Journal of Law, Medicine and Ethics 40 (4):716-750 (2012)

Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products, implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. Nanotherapeutics and in vivo nanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents.
Keywords No keywords specified (fix it)
Categories (categorize this paper)
DOI 10.1111/j.1748-720x.2012.00703.x
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

PhilArchive copy

Upload a copy of this paper     Check publisher's policy     Papers currently archived: 68,916
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library

References found in this work BETA

Limits to Research Risks.F. G. Miller & S. Joffe - 2009 - Journal of Medical Ethics 35 (7):445-449.

View all 16 references / Add more references

Citations of this work BETA

Nanomedicine First-in-Human Research: Challenges for Informed Consent.Nancy M. P. King - 2012 - Journal of Law, Medicine and Ethics 40 (4):823-830.
Concepts of Risk in Nanomedicine Research.Linda F. Hogle - 2012 - Journal of Law, Medicine and Ethics 40 (4):809-822.
Concepts of Risk in Nanomedicine Research.Linda F. Hogle - 2012 - Journal of Law, Medicine and Ethics 40 (4):809-822.

View all 8 citations / Add more citations

Similar books and articles

Gene Therapy Oversight: Lessons for Nanobiotechnology.Susan M. Wolf, Rishi Gupta & Peter Kohlhepp - 2009 - Journal of Law, Medicine and Ethics 37 (4):659-684.
Revolution or Reform in Human Subjects Research Oversight.Steven Joffe - 2012 - Journal of Law, Medicine and Ethics 40 (4):922-929.
New Rules for Research with Human Participants?Jessica Berg & Nicole Deming - 2011 - Hastings Center Report 41 (6):10-11.


Added to PP index

Total views
76 ( #150,137 of 2,497,803 )

Recent downloads (6 months)
3 ( #212,593 of 2,497,803 )

How can I increase my downloads?


My notes