also prove that $\psi_{AC}$ implies that every function $f: \omega_1 \rightarrow \omega_1$ is bounded by some canonical function on a club and use this to produce a model of the Bounded Semiproper Forcing Axiom in which Bounded Martin's Maximum (...) fails. (shrink)

In Chapters 6 and 7 of Language, Truth and Poetry I attempted to solve the ancient problem of fictional reference by claiming that a fictional construct ‘points’ or refers to certain features of reality in rather the same way as an abstraction like ‘gravitation’ or ‘cruelty’ does. I now believe that this theory of mine is unsatisfactory; and I should like to propose a new solution to the problem.